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Tanycytic ependymoma

MedGen UID:
237159
•Concept ID:
C1370500
•
Neoplastic Process
Synonyms: Ependymoma, tanycytic; Tanycytic Ependymoma; tanycytic ependymoma
SNOMED CT: Tanycytic ependymoma (397378002); Ependymoma, tanycytic (397378002)
 
Monarch Initiative: MONDO:0003474

Definition

A variant of ependymoma, often found in the spinal cord, with tumor cells arranged in fascicles of variable width and cell density. Ependymal rosettes are generally absent, so this lesion must be distinguished from astrocytic neoplasms, but its EM characteristics are ependymal. (Adapted from WHO.) [from NCI]

Recent clinical studies

Etiology

Molecular characterization of histopathological ependymoma variants.
Neumann JE, Spohn M, Obrecht D, Mynarek M, Thomas C, Hasselblatt M, Dorostkar MM, Wefers AK, Frank S, Monoranu CM, Koch A, Witt H, Kool M, Pajtler KW, Rutkowski S, Glatzel M, Schüller U
Acta Neuropathol 2020 Feb;139(2):305-318. Epub 2019 Nov 2 doi: 10.1007/s00401-019-02090-0. PMID: 31679042
The clinical features and surgical outcomes of intracranial tanycytic ependymomas: a single-institutional experience.
Tao X, Dong J, Hou Z, Hao S, Zhang Q, Wu Z, Zhang J, Liu B
J Neurooncol 2017 Sep;134(2):339-347. Epub 2017 Jun 26 doi: 10.1007/s11060-017-2531-8. PMID: 28653235
The Clinical Features and Surgical Outcomes of Spinal Cord Tanycytic Ependymomas: A Report of 40 Cases.
Tao X, Hou Z, Hao S, Zhang Q, Wu Z, Zhang J, Liu B
World Neurosurg 2017 Oct;106:60-73. Epub 2017 Jun 21 doi: 10.1016/j.wneu.2017.06.111. PMID: 28647654
Tanycytic ependymoma of the filum terminale associated with multiple endocrine neoplasia type 1: first reported case.
Funayama T, Sakane M, Yoshizawa T, Takeuchi Y, Ochiai N
Spine J 2013 Aug;13(8):e49-54. Epub 2013 Apr 3 doi: 10.1016/j.spinee.2013.02.066. PMID: 23562332
Cyst with a mural nodule tumor of the brain.
Raz E, Zagzag D, Saba L, Mannelli L, Di Paolo PL, D'Ambrosio F, Knopp E
Cancer Imaging 2012 Aug 10;12(1):237-44. doi: 10.1102/1470-7330.2012.0028. PMID: 22935908Free PMC Article

Diagnosis

Tanycytic ependymoma: highlighting challenges in radio-pathological diagnosis.
Jain P, Saran RK, Singh D, Jagetia A, Srivastava AK, Singh H
Indian J Pathol Microbiol 2021 Oct-Dec;64(4):633-637. doi: 10.4103/IJPM.IJPM_1049_20. PMID: 34673578
Molecular characterization of histopathological ependymoma variants.
Neumann JE, Spohn M, Obrecht D, Mynarek M, Thomas C, Hasselblatt M, Dorostkar MM, Wefers AK, Frank S, Monoranu CM, Koch A, Witt H, Kool M, Pajtler KW, Rutkowski S, Glatzel M, Schüller U
Acta Neuropathol 2020 Feb;139(2):305-318. Epub 2019 Nov 2 doi: 10.1007/s00401-019-02090-0. PMID: 31679042
Tanycytic ependymoma of the brain stem, presentations of rare cystic disease variants and review of literature.
Kasper EM, Ippen FM, Maragkos GA, Anderson MP, Rojas R, Mahadevan A
J Neurosurg Sci 2018 Feb;62(1):78-88. Epub 2017 Sep 7 doi: 10.23736/S0390-5616.17.04194-7. PMID: 28884561
Features of intraventricular tanycytic ependymoma: report of a case and review of literature.
Agarwal S, Stevenson ME, Sughrue ME, Wartchow EP, Mierau GW, Fung KM
Int J Clin Exp Pathol 2014;7(6):3399-407. Epub 2014 May 15 PMID: 25031767Free PMC Article
Tanycytic ependymoma.
Langford LA, Barré GM
Ultrastruct Pathol 1997 Mar-Apr;21(2):135-42. doi: 10.3109/01913129709021312. PMID: 9090024

