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Cellular Fibroma

MedGen UID:
266101
•Concept ID:
C1266118
•
Neoplastic Process
Synonym: Cellular fibroma
SNOMED CT: Cellular fibroma (128882001)

Definition

A morphologic variant of fibroma characterized by increased cellularity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCellular Fibroma

Professional guidelines

PubMed

Ovarian Signet-ring Stromal Tumor: A Morphologic, Immunohistochemical, and Molecular Study of 7 Cases With Discussion of the Differential Diagnosis.
Tchrakian N, Oliva E, Chong AS, Rivera-Polo B, Bennett JA, Nucci MR, Sah S, Schoolmeester JK, van der Griend RA, Foulkes WD, Clarke BA, Young RH, McCluggage WG
Am J Surg Pathol 2022 Dec 1;46(12):1599-1610. Epub 2022 Aug 29 doi: 10.1097/PAS.0000000000001954. PMID: 36040033
A diagnostic dilemma for solid ovarian masses: the clinical and radiological aspects with differential diagnosis of 23 cases.
Genç M, Solak A, Genç B, Sivrikoz ON, Kurtulmuş S, Turan A, Sahin N, Gür EB
Eur J Gynaecol Oncol 2015;36(2):186-91. PMID: 26050358
Laparoscopic surgical management and clinical characteristics of ovarian fibromas.
Son CE, Choi JS, Lee JH, Jeon SW, Hong JH, Bae JW
JSLS 2011 Jan-Mar;15(1):16-20. doi: 10.4293/108680810X12924466009087. PMID: 21902936Free PMC Article

Recent clinical studies

Etiology

Benign infiltrative myofibroblastic neoplasms of childhood with USP6 gene rearrangement.
Malik F, Wang L, Yu Z, Edelman MC, Miles L, Clay MR, Hedges D, Brennan RC, Nichols KE, Beth McCarville M, Bahrami A
Histopathology 2020 Nov;77(5):760-768. Epub 2020 Sep 12 doi: 10.1111/his.14182. PMID: 32583473
USP6 genetic rearrangements in cellular fibroma of tendon sheath.
Carter JM, Wang X, Dong J, Westendorf J, Chou MM, Oliveira AM
Mod Pathol 2016 Aug;29(8):865-9. Epub 2016 Apr 29 doi: 10.1038/modpathol.2016.83. PMID: 27125357
Ovarian-sparing local mass excision for ovarian fibroma/fibrothecoma in premenopausal women.
Cho YJ, Lee HS, Kim JM, Lee SY, Song T, Seong SJ, Kim ML
Eur J Obstet Gynecol Reprod Biol 2015 Feb;185:78-82. Epub 2014 Dec 4 doi: 10.1016/j.ejogrb.2014.11.042. PMID: 25528734
Laparoscopic surgical management and clinical characteristics of ovarian fibromas.
Son CE, Choi JS, Lee JH, Jeon SW, Hong JH, Bae JW
JSLS 2011 Jan-Mar;15(1):16-20. doi: 10.4293/108680810X12924466009087. PMID: 21902936Free PMC Article
Imbalances of chromosomes 4, 9, and 12 are recurrent in the thecoma-fibroma group of ovarian stromal tumors.
Streblow RC, Dafferner AJ, Nelson M, Fletcher M, West WW, Stevens RK, Gatalica Z, Novak D, Bridge JA
Cancer Genet Cytogenet 2007 Oct 15;178(2):135-40. doi: 10.1016/j.cancergencyto.2007.07.009. PMID: 17954269Free PMC Article

Diagnosis

Cellular fibroma in the Douglas cavity, mimicking a malignant neoplasia: fibroma, fibrosarcoma or mitotically active cellular fibroma?
Di Lorito A, Viola P, Rosini S, Lattanzio G
Pathologica 2016 Mar;108(1):34-37. PMID: 28195246
Rapid growth of mitotically active cellular fibroma of the ovary: a case report and review of the literature.
Matsuda K, Tateishi S, Akazawa Y, Kinoshita A, Yoshida S, Morisaki S, Fukushima A, Matsuwaki T, Yoshiura KI, Nakashima M
Diagn Pathol 2016 Oct 22;11(1):101. doi: 10.1186/s13000-016-0554-7. PMID: 27770806Free PMC Article
Mitotically active cellular fibroma of ovary should be differentiated from fibrosarcoma: a case report and review of literature.
Zong L, Lin M, Fan X
Int J Clin Exp Pathol 2014;7(11):7578-82. Epub 2014 Oct 15 PMID: 25550794Free PMC Article
Laparoscopic surgical management and clinical characteristics of ovarian fibromas.
Son CE, Choi JS, Lee JH, Jeon SW, Hong JH, Bae JW
JSLS 2011 Jan-Mar;15(1):16-20. doi: 10.4293/108680810X12924466009087. PMID: 21902936Free PMC Article
Mitotically active cellular luteinized thecoma of the ovary and luteinized thecomatosis associated with sclerosing peritonitis: case studies, comparison, and review of the literature.
Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537

