U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adult brain stem neoplasm

MedGen UID:
272292
•Concept ID:
C1332192
•
Neoplastic Process
Synonyms: Adult Brain Stem Neoplasm; adult brain stem neoplasm; Adult Brain Stem Tumor; adult brain stem tumor; adult brain stem tumour; Adult Brainstem Neoplasm; adult brainstem neoplasm; Adult Brainstem Tumor; adult brainstem tumor; adult brainstem tumour; brainstem neoplasm of adults; Neoplasm of Adult Brain Stem; neoplasm of adult brain stem; Neoplasm of Adult Brainstem; neoplasm of adult brainstem; Neoplasm of the Adult Brain Stem; neoplasm of the adult brain stem; Neoplasm of the Adult Brainstem; neoplasm of the adult brainstem; Tumor of Adult Brain Stem; tumor of adult brain stem; Tumor of Adult Brainstem; tumor of adult brainstem; Tumor of the Adult Brain Stem; tumor of the adult brain stem; Tumor of the Adult Brainstem; tumor of the adult brainstem; tumour of adult brain stem; tumour of adult brainstem; tumour of the adult brain stem; tumour of the adult brainstem
 
Monarch Initiative: MONDO:0024797

Definition

A benign or malignant, primary or metastatic neoplasm of the brain stem occurring in adults. [from NCI]

Professional guidelines

PubMed

Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma.
Biserova K, Jakovlevs A, Uljanovs R, Strumfa I
Cells 2021 Mar 11;10(3) doi: 10.3390/cells10030621. PMID: 33799798Free PMC Article
Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients: guidelines from the European Association for Neuro-Oncology.
Hoang-Xuan K, Bessell E, Bromberg J, Hottinger AF, Preusser M, Rudà R, Schlegel U, Siegal T, Soussain C, Abacioglu U, Cassoux N, Deckert M, Dirven CM, Ferreri AJ, Graus F, Henriksson R, Herrlinger U, Taphoorn M, Soffietti R, Weller M; European Association for Neuro-Oncology Task Force on Primary CNS Lymphoma
Lancet Oncol 2015 Jul;16(7):e322-32. doi: 10.1016/S1470-2045(15)00076-5. PMID: 26149884

Recent clinical studies

Etiology

Primary Central Nervous System Lymphomas.
Chukwueke U, Grommes C, Nayak L
Hematol Oncol Clin North Am 2022 Feb;36(1):147-159. doi: 10.1016/j.hoc.2021.09.004. PMID: 34801161
Glioma.
Weller M, Wick W, Aldape K, Brada M, Berger M, Pfister SM, Nishikawa R, Rosenthal M, Wen PY, Stupp R, Reifenberger G
Nat Rev Dis Primers 2015 Jul 16;1:15017. doi: 10.1038/nrdp.2015.17. PMID: 27188790
R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma.
Omuro A, Correa DD, DeAngelis LM, Moskowitz CH, Matasar MJ, Kaley TJ, Gavrilovic IT, Nolan C, Pentsova E, Grommes CC, Panageas KS, Baser RE, Faivre G, Abrey LE, Sauter CS
Blood 2015 Feb 26;125(9):1403-10. Epub 2015 Jan 7 doi: 10.1182/blood-2014-10-604561. PMID: 25568347Free PMC Article
Brainstem glioma: a review.
Grimm SA, Chamberlain MC
Curr Neurol Neurosci Rep 2013 May;13(5):346. doi: 10.1007/s11910-013-0346-3. PMID: 23512689
Cerebellar hemangioblastomas.
Sung DI, Chang CH, Harisiadis L
Cancer 1982 Feb 1;49(3):553-5. doi: 10.1002/1097-0142(19820201)49:3<553::aid-cncr2820490326>3.0.co;2-a. PMID: 7199372

