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Testicular Brenner tumor

MedGen UID:
273631
•Concept ID:
C1515281
•
Neoplastic Process
Synonyms: Paratesticular Brenner Tumor; testes, rudimentary Brenner tumor; testes, rudimentary Brenner tumour; Testicular Adnexa Brenner Tumor; Testicular Brenner Tumor; testicular Brenner tumor; testis Brenner tumor; testis Brenner tumour
 
Monarch Initiative: MONDO:0003118

Definition

A very rare, usually benign neoplasm that arises from the paratesticular structures. It is characterized by the presence of solid and cystic nests of neoplastic urothelial-type cells in a fibrotic stroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Brenner tumor

Recent clinical studies

Etiology

Stage migration of testicular germ cell tumours in Alberta, Canada, during the COVID-19 pandemic: a retrospective cohort study.
Lee-Ying R, O'Sullivan DE, Gagnon R, Bosma N, Stewart RN, Railton C, Tilley D, Alimohamed N, Basappa N, Cheng T, Kolinsky M, Karim S, Ruether D, North S, Yip S, Danielson B, Heng D, Brenner D
CMAJ Open 2022 Jul-Sep;10(3):E633-E642. Epub 2022 Jul 5 doi: 10.9778/cmajo.20210285. PMID: 35790231Free PMC Article
Mutational signatures among young-onset testicular cancers.
Mealey NE, O'Sullivan DE, Peters CE, Heng DYC, Brenner DR
BMC Med Genomics 2021 Nov 24;14(1):280. doi: 10.1186/s12920-021-01121-8. PMID: 34819066Free PMC Article
Runs of homozygosity and testicular cancer risk.
Loveday C, Sud A, Litchfield K, Levy M, Holroyd A, Broderick P, Kote-Jarai Z, Dunning AM, Muir K, Peto J, Eeles R, Easton DF, Dudakia D, Orr N, Pashayan N; UK Testicular Cancer Collaboration; PRACTICAL Consortium, Reid A, Huddart RA, Houlston RS, Turnbull C
Andrology 2019 Jul;7(4):555-564. doi: 10.1111/andr.12667. PMID: 31310061
Survival after a diagnosis of testicular germ cell cancers in Germany and the United States, 2002-2006: a high resolution study by histology and age.
Stang A, Jansen L, Trabert B, Rusner C, Eberle A, Katalinic A, Emrich K, Holleczek B, Brenner H; GEKID Cancer Survival Working Group
Cancer Epidemiol 2013 Aug;37(4):492-7. Epub 2013 Apr 23 doi: 10.1016/j.canep.2013.03.017. PMID: 23623488Free PMC Article
[18F]Fluorodeoxyglucose positron emission tomography in nonseminomatous germ cell tumors after chemotherapy: the German multicenter positron emission tomography study group.
Oechsle K, Hartmann M, Brenner W, Venz S, Weissbach L, Franzius C, Kliesch S, Mueller S, Krege S, Heicappell R, Bares R, Bokemeyer C, de Wit M; German Multicenter Positron Emission Tomography Study Group
J Clin Oncol 2008 Dec 20;26(36):5930-5. Epub 2008 Nov 17 doi: 10.1200/JCO.2008.17.1157. PMID: 19018083

