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Bladder mixed adenocarcinoma

MedGen UID:
267372
•Concept ID:
C1511192
•
Neoplastic Process
Synonyms: Bladder Mixed Adenocarcinoma; bladder mixed adenocarcinoma
 
Monarch Initiative: MONDO:0004458

Definition

A variant of bladder adenocarcinoma that histologically consists of more than one growth pattern such as enteric, mucinous or signet ring types. [from NCI]

Professional guidelines

PubMed

Morphological characteristics of a mucinous adenocarcinoma of the prostate: differential diagnosis considerations.
Enciu M, Aşchie M, Deacu M, Poinăreanu I
Rom J Morphol Embryol 2013;54(1):191-4. PMID: 23529329
Variant forms of bladder cancer: basic considerations on treatment approaches.
Pons F, Orsola A, Morote J, Bellmunt J
Curr Oncol Rep 2011 Jun;13(3):216-21. doi: 10.1007/s11912-011-0161-4. PMID: 21360040
Adenocarcinoma of urinary bladder: classification and management.
Burnett AL, Epstein JI, Marshall FF
Urology 1991 Apr;37(4):315-21. doi: 10.1016/0090-4295(91)80256-7. PMID: 2014595

Recent clinical studies

Etiology

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2: Grading of Mixed Grade, Invasive Urothelial Carcinoma Including Histologic Subtypes and Divergent Differentiations, and Non-Urothelial Carcinomas.
Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel
Am J Surg Pathol 2024 Jan 1;48(1):e11-e23. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002077. PMID: 37382156
FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
Int J Gynaecol Obstet 2023 Aug;162(2):383-394. Epub 2023 Jun 20 doi: 10.1002/ijgo.14923. PMID: 37337978
Classifying Pulmonary and Urinary High-grade Neuroendocrine Carcinoma by CK7 Immunohistochemistry.
Fan J, Li H, Zhou C, Xiong W, Villamil C, Ionescu D, Oo HZ, Contreras-Sanz A, Black PC, Wang G
Appl Immunohistochem Mol Morphol 2022 Jul 1;30(6):459-468. Epub 2022 May 24 doi: 10.1097/PAI.0000000000001036. PMID: 35603802
Epstein-Barr Virus-associated Mixed Lymphoepithelioma-like Carcinoma and Adenocarcinoma of the Gall Bladder: An Unusual Entity.
Jain N, Goyal S, Sakhuja P, Saluja S
Korean J Gastroenterol 2021 Sep 25;78(3):188-194. doi: 10.4166/kjg.2021.045. PMID: 34565789

Diagnosis

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2: Grading of Mixed Grade, Invasive Urothelial Carcinoma Including Histologic Subtypes and Divergent Differentiations, and Non-Urothelial Carcinomas.
Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel
Am J Surg Pathol 2024 Jan 1;48(1):e11-e23. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002077. PMID: 37382156
PEComa-like Neoplasms Characterized by ASPSCR1-TFE3 Fusion: Another Face of TFE3-related Mesenchymal Neoplasia.
Argani P, Wobker SE, Gross JM, Matoso A, Fletcher CDM, Antonescu CR
Am J Surg Pathol 2022 Aug 1;46(8):1153-1159. Epub 2022 Apr 5 doi: 10.1097/PAS.0000000000001894. PMID: 35848761Free PMC Article
Classifying Pulmonary and Urinary High-grade Neuroendocrine Carcinoma by CK7 Immunohistochemistry.
Fan J, Li H, Zhou C, Xiong W, Villamil C, Ionescu D, Oo HZ, Contreras-Sanz A, Black PC, Wang G
Appl Immunohistochem Mol Morphol 2022 Jul 1;30(6):459-468. Epub 2022 May 24 doi: 10.1097/PAI.0000000000001036. PMID: 35603802
Epstein-Barr Virus-associated Mixed Lymphoepithelioma-like Carcinoma and Adenocarcinoma of the Gall Bladder: An Unusual Entity.
Jain N, Goyal S, Sakhuja P, Saluja S
Korean J Gastroenterol 2021 Sep 25;78(3):188-194. doi: 10.4166/kjg.2021.045. PMID: 34565789
The neuroendocrine component in bladder tumors.
Pompas-Veganzones N, Gonzalez-Peramato P, Sanchez-Carbayo M
Curr Med Chem 2014;21(9):1117-28. doi: 10.2174/0929867321666131201141346. PMID: 24304278

