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AIDS-Related Malignant Anal Neoplasm

MedGen UID:
272258
•Concept ID:
C1332049
•
Neoplastic Process
Synonyms: AIDS-Related Malignant Anal Tumor; AIDS-Related Malignant Neoplasm of Anus; AIDS-Related Malignant Neoplasm of the Anus; AIDS-Related Malignant Tumor of Anus; AIDS-Related Malignant Tumor of the Anus

Definition

A malignant neoplasm arising from the anus and occurring in HIV-positive patients. Representative examples include squamous cell carcinoma and non-Hodgkin lymphoma. Homosexual HIV-positive men have an increased risk of developing such malignancies in comparison to the general male population. [from NCI]

Professional guidelines

PubMed

HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Diagnosis and management of lymphomas and other cancers in HIV-infected patients.
Carbone A, Vaccher E, Gloghini A, Pantanowitz L, Abayomi A, de Paoli P, Franceschi S
Nat Rev Clin Oncol 2014 Apr;11(4):223-38. Epub 2014 Mar 11 doi: 10.1038/nrclinonc.2014.31. PMID: 24614140
Diagnosis and management of HPV-related anal dysplasia.
Greene MD
Nurse Pract 2009 May;34(5):45-51. doi: 10.1097/01.NPR.0000350571.53729.74. PMID: 19390399

Recent clinical studies

Etiology

Self-collected and clinician-collected anal swabs show modest agreement for HPV genotyping.
Dube Mandishora RS, Rounge TB, Fitzpatrick M, Christiansen IK, Ambur OH, Lagström S, Stray-Pedersen B, Tommasino M, Palefsky J, Chirenje ZM
PLoS One 2021;16(4):e0250426. Epub 2021 Apr 26 doi: 10.1371/journal.pone.0250426. PMID: 33901223Free PMC Article
Care of Patients With HIV Infection: Medical Complications and Comorbidities.
Bolduc P, Roder N, Colgate E, Cheeseman SH
FP Essent 2016 Apr;443:16-22. PMID: 27092563
The role of viral co-infection in HIV-associated non-AIDS-related cancers.
Riedel DJ, Tang LS, Rositch AF
Curr HIV/AIDS Rep 2015 Sep;12(3):362-72. doi: 10.1007/s11904-015-0276-6. PMID: 26152660Free PMC Article
Colorectal and anal cancer in HIV/AIDS patients: a comprehensive review.
Kan M, Wong PH, Press N, Wiseman SM
Expert Rev Anticancer Ther 2014 Apr;14(4):395-405. Epub 2014 Feb 9 doi: 10.1586/14737140.2013.877843. PMID: 24506785
Opportunistic infections.
Vazquez E
Posit Aware 1996 Sep-Oct;7(5):12-3. PMID: 11363782

Diagnosis

Self-collected and clinician-collected anal swabs show modest agreement for HPV genotyping.
Dube Mandishora RS, Rounge TB, Fitzpatrick M, Christiansen IK, Ambur OH, Lagström S, Stray-Pedersen B, Tommasino M, Palefsky J, Chirenje ZM
PLoS One 2021;16(4):e0250426. Epub 2021 Apr 26 doi: 10.1371/journal.pone.0250426. PMID: 33901223Free PMC Article
HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Diagnosis and management of lymphomas and other cancers in HIV-infected patients.
Carbone A, Vaccher E, Gloghini A, Pantanowitz L, Abayomi A, de Paoli P, Franceschi S
Nat Rev Clin Oncol 2014 Apr;11(4):223-38. Epub 2014 Mar 11 doi: 10.1038/nrclinonc.2014.31. PMID: 24614140
Colorectal and anal cancer in HIV/AIDS patients: a comprehensive review.
Kan M, Wong PH, Press N, Wiseman SM
Expert Rev Anticancer Ther 2014 Apr;14(4):395-405. Epub 2014 Feb 9 doi: 10.1586/14737140.2013.877843. PMID: 24506785
Human papillomavirus, anal cancer, and screening considerations among HIV-infected individuals.
Cachay ER, Mathews WC
AIDS Rev 2013 Apr-Jun;15(2):122-33. PMID: 23681437