Diagnosis

Stage migration of testicular germ cell tumours in Alberta, Canada, during the COVID-19 pandemic: a retrospective cohort study.
Lee-Ying R, O'Sullivan DE, Gagnon R, Bosma N, Stewart RN, Railton C, Tilley D, Alimohamed N, Basappa N, Cheng T, Kolinsky M, Karim S, Ruether D, North S, Yip S, Danielson B, Heng D, Brenner D
CMAJ Open 2022 Jul-Sep;10(3):E633-E642. Epub 2022 Jul 5 doi: 10.9778/cmajo.20210285. PMID: 35790231Free PMC Article
Systems biology of cisplatin resistance: past, present and future.
Galluzzi L, Vitale I, Michels J, Brenner C, Szabadkai G, Harel-Bellan A, Castedo M, Kroemer G
Cell Death Dis 2014 May 29;5(5):e1257. doi: 10.1038/cddis.2013.428. PMID: 24874729Free PMC Article
Survival after a diagnosis of testicular germ cell cancers in Germany and the United States, 2002-2006: a high resolution study by histology and age.
Stang A, Jansen L, Trabert B, Rusner C, Eberle A, Katalinic A, Emrich K, Holleczek B, Brenner H; GEKID Cancer Survival Working Group
Cancer Epidemiol 2013 Aug;37(4):492-7. Epub 2013 Apr 23 doi: 10.1016/j.canep.2013.03.017. PMID: 23623488Free PMC Article
[18F]Fluorodeoxyglucose positron emission tomography in nonseminomatous germ cell tumors after chemotherapy: the German multicenter positron emission tomography study group.
Oechsle K, Hartmann M, Brenner W, Venz S, Weissbach L, Franzius C, Kliesch S, Mueller S, Krege S, Heicappell R, Bares R, Bokemeyer C, de Wit M; German Multicenter Positron Emission Tomography Study Group
J Clin Oncol 2008 Dec 20;26(36):5930-5. Epub 2008 Nov 17 doi: 10.1200/JCO.2008.17.1157. PMID: 19018083
Use of monoclonal antibody against human inhibin as a marker for sex cord-stromal tumors of the ovary.
Rishi M, Howard LN, Bratthauer GL, Tavassoli FA
Am J Surg Pathol 1997 May;21(5):583-9. doi: 10.1097/00000478-199705000-00012. PMID: 9158684

Therapy

Systems biology of cisplatin resistance: past, present and future.
Galluzzi L, Vitale I, Michels J, Brenner C, Szabadkai G, Harel-Bellan A, Castedo M, Kroemer G
Cell Death Dis 2014 May 29;5(5):e1257. doi: 10.1038/cddis.2013.428. PMID: 24874729Free PMC Article
[18F]Fluorodeoxyglucose positron emission tomography in nonseminomatous germ cell tumors after chemotherapy: the German multicenter positron emission tomography study group.
Oechsle K, Hartmann M, Brenner W, Venz S, Weissbach L, Franzius C, Kliesch S, Mueller S, Krege S, Heicappell R, Bares R, Bokemeyer C, de Wit M; German Multicenter Positron Emission Tomography Study Group
J Clin Oncol 2008 Dec 20;26(36):5930-5. Epub 2008 Nov 17 doi: 10.1200/JCO.2008.17.1157. PMID: 19018083
The role of positron emission tomography in the evaluation of residual masses after chemotherapy for advanced stage seminoma.
Hinz S, Schrader M, Kempkensteffen C, Bares R, Brenner W, Krege S, Franzius C, Kliesch S, Heicappel R, Miller K, de Wit M
J Urol 2008 Mar;179(3):936-40; discussion 940. Epub 2008 Jan 22 doi: 10.1016/j.juro.2007.10.054. PMID: 18207171
Cytoreductive surgery for advanced nonseminomatous germ cell tumors of testis.
Brenner J, Vugrin D, Whitmore WF
Urology 1982 Jun;19(6):571-5. doi: 10.1016/0090-4295(82)90001-2. PMID: 6178198

