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Extrahepatic Bile Duct Neuroendocrine Tumor G1

MedGen UID:
272602
•Concept ID:
C1333503
•
Neoplastic Process
Synonyms: Carcinoid Tumor of Extrahepatic Bile Duct; Carcinoid Tumor of the Extrahepatic Bile Duct; Extrahepatic Bile Duct Carcinoid Tumor; Extrahepatic Bile Duct NET G1; Extrahepatic Bile Duct Neuroendocrine Tumor G1 (Carcinoid)

Definition

A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) that arises from the extrahepatic bile ducts. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtrahepatic Bile Duct Neuroendocrine Tumor G1

Professional guidelines

PubMed

Clinicopathological Findings and Treatment Outcomes of Patients with Primary Hepatobiliary Neuroendocrine Neoplasms: A Retrospective Single-institution Analysis.
Komiyama S, Okusaka T, Maruki Y, Ohba A, Nagashio Y, Kondo S, Hijioka S, Morizane C, Ueno H, Sukeda A, Mizui T, Takamoto T, Nara S, Ban D, Esaki M, Hiraoka N, Shimada K
Intern Med 2024 Apr 1;63(7):891-901. Epub 2023 Aug 23 doi: 10.2169/internalmedicine.2016-23. PMID: 37612088Free PMC Article

Recent clinical studies

Etiology

Clinicopathological Findings and Treatment Outcomes of Patients with Primary Hepatobiliary Neuroendocrine Neoplasms: A Retrospective Single-institution Analysis.
Komiyama S, Okusaka T, Maruki Y, Ohba A, Nagashio Y, Kondo S, Hijioka S, Morizane C, Ueno H, Sukeda A, Mizui T, Takamoto T, Nara S, Ban D, Esaki M, Hiraoka N, Shimada K
Intern Med 2024 Apr 1;63(7):891-901. Epub 2023 Aug 23 doi: 10.2169/internalmedicine.2016-23. PMID: 37612088Free PMC Article
Endoscopic papillectomy for tumors of the minor duodenal papilla: A case series of six patients and literature review.
Yamamoto K, Itoi T, Iwasaki E, Tsuchiya T, Ishii K, Tonozuka R, Mukai S, Nagai K, Kitagawa Y
J Hepatobiliary Pancreat Sci 2022 Oct;29(10):1142-1150. Epub 2021 Dec 6 doi: 10.1002/jhbp.1084. PMID: 34826213
Trans-duodenal ampullectomy for ampullary neoplasms: early and long-term outcomes in 36 consecutive patients.
Nappo G, Gentile D, Galvanin J, Capretti G, Ridolfi C, Petitti T, Spaggiari P, Carrara S, Gavazzi F, Repici A, Zerbi A
Surg Endosc 2020 Oct;34(10):4358-4368. Epub 2019 Oct 23 doi: 10.1007/s00464-019-07206-x. PMID: 31646438
Ampullary neuroendocrine neoplasms: surgical experience of a rare and challenging entity.
Milanetto AC, Pasquali C, Da Broi M, Brambilla T, Capretti G, Zerbi A
Langenbecks Arch Surg 2018 Aug;403(5):581-589. Epub 2018 Jul 24 doi: 10.1007/s00423-018-1695-9. PMID: 30043166
Neuroendocrine tumours of the ampulla of Vater: clinico-pathological features, surgical approach and assessment of prognosis.
Dumitrascu T, Dima S, Herlea V, Tomulescu V, Ionescu M, Popescu I
Langenbecks Arch Surg 2012 Aug;397(6):933-43. Epub 2012 Apr 3 doi: 10.1007/s00423-012-0951-7. PMID: 22476195Free PMC Article

Diagnosis

Clinicopathological Findings and Treatment Outcomes of Patients with Primary Hepatobiliary Neuroendocrine Neoplasms: A Retrospective Single-institution Analysis.
Komiyama S, Okusaka T, Maruki Y, Ohba A, Nagashio Y, Kondo S, Hijioka S, Morizane C, Ueno H, Sukeda A, Mizui T, Takamoto T, Nara S, Ban D, Esaki M, Hiraoka N, Shimada K
Intern Med 2024 Apr 1;63(7):891-901. Epub 2023 Aug 23 doi: 10.2169/internalmedicine.2016-23. PMID: 37612088Free PMC Article
Neuroendocrine tumor of the ampulla of Vater showing chronological endoscopic changes.
Fujii M, Okamoto Y, Fujioka S, Yoshioka M, Shiode J
Clin J Gastroenterol 2022 Feb;15(1):205-209. Epub 2022 Feb 3 doi: 10.1007/s12328-021-01553-w. PMID: 35113343
Challenges in treatment of a patient suffering from neuroendocrine tumor G1 of the hilar bile duct: a case report.
Zhang B, Li S, Sun Z, Chen X, Qi B, Zhang Q, Zhang G, Shang D
BMC Gastroenterol 2022 Jan 8;22(1):13. doi: 10.1186/s12876-021-02019-6. PMID: 34998372Free PMC Article
Endoscopic papillectomy for tumors of the minor duodenal papilla: A case series of six patients and literature review.
Yamamoto K, Itoi T, Iwasaki E, Tsuchiya T, Ishii K, Tonozuka R, Mukai S, Nagai K, Kitagawa Y
J Hepatobiliary Pancreat Sci 2022 Oct;29(10):1142-1150. Epub 2021 Dec 6 doi: 10.1002/jhbp.1084. PMID: 34826213
Neuroendocrine Tumors (NETs) of the Minor Papilla/Ampulla: Analysis of 16 Cases Underlines Homology With Major Ampulla NETs and Differences From Extra-Ampullary Duodenal NETs.
Vanoli A, Albarello L, Uncini S, Fassan M, Grillo F, Di Sabatino A, Martino M, Pasquali C, Milanetto AC, Falconi M, Partelli S, Doglioni C, Schiavo-Lena M, Brambilla T, Pietrabissa A, Sessa F, Capella C, Rindi G, La Rosa S, Solcia E, Paulli M
Am J Surg Pathol 2019 Jun;43(6):725-736. doi: 10.1097/PAS.0000000000001234. PMID: 30913089