Prognosis

Molecular characterization of histopathological ependymoma variants.
Neumann JE, Spohn M, Obrecht D, Mynarek M, Thomas C, Hasselblatt M, Dorostkar MM, Wefers AK, Frank S, Monoranu CM, Koch A, Witt H, Kool M, Pajtler KW, Rutkowski S, Glatzel M, Schüller U
Acta Neuropathol 2020 Feb;139(2):305-318. Epub 2019 Nov 2 doi: 10.1007/s00401-019-02090-0. PMID: 31679042
The clinical features and surgical outcomes of intracranial tanycytic ependymomas: a single-institutional experience.
Tao X, Dong J, Hou Z, Hao S, Zhang Q, Wu Z, Zhang J, Liu B
J Neurooncol 2017 Sep;134(2):339-347. Epub 2017 Jun 26 doi: 10.1007/s11060-017-2531-8. PMID: 28653235
Cerebellar ependymoma with overlapping features of clear-cell and tanycytic variants mimicking hemangioblastoma: a case report and literature review.
Zhang XP, Liu Y, Zhang D, Zheng Q, Wang C, Wang L, Li QC, Qiu XS, Wang EH
Diagn Pathol 2017 Mar 20;12(1):28. doi: 10.1186/s13000-017-0619-2. PMID: 28320419Free PMC Article
Intraventricular tanycytic ependymoma: case report and review of the literature.
Ragel BT, Townsend JJ, Arthur AS, Couldwell WT
J Neurooncol 2005 Jan;71(2):189-93. doi: 10.1007/s11060-004-1371-5. PMID: 15690137
Tanycytic ependymoma of the spinal cord. Case report and review of the literature.
Boccardo M, Telera S, Vitali A
Neurochirurgie 2003 Dec;49(6):605-10. PMID: 14735006

Clinical prediction guides

The Clinical Features and Surgical Outcomes of Spinal Cord Tanycytic Ependymomas: A Report of 40 Cases.
Tao X, Hou Z, Hao S, Zhang Q, Wu Z, Zhang J, Liu B
World Neurosurg 2017 Oct;106:60-73. Epub 2017 Jun 21 doi: 10.1016/j.wneu.2017.06.111. PMID: 28647654
Cerebellar ependymoma with overlapping features of clear-cell and tanycytic variants mimicking hemangioblastoma: a case report and literature review.
Zhang XP, Liu Y, Zhang D, Zheng Q, Wang C, Wang L, Li QC, Qiu XS, Wang EH
Diagn Pathol 2017 Mar 20;12(1):28. doi: 10.1186/s13000-017-0619-2. PMID: 28320419Free PMC Article
Imaging features of spinal tanycytic ependymoma.
Tomek M, Jayajothi A, Brandner S, Jaunmuktane Z, Lee CH, Davagnanam I
Neuroradiol J 2016 Feb;29(1):61-5. Epub 2016 Jan 11 doi: 10.1177/1971400915621322. PMID: 26755489Free PMC Article
The WHO classification of tumors of the nervous system.
Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, Cavenee WK
J Neuropathol Exp Neurol 2002 Mar;61(3):215-25; discussion 226-9. doi: 10.1093/jnen/61.3.215. PMID: 11895036
Spinal tanycytic ependymomas.
Kawano N, Yagishita S, Oka H, Utsuki S, Kobayashi I, Suzuki S, Tachibana S, Fujii K
Acta Neuropathol 2001 Jan;101(1):43-8. doi: 10.1007/s004010000265. PMID: 11194940

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