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Acinic cell breast carcinoma

MedGen UID:
272988
•Concept ID:
C1515868
•
Neoplastic Process
Synonyms: acinar cell breast carcinoma; Acinic Cell Breast Carcinoma; acinic cell breast carcinoma; Breast Acinic Cell Carcinoma; breast carcinoma of acinar cell
 
Monarch Initiative: MONDO:0003624

Definition

A breast adenocarcinoma characterized by the presence of serous (acinic cell) differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcinic cell breast carcinoma

Professional guidelines

PubMed

Oncocytoid Salivary Tumors: Differential Diagnosis and Utility of Newly Described Immunohistochemistry.
Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259Free PMC Article
Update on selective special types of breast neoplasms: Focusing on controversies, differential diagnosis, and molecular genetic advances.
Wei S
Semin Diagn Pathol 2022 Sep;39(5):367-379. Epub 2022 Mar 18 doi: 10.1053/j.semdp.2022.03.001. PMID: 35331622
Triple-negative breast carcinomas of low malignant potential: review on diagnostic criteria and differential diagnoses.
Cima L, Kaya H, Marchiò C, Nishimura R, Wen HY, Fabbri VP, Foschini MP
Virchows Arch 2022 Jan;480(1):109-126. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03174-7. PMID: 34458945Free PMC Article

Recent clinical studies

Etiology

TRPS1 immunohistochemical expression in salivary gland tumors: A pilot study.
Tjendra Y, Kerr DA, Gomez-Fernandez C, Velez Torres JM
Am J Clin Pathol 2023 Dec 1;160(6):633-639. doi: 10.1093/ajcp/aqad100. PMID: 37565763
Salivary Gland Secretory Carcinoma: Clinicopathologic and Genetic Characteristics of 215 Cases and Proposal for a Grading System.
Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
Salivary Gland Cancers.
Tchekmedyian V
Hematol Oncol Clin North Am 2021 Oct;35(5):973-990. doi: 10.1016/j.hoc.2021.05.011. PMID: 34503735
Clinical characteristics of acinic cell carcinoma and secretory carcinoma of the parotid gland.
Terada T, Kawata R, Noro K, Higashino M, Nishikawa S, Haginomori SI, Kurisu Y, Kuwabara H, Hirose Y
Eur Arch Otorhinolaryngol 2019 Dec;276(12):3461-3466. Epub 2019 Aug 22 doi: 10.1007/s00405-019-05604-4. PMID: 31440815
Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family.
Geyer FC, Berman SH, Marchiò C, Burke KA, Guerini-Rocco E, Piscuoglio S, Ng CK, Pareja F, Wen HY, Hodi Z, Schnitt SJ, Rakha EA, Ellis IO, Norton L, Weigelt B, Reis-Filho JS
Mod Pathol 2017 Jan;30(1):69-84. Epub 2016 Oct 7 doi: 10.1038/modpathol.2016.161. PMID: 27713419Free PMC Article

Diagnosis

TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma.
Yoon EC, Wang G, Parkinson B, Huo L, Peng Y, Wang J, Salisbury T, Wu Y, Chen H, Albarracin CT, Resetkova E, Middleton LP, Krishnamurthy S, Gan Q, Sun H, Huang X, Shen T, Chen W, Parwani AV, Sahin AA, Li Z, Ding Q
Hum Pathol 2022 Jul;125:97-107. Epub 2022 Apr 9 doi: 10.1016/j.humpath.2022.04.006. PMID: 35413381
Problematic breast tumors reassessed in light of novel molecular data.
Pareja F, Weigelt B, Reis-Filho JS
Mod Pathol 2021 Jan;34(Suppl 1):38-47. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00693-7. PMID: 33024304Free PMC Article
Pure acinic cell carcinoma of the breast: A case report and literature review.
Li H, Wang F, Shen P, Zhou F
Medicine (Baltimore) 2017 Nov;96(47):e8866. doi: 10.1097/MD.0000000000008866. PMID: 29382006Free PMC Article
The morphological spectrum of salivary gland type tumours of the breast.
Foschini MP, Morandi L, Asioli S, Giove G, Corradini AG, Eusebi V
Pathology 2017 Feb;49(2):215-227. Epub 2016 Dec 30 doi: 10.1016/j.pathol.2016.10.011. PMID: 28043647
Mammary Analogue Secretory Carcinoma.
Parekh V, Stevens TM
Arch Pathol Lab Med 2016 Sep;140(9):997-1001. doi: 10.5858/arpa.2015-0075-RS. PMID: 27575269

