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Breast Adenocarcinoma with Spindle Cell Metaplasia

MedGen UID:
267902
•Concept ID:
C1511281
•
Neoplastic Process

Definition

An invasive adenocarcinoma of the breast usually affecting post-menopausal women, characterized by extensive spindle cell metaplasia of the neoplastic glandular cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Adenocarcinoma with Spindle Cell Metaplasia

Professional guidelines

PubMed

AAV-P125A-endostatin and paclitaxel treatment increases endoreduplication in endothelial cells and inhibits metastasis of breast cancer.
Subramanian IV, Devineni S, Ghebre R, Ghosh G, Joshi HP, Jing Y, Truskinovsky AM, Ramakrishnan S
Gene Ther 2011 Feb;18(2):145-54. Epub 2010 Sep 16 doi: 10.1038/gt.2010.118. PMID: 20844568

Recent clinical studies

Etiology

Genomic profiling of metaplastic breast carcinomas reveals genetic heterogeneity and relationship to ductal carcinoma.
Krings G, Chen YY
Mod Pathol 2018 Nov;31(11):1661-1674. Epub 2018 Jun 26 doi: 10.1038/s41379-018-0081-z. PMID: 29946183
Metaplastic Carcinoma of the Breast Is More Aggressive Than Triple-negative Breast Cancer: A Study From a Single Institution and Review of Literature.
El Zein D, Hughes M, Kumar S, Peng X, Oyasiji T, Jabbour H, Khoury T
Clin Breast Cancer 2017 Aug;17(5):382-391. Epub 2017 Apr 26 doi: 10.1016/j.clbc.2017.04.009. PMID: 28529029Free PMC Article
Metaplastic breast carcinoma: clinical-pathologic characteristics and HER2/neu expression.
Barnes PJ, Boutilier R, Chiasson D, Rayson D
Breast Cancer Res Treat 2005 May;91(2):173-8. doi: 10.1007/s10549-004-7260-y. PMID: 15868445
Metaplastic carcinoma of the breast: analysis of eight Asian patients with special emphasis on two unusual cases presenting with inflammatory-type breast cancer.
Kuo SH, Chen CL, Huang CS, Cheng AL
Anticancer Res 2000 May-Jun;20(3B):2219-22. PMID: 10928181
Squamous cell carcinoma of the breast: a clinicopathologic analysis of eight cases and review of the literature.
Eggers JW, Chesney TM
Hum Pathol 1984 Jun;15(6):526-31. doi: 10.1016/s0046-8177(84)80005-2. PMID: 6724572

Diagnosis

Metaplastic carcinoma of the breast with dominant squamous and sebaceous differentiation in the primary tumor and osteochondroid metaplasia in a distant metastasis: report of a case with review of sebaceous differentiation in breast tumors.
Carlucci M, Iacobellis M, Colonna F, Marseglia M, Gambarotti M, Giardina C, Bisceglia M
Int J Surg Pathol 2012 Jun;20(3):284-96. Epub 2011 Aug 24 doi: 10.1177/1066896911417711. PMID: 21865268
Metaplastic breast carcinoma with extensive osseous differentiation: a report of two cases and review of the literature.
Lang R, Fan Y, Fu X, Fu L
Tumori 2011 Jul-Aug;97(4):e1-5. doi: 10.1177/030089161109700421. PMID: 21989447
Increased alpha-B-crystallin expression in mammary metaplastic carcinomas.
Chan SK, Lui PC, Tan PH, Yamaguchi R, Moriya T, Yu AM, Shao MM, Hliang T, Wong SI, Tse GM
Histopathology 2011 Aug;59(2):247-55. doi: 10.1111/j.1365-2559.2011.03882.x. PMID: 21884203
Metaplastic carcinoma of the breast: cytological diagnosis and diagnostic pitfalls.
Joshi D, Singh P, Zonunfawni Y, Gangane N
Acta Cytol 2011;55(4):313-8. Epub 2011 Jul 22 doi: 10.1159/000326932. PMID: 21791899
Metaplastic carcinoma of the breast: analysis of eight Asian patients with special emphasis on two unusual cases presenting with inflammatory-type breast cancer.
Kuo SH, Chen CL, Huang CS, Cheng AL
Anticancer Res 2000 May-Jun;20(3B):2219-22. PMID: 10928181