Therapy

HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Diagnosis and management of lymphomas and other cancers in HIV-infected patients.
Carbone A, Vaccher E, Gloghini A, Pantanowitz L, Abayomi A, de Paoli P, Franceschi S
Nat Rev Clin Oncol 2014 Apr;11(4):223-38. Epub 2014 Mar 11 doi: 10.1038/nrclinonc.2014.31. PMID: 24614140
Human papillomavirus-related cervical and anal disease in HIV-infected individuals in the era of highly active antiretroviral therapy.
Piketty C, Kazatchkine MD
Curr HIV/AIDS Rep 2005 Aug;2(3):140-5. doi: 10.1007/s11904-005-0007-5. PMID: 16091261
AIDS-related tumors: integrating antiviral and anticancer therapy.
Tirelli U, Bernardi D, Spina M, Vaccher E
Crit Rev Oncol Hematol 2002 Mar;41(3):299-315. doi: 10.1016/s1040-8428(01)00165-2. PMID: 11880206
Anal intraepithelial neoplasia in HIV positive people.
Martin F, Bower M
Sex Transm Infect 2001 Oct;77(5):327-31. doi: 10.1136/sti.77.5.327. PMID: 11588276Free PMC Article

Prognosis

Follow-Up to High-Resolution Anoscopy After Abnormal Anal Cytology in People Living with HIV.
Wells J, Flowers L, Mehta CC, Chandler R, Knott R, McDonnell Holstad M, Watkins Bruner D
AIDS Patient Care STDS 2022 Jul;36(7):263-271. Epub 2022 Jun 21 doi: 10.1089/apc.2022.0057. PMID: 35727648Free PMC Article
Colorectal and anal cancer in HIV/AIDS patients: a comprehensive review.
Kan M, Wong PH, Press N, Wiseman SM
Expert Rev Anticancer Ther 2014 Apr;14(4):395-405. Epub 2014 Feb 9 doi: 10.1586/14737140.2013.877843. PMID: 24506785
Human papillomavirus, anal cancer, and screening considerations among HIV-infected individuals.
Cachay ER, Mathews WC
AIDS Rev 2013 Apr-Jun;15(2):122-33. PMID: 23681437
Anal intraepithelial neoplasia in HIV positive people.
Martin F, Bower M
Sex Transm Infect 2001 Oct;77(5):327-31. doi: 10.1136/sti.77.5.327. PMID: 11588276Free PMC Article
Acquired immunodeficiency syndrome-related Kaposi's sarcoma.
Wang CY, Schroeter AL, Su WP
Mayo Clin Proc 1995 Sep;70(9):869-79. PMID: 7643641

Clinical prediction guides

Non-AIDS-Defining Cancer Mortality: Emerging Patterns in the Late HAART Era.
Zucchetto A, Virdone S, Taborelli M, Grande E, Camoni L, Pappagallo M, Regine V, Grippo F, Polesel J, Dal Maso L, Suligoi B, Frova L, Serraino D
J Acquir Immune Defic Syndr 2016 Oct 1;73(2):190-6. doi: 10.1097/QAI.0000000000001033. PMID: 27116048
Cumulative incidence of cancer among individuals with acquired immunodeficiency syndrome in the United States.
Simard EP, Pfeiffer RM, Engels EA
Cancer 2011 Mar 1;117(5):1089-96. Epub 2010 Oct 19 doi: 10.1002/cncr.25547. PMID: 20960504Free PMC Article
Spectrum of cancer risk late after AIDS onset in the United States.
Simard EP, Pfeiffer RM, Engels EA
Arch Intern Med 2010 Aug 9;170(15):1337-45. doi: 10.1001/archinternmed.2010.253. PMID: 20696958Free PMC Article
The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men.
Cranston RD, Hart SD, Gornbein JA, Hirschowitz SL, Cortina G, Moe AA
Int J STD AIDS 2007 Feb;18(2):77-80. doi: 10.1258/095646207779949772. PMID: 17331275
Anal intraepithelial neoplasia in HIV positive people.
Martin F, Bower M
Sex Transm Infect 2001 Oct;77(5):327-31. doi: 10.1136/sti.77.5.327. PMID: 11588276Free PMC Article

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