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Esophagus verrucous carcinoma

MedGen UID:
272594
•Concept ID:
C1333470
•
Neoplastic Process
Synonyms: esophageal verrucous cancer; Esophageal Verrucous Carcinoma; esophageal verrucous carcinoma; esophagus verrucous carcinoma; Verrucous Carcinoma of Esophagus; verrucous carcinoma of esophagus; verrucous carcinoma of oesophagus; Verrucous Carcinoma of the Esophagus; verrucous carcinoma of the esophagus; verrucous carcinoma of the oesophagus
 
Monarch Initiative: MONDO:0002762

Definition

A rare variant of esophageal squamous cell carcinoma. It is an exophytic, cauliflower-like or papillary mass that can arise in any part of the esophagus. This variant of squamous cell carcinoma grows slowly and invades locally, with a very low metastasizing potential. (WHO) [from NCI]

Professional guidelines

PubMed

Endoscopic diagnosis and treatment of esophageal verrucous squamous cell cancer.
Sweetser S, Jacobs NL, Wong Kee Song LM
Dis Esophagus 2014 Jul;27(5):452-6. Epub 2012 Oct 15 doi: 10.1111/j.1442-2050.2012.01434.x. PMID: 23067443

Recent clinical studies

Etiology

Morphological Characteristics of Various Cells in Esophageal Squamous Dysplasia: Extremely Wide Morphological Spectrum.
Hou W, Song S, Duan X, Hou W, Shi Z, Ma L, Niu J, Jin M
Int J Surg Pathol 2024 Jun;32(4):692-707. Epub 2023 Jul 24 doi: 10.1177/10668969231188906. PMID: 37489001
Verrucous carcinoma of the oesophagus is a genetically distinct subtype of oesophageal squamous cell carcinoma.
Isidro RA, Dong F, Hornick JL, Wee JO, Agoston A, Patil DT, Deshpande V, Zhao L
Histopathology 2021 Oct;79(4):642-649. Epub 2021 Jul 8 doi: 10.1111/his.14395. PMID: 33960520
Head and neck verrucous carcinoma: A population-based analysis of incidence, treatment, and prognosis.
Wang N, Huang M, Lv H
Medicine (Baltimore) 2020 Jan;99(2):e18660. doi: 10.1097/MD.0000000000018660. PMID: 31914052Free PMC Article
Endoscopic diagnosis and treatment of esophageal verrucous squamous cell cancer.
Sweetser S, Jacobs NL, Wong Kee Song LM
Dis Esophagus 2014 Jul;27(5):452-6. Epub 2012 Oct 15 doi: 10.1111/j.1442-2050.2012.01434.x. PMID: 23067443
Superficial squamous cell carcinoma of the esophagus. A report of 76 cases and review of the literature.
Bogomoletz WV, Molas G, Gayet B, Potet F
Am J Surg Pathol 1989 Jul;13(7):535-46. doi: 10.1097/00000478-198907000-00001. PMID: 2660607

Diagnosis

Early verrucous cell carcinoma of the esophagus: a case report and endoscopic and histologic features.
Di L, Wu X, Chen Z, Zhu J, Wang H, Tuo B
BMC Gastroenterol 2021 Dec 14;21(1):466. doi: 10.1186/s12876-021-02049-0. PMID: 34906069Free PMC Article
Verrucous carcinoma of the oesophagus is a genetically distinct subtype of oesophageal squamous cell carcinoma.
Isidro RA, Dong F, Hornick JL, Wee JO, Agoston A, Patil DT, Deshpande V, Zhao L
Histopathology 2021 Oct;79(4):642-649. Epub 2021 Jul 8 doi: 10.1111/his.14395. PMID: 33960520
Verrucous carcinoma of the esophagus - a case report and literature review.
Frieling T, Kreysel C, Blank M, Müller D, Euler P, Melchior I, Wullstein C, Hemmerlein B
Z Gastroenterol 2020 Oct;58(10):971-974. Epub 2020 Oct 9 doi: 10.1055/a-1231-5820. PMID: 33036050
Rare tumors of esophageal squamous mucosa.
Tripathi M, Swanson PE
Ann N Y Acad Sci 2016 Oct;1381(1):122-132. Epub 2016 Jun 16 doi: 10.1111/nyas.13108. PMID: 27310830
Endoscopic diagnosis and treatment of esophageal verrucous squamous cell cancer.
Sweetser S, Jacobs NL, Wong Kee Song LM
Dis Esophagus 2014 Jul;27(5):452-6. Epub 2012 Oct 15 doi: 10.1111/j.1442-2050.2012.01434.x. PMID: 23067443

