U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Low Grade Prostatic Intraepithelial Neoplasia

MedGen UID:
257910
•Concept ID:
C1168328
•
Neoplastic Process
Synonyms: Grade 1 Prostatic Intraepithelial Neoplasia; Grade I Prostatic Intraepithelial Neoplasia; Low grade prostatic intraepithelial neoplasia; Low-Grade Intraepithelial Neoplasia of Prostate; Low-Grade Intraepithelial Neoplasia of the Prostate; Low-Grade PIN; Low-Grade Prostatic Intraepithelial Neoplasia
SNOMED CT: Low grade prostatic intraepithelial neoplasia (446710005)

Definition

Prostatic intraepithelial neoplasia characterized by the proliferation of secretory cells with irregular spacing in the ducts and acini. Although some proliferating epithelial cells may contain prominent nucleoli, the cytologic atypia and architectural growth patterns that are seen in the high grade prostatic intraepithelial neoplasia are absent. The presence of low grade prostatic intraepithelial neoplasia in needle biopsy is not a risk factor for the subsequent detection of carcinoma on repeat biopsy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow Grade Prostatic Intraepithelial Neoplasia

Professional guidelines

PubMed

The current recommendation for the management of isolated high-grade prostatic intraepithelial neoplasia.
Morote J, Schwartzmann I, Celma A, Roche S, de Torres IM, Mast R, Semidey ME, Regis L, Santamaria A, Planas J, Trilla E
BJU Int 2022 May;129(5):627-633. Epub 2021 Aug 25 doi: 10.1111/bju.15568. PMID: 34375498
Differential Diagnosis of Intraductal Lesions of the Prostate.
Wobker SE, Epstein JI
Am J Surg Pathol 2016 Jun;40(6):e67-82. doi: 10.1097/PAS.0000000000000609. PMID: 26848801
Pseudohyperplastic prostate carcinoma: histologic patterns and differential diagnosis.
Arista-Nasr J, Martínez-Benítez B, Aguilar-Ayala EL, Aleman-Sanchez CN, Bornstein-Quevedo L, Albores-Saavedra J
Ann Diagn Pathol 2015 Aug;19(4):253-60. Epub 2015 May 22 doi: 10.1016/j.anndiagpath.2015.04.009. PMID: 26101154

Recent clinical studies

Etiology

Long exposure to a mixture of endocrine disruptors prediposes the ventral prostate of rats to preneoplastic lesions.
Sousa TC, de Souza LP, Ricardo MLS, Yoshigae AY, Hinokuma KD, Gorzoni ABR, de Aquino AM, Scarano WR, de Sousa Castillho AC, Tavares MEA, Veras ASC, Teixeira GR, Nai GA, de Oliveira Mendes L
Environ Sci Pollut Res Int 2023 Oct;30(47):104015-104028. Epub 2023 Sep 11 doi: 10.1007/s11356-023-29768-z. PMID: 37697193
Evaluation of global DNA hypomethylation in human prostate cancer and prostatic intraepithelial neoplasm tissues by immunohistochemistry.
Yang B, Sun H, Lin W, Hou W, Li H, Zhang L, Li F, Gu Y, Song Y, Li Q, Zhang F
Urol Oncol 2013 Jul;31(5):628-34. Epub 2011 Jun 25 doi: 10.1016/j.urolonc.2011.05.009. PMID: 21704537
Is low-grade prostatic intraepithelial neoplasia a risk factor for cancer?
Goeman L, Joniau S, Ponette D, Van der Aa F, Roskams T, Oyen R, Van Poppel H
Prostate Cancer Prostatic Dis 2003;6(4):305-10. doi: 10.1038/sj.pcan.4500681. PMID: 14663472
Cell proliferation, apoptosis, oncogene, and tumor suppressor gene status in adenosis with comparison to benign prostatic hyperplasia, prostatic intraepithelial neoplasia, and cancer.
Häussler O, Epstein JI, Amin MB, Heitz PU, Hailemariam S
Hum Pathol 1999 Sep;30(9):1077-86. doi: 10.1016/s0046-8177(99)90226-5. PMID: 10492043
Prostatic intraepithelial neoplasia: influence of clinical and pathological data on the detection of prostate cancer.
Raviv G, Janssen T, Zlotta AR, Descamps F, Verhest A, Schulman CC
J Urol 1996 Sep;156(3):1050-4; discussion 1054-5. doi: 10.1016/s0022-5347(01)65699-4. PMID: 8709305

