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Leptomeningeal melanoma

MedGen UID:: 272793
•Concept ID:: C1334386
•: Neoplastic Process

Synonyms:	Leptomeningeal Melanoma; leptomeningeal melanoma; leptomeninx melanoma; leptomeninx melanoma (disease); malignant melanoma of meninges; melanoma (disease) of leptomeninx; Melanoma of Leptomeninges; melanoma of leptomeninges; Melanoma of the Leptomeninges; melanoma of the leptomeninges; Meningeal Melanoma; Meningeal melanoma; meningeal melanoma
SNOMED CT:	Meningeal melanoma (726420002)

Monarch Initiative:	MONDO:0003761

Definition

A melanoma that arises from leptomeningeal melanocytes. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLeptomeningeal melanoma

Disease
- Neoplasm
  - Neoplasm by Morphology
    - Melanocytic neoplasm
      - Central nervous system melanocytic neoplasm
        Central Nervous System Melanoma
        Leptomeningeal melanoma
        Adult leptomeningeal melanoma
        Meningeal melanomatosis
        Pediatric leptomeningeal melanoma

Professional guidelines

PubMed

Advances in Diagnosis and Treatment for Leptomeningeal Disease in Melanoma.

Piña Y, Yadugiri S, Yeboa DN, Ferguson SD, Forsyth PA, Oliva ICG
Curr Oncol Rep 2022 Jan;24(1):43-54. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01162-3. PMID: 35059999

Malignant Melanoma: Skin Cancer-Diagnosis, Prevention, and Treatment.

Ahmed B, Qadir MI, Ghafoor S
Crit Rev Eukaryot Gene Expr 2020;30(4):291-297. doi: 10.1615/CritRevEukaryotGeneExpr.2020028454. PMID: 32894659

Management of neoplastic meningitis.

Roth P, Weller M
Chin Clin Oncol 2015 Jun;4(2):26. doi: 10.3978/j.issn.2304-3865.2015.05.02. PMID: 26112812

See all (29)

Recent clinical studies

Etiology

Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.

Mitre V, Heym K, Clark GD, Venkatramani R
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e195-e197. doi: 10.1097/MPH.0000000000001680. PMID: 31764519

Primary leptomeningeal melanoma.

Xie ZY, Hsieh KL, Tsang YM, Cheung WK, Hsieh CH
J Clin Neurosci 2014 Jun;21(6):1051-2. Epub 2013 Oct 23 doi: 10.1016/j.jocn.2013.08.018. PMID: 24331626

Congenital melanocytic naevi.

Kovalyshyn I, Braun R, Marghoob A
Australas J Dermatol 2009 Nov;50(4):231-40; quiz 241-2. doi: 10.1111/j.1440-0960.2009.00553_1.x. PMID: 19916964

Association of melanoma and neurocutaneous melanocytosis with large congenital melanocytic naevi--results from the NYU-LCMN registry.

Hale EK, Stein J, Ben-Porat L, Panageas KS, Eichenbaum MS, Marghoob AA, Osman I, Kopf AW, Polsky D
Br J Dermatol 2005 Mar;152(3):512-7. doi: 10.1111/j.1365-2133.2005.06316.x. PMID: 15787820

Melanoma in children and adolescents.

Wu SJ, Lambert DR
Pediatr Dermatol 1997 Mar-Apr;14(2):87-92. doi: 10.1111/j.1525-1470.1997.tb00211.x. PMID: 9144691

See all (13)

Diagnosis

Primary leptomeningeal melanoma: the prognostic significance of its genetic signature and embryological origin.

Buckland A, Green C, Kho LK, Prentice D
BMJ Case Rep 2021 May 24;14(5) doi: 10.1136/bcr-2020-239496. PMID: 34031065 Free PMC Article

Managing leptomeningeal melanoma metastases in the era of immune and targeted therapy.

Smalley KS, Fedorenko IV, Kenchappa RS, Sahebjam S, Forsyth PA
Int J Cancer 2016 Sep 15;139(6):1195-201. Epub 2016 Apr 30 doi: 10.1002/ijc.30147. PMID: 27084046 Free PMC Article

Primary leptomeningeal melanoma.

Xie ZY, Hsieh KL, Tsang YM, Cheung WK, Hsieh CH
J Clin Neurosci 2014 Jun;21(6):1051-2. Epub 2013 Oct 23 doi: 10.1016/j.jocn.2013.08.018. PMID: 24331626

Primary leptomeningeal melanoma.

