U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pleural mesothelioma

MedGen UID:
237179
Concept ID:
C1377913
Neoplastic Process
Synonyms: mesothelioma of pleura; mesothelioma of the pleura; pleura mesothelioma; pleural mesothelioma; pleural mesothelioma (disease)
 
Monarch Initiative: MONDO:0003308

Definition

A neoplasm that arises from the mesothelial cells of the pleura. The primary cause is exposure to asbestos. The major histologic variants are the epithelioid malignant mesothelioma, desmoplastic malignant mesothelioma, and sarcomatoid malignant mesothelioma. Patients present with persistent cough and shortness of breath. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleural mesothelioma

Professional guidelines

PubMed

Janes SM, Alrifai D, Fennell DA
N Engl J Med 2021 Sep 23;385(13):1207-1218. doi: 10.1056/NEJMra1912719. PMID: 34551230
Asciak R, George V, Rahman NM
Eur Respir Rev 2021 Mar 31;30(159) Epub 2021 Jan 19 doi: 10.1183/16000617.0226-2020. PMID: 33472960Free PMC Article
Scherpereel A, Opitz I, Berghmans T, Psallidas I, Glatzer M, Rigau D, Astoul P, Bölükbas S, Boyd J, Coolen J, De Bondt C, De Ruysscher D, Durieux V, Faivre-Finn C, Fennell D, Galateau-Salle F, Greillier L, Hoda MA, Klepetko W, Lacourt A, McElnay P, Maskell NA, Mutti L, Pairon JC, Van Schil P, van Meerbeeck JP, Waller D, Weder W, Cardillo G, Putora PM
Eur Respir J 2020 Jun;55(6) Epub 2020 Jun 11 doi: 10.1183/13993003.00953-2019. PMID: 32451346

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Mesothelioma: Pleural, 2022

Recent clinical studies

Etiology

Chun CP, Song LX, Zhang HP, Guo DD, Xu GX, Li Y, Xin X, Cao J, Li F
Am J Med Sci 2023 Jan;365(1):99-103. Epub 2022 Aug 6 doi: 10.1016/j.amjms.2022.07.008. PMID: 35940275
Dacic S
Mod Pathol 2022 Jan;35(Suppl 1):51-56. Epub 2021 Aug 31 doi: 10.1038/s41379-021-00895-7. PMID: 34465883
Strange CD, Shroff GS, Ahuja J, Vlahos I, Benveniste MFK, Truong MT
Semin Ultrasound CT MR 2021 Dec;42(6):542-551. Epub 2021 May 8 doi: 10.1053/j.sult.2021.04.011. PMID: 34895610
Sinn K, Mosleh B, Hoda MA
Curr Opin Oncol 2021 Jan;33(1):80-86. doi: 10.1097/CCO.0000000000000697. PMID: 33186182
Ascoli V, Murer B, Nottegar A, Luchini C, Carella R, Calabrese F, Lunardi F, Cozzi I, Righi L
Pathologica 2018 Mar;110(1):12-28. PMID: 30259910

Diagnosis

Chun CP, Song LX, Zhang HP, Guo DD, Xu GX, Li Y, Xin X, Cao J, Li F
Am J Med Sci 2023 Jan;365(1):99-103. Epub 2022 Aug 6 doi: 10.1016/j.amjms.2022.07.008. PMID: 35940275
Ascoli V, Murer B, Nottegar A, Luchini C, Carella R, Calabrese F, Lunardi F, Cozzi I, Righi L
Pathologica 2018 Mar;110(1):12-28. PMID: 30259910
Anevlavis S, Froudarakis ME
Clin Respir J 2018 Mar;12(3):839-847. Epub 2017 Jan 11 doi: 10.1111/crj.12597. PMID: 27997741
Klepetko W
Wien Klin Wochenschr 2016 Sep;128(17-18):609-10. doi: 10.1007/s00508-016-1039-0. PMID: 27457871
Rodríguez Panadero F
Arch Bronconeumol 2015 Apr;51(4):177-84. Epub 2014 Jul 22 doi: 10.1016/j.arbres.2014.06.005. PMID: 25059587

Therapy

Peters S, Scherpereel A, Cornelissen R, Oulkhouir Y, Greillier L, Kaplan MA, Talbot T, Monnet I, Hiret S, Baas P, Nowak AK, Fujimoto N, Tsao AS, Mansfield AS, Popat S, Zhang X, Hu N, Balli D, Spires T, Zalcman G
Ann Oncol 2022 May;33(5):488-499. Epub 2022 Feb 3 doi: 10.1016/j.annonc.2022.01.074. PMID: 35124183
Baas P, Scherpereel A, Nowak AK, Fujimoto N, Peters S, Tsao AS, Mansfield AS, Popat S, Jahan T, Antonia S, Oulkhouir Y, Bautista Y, Cornelissen R, Greillier L, Grossi F, Kowalski D, Rodríguez-Cid J, Aanur P, Oukessou A, Baudelet C, Zalcman G
Lancet 2021 Jan 30;397(10272):375-386. Epub 2021 Jan 21 doi: 10.1016/S0140-6736(20)32714-8. PMID: 33485464
Sinn K, Mosleh B, Hoda MA
Curr Opin Oncol 2021 Jan;33(1):80-86. doi: 10.1097/CCO.0000000000000697. PMID: 33186182
Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-1414. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. PMID: 26719230
Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, Gatzemeier U, Boyer M, Emri S, Manegold C, Niyikiza C, Paoletti P
J Clin Oncol 2003 Jul 15;21(14):2636-44. doi: 10.1200/JCO.2003.11.136. PMID: 12860938

