U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atypical Adenoma

MedGen UID:
266283
•Concept ID:
C1305409
•
Neoplastic Process
Synonym: Atypical adenoma
SNOMED CT: Atypical adenoma (24482001)

Definition

An adenoma characterized by increased cellularity and nuclear atypia without evidence of vascular or capsular invasion. A representative example is thyroid gland atypical follicular adenoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical Adenoma

Professional guidelines

PubMed

Editorial: Parathyroid atypical adenomas and carcinoma: An update on clinical management.
Gianotti L, Cetani F
Front Endocrinol (Lausanne) 2023;14:1163996. Epub 2023 Feb 24 doi: 10.3389/fendo.2023.1163996. PMID: 36909324Free PMC Article
Management of aggressive growth hormone secreting pituitary adenomas.
Donoho DA, Bose N, Zada G, Carmichael JD
Pituitary 2017 Feb;20(1):169-178. doi: 10.1007/s11102-016-0781-7. PMID: 27987061
Management of bleeding liver tumors.
Darnis B, Rode A, Mohkam K, Ducerf C, Mabrut JY
J Visc Surg 2014 Oct;151(5):365-75. Epub 2014 Jun 18 doi: 10.1016/j.jviscsurg.2014.05.007. PMID: 24950941

Recent clinical studies

Etiology

Clinical Implications of the New WHO Classification 2017 for Pituitary Tumors.
Saeger W, Koch A
Exp Clin Endocrinol Diabetes 2021 Mar;129(3):146-156. Epub 2021 Mar 9 doi: 10.1055/a-1310-7900. PMID: 33690870
A standardised diagnostic approach to pituitary neuroendocrine tumours (PitNETs): a European Pituitary Pathology Group (EPPG) proposal.
Villa C, Vasiljevic A, Jaffrain-Rea ML, Ansorge O, Asioli S, Barresi V, Chinezu L, Gardiman MP, Lania A, Lapshina AM, Poliani L, Reiniger L, Righi A, Saeger W, Soukup J, Theodoropoulou M, Uccella S, Trouillas J, Roncaroli F
Virchows Arch 2019 Dec;475(6):687-692. Epub 2019 Oct 2 doi: 10.1007/s00428-019-02655-0. PMID: 31578606
Invasive, atypical and aggressive pituitary adenomas and carcinomas.
Sav A, Rotondo F, Syro LV, Di Ieva A, Cusimano MD, Kovacs K
Endocrinol Metab Clin North Am 2015 Mar;44(1):99-104. Epub 2014 Nov 4 doi: 10.1016/j.ecl.2014.10.008. PMID: 25732646
Management of bleeding liver tumors.
Darnis B, Rode A, Mohkam K, Ducerf C, Mabrut JY
J Visc Surg 2014 Oct;151(5):365-75. Epub 2014 Jun 18 doi: 10.1016/j.jviscsurg.2014.05.007. PMID: 24950941
Parathyroid carcinoma: etiology, diagnosis, and treatment.
Okamoto T, Iihara M, Obara T, Tsukada T
World J Surg 2009 Nov;33(11):2343-54. doi: 10.1007/s00268-009-9999-0. PMID: 19350316

Diagnosis

The 2017 WHO classification of pituitary adenoma: overview and comments.
Inoshita N, Nishioka H
Brain Tumor Pathol 2018 Apr;35(2):51-56. Epub 2018 Apr 23 doi: 10.1007/s10014-018-0314-3. PMID: 29687298
Atypical Hepatocellular Neoplasms: Review of Clinical, Morphologic, Immunohistochemical, Molecular, and Cytogenetic Features.
Choi WT, Kakar S
Adv Anat Pathol 2018 Jul;25(4):254-262. doi: 10.1097/PAP.0000000000000189. PMID: 29649004
Immunohistochemistry in Diagnostic Parathyroid Pathology.
Erickson LA, Mete O
Endocr Pathol 2018 Jun;29(2):113-129. doi: 10.1007/s12022-018-9527-6. PMID: 29626276
Invasive, atypical and aggressive pituitary adenomas and carcinomas.
Sav A, Rotondo F, Syro LV, Di Ieva A, Cusimano MD, Kovacs K
Endocrinol Metab Clin North Am 2015 Mar;44(1):99-104. Epub 2014 Nov 4 doi: 10.1016/j.ecl.2014.10.008. PMID: 25732646
Management of bleeding liver tumors.
Darnis B, Rode A, Mohkam K, Ducerf C, Mabrut JY
J Visc Surg 2014 Oct;151(5):365-75. Epub 2014 Jun 18 doi: 10.1016/j.jviscsurg.2014.05.007. PMID: 24950941