Therapy

Endoscopic Resection of Ampullary Neuroendocrine Tumor.
Fukasawa H, Tounou S, Nabetani M, Michida T
Intern Med 2017;56(5):499-503. Epub 2017 Mar 1 doi: 10.2169/internalmedicine.56.7520. PMID: 28250294Free PMC Article

Prognosis

Clinicopathological Findings and Treatment Outcomes of Patients with Primary Hepatobiliary Neuroendocrine Neoplasms: A Retrospective Single-institution Analysis.
Komiyama S, Okusaka T, Maruki Y, Ohba A, Nagashio Y, Kondo S, Hijioka S, Morizane C, Ueno H, Sukeda A, Mizui T, Takamoto T, Nara S, Ban D, Esaki M, Hiraoka N, Shimada K
Intern Med 2024 Apr 1;63(7):891-901. Epub 2023 Aug 23 doi: 10.2169/internalmedicine.2016-23. PMID: 37612088Free PMC Article
Ampullary neuroendocrine neoplasms: surgical experience of a rare and challenging entity.
Milanetto AC, Pasquali C, Da Broi M, Brambilla T, Capretti G, Zerbi A
Langenbecks Arch Surg 2018 Aug;403(5):581-589. Epub 2018 Jul 24 doi: 10.1007/s00423-018-1695-9. PMID: 30043166
Neuroendocrine tumours of the ampulla of Vater: clinico-pathological features, surgical approach and assessment of prognosis.
Dumitrascu T, Dima S, Herlea V, Tomulescu V, Ionescu M, Popescu I
Langenbecks Arch Surg 2012 Aug;397(6):933-43. Epub 2012 Apr 3 doi: 10.1007/s00423-012-0951-7. PMID: 22476195Free PMC Article
Nodal microinvolvement in patients with carcinoma of the papilla of vater receiving no adjuvant chemotherapy.
Bogoevski D, Chayeb H, Cataldegirmen G, Schurr PG, Kaifi JT, Mann O, Yekebas EF, Izbicki JR
J Gastrointest Surg 2008 Nov;12(11):1830-7; discussion 1837-8. Epub 2008 Sep 13 doi: 10.1007/s11605-008-0683-8. PMID: 18791769

Clinical prediction guides

Clinicopathological Findings and Treatment Outcomes of Patients with Primary Hepatobiliary Neuroendocrine Neoplasms: A Retrospective Single-institution Analysis.
Komiyama S, Okusaka T, Maruki Y, Ohba A, Nagashio Y, Kondo S, Hijioka S, Morizane C, Ueno H, Sukeda A, Mizui T, Takamoto T, Nara S, Ban D, Esaki M, Hiraoka N, Shimada K
Intern Med 2024 Apr 1;63(7):891-901. Epub 2023 Aug 23 doi: 10.2169/internalmedicine.2016-23. PMID: 37612088Free PMC Article
Trans-duodenal ampullectomy for ampullary neoplasms: early and long-term outcomes in 36 consecutive patients.
Nappo G, Gentile D, Galvanin J, Capretti G, Ridolfi C, Petitti T, Spaggiari P, Carrara S, Gavazzi F, Repici A, Zerbi A
Surg Endosc 2020 Oct;34(10):4358-4368. Epub 2019 Oct 23 doi: 10.1007/s00464-019-07206-x. PMID: 31646438
Neuroendocrine Tumors (NETs) of the Minor Papilla/Ampulla: Analysis of 16 Cases Underlines Homology With Major Ampulla NETs and Differences From Extra-Ampullary Duodenal NETs.
Vanoli A, Albarello L, Uncini S, Fassan M, Grillo F, Di Sabatino A, Martino M, Pasquali C, Milanetto AC, Falconi M, Partelli S, Doglioni C, Schiavo-Lena M, Brambilla T, Pietrabissa A, Sessa F, Capella C, Rindi G, La Rosa S, Solcia E, Paulli M
Am J Surg Pathol 2019 Jun;43(6):725-736. doi: 10.1097/PAS.0000000000001234. PMID: 30913089
Neuroendocrine tumours of the ampulla of Vater: clinico-pathological features, surgical approach and assessment of prognosis.
Dumitrascu T, Dima S, Herlea V, Tomulescu V, Ionescu M, Popescu I
Langenbecks Arch Surg 2012 Aug;397(6):933-43. Epub 2012 Apr 3 doi: 10.1007/s00423-012-0951-7. PMID: 22476195Free PMC Article

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