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Neoplasm of the inner ear

MedGen UID:: 268582
•Concept ID:: C1512779
•: Neoplastic Process

Synonyms:	Inner Ear Neoplasm; inner ear neoplasm; inner Ear neoplasm; Inner ear tumor; Inner ear tumour; Internal Ear Neoplasm; internal Ear neoplasm; internal ear neoplasm; internal ear neoplasm (disease); internal ear tumor; internal ear tumour; neoplasm of internal ear; tumor of internal ear; tumour of internal ear

HPO:	HP:0040096
Monarch Initiative:	MONDO:0024320

Definition

A tumor (abnormal growth of tissue) of the inner ear. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeoplasm of the inner ear

Disease
- Disorder by Site
  - Head and Neck Disorder
    - Otolaryngologic Disorder
      - Disorder of ear
        Inner ear disorder
        Neoplasm of the inner ear
        Benign Inner Ear Neoplasm
        Acoustic neuroma
        Bilateral vestibular schwannoma
        Neurofibromatosis, type 2
        Unilateral vestibular schwannoma
        Internal auditory canal lipoma
        Endolymphatic sac tumor
        Malignant Inner Ear Neoplasm

Professional guidelines

PubMed

The Future of Vestibular Schwannoma Management.

Moore LS, Stankovic KM
Otolaryngol Clin North Am 2023 Jun;56(3):611-622. Epub 2023 Apr 3 doi: 10.1016/j.otc.2023.02.018. PMID: 37019772

Contemporary review of the causes and differential diagnosis of sudden sensorineural hearing loss.

Young YH
Int J Audiol 2020 Apr;59(4):243-253. Epub 2019 Nov 12 doi: 10.1080/14992027.2019.1689432. PMID: 31714154

Current Treatment of Endolymphatic Sac Tumor of the Temporal Bone.

Mendenhall WM, Suárez C, Skálová A, Strojan P, Triantafyllou A, Devaney KO, Williams MD, Rinaldo A, Ferlito A
Adv Ther 2018 Jul;35(7):887-898. Epub 2018 Jun 19 doi: 10.1007/s12325-018-0730-0. PMID: 29923043

See all (71)

Recent clinical studies

Etiology

SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.

Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088 Free PMC Article

Contemporary review of the causes and differential diagnosis of sudden sensorineural hearing loss.

Young YH
Int J Audiol 2020 Apr;59(4):243-253. Epub 2019 Nov 12 doi: 10.1080/14992027.2019.1689432. PMID: 31714154

Tumors of the temporal bone.

Chovanec M, Fík Z
Cas Lek Cesk 2019 Winter;158(6):248-252. PMID: 31931585

Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.

Kros CJ, Steyger PS
Cold Spring Harb Perspect Med 2019 Nov 1;9(11) doi: 10.1101/cshperspect.a033548. PMID: 30559254 Free PMC Article

Positional nystagmus.

Barber HO
Otolaryngol Head Neck Surg 1984 Dec;92(6):649-55. doi: 10.1177/019459988409200611. PMID: 6440083

See all (777)

Diagnosis

The Vestibulocochlear Nerve: Anatomy and Pathology.

Corrêa DG, Hygino da Cruz LC Jr, Freddi TAL
Semin Ultrasound CT MR 2023 Apr;44(2):81-94. Epub 2023 Mar 22 doi: 10.1053/j.sult.2023.03.007. PMID: 37055143

Intralabyrinthine schwannomas.

Frisch CD, Eckel LJ, Lane JI, Neff BA
Otolaryngol Clin North Am 2015 Jun;48(3):423-41. Epub 2015 Apr 9 doi: 10.1016/j.otc.2015.02.004. PMID: 25863567

Endolymphatic sac tumors.

Wick CC, Manzoor NF, Semaan MT, Megerian CA
Otolaryngol Clin North Am 2015 Apr;48(2):317-30. Epub 2015 Jan 31 doi: 10.1016/j.otc.2014.12.006. PMID: 25650230

The vestibulocochlear nerve (VIII).

Benoudiba F, Toulgoat F, Sarrazin JL
Diagn Interv Imaging 2013 Oct;94(10):1043-50. Epub 2013 Oct 1 doi: 10.1016/j.diii.2013.08.015. PMID: 24095603

Positional nystagmus.

Barber HO
Otolaryngol Head Neck Surg 1984 Dec;92(6):649-55. doi: 10.1177/019459988409200611. PMID: 6440083

See all (1060)

Therapy

In vivo delivery of CRISPR-Cas9 genome editing components for therapeutic applications.

Huang K, Zapata D, Tang Y, Teng Y, Li Y
Biomaterials 2022 Dec;291:121876. Epub 2022 Oct 28 doi: 10.1016/j.biomaterials.2022.121876. PMID: 36334354 Free PMC Article

Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.

Kros CJ, Steyger PS
Cold Spring Harb Perspect Med 2019 Nov 1;9(11) doi: 10.1101/cshperspect.a033548. PMID: 30559254 Free PMC Article

Irradiated ears in nasopharyngeal carcinoma survivors: A review.

Young YH
Laryngoscope 2019 Mar;129(3):637-642. Epub 2018 Sep 8 doi: 10.1002/lary.27303. PMID: 30194730

Radiation therapy and hearing loss.