Schneider F, Putzier M
Spine (Phila Pa 1976) 2002 Dec 15;27(24):E545-7. doi: 10.1097/00007632-200212150-00026. PMID: 12486366

Neurocutaneous melanosis: definition and review of the literature.

Kadonaga JN, Frieden IJ
J Am Acad Dermatol 1991 May;24(5 Pt 1):747-55. doi: 10.1016/0190-9622(91)70115-i. PMID: 1869648

See all (43)

Therapy

Durable complete remission of leptomeningeal melanoma by intrathecal methotrexate maintained with systemic ipilimumab.

Dietrich C, Salzmann M, Steinbrecher A, Herbst R, Hassel JC
Immunotherapy 2021 Sep;13(13):1079-1083. Epub 2021 Jul 14 doi: 10.2217/imt-2021-0031. PMID: 34259028

Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.

Mitre V, Heym K, Clark GD, Venkatramani R
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e195-e197. doi: 10.1097/MPH.0000000000001680. PMID: 31764519

Inflammatory demyelinating polyneuropathy versus leptomeningeal disease following Ipilimumab.

Cafuir L, Lawson D, Desai N, Kesner V, Voloschin A
J Immunother Cancer 2018 Jan 30;6(1):11. doi: 10.1186/s40425-018-0318-x. PMID: 29382383 Free PMC Article

Managing leptomeningeal melanoma metastases in the era of immune and targeted therapy.

Smalley KS, Fedorenko IV, Kenchappa RS, Sahebjam S, Forsyth PA
Int J Cancer 2016 Sep 15;139(6):1195-201. Epub 2016 Apr 30 doi: 10.1002/ijc.30147. PMID: 27084046 Free PMC Article

Fatal leptomeningeal melanoma in neurocutaneous melanosis.

Furtado S, Furtado SV, Ghosal N, Hegde AS
Pediatr Dermatol 2012 May-Jun;29(3):358-61. Epub 2011 Sep 9 doi: 10.1111/j.1525-1470.2011.01424.x. PMID: 21906139

See all (11)

Prognosis

Primary leptomeningeal melanoma: the prognostic significance of its genetic signature and embryological origin.

Buckland A, Green C, Kho LK, Prentice D
BMJ Case Rep 2021 May 24;14(5) doi: 10.1136/bcr-2020-239496. PMID: 34031065 Free PMC Article

Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.

Mitre V, Heym K, Clark GD, Venkatramani R
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e195-e197. doi: 10.1097/MPH.0000000000001680. PMID: 31764519

Managing leptomeningeal melanoma metastases in the era of immune and targeted therapy.

Smalley KS, Fedorenko IV, Kenchappa RS, Sahebjam S, Forsyth PA
Int J Cancer 2016 Sep 15;139(6):1195-201. Epub 2016 Apr 30 doi: 10.1002/ijc.30147. PMID: 27084046 Free PMC Article

Primary leptomeningeal melanoma.

Xie ZY, Hsieh KL, Tsang YM, Cheung WK, Hsieh CH
J Clin Neurosci 2014 Jun;21(6):1051-2. Epub 2013 Oct 23 doi: 10.1016/j.jocn.2013.08.018. PMID: 24331626

Primary leptomeningeal melanoma.

Schneider F, Putzier M
Spine (Phila Pa 1976) 2002 Dec 15;27(24):E545-7. doi: 10.1097/00007632-200212150-00026. PMID: 12486366

See all (29)

Clinical prediction guides

Durable complete remission of leptomeningeal melanoma by intrathecal methotrexate maintained with systemic ipilimumab.

Dietrich C, Salzmann M, Steinbrecher A, Herbst R, Hassel JC
Immunotherapy 2021 Sep;13(13):1079-1083. Epub 2021 Jul 14 doi: 10.2217/imt-2021-0031. PMID: 34259028

Genomic analysis reveals low tumor mutation burden which may be associated with GNAQ/11 alteration in a series of primary leptomeningeal melanomas.

Fortin Ensign S, Bollin K, Millis SZ, Hinds BR, Kosty M, Uchiyama C
Pigment Cell Melanoma Res 2020 May;33(3):458-465. Epub 2019 Dec 18 doi: 10.1111/pcmr.12839. PMID: 31663661

Intrathecal cytotoxic T-cell immunotherapy for metastatic leptomeningeal melanoma.

Clemons-Miller AR, Chatta GS, Hutchins L, Angtuaco EJ, Ravaggi A, Santin AD, Cannon MJ
Clin Cancer Res 2001 Mar;7(3 Suppl):917s-924s. PMID: 11300492

See all (3)

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Leptomeningeal melanoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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