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Pediatric infratentorial ependymoblastoma

MedGen UID:
272462
•Concept ID:
C1332972
•
Neoplastic Process
Synonyms: Childhood Infratentorial Embryonal Tumor with Multilayered Rosettes, C19MC-Altered; childhood infratentorial embryonal tumor with Multilayered Rosettes, C19MC-altered; childhood infratentorial embryonal tumour with Multilayered Rosettes, C19MC-altered; Childhood Infratentorial Ependymoblastoma; childhood infratentorial ependymoblastoma; Pediatric Infratentorial Ependymoblastoma; pediatric infratentorial ependymoblastoma
 
Monarch Initiative: MONDO:0004263

Definition

An embryonal tumor with multilayered rosettes, C19MC-altered that arises from the infratentorial region and occurs in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPediatric infratentorial ependymoblastoma

Professional guidelines

PubMed

A dosimetric comparison between three-dimensional conformal radiation therapy and intensity-modulated radiation therapy in the treatment of posterior fossa boost in medulloblastoma.
Gupta M, Kant R, Nautiyal V, Bisht J, Raghuvanshi S, Saini M, Kalra BP, Ahmad M
J Cancer Res Ther 2017 Oct-Dec;13(6):1027-1031. doi: 10.4103/0973-1482.220416. PMID: 29237970
Cognitive consequences of the treatment of medulloblastoma among children.
Saury JM, Emanuelson I
Pediatr Neurol 2011 Jan;44(1):21-30. doi: 10.1016/j.pediatrneurol.2010.07.004. PMID: 21147383
In vivo metabolism of childhood posterior fossa tumors and primitive neuroectodermal tumors before and after treatment.
Holthoff VA, Herholz K, Berthold F, Widemann B, Schröder R, Neubauer I, Heiss WD
Cancer 1993 Aug 15;72(4):1394-403. doi: 10.1002/1097-0142(19930815)72:4<1394::aid-cncr2820720440>3.0.co;2-d. PMID: 8339230

Recent clinical studies

Etiology

Postoperative cerebellar mutism syndrome is an acquired autism-like network disturbance.
Suresh H, Morgan BR, Mithani K, Warsi NM, Yan H, Germann J, Boutet A, Loh A, Gouveia FV, Young J, Quon J, Morgado F, Lerch J, Lozano AM, Al-Fatly B, Kühn AA, Laughlin S, Dewan MC, Mabbott D, Gorodetsky C, Bartels U, Huang A, Tabori U, Rutka JT, Drake JM, Kulkarni AV, Dirks P, Taylor MD, Ramaswamy V, Ibrahim GM
Neuro Oncol 2024 May 3;26(5):950-964. doi: 10.1093/neuonc/noad230. PMID: 38079480Free PMC Article
Mapping pediatric brain tumors to their origins in the developing cerebellum.
Okonechnikov K, Joshi P, Sepp M, Leiss K, Sarropoulos I, Murat F, Sill M, Beck P, Chan KC, Korshunov A, Sah F, Deng MY, Sturm D, DeSisto J, Donson AM, Foreman NK, Green AL, Robinson G, Orr BA, Gao Q, Darrow E, Hadley JL, Northcott PA, Gojo J, Kawauchi D, Hovestadt V, Filbin MG, von Deimling A, Zuckermann M, Pajtler KW, Kool M, Jones DTW, Jäger N, Kutscher LM, Kaessmann H, Pfister SM
Neuro Oncol 2023 Oct 3;25(10):1895-1909. doi: 10.1093/neuonc/noad124. PMID: 37534924Free PMC Article
Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma.
Dury RJ, Lourdusamy A, Macarthur DC, Peet AC, Auer DP, Grundy RG, Dineen RA
J Magn Reson Imaging 2022 Jul;56(1):147-157. Epub 2021 Nov 29 doi: 10.1002/jmri.28007. PMID: 34842328
Medulloblastoma: Clinical presentation.
Vinchon M, Leblond P
Neurochirurgie 2021 Feb;67(1):23-27. Epub 2019 Sep 5 doi: 10.1016/j.neuchi.2019.04.006. PMID: 31494131
Cerebellar mutism.
Pitsika M, Tsitouras V
J Neurosurg Pediatr 2013 Dec;12(6):604-14. Epub 2013 Sep 27 doi: 10.3171/2013.8.PEDS13168. PMID: 24073751