Therapy

Mitotically active cellular luteinized thecoma of the ovary and luteinized thecomatosis associated with sclerosing peritonitis: case studies, comparison, and review of the literature.
Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537

Prognosis

Cellular fibroma in the Douglas cavity, mimicking a malignant neoplasia: fibroma, fibrosarcoma or mitotically active cellular fibroma?
Di Lorito A, Viola P, Rosini S, Lattanzio G
Pathologica 2016 Mar;108(1):34-37. PMID: 28195246
Rapid growth of mitotically active cellular fibroma of the ovary: a case report and review of the literature.
Matsuda K, Tateishi S, Akazawa Y, Kinoshita A, Yoshida S, Morisaki S, Fukushima A, Matsuwaki T, Yoshiura KI, Nakashima M
Diagn Pathol 2016 Oct 22;11(1):101. doi: 10.1186/s13000-016-0554-7. PMID: 27770806Free PMC Article
Mitotically active cellular fibroma of the ovary: a case report and literature review.
Yamada T, Hattori K, Satomi H, Hirose Y, Nakai G, Daimon A, Hayashi A, Terai Y, Ohmichi M, Fukunaga M
J Ovarian Res 2015 Oct 6;8:65. doi: 10.1186/s13048-015-0191-x. PMID: 26437718Free PMC Article
Mitotically active cellular fibroma of ovary should be differentiated from fibrosarcoma: a case report and review of literature.
Zong L, Lin M, Fan X
Int J Clin Exp Pathol 2014;7(11):7578-82. Epub 2014 Oct 15 PMID: 25550794Free PMC Article
Mitotically active cellular fibroma of the ovary: a case report and a review of the literature.
Wu H, Xie J, Huang W, Wu J
Eur J Gynaecol Oncol 2014;35(1):81-3. PMID: 24654469

Clinical prediction guides

Clinicopathological Characteristics of Mitotically-active Cellular Fibroma of the Ovary: A Single-institutional Experience.
Kim JY, Na K, Kim HS
Anticancer Res 2017 May;37(5):2557-2564. doi: 10.21873/anticanres.11599. PMID: 28476827
Cellular fibroma in the Douglas cavity, mimicking a malignant neoplasia: fibroma, fibrosarcoma or mitotically active cellular fibroma?
Di Lorito A, Viola P, Rosini S, Lattanzio G
Pathologica 2016 Mar;108(1):34-37. PMID: 28195246
Rapid growth of mitotically active cellular fibroma of the ovary: a case report and review of the literature.
Matsuda K, Tateishi S, Akazawa Y, Kinoshita A, Yoshida S, Morisaki S, Fukushima A, Matsuwaki T, Yoshiura KI, Nakashima M
Diagn Pathol 2016 Oct 22;11(1):101. doi: 10.1186/s13000-016-0554-7. PMID: 27770806Free PMC Article
Laparoscopic surgical management and clinical characteristics of ovarian fibromas.
Son CE, Choi JS, Lee JH, Jeon SW, Hong JH, Bae JW
JSLS 2011 Jan-Mar;15(1):16-20. doi: 10.4293/108680810X12924466009087. PMID: 21902936Free PMC Article
Mitotically active cellular luteinized thecoma of the ovary and luteinized thecomatosis associated with sclerosing peritonitis: case studies, comparison, and review of the literature.
Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537

Recent systematic reviews

Mitotically Active Cellular Fibroma of the Ovary Recurring After the Longest Interval of Time (16 yr): A Challenging Case With Systematic Literature Review.
Olivadese R, Ramponi A, Boldorini R, Dalla Dea G, Palicelli A
Int J Gynecol Pathol 2021 Sep 1;40(5):441-447. doi: 10.1097/PGP.0000000000000731. PMID: 33252401

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