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Positive Regulation of Oxidative Stress Process

MedGen UID:
274098
•Concept ID:
C1518761
•
Cell or Molecular Dysfunction
Synonym: Oxidative Stress Induction

Definition

Oxidative Stress Induction involves initiation of activities that induce a disturbance in the pro-oxidant/antioxidant balance, leading to disruption of cell function by superoxide and other free radicals through damage to DNA bases, protein oxidation products, and lipid peroxidation products. Not synonymous with hypoxia or hyperoxia, oxidative stress promotes a range of degenerative disorders. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPositive Regulation of Oxidative Stress Process

Professional guidelines

PubMed

Clinical Efficacy and Short-Term Prognosis of Butylphthalide and Sodium Chloride Injection Compared to Edaravone in the Treatment of Patients with Acute Stroke.
Yang D, Zhang M, Wang X, Zhang J
Altern Ther Health Med 2023 Oct;29(7):370-375. PMID: 37499159
Gut Dysbiosis Dysregulates Central and Systemic Homeostasis via Suboptimal Mitochondrial Function: Assessment, Treatment and Classification Implications.
Anderson G, Maes M
Curr Top Med Chem 2020;20(7):524-539. doi: 10.2174/1568026620666200131094445. PMID: 32003689
Targeting the Canonical WNT/β-Catenin Pathway in Cancer Treatment Using Non-Steroidal Anti-Inflammatory Drugs.
Vallée A, Lecarpentier Y, Vallée JN
Cells 2019 Jul 15;8(7) doi: 10.3390/cells8070726. PMID: 31311204Free PMC Article

Recent clinical studies

Etiology

Oxidative stress: A common pathological state in a high-risk population for osteoporosis.
Zhang C, Li H, Li J, Hu J, Yang K, Tao L
Biomed Pharmacother 2023 Jul;163:114834. Epub 2023 May 8 doi: 10.1016/j.biopha.2023.114834. PMID: 37163779
Vitamin C, Aging and Alzheimer's Disease.
Monacelli F, Acquarone E, Giannotti C, Borghi R, Nencioni A
Nutrients 2017 Jun 27;9(7) doi: 10.3390/nu9070670. PMID: 28654021Free PMC Article
Positive and negative regulators of the metallothionein gene (review).
Takahashi S
Mol Med Rep 2015 Jul;12(1):795-9. Epub 2015 Mar 9 doi: 10.3892/mmr.2015.3459. PMID: 25760317
Genetic mouse models of brain ageing and Alzheimer's disease.
Bilkei-Gorzo A
Pharmacol Ther 2014 May;142(2):244-57. Epub 2013 Dec 19 doi: 10.1016/j.pharmthera.2013.12.009. PMID: 24362083
Nrf2 and cardiovascular defense.
Howden R
Oxid Med Cell Longev 2013;2013:104308. Epub 2013 Apr 4 doi: 10.1155/2013/104308. PMID: 23691261Free PMC Article

Diagnosis

Leveraging senescence-oxidative stress co-relation to predict prognosis and drug sensitivity in breast invasive carcinoma.
Ye Y, Luo Y, Guo T, Zhang C, Sun Y, Xu A, Ji L, Ou J, Wu SY
Front Endocrinol (Lausanne) 2023;14:1179050. Epub 2023 Aug 4 doi: 10.3389/fendo.2023.1179050. PMID: 37600707Free PMC Article
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
Tong Y, Guo D, Lin SH, Liang J, Yang D, Ma C, Shao F, Li M, Yu Q, Jiang Y, Li L, Fang J, Yu R, Lu Z
Mol Cell 2021 Jun 3;81(11):2303-2316.e8. Epub 2021 May 14 doi: 10.1016/j.molcel.2021.04.002. PMID: 33991485
Long Noncoding RNAs in the Regulation of Oxidative Stress.
Wang X, Shen C, Zhu J, Shen G, Li Z, Dong J
Oxid Med Cell Longev 2019;2019:1318795. Epub 2019 Feb 17 doi: 10.1155/2019/1318795. PMID: 30911342Free PMC Article
Mitochondrial biogenesis: pharmacological approaches.
Valero T
Curr Pharm Des 2014;20(35):5507-9. doi: 10.2174/138161282035140911142118. PMID: 24606795
Genetic mouse models of brain ageing and Alzheimer's disease.
Bilkei-Gorzo A
Pharmacol Ther 2014 May;142(2):244-57. Epub 2013 Dec 19 doi: 10.1016/j.pharmthera.2013.12.009. PMID: 24362083

