U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Lesion

MedGen UID:
268675
•Concept ID:
C1513183
•
Finding
Synonyms: Metastases; Metastasis; Metastatic Disease

Definition

A tumor arising at a location distant to the primary lesion. [from NCI]

Professional guidelines

PubMed

Clinicopathological characteristics, evolution, treatment pattern and outcomes of hormone-receptor-positive/HER2-low metastatic breast cancer.
You S, Gong C, Li Y, Xie Y, Li Y, Zhao Y, Wang B
Front Endocrinol (Lausanne) 2023;14:1270453. Epub 2023 Oct 10 doi: 10.3389/fendo.2023.1270453. PMID: 37881502Free PMC Article
Clinical features and management of trophoblastic epithelioid tumors: A systematic review.
Gorun F, Tomescu L, Motoc A, Citu C, Sas I, Serban DM, Forga M, Citu IM, Gorun OM
Medicine (Baltimore) 2022 Jul 29;101(30):e29934. doi: 10.1097/MD.0000000000029934. PMID: 35905248Free PMC Article
Treatment for patients with unknown primary cancer and favorable prognostic factors.
Hainsworth JD, Fizazi K
Semin Oncol 2009 Feb;36(1):44-51. doi: 10.1053/j.seminoncol.2008.10.006. PMID: 19179187

Recent clinical studies

Etiology

Vasogenic Edema Pattern in Brain Metastasis.
Yaltirik Bilgin E, Unal O, Ciledag N
J Coll Physicians Surg Pak 2022 Aug;32(8):1020-1025. doi: 10.29271/jcpsp.2022.08.1020. PMID: 35932126
Mini-Review: Can the Metastatic Cascade Be Inhibited by Targeting CD147/EMMPRIN to Prevent Tumor Recurrence?
Rahat MA
Front Immunol 2022;13:855978. Epub 2022 Mar 28 doi: 10.3389/fimmu.2022.855978. PMID: 35418981Free PMC Article
Single-cell RNA sequencing reveals spatiotemporal heterogeneity and malignant progression in pancreatic neuroendocrine tumor.
Zhou Y, Liu S, Liu C, Yang J, Lin Q, Zheng S, Chen C, Zhou Q, Chen R
Int J Biol Sci 2021;17(14):3760-3775. Epub 2021 Aug 28 doi: 10.7150/ijbs.61717. PMID: 34671197Free PMC Article
Pituitary metastasis: From pathology to clinical and radiological considerations.
Kameda-Smith MM, Zhang E, Lannon M, Algird A, Reddy K, Lu JQ
J Clin Neurosci 2021 Nov;93:231-240. Epub 2021 Sep 24 doi: 10.1016/j.jocn.2021.09.016. PMID: 34656254
Brain metastatic lesions.
O'Neill BP, Buckner JC, Coffey RJ, Dinapoli RP, Shaw EG
Mayo Clin Proc 1994 Nov;69(11):1062-8. doi: 10.1016/s0025-6196(12)61374-3. PMID: 7967760

Diagnosis

Genetic insights into the morass of metastatic heterogeneity.
Hunter KW, Amin R, Deasy S, Ha NH, Wakefield L
Nat Rev Cancer 2018 Apr;18(4):211-223. Epub 2018 Feb 9 doi: 10.1038/nrc.2017.126. PMID: 29422598Free PMC Article
Impending fracture: A difficult diagnosis.
Piccioli A, Spinelli MS, Maccauro G
Injury 2014 Dec;45 Suppl 6:S138-41. Epub 2014 Nov 4 doi: 10.1016/j.injury.2014.10.038. PMID: 25457334
Gallbladder carcinosarcoma.
Pu JJ, Wu W
BMJ Case Rep 2011 Apr 1;2011 doi: 10.1136/bcr.05.2010.3009. PMID: 22700610Free PMC Article
Adrenal schwannoma.
Târcoveanu E, Dimofte G, Bradea C, Moldovanu R, Vasilescu A, Anton R, Ferariu D
JSLS 2009 Jan-Mar;13(1):116-9. PMID: 19366556Free PMC Article
Brain metastatic lesions.
O'Neill BP, Buckner JC, Coffey RJ, Dinapoli RP, Shaw EG
Mayo Clin Proc 1994 Nov;69(11):1062-8. doi: 10.1016/s0025-6196(12)61374-3. PMID: 7967760

