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Ampulla of Vater Intestinal-Type Adenocarcinoma

MedGen UID:
272303
•Concept ID:
C1332247
•
Neoplastic Process
Synonym: Ampulla of Vater Invasive Intestinal Type Adenocarcinoma

Definition

An invasive adenocarcinoma arising from the ampulla of Vater. Morphologically, it is characterized by the presence of intestinal-type malignant epithelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmpulla of Vater Intestinal-Type Adenocarcinoma

Recent clinical studies

Etiology

Impact of extra-ampullary duodenal adenocarcinoma subtypes on surgical and oncological outcomes following pancreaticoduodenectomy.
De Pastena M, Zingaretti CC, Paiella S, Guerriero M, De Santis N, Luchini C, Bassi C, Malleo G, Salvia R
Updates Surg 2024 Jan;76(1):87-95. Epub 2023 Dec 13 doi: 10.1007/s13304-023-01688-0. PMID: 38093152
Association of Histopathologic Phenotype of Periampullary Adenocarcinomas With Survival.
Williams JL, Chan CK, Toste PA, Elliott IA, Vasquez CR, Sunjaya DB, Swanson EA, Koo J, Hines OJ, Reber HA, Dawson DW, Donahue TR
JAMA Surg 2017 Jan 1;152(1):82-88. doi: 10.1001/jamasurg.2016.3466. PMID: 27732711
Intestinal-type and pancreatobiliary-type adenocarcinomas: how does ampullary carcinoma differ from other periampullary malignancies?
Westgaard A, Pomianowska E, Clausen OP, Gladhaug IP
Ann Surg Oncol 2013 Feb;20(2):430-9. Epub 2012 Sep 7 doi: 10.1245/s10434-012-2603-0. PMID: 22956064
Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up.
Zhou H, Schaefer N, Wolff M, Fischer HP
Am J Surg Pathol 2004 Jul;28(7):875-82. doi: 10.1097/00000478-200407000-00005. PMID: 15223956
The histopathology and staging of carcinoma of the ampulla of Vater.
Talbot IC, Neoptolemos JP, Shaw DE, Carr-Locke D
Histopathology 1988 Feb;12(2):155-65. doi: 10.1111/j.1365-2559.1988.tb01926.x. PMID: 3366434

Diagnosis

Rare Orbital Metastasis Originating from Ampullary Adenocarcinoma.
Tsai YE, Chien KH, Li YF, Lai SW
Medicina (Kaunas) 2021 Nov 12;57(11) doi: 10.3390/medicina57111238. PMID: 34833456Free PMC Article
Cytological features of mixed adenoneuroendocrine carcinoma of the ampulla: two case reports with review of literature.
Zhang L, DeMay RM
Diagn Cytopathol 2014 Dec;42(12):1075-84. Epub 2014 Feb 19 doi: 10.1002/dc.23107. PMID: 24554593
Intestinal and pancreatobiliary differentiation in periampullary carcinoma: the role of immunohistochemistry.
Kumari N, Prabha K, Singh RK, Baitha DK, Krishnani N
Hum Pathol 2013 Oct;44(10):2213-9. Epub 2013 Jul 5 doi: 10.1016/j.humpath.2013.05.003. PMID: 23834763
MicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinoma.
Schultz NA, Werner J, Willenbrock H, Roslind A, Giese N, Horn T, Wøjdemann M, Johansen JS
Mod Pathol 2012 Dec;25(12):1609-22. Epub 2012 Aug 10 doi: 10.1038/modpathol.2012.122. PMID: 22878649
Pathogenesis of carcinoma of the papilla of Vater.
Fischer HP, Zhou H
J Hepatobiliary Pancreat Surg 2004;11(5):301-9. doi: 10.1007/s00534-004-0898-3. PMID: 15549428