Diagnosis

Postoperative cerebellar mutism syndrome is an acquired autism-like network disturbance.
Suresh H, Morgan BR, Mithani K, Warsi NM, Yan H, Germann J, Boutet A, Loh A, Gouveia FV, Young J, Quon J, Morgado F, Lerch J, Lozano AM, Al-Fatly B, Kühn AA, Laughlin S, Dewan MC, Mabbott D, Gorodetsky C, Bartels U, Huang A, Tabori U, Rutka JT, Drake JM, Kulkarni AV, Dirks P, Taylor MD, Ramaswamy V, Ibrahim GM
Neuro Oncol 2024 May 3;26(5):950-964. doi: 10.1093/neuonc/noad230. PMID: 38079480Free PMC Article
Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma.
Dury RJ, Lourdusamy A, Macarthur DC, Peet AC, Auer DP, Grundy RG, Dineen RA
J Magn Reson Imaging 2022 Jul;56(1):147-157. Epub 2021 Nov 29 doi: 10.1002/jmri.28007. PMID: 34842328
Presenting symptoms and time to diagnosis for Pediatric Central Nervous System Tumors in Qatar: a report from Pediatric Neuro-Oncology Service in Qatar.
Maaz AUR, Yousif T, Saleh A, Pople I, Al-Kharazi K, Al-Rayahi J, Elkum N, Malik M
Childs Nerv Syst 2021 Feb;37(2):465-474. Epub 2020 Jul 24 doi: 10.1007/s00381-020-04815-z. PMID: 32710251Free PMC Article
Medulloblastoma: Clinical presentation.
Vinchon M, Leblond P
Neurochirurgie 2021 Feb;67(1):23-27. Epub 2019 Sep 5 doi: 10.1016/j.neuchi.2019.04.006. PMID: 31494131
Neuroimaging of pediatric posterior fossa tumors including review of the literature.
Poretti A, Meoded A, Huisman TA
J Magn Reson Imaging 2012 Jan;35(1):32-47. Epub 2011 Oct 11 doi: 10.1002/jmri.22722. PMID: 21989968

Therapy

Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma.
Dury RJ, Lourdusamy A, Macarthur DC, Peet AC, Auer DP, Grundy RG, Dineen RA
J Magn Reson Imaging 2022 Jul;56(1):147-157. Epub 2021 Nov 29 doi: 10.1002/jmri.28007. PMID: 34842328
The feasibility and efficacy of short-term visual-motor training in pediatric posterior fossa tumor survivors.
Kasatkin V, Deviaterikova A, Shurupova M, Karelin A
Eur J Phys Rehabil Med 2022 Feb;58(1):51-59. Epub 2021 Jul 12 doi: 10.23736/S1973-9087.21.06854-4. PMID: 34247471Free PMC Article
Brainstem Injury in Pediatric Patients Receiving Posterior Fossa Photon Radiation.
Devine CA, Liu KX, Ioakeim-Ioannidou M, Susko M, Poussaint TY, Huisman TAGM, Aboian M, Brown D, Zaslowe-Dude C, Rao AD, Orlina LT, Rawal B, Mueller S, Marcus KJ, Terezakis SA, Braunstein SE, Haas-Kogan DA
Int J Radiat Oncol Biol Phys 2019 Dec 1;105(5):1034-1042. Epub 2019 Aug 28 doi: 10.1016/j.ijrobp.2019.08.039. PMID: 31472183
Cerebellar mutism.
Pitsika M, Tsitouras V
J Neurosurg Pediatr 2013 Dec;12(6):604-14. Epub 2013 Sep 27 doi: 10.3171/2013.8.PEDS13168. PMID: 24073751
Adult medulloblastoma: multiagent chemotherapy.
Greenberg HS, Chamberlain MC, Glantz MJ, Wang S
Neuro Oncol 2001 Jan;3(1):29-34. doi: 10.1093/neuonc/3.1.29. PMID: 11305414Free PMC Article