Therapy

PD-1 Inhibitor Combined With Radiotherapy and GM-CSF (PRaG) in Patients With Metastatic Solid Tumors: An Open-Label Phase II Study.
Kong Y, Zhao X, Xu M, Pan J, Ma Y, Zou L, Peng Q, Zhang J, Su C, Xu Z, Zhou W, Peng Y, Yang J, Zhou C, Li Y, Guo Q, Chen G, Wu H, Xing P, Zhang L
Front Immunol 2022;13:952066. Epub 2022 Jul 8 doi: 10.3389/fimmu.2022.952066. PMID: 35874780Free PMC Article
Breast Cancers Are Immunogenic: Immunologic Analyses and a Phase II Pilot Clinical Trial Using Mutation-Reactive Autologous Lymphocytes.
Zacharakis N, Huq LM, Seitter SJ, Kim SP, Gartner JJ, Sindiri S, Hill VK, Li YF, Paria BC, Ray S, Gasmi B, Lee CC, Prickett TD, Parkhurst MR, Robbins PF, Langhan MM, Shelton TE, Parikh AY, Levi ST, Hernandez JM, Hoang CD, Sherry RM, Yang JC, Feldman SA, Goff SL, Rosenberg SA
J Clin Oncol 2022 Jun 1;40(16):1741-1754. Epub 2022 Feb 1 doi: 10.1200/JCO.21.02170. PMID: 35104158Free PMC Article
Integrative evaluation of primary and metastatic lesion spectrum to guide anti-PD-L1 therapy of non-small cell lung cancer: results from two randomized studies.
Ma SC, Tang XR, Long LL, Bai X, Zhou JG, Duan ZJ, Wang J, Fu QJ, Zhu HB, Guo XJ, Zhang YP, Guo ZQ, Wu DH, Dong ZY
Oncoimmunology 2021 Apr 26;10(1):1909296. doi: 10.1080/2162402X.2021.1909296. PMID: 33996262Free PMC Article
Copy number and transcriptome alterations associated with metastatic lesion response to treatment in colorectal cancer.
Gambaro K, Marques M, McNamara S, Couetoux du Tertre M, Diaz Z, Hoffert C, Srivastava A, Hébert S, Samson B, Lespérance B, Ko YJ, Dalfen R, St-Hilaire E, Sideris L, Couture F, Burkes R, Harb M, Camlioglu E, Gologan A, Pelsser V, Constantin A, Greenwood CMT, Tejpar S, Kavan P, Kleinman CL, Batist G
Clin Transl Med 2021 Apr;11(4):e401. doi: 10.1002/ctm2.401. PMID: 33931971Free PMC Article
Progress in Targeted Alpha-Particle-Emitting Radiopharmaceuticals as Treatments for Prostate Cancer Patients with Bone Metastases.
Patel CM, Wadas TJ, Shiozawa Y
Molecules 2021 Apr 9;26(8) doi: 10.3390/molecules26082162. PMID: 33918705Free PMC Article

Prognosis

The Role of Metastasectomy in Urothelial Carcinoma: Where Are We in 2020?
Lemke E, Sahasrabudhe D, Guancial E, Bylow K, Johnson S, Messing E, Kilari D
Clin Genitourin Cancer 2020 Aug;18(4):e478-e483. Epub 2020 Jan 27 doi: 10.1016/j.clgc.2020.01.003. PMID: 32085986
Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis.
Graham N, Qian BZ
Int J Mol Sci 2018 Apr 9;19(4) doi: 10.3390/ijms19041121. PMID: 29642534Free PMC Article
Impending fracture: A difficult diagnosis.
Piccioli A, Spinelli MS, Maccauro G
Injury 2014 Dec;45 Suppl 6:S138-41. Epub 2014 Nov 4 doi: 10.1016/j.injury.2014.10.038. PMID: 25457334
Osteosarcoma of the skin.
Larsen S, Davis DM, Comfere NI, Folpe AL, Sciallis GF
Int J Dermatol 2010 May;49(5):532-40. doi: 10.1111/j.1365-4632.2010.04315.x. PMID: 20534087
Adrenal schwannoma.
Târcoveanu E, Dimofte G, Bradea C, Moldovanu R, Vasilescu A, Anton R, Ferariu D
JSLS 2009 Jan-Mar;13(1):116-9. PMID: 19366556Free PMC Article