Therapy

Clinico-pathological correlates and survival outcomes in 214 resected ampullary adenocarcinomas - are outcomes different in intestinal and pancreatobiliary subtypes with adjuvant gemcitabine?
Ramaswamy A, Bhandare M, Bal M, Shrirangwar S, Kataria P, Majumdar S, Swami R, Rohila J, Chaudhari V, Mandavkar S, Chavan N, Shrikhande SV, Ostwal V
HPB (Oxford) 2020 Mar;22(3):376-382. Epub 2019 Aug 9 doi: 10.1016/j.hpb.2019.07.006. PMID: 31405778
Histomorphologic and molecular phenotypes predict gemcitabine response and overall survival in adenocarcinoma of the ampulla of Vater.
Schiergens TS, Reu S, Neumann J, Renz BW, Niess H, Boeck S, Heinemann V, Bruns CJ, Jauch KW, Kleespies A
Surgery 2015 Jul;158(1):151-61. Epub 2015 Mar 26 doi: 10.1016/j.surg.2015.02.001. PMID: 25819575
Twenty-six cases of advanced ampullary adenocarcinoma treated with systemic chemotherapy.
Shoji H, Morizane C, Hiraoka N, Kondo S, Ueno H, Ohno I, Shimizu S, Mitsunaga S, Ikeda M, Okusaka T
Jpn J Clin Oncol 2014 Apr;44(4):324-30. Epub 2014 Jan 30 doi: 10.1093/jjco/hyt237. PMID: 24482413
Better outcome of XELOX chemotherapy in patients with advanced intestinal-type adenocarcinoma of the ampulla of Vater.
Kim HS, Shin SJ, Kim JH, Kim H, Choi HJ
Tohoku J Exp Med 2013 Sep;231(1):21-8. doi: 10.1620/tjem.231.21. PMID: 23994910

Prognosis

Poorly Cohesive (Signet Ring Cell) Carcinoma of the Ampulla of Vater.
Tuncel D, Basturk O, Bradley KT, Kim GE, Xue Y, Reid MD, Balci S, Erbarut I, Adsay V
Int J Surg Pathol 2020 May;28(3):236-244. Epub 2019 Oct 15 doi: 10.1177/1066896919880968. PMID: 31612756
Ampullary cancer--a separate clinical entity?
Perysinakis I, Margaris I, Kouraklis G
Histopathology 2014 May;64(6):759-68. Epub 2014 Jan 24 doi: 10.1111/his.12324. PMID: 24456259
Intestinal-type and pancreatobiliary-type adenocarcinomas: how does ampullary carcinoma differ from other periampullary malignancies?
Westgaard A, Pomianowska E, Clausen OP, Gladhaug IP
Ann Surg Oncol 2013 Feb;20(2):430-9. Epub 2012 Sep 7 doi: 10.1245/s10434-012-2603-0. PMID: 22956064
The clinicopathologic and immunohistochemical characteristics of ampulla of Vater carcinoma: the intestinal type is associated with a better prognosis.
Roh YH, Kim YH, Lee HW, Kim SJ, Roh MS, Jeong JS, Jung GJ
Hepatogastroenterology 2007 Sep;54(78):1641-4. PMID: 18019683
Pathogenesis of carcinoma of the papilla of Vater.
Fischer HP, Zhou H
J Hepatobiliary Pancreat Surg 2004;11(5):301-9. doi: 10.1007/s00534-004-0898-3. PMID: 15549428

Clinical prediction guides

Clinico-pathological correlates and survival outcomes in 214 resected ampullary adenocarcinomas - are outcomes different in intestinal and pancreatobiliary subtypes with adjuvant gemcitabine?
Ramaswamy A, Bhandare M, Bal M, Shrirangwar S, Kataria P, Majumdar S, Swami R, Rohila J, Chaudhari V, Mandavkar S, Chavan N, Shrikhande SV, Ostwal V
HPB (Oxford) 2020 Mar;22(3):376-382. Epub 2019 Aug 9 doi: 10.1016/j.hpb.2019.07.006. PMID: 31405778
MiR-21 up-regulation in ampullary adenocarcinoma and its pre-invasive lesions.
Saraggi D, Galuppini F, Fanelli GN, Remo A, Urso EDL, Bao RQ, Bacchin D, Guzzardo V, Luchini C, Braconi C, Farinati F, Rugge M, Fassan M
Pathol Res Pract 2018 Jun;214(6):835-839. Epub 2018 May 1 doi: 10.1016/j.prp.2018.04.018. PMID: 29731265
MicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinoma.
Schultz NA, Werner J, Willenbrock H, Roslind A, Giese N, Horn T, Wøjdemann M, Johansen JS
Mod Pathol 2012 Dec;25(12):1609-22. Epub 2012 Aug 10 doi: 10.1038/modpathol.2012.122. PMID: 22878649
Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma.
Westgaard A, Tafjord S, Farstad IN, Cvancarova M, Eide TJ, Mathisen O, Clausen OP, Gladhaug IP
BMC Cancer 2008 Jun 11;8:170. doi: 10.1186/1471-2407-8-170. PMID: 18547417Free PMC Article
The histopathology and staging of carcinoma of the ampulla of Vater.
Talbot IC, Neoptolemos JP, Shaw DE, Carr-Locke D
Histopathology 1988 Feb;12(2):155-65. doi: 10.1111/j.1365-2559.1988.tb01926.x. PMID: 3366434

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