Diagnosis

The Role of Advanced MRI Sequences in the Diagnosis and Follow-Up of Adult Brainstem Gliomas: A Neuroradiological Review.
Guarnera A, Romano A, Moltoni G, Ius T, Palizzi S, Romano A, Bagatto D, Minniti G, Bozzao A
Tomography 2023 Aug 18;9(4):1526-1537. doi: 10.3390/tomography9040122. PMID: 37624115Free PMC Article
Oncolytic virotherapy for the treatment of pediatric brainstem gliomas.
Gállego Pérez-Larraya J, García-Moure M, Alonso MM
Rev Neurol (Paris) 2023 Jun;179(5):475-480. Epub 2023 Apr 13 doi: 10.1016/j.neurol.2023.03.016. PMID: 37061388
Lymphoblastic lymphoma.
Cortelazzo S, Ferreri A, Hoelzer D, Ponzoni M
Crit Rev Oncol Hematol 2017 May;113:304-317. Epub 2017 Mar 18 doi: 10.1016/j.critrevonc.2017.03.020. PMID: 28427520
Brainstem gliomas.
Ramos A, Hilario A, Lagares A, Salvador E, Perez-Nuñez A, Sepulveda J
Semin Ultrasound CT MR 2013 Apr;34(2):104-12. doi: 10.1053/j.sult.2013.01.001. PMID: 23522775
Brainstem glioma: a review.
Grimm SA, Chamberlain MC
Curr Neurol Neurosci Rep 2013 May;13(5):346. doi: 10.1007/s11910-013-0346-3. PMID: 23512689

Therapy

How I treat secondary CNS involvement by aggressive lymphomas.
Alderuccio JP, Nayak L, Cwynarski K
Blood 2023 Nov 23;142(21):1771-1783. doi: 10.1182/blood.2023020168. PMID: 37702537Free PMC Article
Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma.
Biserova K, Jakovlevs A, Uljanovs R, Strumfa I
Cells 2021 Mar 11;10(3) doi: 10.3390/cells10030621. PMID: 33799798Free PMC Article
Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma.
Ahir BK, Engelhard HH, Lakka SS
Mol Neurobiol 2020 May;57(5):2461-2478. Epub 2020 Mar 9 doi: 10.1007/s12035-020-01892-8. PMID: 32152825Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ferreri A, Hoelzer D, Ponzoni M
Crit Rev Oncol Hematol 2017 May;113:304-317. Epub 2017 Mar 18 doi: 10.1016/j.critrevonc.2017.03.020. PMID: 28427520
R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma.
Omuro A, Correa DD, DeAngelis LM, Moskowitz CH, Matasar MJ, Kaley TJ, Gavrilovic IT, Nolan C, Pentsova E, Grommes CC, Panageas KS, Baser RE, Faivre G, Abrey LE, Sauter CS
Blood 2015 Feb 26;125(9):1403-10. Epub 2015 Jan 7 doi: 10.1182/blood-2014-10-604561. PMID: 25568347Free PMC Article

Prognosis

Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma.
Biserova K, Jakovlevs A, Uljanovs R, Strumfa I
Cells 2021 Mar 11;10(3) doi: 10.3390/cells10030621. PMID: 33799798Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ferreri A, Hoelzer D, Ponzoni M
Crit Rev Oncol Hematol 2017 May;113:304-317. Epub 2017 Mar 18 doi: 10.1016/j.critrevonc.2017.03.020. PMID: 28427520
Adult brainstem gliomas.
Eisele SC, Reardon DA
Cancer 2016 Sep 15;122(18):2799-809. Epub 2016 Jun 21 doi: 10.1002/cncr.29920. PMID: 27327773
R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma.
Omuro A, Correa DD, DeAngelis LM, Moskowitz CH, Matasar MJ, Kaley TJ, Gavrilovic IT, Nolan C, Pentsova E, Grommes CC, Panageas KS, Baser RE, Faivre G, Abrey LE, Sauter CS
Blood 2015 Feb 26;125(9):1403-10. Epub 2015 Jan 7 doi: 10.1182/blood-2014-10-604561. PMID: 25568347Free PMC Article
Cerebellar hemangioblastomas.
Sung DI, Chang CH, Harisiadis L
Cancer 1982 Feb 1;49(3):553-5. doi: 10.1002/1097-0142(19820201)49:3<553::aid-cncr2820490326>3.0.co;2-a. PMID: 7199372