Therapy

Mitochondria as a Source and a Target for Uremic Toxins.
Popkov VA, Silachev DN, Zalevsky AO, Zorov DB, Plotnikov EY
Int J Mol Sci 2019 Jun 25;20(12) doi: 10.3390/ijms20123094. PMID: 31242575Free PMC Article
l-Carnitine Supplementation in Recovery after Exercise.
Fielding R, Riede L, Lugo JP, Bellamine A
Nutrients 2018 Mar 13;10(3) doi: 10.3390/nu10030349. PMID: 29534031Free PMC Article
Vitamin C, Aging and Alzheimer's Disease.
Monacelli F, Acquarone E, Giannotti C, Borghi R, Nencioni A
Nutrients 2017 Jun 27;9(7) doi: 10.3390/nu9070670. PMID: 28654021Free PMC Article
Mitochondrial biogenesis: pharmacological approaches.
Valero T
Curr Pharm Des 2014;20(35):5507-9. doi: 10.2174/138161282035140911142118. PMID: 24606795
Oxidative stress and antioxidant therapy in cystic fibrosis.
Galli F, Battistoni A, Gambari R, Pompella A, Bragonzi A, Pilolli F, Iuliano L, Piroddi M, Dechecchi MC, Cabrini G; Working Group on Inflammation in Cystic Fibrosis
Biochim Biophys Acta 2012 May;1822(5):690-713. Epub 2011 Dec 28 doi: 10.1016/j.bbadis.2011.12.012. PMID: 22226887

Prognosis

Leveraging senescence-oxidative stress co-relation to predict prognosis and drug sensitivity in breast invasive carcinoma.
Ye Y, Luo Y, Guo T, Zhang C, Sun Y, Xu A, Ji L, Ou J, Wu SY
Front Endocrinol (Lausanne) 2023;14:1179050. Epub 2023 Aug 4 doi: 10.3389/fendo.2023.1179050. PMID: 37600707Free PMC Article
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
Tong Y, Guo D, Lin SH, Liang J, Yang D, Ma C, Shao F, Li M, Yu Q, Jiang Y, Li L, Fang J, Yu R, Lu Z
Mol Cell 2021 Jun 3;81(11):2303-2316.e8. Epub 2021 May 14 doi: 10.1016/j.molcel.2021.04.002. PMID: 33991485
Food, Nutrition, Physical Activity and Microbiota: Which Impact on Lung Cancer?
Nigro E, Perrotta F, Scialò F, D'Agnano V, Mallardo M, Bianco A, Daniele A
Int J Environ Res Public Health 2021 Mar 1;18(5) doi: 10.3390/ijerph18052399. PMID: 33804536Free PMC Article
Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) in autophagy-induced hepatocellular carcinoma.
Zhou J, Zhang X, Tang H, Yu J, Zu X, Xie Z, Yang X, Hu J, Tan F, Li Q, Lei X
Clin Chim Acta 2020 Jul;506:1-8. Epub 2020 Feb 25 doi: 10.1016/j.cca.2020.02.028. PMID: 32109431
Mitochondrial biogenesis: pharmacological approaches.
Valero T
Curr Pharm Des 2014;20(35):5507-9. doi: 10.2174/138161282035140911142118. PMID: 24606795

Clinical prediction guides

Oxidative stress specifically inhibits replication of dengue virus.
Khan NA, Kar M, Panwar A, Wangchuk J, Kumar S, Das A, Pandey AK, Lodha R, Medigeshi GR
J Gen Virol 2021 Apr;102(4) doi: 10.1099/jgv.0.001596. PMID: 33904816Free PMC Article
Factors inducing transdifferentiation of myoblasts into adipocytes.
Wang L, Shan T
J Cell Physiol 2021 Apr;236(4):2276-2289. Epub 2020 Sep 28 doi: 10.1002/jcp.30074. PMID: 32989814
Immunity and longevity.
Csaba G
Acta Microbiol Immunol Hung 2019 Mar 1;66(1):1-17. Epub 2018 Jul 3 doi: 10.1556/030.65.2018.029. PMID: 29968490
Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2/Nrf2 and mitochondria.
Ryoo IG, Kwak MK
Toxicol Appl Pharmacol 2018 Nov 15;359:24-33. Epub 2018 Sep 18 doi: 10.1016/j.taap.2018.09.014. PMID: 30236989
Mitochondrial biogenesis: pharmacological approaches.
Valero T
Curr Pharm Des 2014;20(35):5507-9. doi: 10.2174/138161282035140911142118. PMID: 24606795

Recent systematic reviews

Mass Spectrometry as a Quantitative Proteomic Analysis Tool for the Search for Temporal Lobe Epilepsy Biomarkers: A Systematic Review.
Timechko EE, Yakimov AM, Paramonova AI, Usoltseva AA, Utyashev NP, Ivin NO, Utyasheva AA, Yakunina AV, Kalinin VA, Dmitrenko DV
Int J Mol Sci 2023 Jul 5;24(13) doi: 10.3390/ijms241311130. PMID: 37446307Free PMC Article
Panax ginseng and aging related disorders: A systematic review.
de Oliveira Zanuso B, de Oliveira Dos Santos AR, Miola VFB, Guissoni Campos LM, Spilla CSG, Barbalho SM
Exp Gerontol 2022 May;161:111731. Epub 2022 Feb 7 doi: 10.1016/j.exger.2022.111731. PMID: 35143871

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