Therapy

Exceptional Response of Pancreatic Acinar Cell Carcinoma and Bile Duct Cancer to Platinum-Based Chemotherapy in a Family With a Germline BRCA2 Variant.
Sunami T, Yamada A, Kondo T, Kanai M, Nagai K, Uchida Y, Yokode M, Matsumori T, Uza N, Murakami H, Yamada T, Muto M
Pancreas 2022 Oct 1;51(9):1258-1262. doi: 10.1097/MPA.0000000000002150. PMID: 37078954
CD138 Is Expressed in Different Entities of Salivary Gland Cancer and Their Lymph Node Metastases and Therefore Represents a Potential Therapeutic Target.
Mayer M, Nachtsheim L, Hoffmann F, von Eggeling F, Guntinas-Lichius O, Prinz J, Klußmann JP, Quaas A, Arolt C, Wolber P
Int J Mol Sci 2022 Aug 12;23(16) doi: 10.3390/ijms23169037. PMID: 36012301Free PMC Article
Targeting Aberrant p70S6K Activation for Estrogen Receptor-Negative Breast Cancer Prevention.
Wang X, Yao J, Wang J, Zhang Q, Brady SW, Arun B, Seewaldt VL, Yu D
Cancer Prev Res (Phila) 2017 Nov;10(11):641-650. Epub 2017 Sep 6 doi: 10.1158/1940-6207.CAPR-17-0106. PMID: 28877935Free PMC Article
Molecular pathways: digoxin use and estrogen-sensitive cancers--risks and possible therapeutic implications.
Biggar RJ
Clin Cancer Res 2012 Apr 15;18(8):2133-7. Epub 2012 Feb 24 doi: 10.1158/1078-0432.CCR-11-1389. PMID: 22368159
Primary acinic cell carcinoma of the breast.
Coyne JD, Dervan PA
J Clin Pathol 2002 Jul;55(7):545-7. doi: 10.1136/jcp.55.7.545. PMID: 12101208Free PMC Article

Prognosis

Acinic cell carcinoma of the breast: A comprehensive review.
Ajkunic A, Skenderi F, Shaker N, Akhtar S, Lamovec J, Gatalica Z, Vranic S
Breast 2022 Dec;66:208-216. Epub 2022 Oct 28 doi: 10.1016/j.breast.2022.10.012. PMID: 36332545Free PMC Article
Pure acinic cell carcinoma of the breast: A case report and literature review.
Li H, Wang F, Shen P, Zhou F
Medicine (Baltimore) 2017 Nov;96(47):e8866. doi: 10.1097/MD.0000000000008866. PMID: 29382006Free PMC Article
The morphological spectrum of salivary gland type tumours of the breast.
Foschini MP, Morandi L, Asioli S, Giove G, Corradini AG, Eusebi V
Pathology 2017 Feb;49(2):215-227. Epub 2016 Dec 30 doi: 10.1016/j.pathol.2016.10.011. PMID: 28043647
Mammary Analogue Secretory Carcinoma.
Parekh V, Stevens TM
Arch Pathol Lab Med 2016 Sep;140(9):997-1001. doi: 10.5858/arpa.2015-0075-RS. PMID: 27575269
Acinic cell carcinoma of the breast: review of the literature.
Limite G, Di Micco R, Esposito E, Sollazzo V, Cervotti M, Pettinato G, Varone V, Benassai G, Amato B, Pilone V, Luglio G, Vitiello A, Hasani A, Liccardo F, Forestieri P
Int J Surg 2014;12 Suppl 1:S35-9. Epub 2014 May 22 doi: 10.1016/j.ijsu.2014.05.004. PMID: 24859406

Clinical prediction guides

TRPS1 immunohistochemical expression in salivary gland tumors: A pilot study.
Tjendra Y, Kerr DA, Gomez-Fernandez C, Velez Torres JM
Am J Clin Pathol 2023 Dec 1;160(6):633-639. doi: 10.1093/ajcp/aqad100. PMID: 37565763
Salivary Gland Secretory Carcinoma: Clinicopathologic and Genetic Characteristics of 215 Cases and Proposal for a Grading System.
Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
NR4A3 Expression Is Consistently Absent in Acinic Cell Carcinomas of the Breast: A Potential Nosologic Shift.
Richardson ET, Selenica P, Pareja F, Cin PD, Hanlon E, Weigelt B, Reis-Filho JS, Hornick JL, Jo VY, Schnitt SJ
Mod Pathol 2023 Jun;36(6):100144. Epub 2023 Feb 22 doi: 10.1016/j.modpat.2023.100144. PMID: 36828363Free PMC Article
Microglandular adenosis of the breast: a deceptive and still mysterious benign lesion.
Foschini MP, Eusebi V
Hum Pathol 2018 Dec;82:1-9. Epub 2018 Jun 24 doi: 10.1016/j.humpath.2018.06.025. PMID: 29949742
Connexins, important players in the dissemination of prostate cancer cells.
Boucher J, Monvoisin A, Vix J, Mesnil M, Thuringer D, Debiais F, Cronier L
Biochim Biophys Acta Biomembr 2018 Jan;1860(1):202-215. Epub 2017 Jul 8 doi: 10.1016/j.bbamem.2017.06.020. PMID: 28693897

Recent systematic reviews

Diagnostic accuracy of pan-TRK immunohistochemistry in differentiating secretory carcinoma from acinic cell carcinoma of salivary gland-A systematic review.
Sharma P, Sivakumar N, Pandiar D
J Oral Pathol Med 2023 Mar;52(3):255-262. Epub 2022 Oct 27 doi: 10.1111/jop.13373. PMID: 36207812
A systematic review including an additional pediatric case report: Pediatric cases of mammary analogue secretory carcinoma.
Ngouajio AL, Drejet SM, Phillips DR, Summerlin DJ, Dahl JP
Int J Pediatr Otorhinolaryngol 2017 Sep;100:187-193. Epub 2017 Jul 6 doi: 10.1016/j.ijporl.2017.07.004. PMID: 28802370

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