Clinical prediction guides

How I treat secondary CNS involvement by aggressive lymphomas.
Alderuccio JP, Nayak L, Cwynarski K
Blood 2023 Nov 23;142(21):1771-1783. doi: 10.1182/blood.2023020168. PMID: 37702537Free PMC Article
TRAF4 Maintains Deubiquitination of Caveolin-1 to Drive Glioblastoma Stemness and Temozolomide Resistance.
Li Y, Wang T, Wan Q, Wang Q, Chen Z, Gao Y, Ye Y, Lin J, Zhao B, Wang H, Yang J, Zhao K, Lu N
Cancer Res 2022 Oct 4;82(19):3573-3587. doi: 10.1158/0008-5472.CAN-21-3882. PMID: 35895752
Response assessment in paediatric high-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group.
Erker C, Tamrazi B, Poussaint TY, Mueller S, Mata-Mbemba D, Franceschi E, Brandes AA, Rao A, Haworth KB, Wen PY, Goldman S, Vezina G, MacDonald TJ, Dunkel IJ, Morgan PS, Jaspan T, Prados MD, Warren KE
Lancet Oncol 2020 Jun;21(6):e317-e329. doi: 10.1016/S1470-2045(20)30173-X. PMID: 32502458
Response assessment in paediatric low-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group.
Fangusaro J, Witt O, Hernáiz Driever P, Bag AK, de Blank P, Kadom N, Kilburn L, Lober RM, Robison NJ, Fisher MJ, Packer RJ, Young Poussaint T, Papusha L, Avula S, Brandes AA, Bouffet E, Bowers D, Artemov A, Chintagumpala M, Zurakowski D, van den Bent M, Bison B, Yeom KW, Taal W, Warren KE
Lancet Oncol 2020 Jun;21(6):e305-e316. doi: 10.1016/S1470-2045(20)30064-4. PMID: 32502457
R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma.
Omuro A, Correa DD, DeAngelis LM, Moskowitz CH, Matasar MJ, Kaley TJ, Gavrilovic IT, Nolan C, Pentsova E, Grommes CC, Panageas KS, Baser RE, Faivre G, Abrey LE, Sauter CS
Blood 2015 Feb 26;125(9):1403-10. Epub 2015 Jan 7 doi: 10.1182/blood-2014-10-604561. PMID: 25568347Free PMC Article

Recent systematic reviews

Brain and Brain Stem Necrosis After Reirradiation for Recurrent Childhood Primary Central Nervous System Tumors: A PENTEC Comprehensive Review.
Ajithkumar T, Avanzo M, Yorke E, Tsang DS, Milano MT, Olch AJ, Merchant TE, Dieckmann K, Mahajan A, Fuji H, Paulino AC, Timmermann B, Marks LB, Bentzen SM, Jackson A, Constine LS
Int J Radiat Oncol Biol Phys 2024 Jun 1;119(2):655-668. Epub 2024 Feb 1 doi: 10.1016/j.ijrobp.2023.12.043. PMID: 38300187
Surgical Management of Adult Brainstem Gliomas: A Systematic Review and Meta-Analysis.
Ius T, Lombardi G, Baiano C, Berardinelli J, Romano A, Montemurro N, Cavallo LM, Pasqualetti F, Feletti A
Curr Oncol 2023 Nov 7;30(11):9772-9785. doi: 10.3390/curroncol30110709. PMID: 37999129Free PMC Article
Overweight, obesity and adiposity in survivors of childhood brain tumours: a systematic review and meta-analysis.
Wang KW, Fleming A, Johnston DL, Zelcer SM, Rassekh SR, Ladhani S, Socha A, Shinuda J, Jaber S, Burrow S, Singh SK, Banfield L, de Souza RJ, Thabane L, Samaan MC
Clin Obes 2018 Feb;8(1):55-67. Epub 2017 Oct 11 doi: 10.1111/cob.12224. PMID: 29024558
Sphingosine 1-phosphate (S1P) signaling in glioblastoma multiforme-A systematic review.
Mahajan-Thakur S, Bien-Möller S, Marx S, Schroeder H, Rauch BH
Int J Mol Sci 2017 Nov 17;18(11) doi: 10.3390/ijms18112448. PMID: 29149079Free PMC Article
Challenges and opportunities in primary CNS lymphoma: A systematic review.
Kerbauy MN, Moraes FY, Lok BH, Ma J, Kerbauy LN, Spratt DE, Santos FP, Perini GF, Berlin A, Chung C, Hamerschlak N, Yahalom J
Radiother Oncol 2017 Mar;122(3):352-361. Epub 2017 Jan 16 doi: 10.1016/j.radonc.2016.12.033. PMID: 28104300

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...