Therapy

AAV-P125A-endostatin and paclitaxel treatment increases endoreduplication in endothelial cells and inhibits metastasis of breast cancer.
Subramanian IV, Devineni S, Ghebre R, Ghosh G, Joshi HP, Jing Y, Truskinovsky AM, Ramakrishnan S
Gene Ther 2011 Feb;18(2):145-54. Epub 2010 Sep 16 doi: 10.1038/gt.2010.118. PMID: 20844568
Clinicopathological analyses of triple negative breast cancer using surveillance data from the Registration Committee of the Japanese Breast Cancer Society.
Iwase H, Kurebayashi J, Tsuda H, Ohta T, Kurosumi M, Miyamoto K, Yamamoto Y, Iwase T
Breast Cancer 2010 Apr;17(2):118-24. Epub 2009 May 23 doi: 10.1007/s12282-009-0113-0. PMID: 19466512
Metaplastic breast carcinoma with melanocytic differentiation.
Bendic A, Bozic M, Durdov MG
Pathol Int 2009 Sep;59(9):676-80. doi: 10.1111/j.1440-1827.2009.02426.x. PMID: 19712138
Malignant fibrous histiocytoma of the chest wall masquerading as medullary breast carcinoma: a case report.
Sharma P, Jain S, Nigam S, Bahadur AK, Ouseph MM
Acta Cytol 2006 Sep-Oct;50(5):577-80. doi: 10.1159/000326020. PMID: 17017451
Metaplastic carcinoma of the breast: analysis of eight Asian patients with special emphasis on two unusual cases presenting with inflammatory-type breast cancer.
Kuo SH, Chen CL, Huang CS, Cheng AL
Anticancer Res 2000 May-Jun;20(3B):2219-22. PMID: 10928181

Prognosis

Matrix-producing metaplastic breast carcinoma - a rare tumor with heterologous elements.
Shruti S, Siraj F
Ger Med Sci 2017;15:Doc17. Epub 2017 Dec 6 doi: 10.3205/000258. PMID: 29255401Free PMC Article
Metaplastic Carcinoma of the Breast Is More Aggressive Than Triple-negative Breast Cancer: A Study From a Single Institution and Review of Literature.
El Zein D, Hughes M, Kumar S, Peng X, Oyasiji T, Jabbour H, Khoury T
Clin Breast Cancer 2017 Aug;17(5):382-391. Epub 2017 Apr 26 doi: 10.1016/j.clbc.2017.04.009. PMID: 28529029Free PMC Article
Increased alpha-B-crystallin expression in mammary metaplastic carcinomas.
Chan SK, Lui PC, Tan PH, Yamaguchi R, Moriya T, Yu AM, Shao MM, Hliang T, Wong SI, Tse GM
Histopathology 2011 Aug;59(2):247-55. doi: 10.1111/j.1365-2559.2011.03882.x. PMID: 21884203
Metaplastic carcinoma of the breast: analysis of eight Asian patients with special emphasis on two unusual cases presenting with inflammatory-type breast cancer.
Kuo SH, Chen CL, Huang CS, Cheng AL
Anticancer Res 2000 May-Jun;20(3B):2219-22. PMID: 10928181
Carcinoma of the breast with pseudosarcomatous metaplasia.
Kaufman MW, Marti JR, Gallager HS, Hoehn JL
Cancer 1984 May 1;53(9):1908-17. doi: 10.1002/1097-0142(19840501)53:9<1908::aid-cncr2820530917>3.0.co;2-f. PMID: 6322962

Clinical prediction guides

Development of ipsilateral chest wall spindle cell carcinoma in a patient with invasive ductal breast carcinoma during postoperative adjuvant therapy: A case report.
Li K, Kang H, Wang Y, Hai T, Wang B
Medicine (Baltimore) 2018 May;97(19):e0739. doi: 10.1097/MD.0000000000010739. PMID: 29742739Free PMC Article
Whole-Exome Sequencing of Metaplastic Breast Carcinoma Indicates Monoclonality with Associated Ductal Carcinoma Component.
Avigdor BE, Beierl K, Gocke CD, Zabransky DJ, Cravero K, Kyker-Snowman K, Button B, Chu D, Croessmann S, Cochran RL, Connolly RM, Park BH, Wheelan SJ, Cimino-Mathews A
Clin Cancer Res 2017 Aug 15;23(16):4875-4884. Epub 2017 Apr 19 doi: 10.1158/1078-0432.CCR-17-0108. PMID: 28424200Free PMC Article
Increased alpha-B-crystallin expression in mammary metaplastic carcinomas.
Chan SK, Lui PC, Tan PH, Yamaguchi R, Moriya T, Yu AM, Shao MM, Hliang T, Wong SI, Tse GM
Histopathology 2011 Aug;59(2):247-55. doi: 10.1111/j.1365-2559.2011.03882.x. PMID: 21884203
Metaplastic carcinoma of the breast: cytological diagnosis and diagnostic pitfalls.
Joshi D, Singh P, Zonunfawni Y, Gangane N
Acta Cytol 2011;55(4):313-8. Epub 2011 Jul 22 doi: 10.1159/000326932. PMID: 21791899
Specific morphological features predictive for the basal phenotype in grade 3 invasive ductal carcinoma of breast.
Fulford LG, Easton DF, Reis-Filho JS, Sofronis A, Gillett CE, Lakhani SR, Hanby A
Histopathology 2006 Jul;49(1):22-34. doi: 10.1111/j.1365-2559.2006.02453.x. PMID: 16842243

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