Therapy

Primary MiNEN of the urinary bladder: an hitherto undescribed entity composed of large cell neuroendocrine carcinoma and adenocarcinoma with a distinct clinical behavior : Description of a case and review of the pertinent literature.
Pini GM, Uccella S, Corinti M, Colecchia M, Pelosi G, Patriarca C
Virchows Arch 2021 Jul;479(1):69-78. Epub 2021 Jan 17 doi: 10.1007/s00428-021-03023-7. PMID: 33454836Free PMC Article
Opium: an emerging risk factor for gastric adenocarcinoma.
Shakeri R, Malekzadeh R, Etemadi A, Nasrollahzadeh D, Aghcheli K, Sotoudeh M, Islami F, Pourshams A, Pawlita M, Boffetta P, Dawsey SM, Abnet CC, Kamangar F
Int J Cancer 2013 Jul 15;133(2):455-61. Epub 2013 Feb 13 doi: 10.1002/ijc.28018. PMID: 23319416Free PMC Article
Variant forms of bladder cancer: basic considerations on treatment approaches.
Pons F, Orsola A, Morote J, Bellmunt J
Curr Oncol Rep 2011 Jun;13(3):216-21. doi: 10.1007/s11912-011-0161-4. PMID: 21360040
Bladder cancer in spinal cord injury patients.
Kalisvaart JF, Katsumi HK, Ronningen LD, Hovey RM
Spinal Cord 2010 Mar;48(3):257-61. Epub 2009 Sep 15 doi: 10.1038/sc.2009.118. PMID: 19752870
Review of the clinical results of fast neutron therapy.
Schmitt G, Wambersie A
Radiother Oncol 1990 Jan;17(1):47-56. doi: 10.1016/0167-8140(90)90048-2. PMID: 2108475

Prognosis

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2: Grading of Mixed Grade, Invasive Urothelial Carcinoma Including Histologic Subtypes and Divergent Differentiations, and Non-Urothelial Carcinomas.
Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel
Am J Surg Pathol 2024 Jan 1;48(1):e11-e23. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002077. PMID: 37382156
FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
Int J Gynaecol Obstet 2023 Aug;162(2):383-394. Epub 2023 Jun 20 doi: 10.1002/ijgo.14923. PMID: 37337978
Epstein-Barr Virus-associated Mixed Lymphoepithelioma-like Carcinoma and Adenocarcinoma of the Gall Bladder: An Unusual Entity.
Jain N, Goyal S, Sakhuja P, Saluja S
Korean J Gastroenterol 2021 Sep 25;78(3):188-194. doi: 10.4166/kjg.2021.045. PMID: 34565789
The neuroendocrine component in bladder tumors.
Pompas-Veganzones N, Gonzalez-Peramato P, Sanchez-Carbayo M
Curr Med Chem 2014;21(9):1117-28. doi: 10.2174/0929867321666131201141346. PMID: 24304278

Clinical prediction guides

Primary MiNEN of the urinary bladder: an hitherto undescribed entity composed of large cell neuroendocrine carcinoma and adenocarcinoma with a distinct clinical behavior : Description of a case and review of the pertinent literature.
Pini GM, Uccella S, Corinti M, Colecchia M, Pelosi G, Patriarca C
Virchows Arch 2021 Jul;479(1):69-78. Epub 2021 Jan 17 doi: 10.1007/s00428-021-03023-7. PMID: 33454836Free PMC Article
Updates in the Pathologic Diagnosis and Classification of Epithelial Neoplasms of Urachal Origin.
Paner GP, Lopez-Beltran A, Sirohi D, Amin MB
Adv Anat Pathol 2016 Mar;23(2):71-83. doi: 10.1097/PAP.0000000000000110. PMID: 26849813
The zinc-finger transcription factor SALL4 is frequently expressed in human cancers: association with clinical outcome in squamous cell carcinoma but not in adenocarcinoma of the esophagus.
Kilic E, Tennstedt P, Högner A, Lebok P, Sauter G, Bokemeyer C, Izbicki JR, Wilczak W
Virchows Arch 2016 Apr;468(4):483-92. Epub 2016 Jan 27 doi: 10.1007/s00428-016-1908-y. PMID: 26818834
Urachal carcinomas of the nonglandular type: salient features and considerations in pathologic diagnosis.
Paner GP, Barkan GA, Mehta V, Sirintrapun SJ, Tsuzuki T, Sebo TJ, Jimenez RE
Am J Surg Pathol 2012 Mar;36(3):432-42. doi: 10.1097/PAS.0b013e31823fe49c. PMID: 22301493
Immunohistochemical distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma.
Wang HL, Lu DW, Yerian LM, Alsikafi N, Steinberg G, Hart J, Yang XJ
Am J Surg Pathol 2001 Nov;25(11):1380-7. doi: 10.1097/00000478-200111000-00005. PMID: 11684954

Recent systematic reviews

Large Cell Neuroendocrine Carcinoma of the Prostate: A Systematic Review and Pooled Analysis.
Tu X, Chang T, Nie L, Qiu S, Xu H, Huang Y, Bao Y, Liu Z, Yang L, Wei Q
Urol Int 2019;103(4):383-390. Epub 2019 Apr 9 doi: 10.1159/000499883. PMID: 30965328

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