Therapy

Histological alterations following fine-needle aspiration for parathyroid adenoma: Incidence and diagnostic problems.
Hirokawa M, Suzuki A, Higuchi M, Hayashi T, Kuma S, Miya A, Miyauchi A
Pathol Int 2021 Jun;71(6):400-405. Epub 2021 Mar 19 doi: 10.1111/pin.13091. PMID: 33740321Free PMC Article
Distinguishing Parathyromatosis, Atypical Parathyroid Adenomas, and Parathyroid Carcinomas Utilizing Histologic and Clinical Features.
Schulte JJ, Pease G, Taxy JB, Hall C, Cipriani NA
Head Neck Pathol 2021 Sep;15(3):727-736. Epub 2021 Jan 4 doi: 10.1007/s12105-020-01281-6. PMID: 33394375Free PMC Article
Reasons and results of endoscopic surgery for prolactinomas: 142 surgical cases.
Akin S, Isikay I, Soylemezoglu F, Yucel T, Gurlek A, Berker M
Acta Neurochir (Wien) 2016 May;158(5):933-42. Epub 2016 Mar 12 doi: 10.1007/s00701-016-2762-z. PMID: 26970763
Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide.
Matsuno A, Murakami M, Hoya K, Yamada SM, Miyamoto S, Yamada S, Son JH, Nishido H, Ide F, Nagashima H, Sugaya M, Hirohata T, Mizutani A, Okinaga H, Ishii Y, Tahara S, Teramoto A, Osamura RY
Med Mol Morphol 2014 Mar;47(1):1-7. Epub 2013 Aug 17 doi: 10.1007/s00795-013-0050-z. PMID: 23955641
A case of atypical thyrotroph cell adenoma, which re-grew within 3 months after surgery and required multimodal treatment.
Ogawa Y, Tominaga T
J Neurooncol 2008 Mar;87(1):91-5. Epub 2007 Nov 7 doi: 10.1007/s11060-007-9492-2. PMID: 17987261

Prognosis

Clinical Implications of the New WHO Classification 2017 for Pituitary Tumors.
Saeger W, Koch A
Exp Clin Endocrinol Diabetes 2021 Mar;129(3):146-156. Epub 2021 Mar 9 doi: 10.1055/a-1310-7900. PMID: 33690870
Newer Concepts in the Classification of Pituitary Adenomas.
Sathyakumar R, Chacko G
Neurol India 2020 May-Jun;68(Supplement):S7-S12. doi: 10.4103/0028-3886.287667. PMID: 32611886
The 2017 WHO classification of pituitary adenoma: overview and comments.
Inoshita N, Nishioka H
Brain Tumor Pathol 2018 Apr;35(2):51-56. Epub 2018 Apr 23 doi: 10.1007/s10014-018-0314-3. PMID: 29687298
Immunohistochemistry in Diagnostic Parathyroid Pathology.
Erickson LA, Mete O
Endocr Pathol 2018 Jun;29(2):113-129. doi: 10.1007/s12022-018-9527-6. PMID: 29626276
Invasive, atypical and aggressive pituitary adenomas and carcinomas.
Sav A, Rotondo F, Syro LV, Di Ieva A, Cusimano MD, Kovacs K
Endocrinol Metab Clin North Am 2015 Mar;44(1):99-104. Epub 2014 Nov 4 doi: 10.1016/j.ecl.2014.10.008. PMID: 25732646

Clinical prediction guides

Correlation exploration among CT imaging, pathology and genotype of pulmonary ground-glass opacity.
Cai Y, Chen T, Zhang S, Tan M, Wang J
J Cell Mol Med 2023 Jul;27(14):2021-2031. Epub 2023 Jun 20 doi: 10.1111/jcmm.17797. PMID: 37340599Free PMC Article
Recurrence and mortality rate in an Italian multi-center case series of parathyroid atypical adenomas and carcinomas.
Barale M, Nervo A, Craparo A, Pusterla A, Retta F, Maiorino F, Castellano E, Piovesan A, Gianotti L, Borretta G, Procopio M, Arvat E
Front Endocrinol (Lausanne) 2023;14:1158474. Epub 2023 May 8 doi: 10.3389/fendo.2023.1158474. PMID: 37223026Free PMC Article
The spectrum of manifestations of primary hyperparathyroidism in children and adolescents.
Boro H, Khatiwada S, Alam S, Kubihal S, Dogra V, Malla S, Kumar C
Pediatr Endocrinol Diabetes Metab 2022;28(3):178-187. doi: 10.5114/pedm.2022.118315. PMID: 35942826Free PMC Article
The 2017 WHO classification of pituitary adenoma: overview and comments.
Inoshita N, Nishioka H
Brain Tumor Pathol 2018 Apr;35(2):51-56. Epub 2018 Apr 23 doi: 10.1007/s10014-018-0314-3. PMID: 29687298
Invasive, atypical and aggressive pituitary adenomas and carcinomas.
Sav A, Rotondo F, Syro LV, Di Ieva A, Cusimano MD, Kovacs K
Endocrinol Metab Clin North Am 2015 Mar;44(1):99-104. Epub 2014 Nov 4 doi: 10.1016/j.ecl.2014.10.008. PMID: 25732646

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...