Prognosis

Postoperative cerebellar mutism syndrome is an acquired autism-like network disturbance.
Suresh H, Morgan BR, Mithani K, Warsi NM, Yan H, Germann J, Boutet A, Loh A, Gouveia FV, Young J, Quon J, Morgado F, Lerch J, Lozano AM, Al-Fatly B, Kühn AA, Laughlin S, Dewan MC, Mabbott D, Gorodetsky C, Bartels U, Huang A, Tabori U, Rutka JT, Drake JM, Kulkarni AV, Dirks P, Taylor MD, Ramaswamy V, Ibrahim GM
Neuro Oncol 2024 May 3;26(5):950-964. doi: 10.1093/neuonc/noad230. PMID: 38079480Free PMC Article
Medulloblastoma: Clinical presentation.
Vinchon M, Leblond P
Neurochirurgie 2021 Feb;67(1):23-27. Epub 2019 Sep 5 doi: 10.1016/j.neuchi.2019.04.006. PMID: 31494131
Pediatric Posterior Fossa Medulloblastoma: The Role of Diffusion Imaging in Identifying Molecular Groups.
Reddy N, Ellison DW, Soares BP, Carson KA, Huisman TAGM, Patay Z
J Neuroimaging 2020 Jul;30(4):503-511. Epub 2020 Jun 12 doi: 10.1111/jon.12704. PMID: 32529709
Cerebellar mutism: the predictive role of preoperative language evaluation.
Bianchi F, Chieffo DPR, Frassanito P, Di Rocco C, Tamburrini G
Childs Nerv Syst 2020 Jun;36(6):1153-1157. Epub 2019 Jun 14 doi: 10.1007/s00381-019-04252-7. PMID: 31201497
Posterior fossa tumors in children: developmental anatomy and diagnostic imaging.
Raybaud C, Ramaswamy V, Taylor MD, Laughlin S
Childs Nerv Syst 2015 Oct;31(10):1661-76. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2834-z. PMID: 26351220

Clinical prediction guides

Comparison of neuropsychological functioning in pediatric posterior fossa tumor survivors: Medulloblastoma, low-grade astrocytoma, and healthy controls.
Levitch CF, Holland AA, Bledsoe J, Kim SY, Barnett M, Ramjan S, Sands SA
Pediatr Blood Cancer 2022 Feb;69(2):e29491. Epub 2021 Nov 29 doi: 10.1002/pbc.29491. PMID: 34842359Free PMC Article
Machine Assist for Pediatric Posterior Fossa Tumor Diagnosis: A Multinational Study.
Zhang M, Wong SW, Wright JN, Toescu S, Mohammadzadeh M, Han M, Lummus S, Wagner MW, Yecies D, Lai H, Eghbal A, Radmanesh A, Nemelka J, Harward S, Malinzak M, Laughlin S, Perreault S, Braun KRM, Vossough A, Poussaint T, Goetti R, Ertl-Wagner B, Ho CY, Oztekin O, Ramaswamy V, Mankad K, Vitanza NA, Cheshier SH, Said M, Aquilina K, Thompson E, Jaju A, Grant GA, Lober RM, Yeom KW
Neurosurgery 2021 Oct 13;89(5):892-900. doi: 10.1093/neuros/nyab311. PMID: 34392363Free PMC Article
Medulloblastoma: Clinical presentation.
Vinchon M, Leblond P
Neurochirurgie 2021 Feb;67(1):23-27. Epub 2019 Sep 5 doi: 10.1016/j.neuchi.2019.04.006. PMID: 31494131
Pediatric Posterior Fossa Medulloblastoma: The Role of Diffusion Imaging in Identifying Molecular Groups.
Reddy N, Ellison DW, Soares BP, Carson KA, Huisman TAGM, Patay Z
J Neuroimaging 2020 Jul;30(4):503-511. Epub 2020 Jun 12 doi: 10.1111/jon.12704. PMID: 32529709
Cerebellar mutism: the predictive role of preoperative language evaluation.
Bianchi F, Chieffo DPR, Frassanito P, Di Rocco C, Tamburrini G
Childs Nerv Syst 2020 Jun;36(6):1153-1157. Epub 2019 Jun 14 doi: 10.1007/s00381-019-04252-7. PMID: 31201497

Recent systematic reviews

Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma.
Dury RJ, Lourdusamy A, Macarthur DC, Peet AC, Auer DP, Grundy RG, Dineen RA
J Magn Reson Imaging 2022 Jul;56(1):147-157. Epub 2021 Nov 29 doi: 10.1002/jmri.28007. PMID: 34842328

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