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True Thymic Hyperplasia

MedGen UID:
237024
•Concept ID:
C1336828
•
Disease or Syndrome

Definition

An increase in gross volume and weight of the thymus gland, with maintenance of normal lobular architecture, and preservation of corticomedullary differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrue Thymic Hyperplasia

Professional guidelines

PubMed

Thymic Hyperplasia Associated with Graves' Disease: Pathophysiology and Proposed Management Algorithm.
Haider U, Richards P, Gianoukakis AG
Thyroid 2017 Aug;27(8):994-1000. Epub 2017 Jul 7 doi: 10.1089/thy.2017.0086. PMID: 28578595

Recent clinical studies

Etiology

Benign lesions of the mediastinum.
Gerber TS, Porubsky S
Histopathology 2024 Jan;84(1):183-195. Epub 2023 Nov 21 doi: 10.1111/his.15088. PMID: 37988262
Thymic Hyperplasia Associated with Graves' Disease: Pathophysiology and Proposed Management Algorithm.
Haider U, Richards P, Gianoukakis AG
Thyroid 2017 Aug;27(8):994-1000. Epub 2017 Jul 7 doi: 10.1089/thy.2017.0086. PMID: 28578595
True thymic hyperplasia versus follicular thymic hyperplasia: a retrospective analysis of 13 cases.
Mlika M, Ayadi-Kaddour A, Marghli A, Ismail O, Kilani T, El Mezni F
Pathologica 2009 Oct;101(5):175-9. PMID: 20218057
Thymic enlargement in a patient with juvenile idiopathic arthritis during etanercept therapy.
Sari I, Binicier O, Birlik M, Akar S, Yilmaz E, Kargi A, Onen F, Akkoc N
Rheumatol Int 2009 Mar;29(5):591-3. Epub 2008 Sep 23 doi: 10.1007/s00296-008-0726-1. PMID: 18810448
Difficult diagnostic and therapeutic cases: CASE 1. true thymic hyperplasia in a patient treated for T-cell lymphoma.
Ascani S, Went P, Liberati AM, Piccaluga PP, Zinzani PL, Pileri SA
J Clin Oncol 2004 Mar 1;22(5):953-4. doi: 10.1200/JCO.2004.03.198. PMID: 14990652

Diagnosis

Benign lesions of the mediastinum.
Gerber TS, Porubsky S
Histopathology 2024 Jan;84(1):183-195. Epub 2023 Nov 21 doi: 10.1111/his.15088. PMID: 37988262
Thymic Parenchymal Hyperplasia.
Suster D, Ronen N, Pierce DC, Suster S
Mod Pathol 2023 Aug;36(8):100207. Epub 2023 May 5 doi: 10.1016/j.modpat.2023.100207. PMID: 37149223
Massive true thymic hyperplasia in a 3-month-old infant: case report and literature review.
Yang M, Zeng L, Ji Y, Xiang B, Xu ZC
Turk J Pediatr 2021;63(4):721-726. doi: 10.24953/turkjped.2021.04.022. PMID: 34449157
Thymic Hyperplasia Associated with Graves' Disease: Pathophysiology and Proposed Management Algorithm.
Haider U, Richards P, Gianoukakis AG
Thyroid 2017 Aug;27(8):994-1000. Epub 2017 Jul 7 doi: 10.1089/thy.2017.0086. PMID: 28578595
Tumors of the thymus.
Strollo DC, Rosado-de-Christenson ML
J Thorac Imaging 1999 Jul;14(3):152-71. doi: 10.1097/00005382-199907000-00002. PMID: 10404501

