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t(3;3)(q21.3;q26.2)

MedGen UID:
273750
•Concept ID:
C1515764
•
Cell or Molecular Dysfunction
Synonyms: t(3;3)(q21.3q26.2); t(3;3)(q21;q26.2); t(3;3)(q26;q21)

Definition

A cytogenetic abnormality that refers to the translocation where both breakpoints are on the long arm (q23.1 and q26.2) of chromosome 3. It is associated with acute myeloid leukemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(3;3)(q21.3;q26.2)

Professional guidelines

PubMed

Lenalidomide Plus Hypomethylating Agent as a Treatment Option in Acute Myeloid Leukemia With Recurrent Genetic Abnormalities-AML With inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM.
Merz LE, Perissinotti AJ, Marini BL, Burke PW, Crouch A, Erba HP, Bixby D
Clin Lymphoma Myeloma Leuk 2020 Jan;20(1):24-30. Epub 2019 Sep 28 doi: 10.1016/j.clml.2019.09.615. PMID: 31711889
Azacitidine treatment for patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 3q abnormalities.
Wanquet A, Prebet T, Berthon C, Sebert M, Roux C, Kulasekararaj A, Micol JB, Esterni B, Itzykson R, Thepot S, Recher C, Delaunay J, Dreyfus F, Mufti G, Fenaux P, Vey N
Am J Hematol 2015 Oct;90(10):859-63. Epub 2015 Jul 14 doi: 10.1002/ajh.24099. PMID: 26113240

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