Diagnosis

Evaluation of global DNA hypomethylation in human prostate cancer and prostatic intraepithelial neoplasm tissues by immunohistochemistry.
Yang B, Sun H, Lin W, Hou W, Li H, Zhang L, Li F, Gu Y, Song Y, Li Q, Zhang F
Urol Oncol 2013 Jul;31(5):628-34. Epub 2011 Jun 25 doi: 10.1016/j.urolonc.2011.05.009. PMID: 21704537
Mechanisms of disease: high-grade prostatic intraepithelial neoplasia and other proposed preneoplastic lesions in the prostate.
Montironi R, Mazzucchelli R, Lopez-Beltran A, Cheng L, Scarpelli M
Nat Clin Pract Urol 2007 Jun;4(6):321-32. doi: 10.1038/ncpuro0815. PMID: 17551536
Epigenetic events, remodelling enzymes and their relationship to chromatin organization in prostatic intraepithelial neoplasia and prostatic adenocarcinoma.
Mohamed MA, Greif PA, Diamond J, Sharaf O, Maxwell P, Montironi R, Young RA, Hamilton PW
BJU Int 2007 Apr;99(4):908-15. doi: 10.1111/j.1464-410X.2006.06704.x. PMID: 17378849
Is low-grade prostatic intraepithelial neoplasia a risk factor for cancer?
Goeman L, Joniau S, Ponette D, Van der Aa F, Roskams T, Oyen R, Van Poppel H
Prostate Cancer Prostatic Dis 2003;6(4):305-10. doi: 10.1038/sj.pcan.4500681. PMID: 14663472
Prostatic intraepithelial neoplasia: influence of clinical and pathological data on the detection of prostate cancer.
Raviv G, Janssen T, Zlotta AR, Descamps F, Verhest A, Schulman CC
J Urol 1996 Sep;156(3):1050-4; discussion 1054-5. doi: 10.1016/s0022-5347(01)65699-4. PMID: 8709305

Therapy

Long exposure to a mixture of endocrine disruptors prediposes the ventral prostate of rats to preneoplastic lesions.
Sousa TC, de Souza LP, Ricardo MLS, Yoshigae AY, Hinokuma KD, Gorzoni ABR, de Aquino AM, Scarano WR, de Sousa Castillho AC, Tavares MEA, Veras ASC, Teixeira GR, Nai GA, de Oliveira Mendes L
Environ Sci Pollut Res Int 2023 Oct;30(47):104015-104028. Epub 2023 Sep 11 doi: 10.1007/s11356-023-29768-z. PMID: 37697193
Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice.
Li G, Wang H, Liu AB, Cheung C, Reuhl KR, Bosland MC, Yang CS
Cancer Prev Res (Phila) 2012 Jul;5(7):963-72. Epub 2012 May 11 doi: 10.1158/1940-6207.CAPR-12-0023. PMID: 22581815Free PMC Article
The pace of prostatic intraepithelial neoplasia development is determined by the timing of Pten tumor suppressor gene excision.
Luchman HA, Benediktsson H, Villemaire ML, Peterson AC, Jirik FR
PLoS One 2008;3(12):e3940. Epub 2008 Dec 15 doi: 10.1371/journal.pone.0003940. PMID: 19081794Free PMC Article
Alteration of proliferation and apoptotic markers in normal and premalignant tissue associated with prostate cancer.
Ananthanarayanan V, Deaton RJ, Yang XJ, Pins MR, Gann PH
BMC Cancer 2006 Mar 17;6:73. doi: 10.1186/1471-2407-6-73. PMID: 16545117Free PMC Article
Is low-grade prostatic intraepithelial neoplasia a risk factor for cancer?
Goeman L, Joniau S, Ponette D, Van der Aa F, Roskams T, Oyen R, Van Poppel H
Prostate Cancer Prostatic Dis 2003;6(4):305-10. doi: 10.1038/sj.pcan.4500681. PMID: 14663472