Clinical prediction guides

Pituitary metastasis: From pathology to clinical and radiological considerations.
Kameda-Smith MM, Zhang E, Lannon M, Algird A, Reddy K, Lu JQ
J Clin Neurosci 2021 Nov;93:231-240. Epub 2021 Sep 24 doi: 10.1016/j.jocn.2021.09.016. PMID: 34656254
Development and validation of a longitudinal soft-tissue metastatic lesion matching algorithm.
Santoro-Fernandes V, Huff D, Scarpelli ML, Perk TG, Albertini MR, Perlman S, Yip SSF, Jeraj R
Phys Med Biol 2021 Jul 30;66(15) doi: 10.1088/1361-6560/ac1457. PMID: 34261045
The effects of metastatic lesion on the structural determinants of bone: Current clinical and experimental approaches.
Bailey S, Hackney D, Vashishth D, Alkalay RN
Bone 2020 Sep;138:115159. Epub 2019 Nov 21 doi: 10.1016/j.bone.2019.115159. PMID: 31759204Free PMC Article
Personalizing Therapy for Metastatic Prostate Cancer: The Role of Solid and Liquid Tumor Biopsies.
Friedlander TW, Pritchard CC, Beltran H
Am Soc Clin Oncol Educ Book 2017;37:358-369. doi: 10.1200/EDBK_175510. PMID: 28561699
Impending fracture: A difficult diagnosis.
Piccioli A, Spinelli MS, Maccauro G
Injury 2014 Dec;45 Suppl 6:S138-41. Epub 2014 Nov 4 doi: 10.1016/j.injury.2014.10.038. PMID: 25457334

Recent systematic reviews

Clinical features and management of trophoblastic epithelioid tumors: A systematic review.
Gorun F, Tomescu L, Motoc A, Citu C, Sas I, Serban DM, Forga M, Citu IM, Gorun OM
Medicine (Baltimore) 2022 Jul 29;101(30):e29934. doi: 10.1097/MD.0000000000029934. PMID: 35905248Free PMC Article
Malignant Outcomes of Architectural Distortion on Tomosynthesis: A Systematic Review and Meta-Analysis.
Choudhery S, Johnson MP, Larson NB, Anderson T
AJR Am J Roentgenol 2021 Aug;217(2):295-303. Epub 2020 Sep 23 doi: 10.2214/AJR.20.23935. PMID: 32966111
Primary gastric melanoma in adult population: a systematic review of the literature.
Schizas D, Tomara N, Katsaros I, Sakellariou S, Machairas N, Paspala A, Tsilimigras DI, Papanikolaou IS, Mantas D
ANZ J Surg 2021 Mar;91(3):269-275. Epub 2020 Jul 20 doi: 10.1111/ans.16160. PMID: 32687691
A systematic review of interventions and outcomes in lung cancer metastases to the spine.
Armstrong V, Schoen N, Madhavan K, Vanni S
J Clin Neurosci 2019 Apr;62:66-71. Epub 2019 Jan 14 doi: 10.1016/j.jocn.2019.01.006. PMID: 30655233
Treatment for long bone metastases based on a systematic literature review.
Errani C, Mavrogenis AF, Cevolani L, Spinelli S, Piccioli A, Maccauro G, Baldini N, Donati D
Eur J Orthop Surg Traumatol 2017 Feb;27(2):205-211. Epub 2016 Sep 20 doi: 10.1007/s00590-016-1857-9. PMID: 27650452

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...