Prognosis

Survival after a diagnosis of testicular germ cell cancers in Germany and the United States, 2002-2006: a high resolution study by histology and age.
Stang A, Jansen L, Trabert B, Rusner C, Eberle A, Katalinic A, Emrich K, Holleczek B, Brenner H; GEKID Cancer Survival Working Group
Cancer Epidemiol 2013 Aug;37(4):492-7. Epub 2013 Apr 23 doi: 10.1016/j.canep.2013.03.017. PMID: 23623488Free PMC Article
Testicular cancer survival in Estonia: improving but still relatively low.
Aareleid T, Gondos A, Brenner H, Pokker H, Leppik K, Mägi M
Acta Oncol 2011 Jan;50(1):99-105. Epub 2010 Apr 29 doi: 10.3109/0284186X.2010.480981. PMID: 20429722
[18F]Fluorodeoxyglucose positron emission tomography in nonseminomatous germ cell tumors after chemotherapy: the German multicenter positron emission tomography study group.
Oechsle K, Hartmann M, Brenner W, Venz S, Weissbach L, Franzius C, Kliesch S, Mueller S, Krege S, Heicappell R, Bares R, Bokemeyer C, de Wit M; German Multicenter Positron Emission Tomography Study Group
J Clin Oncol 2008 Dec 20;26(36):5930-5. Epub 2008 Nov 17 doi: 10.1200/JCO.2008.17.1157. PMID: 19018083
The role of positron emission tomography in the evaluation of residual masses after chemotherapy for advanced stage seminoma.
Hinz S, Schrader M, Kempkensteffen C, Bares R, Brenner W, Krege S, Franzius C, Kliesch S, Heicappel R, Miller K, de Wit M
J Urol 2008 Mar;179(3):936-40; discussion 940. Epub 2008 Jan 22 doi: 10.1016/j.juro.2007.10.054. PMID: 18207171
Simultaneous retroperitoneal, thoracic, and cervical resection of postchemotherapy residual masses in patients with metastatic nonseminomatous germ cell tumors of the testis.
Brenner PC, Herr HW, Morse MJ, Sheinfeld J, Aprikian A, Bosl GJ, Motzer RJ, Bajorin DF, Schantz S, Fair WR, Burt M
J Clin Oncol 1996 Jun;14(6):1765-9. doi: 10.1200/JCO.1996.14.6.1765. PMID: 8656244

Clinical prediction guides

Antitumor and antiangiogenic activity of the novel chimeric inhibitor animacroxam in testicular germ cell cancer.
Steinemann G, Dittmer A, Schmidt J, Josuttis D, Fähling M, Biersack B, Beindorff N, Jolante Koziolek E, Schobert R, Brenner W, Müller T, Nitzsche B, Höpfner M
Mol Oncol 2019 Dec;13(12):2679-2696. Epub 2019 Oct 22 doi: 10.1002/1878-0261.12582. PMID: 31583820Free PMC Article
Runs of homozygosity and testicular cancer risk.
Loveday C, Sud A, Litchfield K, Levy M, Holroyd A, Broderick P, Kote-Jarai Z, Dunning AM, Muir K, Peto J, Eeles R, Easton DF, Dudakia D, Orr N, Pashayan N; UK Testicular Cancer Collaboration; PRACTICAL Consortium, Reid A, Huddart RA, Houlston RS, Turnbull C
Andrology 2019 Jul;7(4):555-564. doi: 10.1111/andr.12667. PMID: 31310061
[18F]Fluorodeoxyglucose positron emission tomography in nonseminomatous germ cell tumors after chemotherapy: the German multicenter positron emission tomography study group.
Oechsle K, Hartmann M, Brenner W, Venz S, Weissbach L, Franzius C, Kliesch S, Mueller S, Krege S, Heicappell R, Bares R, Bokemeyer C, de Wit M; German Multicenter Positron Emission Tomography Study Group
J Clin Oncol 2008 Dec 20;26(36):5930-5. Epub 2008 Nov 17 doi: 10.1200/JCO.2008.17.1157. PMID: 19018083
A brief history of the pathology of the gonads.
Young RH
Mod Pathol 2005 Feb;18 Suppl 2:S3-S17. doi: 10.1038/modpathol.3800305. PMID: 15529187
Use of monoclonal antibody against human inhibin as a marker for sex cord-stromal tumors of the ovary.
Rishi M, Howard LN, Bratthauer GL, Tavassoli FA
Am J Surg Pathol 1997 May;21(5):583-9. doi: 10.1097/00000478-199705000-00012. PMID: 9158684

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