Bhandare N, Jackson A, Eisbruch A, Pan CC, Flickinger JC, Antonelli P, Mendenhall WM
Int J Radiat Oncol Biol Phys 2010 Mar 1;76(3 Suppl):S50-7. doi: 10.1016/j.ijrobp.2009.04.096. PMID: 20171518 Free PMC Article

Relapsing polychondritis.

Gergely P Jr, Poór G
Best Pract Res Clin Rheumatol 2004 Oct;18(5):723-38. doi: 10.1016/j.berh.2004.05.012. PMID: 15454129

See all (347)

Prognosis

Contemporary review of the causes and differential diagnosis of sudden sensorineural hearing loss.

Young YH
Int J Audiol 2020 Apr;59(4):243-253. Epub 2019 Nov 12 doi: 10.1080/14992027.2019.1689432. PMID: 31714154

Utility of optical coherence tomography in the evaluation of sellar and parasellar mass lesions.

Al-Louzi O, Prasad S, Mallery RM
Curr Opin Endocrinol Diabetes Obes 2018 Aug;25(4):274-284. doi: 10.1097/MED.0000000000000415. PMID: 29771751

Growth rate of vestibular schwannoma.

Paldor I, Chen AS, Kaye AH
J Clin Neurosci 2016 Oct;32:1-8. Epub 2016 Jul 20 doi: 10.1016/j.jocn.2016.05.003. PMID: 27450283

Multisession Radiosurgery for Hearing Preservation.

Rashid A, Karam SD, Rashid B, Kim JH, Pang D, Jean W, Grimm J, Collins SP
Semin Radiat Oncol 2016 Apr;26(2):105-11. Epub 2015 Nov 25 doi: 10.1016/j.semradonc.2015.11.004. PMID: 27000506

Relapsing polychondritis.

Gergely P Jr, Poór G
Best Pract Res Clin Rheumatol 2004 Oct;18(5):723-38. doi: 10.1016/j.berh.2004.05.012. PMID: 15454129

See all (434)

Clinical prediction guides

Burden of serious harms from diagnostic error in the USA.

Newman-Toker DE, Nassery N, Schaffer AC, Yu-Moe CW, Clemens GD, Wang Z, Zhu Y, Saber Tehrani AS, Fanai M, Hassoon A, Siegal D
BMJ Qual Saf 2024 Jan 19;33(2):109-120. doi: 10.1136/bmjqs-2021-014130. PMID: 37460118 Free PMC Article

SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.

Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088 Free PMC Article

Histopathologic Evaluation of Intralabyrinthine Schwannoma.

Bagattini M, Quesnel AM, Röösli C
Audiol Neurootol 2021;26(4):265-272. Epub 2020 Dec 22 doi: 10.1159/000511634. PMID: 33352553 Free PMC Article

Pendred syndrome.

Wémeau JL, Kopp P
Best Pract Res Clin Endocrinol Metab 2017 Mar;31(2):213-224. Epub 2017 May 10 doi: 10.1016/j.beem.2017.04.011. PMID: 28648509

Management of sporadic vestibular schwannoma.

Carlson ML, Link MJ, Wanna GB, Driscoll CL
Otolaryngol Clin North Am 2015 Jun;48(3):407-22. Epub 2015 Apr 15 doi: 10.1016/j.otc.2015.02.003. PMID: 25886814

See all (431)

Recent systematic reviews

Surgical Management of Endolymphatic Sac Tumor: A Systematic Review and Meta-Analysis.

Gioacchini FM, Chiarella G, Kaleci S, Iannella G, Viola P, Pisani D, Scarpa A, Tulli M, Re M
J Int Adv Otol 2023 Jun;19(3):248-254. doi: 10.5152/iao.2023.22957. PMID: 37272644 Free PMC Article

Systematic Review of Endolymphatic Sac Tumor Treatment and Outcomes.

Tang JD, Grady AJ, Nickel CJ, Ryan LE, Malone A, Canvasser L, Boyev KP
Otolaryngol Head Neck Surg 2023 Mar;168(3):282-290. Epub 2023 Jan 27 doi: 10.1177/01945998221108313. PMID: 35763364

Symptoms and clinical features in patients affected by endolymphatic sac tumor: a systematic review and meta-analysis.

Gioacchini FM, Kaleci S, Chiarella G, Viola P, Pisani D, Scarpa A, Tulli M, Pace A, Iannella G, Re M
Eur Arch Otorhinolaryngol 2022 Nov;279(11):5081-5088. Epub 2022 Jun 15 doi: 10.1007/s00405-022-07469-6. PMID: 35704074

Indications and contraindications of auditory brainstem implants: systematic review and illustrative cases.

Merkus P, Di Lella F, Di Trapani G, Pasanisi E, Beltrame MA, Zanetti D, Negri M, Sanna M
Eur Arch Otorhinolaryngol 2014 Jan;271(1):3-13. Epub 2013 Feb 13 doi: 10.1007/s00405-013-2378-3. PMID: 23404468

Primary inner ear schwannomas: a case series and systematic review of the literature.

Van Abel KM, Carlson ML, Link MJ, Neff BA, Beatty CW, Lohse CM, Eckel LJ, Lane JI, Driscoll CL
Laryngoscope 2013 Aug;123(8):1957-66. Epub 2013 Jan 18 doi: 10.1002/lary.23928. PMID: 23335152

See all (18)

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Neoplasm of the inner ear

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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