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Thymus clear cell carcinoma

MedGen UID:
272488
•Concept ID:
C1333069
•
Neoplastic Process
Synonyms: Clear Cell Carcinoma of the Thymus; clear cell carcinoma of the Thymus; Clear Cell Carcinoma of Thymus; clear cell carcinoma of Thymus; Thymic Clear Cell Carcinoma; thymic clear cell carcinoma; Thymus Clear Cell Carcinoma; thymus clear cell carcinoma
 
Monarch Initiative: MONDO:0004475

Definition

A rare, usually aggressive, primary thymic carcinoma, characterized by the presence of carcinoma cells with clear cytoplasm. [from NCI]

Professional guidelines

PubMed

About thymic carcinomas: challenges in diagnosis and management.
Mlika M, Boudaya S, Braham E, Chermiti F, Sayi A, Marghli A, El Mezni F
Asian Cardiovasc Thorac Ann 2016 May;24(4):350-4. Epub 2016 Mar 21 doi: 10.1177/0218492316640129. PMID: 27002097

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Sema4D correlates with tumour immune infiltration and is a prognostic biomarker in bladder cancer, renal clear cell carcinoma, melanoma and thymoma.
Lu Q, Cai P, Yu Y, Liu Z, Chen G, Zeng Z
Autoimmunity 2021 Aug;54(5):294-302. Epub 2021 May 11 doi: 10.1080/08916934.2021.1925885. PMID: 33974462
EWSR1 translocation in primary hyalinising clear cell carcinoma of the thymus.
Porubsky S, Rudolph B, Rückert JC, Küffer S, Ströbel P, Roden AC, Jain D, Tousseyn T, Van Veer H, Huang J, Antonicelli A, Kuo TT, Rosai J, Marx A; International Thymic Malignancy Interest Group (ITMIG)
Histopathology 2019 Sep;75(3):431-436. Epub 2019 Jul 19 doi: 10.1111/his.13890. PMID: 31050844
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
Clear cell neoplasms of the endocrine system and thymus.
Wick MR, Ritter JH, Humphrey PA, Nappi O
Semin Diagn Pathol 1997 Aug;14(3):183-202. PMID: 9279975

Diagnosis

Chromophobe-like carcinoma of the thymus: A clinicopathological and immunohistochemical correlation of 5 cases.
Weissferdt A, Moran CA
Pathol Res Pract 2023 Aug;248:154629. Epub 2023 Jun 19 doi: 10.1016/j.prp.2023.154629. PMID: 37348289
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors?
Marx A, Chan JKC, Chalabreysse L, Dacic S, Detterbeck F, French CA, Hornick JL, Inagaki H, Jain D, Lazar AJ, Marino M, Marom EM, Moreira AL, Nicholson AG, Noguchi M, Nonaka D, Papotti MG, Porubsky S, Sholl LM, Tateyama H, Thomas de Montpréville V, Travis WD, Rajan A, Roden AC, Ströbel P
J Thorac Oncol 2022 Feb;17(2):200-213. Epub 2021 Oct 22 doi: 10.1016/j.jtho.2021.10.010. PMID: 34695605
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
Carcinoma of the thymus with clear-cell features. Report of eight cases and review of the literature.
Hasserjian RP, Klimstra DS, Rosai J
Am J Surg Pathol 1995 Jul;19(7):835-41. doi: 10.1097/00000478-199507000-00012. PMID: 7793482

Therapy

Clear cell thymic carcinoma: a case report.
Bertocchi P, Meriggi F, Zambelli C, Zorzi F, Zaniboni A
Tumori 2015 Mar-Apr;101(2):e73-4. doi: 10.5301/je.5000255. PMID: 25702670
Thymic carcinoid responds to neoadjuvant therapy with sunitinib and octreotide: a case report.
Dham A, Truskinovsky AM, Dudek AZ
J Thorac Oncol 2008 Jan;3(1):94-7. doi: 10.1097/JTO.0b013e31815eb7a2. PMID: 18166847

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Thymomas With Extensive Clear Cell Component:  A Clinicopathologic and Immunohistochemical Study of Nine Cases.
Weissferdt A, Kalhor N, Moran CA
Am J Clin Pathol 2016 Jul;146(1):132-6. Epub 2016 Jun 30 doi: 10.1093/ajcp/aqw094. PMID: 27371363
Primary carcinomas of the thymus gland.
Ritter JH, Wick MR
Semin Diagn Pathol 1999 Feb;16(1):18-31. PMID: 10355651
The diagnosis of thymoma: a review.
Hammond EH, Flinner RL
Ultrastruct Pathol 1991 Jul-Oct;15(4-5):419-38. doi: 10.3109/01913129109016250. PMID: 1755103
Thymomas and thymic carcinomas.
Walker AN, Mills SE, Fechner RE
Semin Diagn Pathol 1990 Nov;7(4):250-65. PMID: 2284513

Clinical prediction guides

ESCO2's oncogenic role in human tumors: a pan-cancer analysis and experimental validation.
Huang Y, Chen D, Bai Y, Zhang Y, Zheng Z, Fu Q, Yi B, Jiang Y, Zhang Z, Zhu J
BMC Cancer 2024 Apr 11;24(1):452. doi: 10.1186/s12885-024-12213-w. PMID: 38605349Free PMC Article
Poorly Differentiated Nonkeratinizing Squamous Cell Carcinoma of the Thymus: Clinicopathologic and Molecular Genetic Study of 25 Cases.
Suster D, Pihan G, Mackinnon AC, Suster S
Am J Surg Pathol 2018 Sep;42(9):1224-1236. doi: 10.1097/PAS.0000000000001101. PMID: 29975245
Thymomas With Extensive Clear Cell Component:  A Clinicopathologic and Immunohistochemical Study of Nine Cases.
Weissferdt A, Kalhor N, Moran CA
Am J Clin Pathol 2016 Jul;146(1):132-6. Epub 2016 Jun 30 doi: 10.1093/ajcp/aqw094. PMID: 27371363
Clear cell thymic carcinoma: a case report.
Bertocchi P, Meriggi F, Zambelli C, Zorzi F, Zaniboni A
Tumori 2015 Mar-Apr;101(2):e73-4. doi: 10.5301/je.5000255. PMID: 25702670
Expression and regulation of non-classical HLA-G in renal cell carcinoma.
Dunker K, Schlaf G, Bukur J, Altermann WW, Handke D, Seliger B
Tissue Antigens 2008 Aug;72(2):137-48. doi: 10.1111/j.1399-0039.2008.01090.x. PMID: 18721274

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