Prognosis

Evaluation of global DNA hypomethylation in human prostate cancer and prostatic intraepithelial neoplasm tissues by immunohistochemistry.
Yang B, Sun H, Lin W, Hou W, Li H, Zhang L, Li F, Gu Y, Song Y, Li Q, Zhang F
Urol Oncol 2013 Jul;31(5):628-34. Epub 2011 Jun 25 doi: 10.1016/j.urolonc.2011.05.009. PMID: 21704537
Mechanisms of disease: high-grade prostatic intraepithelial neoplasia and other proposed preneoplastic lesions in the prostate.
Montironi R, Mazzucchelli R, Lopez-Beltran A, Cheng L, Scarpelli M
Nat Clin Pract Urol 2007 Jun;4(6):321-32. doi: 10.1038/ncpuro0815. PMID: 17551536
Aberrant neuropeptide Y and macrophage inhibitory cytokine-1 expression are early events in prostate cancer development and are associated with poor prognosis.
Rasiah KK, Kench JG, Gardiner-Garden M, Biankin AV, Golovsky D, Brenner PC, Kooner R, O'neill GF, Turner JJ, Delprado W, Lee CS, Brown DA, Breit SN, Grygiel JJ, Horvath LG, Stricker PD, Sutherland RL, Henshall SM
Cancer Epidemiol Biomarkers Prev 2006 Apr;15(4):711-6. doi: 10.1158/1055-9965.EPI-05-0752. PMID: 16614113
Is low-grade prostatic intraepithelial neoplasia a risk factor for cancer?
Goeman L, Joniau S, Ponette D, Van der Aa F, Roskams T, Oyen R, Van Poppel H
Prostate Cancer Prostatic Dis 2003;6(4):305-10. doi: 10.1038/sj.pcan.4500681. PMID: 14663472
Prostatic intraepithelial neoplasia: influence of clinical and pathological data on the detection of prostate cancer.
Raviv G, Janssen T, Zlotta AR, Descamps F, Verhest A, Schulman CC
J Urol 1996 Sep;156(3):1050-4; discussion 1054-5. doi: 10.1016/s0022-5347(01)65699-4. PMID: 8709305

Clinical prediction guides

Long exposure to a mixture of endocrine disruptors prediposes the ventral prostate of rats to preneoplastic lesions.
Sousa TC, de Souza LP, Ricardo MLS, Yoshigae AY, Hinokuma KD, Gorzoni ABR, de Aquino AM, Scarano WR, de Sousa Castillho AC, Tavares MEA, Veras ASC, Teixeira GR, Nai GA, de Oliveira Mendes L
Environ Sci Pollut Res Int 2023 Oct;30(47):104015-104028. Epub 2023 Sep 11 doi: 10.1007/s11356-023-29768-z. PMID: 37697193
Estrogen receptor expression is modulated in human and mouse prostate epithelial cells during cancer progression.
Gadkar S, Thakur M, Desouza J, Bhowmick S, Patel V, Chaudhari U, Acharya KK, Sachdeva G
Steroids 2022 Aug;184:109036. Epub 2022 Apr 9 doi: 10.1016/j.steroids.2022.109036. PMID: 35413338
Evaluation of global DNA hypomethylation in human prostate cancer and prostatic intraepithelial neoplasm tissues by immunohistochemistry.
Yang B, Sun H, Lin W, Hou W, Li H, Zhang L, Li F, Gu Y, Song Y, Li Q, Zhang F
Urol Oncol 2013 Jul;31(5):628-34. Epub 2011 Jun 25 doi: 10.1016/j.urolonc.2011.05.009. PMID: 21704537
Mechanisms of disease: high-grade prostatic intraepithelial neoplasia and other proposed preneoplastic lesions in the prostate.
Montironi R, Mazzucchelli R, Lopez-Beltran A, Cheng L, Scarpelli M
Nat Clin Pract Urol 2007 Jun;4(6):321-32. doi: 10.1038/ncpuro0815. PMID: 17551536
Prostatic intraepithelial neoplasia: influence of clinical and pathological data on the detection of prostate cancer.
Raviv G, Janssen T, Zlotta AR, Descamps F, Verhest A, Schulman CC
J Urol 1996 Sep;156(3):1050-4; discussion 1054-5. doi: 10.1016/s0022-5347(01)65699-4. PMID: 8709305

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...