Therapy

True thymic hyperplasia causing pure red cell aplasia: a case report.
Mohammad A, Dawson AG, Bajaj A, Rathinam S
Interact Cardiovasc Thorac Surg 2022 Mar 31;34(4):697-699. doi: 10.1093/icvts/ivab301. PMID: 34791240Free PMC Article
Thymic hyperplasia following double immune checkpoint inhibitor therapy in two patients with stage IV melanoma.
Mencel J, Gargett T, Karanth N, Pokorny A, Brown MP, Charakidis M
Asia Pac J Clin Oncol 2019 Dec;15(6):383-386. Epub 2019 Aug 1 doi: 10.1111/ajco.13233. PMID: 31373116
Thymic Hyperplasia Associated with Graves' Disease: Pathophysiology and Proposed Management Algorithm.
Haider U, Richards P, Gianoukakis AG
Thyroid 2017 Aug;27(8):994-1000. Epub 2017 Jul 7 doi: 10.1089/thy.2017.0086. PMID: 28578595
Difficult diagnostic and therapeutic cases: CASE 1. true thymic hyperplasia in a patient treated for T-cell lymphoma.
Ascani S, Went P, Liberati AM, Piccaluga PP, Zinzani PL, Pileri SA
J Clin Oncol 2004 Mar 1;22(5):953-4. doi: 10.1200/JCO.2004.03.198. PMID: 14990652
Thymic hyperplasia following successful chemotherapy. A report of two cases and review of the literature.
Carmosino L, DiBenedetto A, Feffer S
Cancer 1985 Oct 1;56(7):1526-8. doi: 10.1002/1097-0142(19851001)56:7<1526::aid-cncr2820560709>3.0.co;2-x. PMID: 4027888

Prognosis

Massive true thymic hyperplasia in a 3-month-old infant: case report and literature review.
Yang M, Zeng L, Ji Y, Xiang B, Xu ZC
Turk J Pediatr 2021;63(4):721-726. doi: 10.24953/turkjped.2021.04.022. PMID: 34449157
Thymic Hyperplasia Associated with Graves' Disease: Pathophysiology and Proposed Management Algorithm.
Haider U, Richards P, Gianoukakis AG
Thyroid 2017 Aug;27(8):994-1000. Epub 2017 Jul 7 doi: 10.1089/thy.2017.0086. PMID: 28578595
Tumors of the thymus.
Strollo DC, Rosado-de-Christenson ML
J Thorac Imaging 1999 Jul;14(3):152-71. doi: 10.1097/00005382-199907000-00002. PMID: 10404501
Massive thymic hyperplasia.
Linegar AG, Odell JA, Fennell WM, Close PM, De Groot MK, Casserly DR, Perold JI
Ann Thorac Surg 1993 May;55(5):1197-201. doi: 10.1016/0003-4975(93)90033-e. PMID: 8494431
Thymic hyperplasia. I. True thymic hyperplasia. Review of the literature.
Hofmann WJ, Möller P, Otto HF
Klin Wochenschr 1987 Jan 15;65(2):49-52. doi: 10.1007/BF01745472. PMID: 3560787

Clinical prediction guides

A rare association between true thymic hyperplasia and thyroid follicular tumor: a case report.
Kiwaki T, Tanaka H, Akiyama Y, Akaki M, Tomita M, Kataoka H
J Med Case Rep 2020 Jan 15;14(1):9. doi: 10.1186/s13256-019-2332-0. PMID: 31937367Free PMC Article
True thymic hyperplasia associated with thymic hemorrhage in an adult patient.
Pilozzi E, Del Prete F, De Dominicis C, Rendina EA, Ruco LP
Pathol Res Pract 2010 May 15;206(5):331-3. Epub 2009 Jul 28 doi: 10.1016/j.prp.2009.06.017. PMID: 19640657
True thymic hyperplasia versus follicular thymic hyperplasia: a retrospective analysis of 13 cases.
Mlika M, Ayadi-Kaddour A, Marghli A, Ismail O, Kilani T, El Mezni F
Pathologica 2009 Oct;101(5):175-9. PMID: 20218057
Atrio-ventricular nodal tumor associated with polyendocrine anomalies.
Declich P, Sironi M, Isimbaldi G, Bana R
Pathol Res Pract 1996 Jan;192(1):54-9; discussion 60-1. doi: 10.1016/S0344-0338(96)80130-0. PMID: 8685042
Myoid cell differentiation in true thymic hyperplasia and lymphoid hyperplasia.
Judd RL, Welch SL
Arch Pathol Lab Med 1988 Nov;112(11):1140-4. PMID: 3178429

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