Therapy

Verrucous carcinoma of the renal pelvis with a focus of conventional squamous cell carcinoma.
Baseskioğlu B, Yenilmez A, Acıkalın M, Can C, Dönmez T
Urol Int 2012;88(1):115-7. Epub 2011 Sep 28 doi: 10.1159/000330906. PMID: 21968520
Association of laryngeal cancer with previous gastric resection.
Cammarota G, Galli J, Cianci R, De Corso E, Pasceri V, Palli D, Masala G, Buffon A, Gasbarrini A, Almadori G, Paludetti G, Gasbarrini G, Maurizi M
Ann Surg 2004 Nov;240(5):817-24. doi: 10.1097/01.sla.0000143244.76135.ca. PMID: 15492563Free PMC Article
Bleomycin in verrucous squamous cell carcinoma of the oesophagus.
Sakurai T, Fuchigami T, Omae T, Iwashita A, Kume K, Asano S
Postgrad Med J 1983 Sep;59(695):578-80. doi: 10.1136/pgmj.59.695.578. PMID: 6195653Free PMC Article
Verrucous squamous cell carcinoma of the esophagus following lye stricture.
Parkinson AT, Haidak GL, McInerney RP
Chest 1970 May;57(5):489-92. doi: 10.1378/chest.57.5.489. PMID: 5441832

Prognosis

Early verrucous cell carcinoma of the esophagus: a case report and endoscopic and histologic features.
Di L, Wu X, Chen Z, Zhu J, Wang H, Tuo B
BMC Gastroenterol 2021 Dec 14;21(1):466. doi: 10.1186/s12876-021-02049-0. PMID: 34906069Free PMC Article
Head and neck verrucous carcinoma: A population-based analysis of incidence, treatment, and prognosis.
Wang N, Huang M, Lv H
Medicine (Baltimore) 2020 Jan;99(2):e18660. doi: 10.1097/MD.0000000000018660. PMID: 31914052Free PMC Article
Rare tumors of esophageal squamous mucosa.
Tripathi M, Swanson PE
Ann N Y Acad Sci 2016 Oct;1381(1):122-132. Epub 2016 Jun 16 doi: 10.1111/nyas.13108. PMID: 27310830
Polypoid carcinoma of the esophagus.
Mori M, Mimori K, Sadanaga N, Watanabe M, Kuwano H, Sugimachi K
Jpn J Cancer Res 1994 Nov;85(11):1131-6. doi: 10.1111/j.1349-7006.1994.tb02918.x. PMID: 7829398Free PMC Article
Superficial squamous cell carcinoma of the esophagus. A report of 76 cases and review of the literature.
Bogomoletz WV, Molas G, Gayet B, Potet F
Am J Surg Pathol 1989 Jul;13(7):535-46. doi: 10.1097/00000478-198907000-00001. PMID: 2660607

Clinical prediction guides

Esophageal carcinoma cuniculatum: systematic review of the literature and report of two cases.
Lai Q, de Giacomo T, Consolo A, Castrovillari M, Melandro F, Cerbelli B, Pernazza A, Berloco PB, d'Amati G, Francioni F
Pathol Res Pract 2019 Oct;215(10):152602. Epub 2019 Aug 17 doi: 10.1016/j.prp.2019.152602. PMID: 31472995
Prevalence of oesophageal epidermoid metaplasia in 1048 consecutive patients and 58 patients with squamous neoplasms.
Cottreau J, Gruchy S, Kamionek M, Lauwers GY, Arnason T
Histopathology 2016 Jun;68(7):988-95. Epub 2016 Jan 4 doi: 10.1111/his.12886. PMID: 26426946
Caustic ingestion and oesophageal cancer: intra- and peri-tumoral fibrosis is associated with a better prognosis.
Ruol A, Rampado S, Parenti A, Portale G, Giacomelli L, Battaglia G, Cagol M, Ancona E
Eur J Cardiothorac Surg 2010 Dec;38(6):659-64. Epub 2010 May 7 doi: 10.1016/j.ejcts.2010.03.057. PMID: 20452236
Transforming growth factor-alpha (TGF alpha)-producing gastric carcinoma with acanthosis nigricans: an endocrine effect of TGF alpha in the pathogenesis of cutaneous paraneoplastic syndrome and epithelial hyperplasia of the esophagus.
Koyama S, Ikeda K, Sato M, Shibahara K, Yuhara K, Fukutomi H, Fukunaga K, Kanazawa N, Yuzawa K, Fukao K, Iijima T, Kikuchi M, Tomiya T, Fujiwara K
J Gastroenterol 1997 Feb;32(1):71-7. doi: 10.1007/BF01213299. PMID: 9058298
Verrucous acanthosis--so-called verrucous carcinoma--of the esophagus.
Barbier PA, Luder PJ, Wagner HE, Becker CD, Scheurer U, Ruchti C
Z Gastroenterol 1987 Feb;25(2):93-7. PMID: 3564599

Recent systematic reviews

Esophageal carcinoma cuniculatum: systematic review of the literature and report of two cases.
Lai Q, de Giacomo T, Consolo A, Castrovillari M, Melandro F, Cerbelli B, Pernazza A, Berloco PB, d'Amati G, Francioni F
Pathol Res Pract 2019 Oct;215(10):152602. Epub 2019 Aug 17 doi: 10.1016/j.prp.2019.152602. PMID: 31472995

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