Prognosis

The Lancet Respiratory Medicine
Lancet Respir Med 2019 Feb;7(2):99. Epub 2019 Jan 16 doi: 10.1016/S2213-2600(19)30004-9. PMID: 30660508
Mencoboni M, Filiberti RA, Taveggia P, Grosso F, Pasello G, Del Corso L, Muzio A, Polo V, Zucali P, Ceresoli GL, Soto Parra HJ, Auriati L, Simonassi C
Oncol Res Treat 2017;40(6):364-369. Epub 2017 May 9 doi: 10.1159/000464410. PMID: 28472807
Chen SE, Pace MB
Am J Health Syst Pharm 2012 Mar 1;69(5):377-85. doi: 10.2146/ajhp110281. PMID: 22345416
Vigneswaran WT, Stefanacci PR
Curr Treat Options Oncol 2000 Oct;1(4):299-302. doi: 10.1007/s11864-000-0045-6. PMID: 12057155
Astoul P
Curr Opin Pulm Med 1999 Jul;5(4):259-68. doi: 10.1097/00063198-199907000-00015. PMID: 10407698

Clinical prediction guides

Chun CP, Song LX, Zhang HP, Guo DD, Xu GX, Li Y, Xin X, Cao J, Li F
Am J Med Sci 2023 Jan;365(1):99-103. Epub 2022 Aug 6 doi: 10.1016/j.amjms.2022.07.008. PMID: 35940275
Ascoli V, Murer B, Nottegar A, Luchini C, Carella R, Calabrese F, Lunardi F, Cozzi I, Righi L
Pathologica 2018 Mar;110(1):12-28. PMID: 30259910
Anevlavis S, Froudarakis ME
Clin Respir J 2018 Mar;12(3):839-847. Epub 2017 Jan 11 doi: 10.1111/crj.12597. PMID: 27997741
Mencoboni M, Filiberti RA, Taveggia P, Grosso F, Pasello G, Del Corso L, Muzio A, Polo V, Zucali P, Ceresoli GL, Soto Parra HJ, Auriati L, Simonassi C
Oncol Res Treat 2017;40(6):364-369. Epub 2017 May 9 doi: 10.1159/000464410. PMID: 28472807
Bibby AC, Tsim S, Kanellakis N, Ball H, Talbot DC, Blyth KG, Maskell NA, Psallidas I
Eur Respir Rev 2016 Dec;25(142):472-486. doi: 10.1183/16000617.0063-2016. PMID: 27903668Free PMC Article

Recent systematic reviews

Hung YP, Chirieac LR
Thorac Surg Clin 2020 Nov;30(4):367-382. doi: 10.1016/j.thorsurg.2020.08.007. PMID: 33012427
Scherpereel A, Opitz I, Berghmans T, Psallidas I, Glatzer M, Rigau D, Astoul P, Bölükbas S, Boyd J, Coolen J, De Bondt C, De Ruysscher D, Durieux V, Faivre-Finn C, Fennell D, Galateau-Salle F, Greillier L, Hoda MA, Klepetko W, Lacourt A, McElnay P, Maskell NA, Mutti L, Pairon JC, Van Schil P, van Meerbeeck JP, Waller D, Weder W, Cardillo G, Putora PM
Eur Respir J 2020 Jun;55(6) Epub 2020 Jun 11 doi: 10.1183/13993003.00953-2019. PMID: 32451346
Faccioli E, Bellini A, Mammana M, Monaci N, Schiavon M, Rea F
Expert Rev Respir Med 2020 Jan;14(1):67-79. Epub 2019 Nov 13 doi: 10.1080/17476348.2020.1688147. PMID: 31674841
Arnold DT, De Fonseka D, Hamilton FW, Rahman NM, Maskell NA
Br J Cancer 2017 Mar 14;116(6):731-741. Epub 2017 Feb 7 doi: 10.1038/bjc.2017.22. PMID: 28170372Free PMC Article
Ren R, Yin P, Zhang Y, Zhou J, Zhou Y, Xu R, Lin H, Huang C
Oncotarget 2016 Dec 20;7(51):84851-84859. doi: 10.18632/oncotarget.12707. PMID: 27769044Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2022
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Mesothelioma: Pleural, 2022

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...