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Vulvar Dysplastic Melanocytic Nevus

MedGen UID:
274413
•Concept ID:
C1520079
•
Neoplastic Process

Definition

A rare, elevated and pigmented, compound or junctional nevus that arises from the vulva. It affects women in their reproductive years and may be associated with the presence of dysplastic nevi in other anatomic areas. It is characterized by the presence of epithelioid or spindle-shaped melanocytes exhibiting nuclear pleomorphism and prominent nucleoli. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar Dysplastic Melanocytic Nevus

Recent clinical studies

Etiology

Atypical melanocytic nevi of the genital type with a discussion of reciprocal parenchymal-stromal interactions in the biology of neoplasia.
Clark WH Jr, Hood AF, Tucker MA, Jampel RM
Hum Pathol 1998 Jan;29(1 Suppl 1):S1-24. doi: 10.1016/s0046-8177(98)80028-2. PMID: 9445124
Dysplastic vulvar nevi.
Blickstein I, Feldberg E, Dgani R, Ben-Hur H, Czernobilsky B
Obstet Gynecol 1991 Nov;78(5 Pt 2):968-70. PMID: 1923241
Histologic characteristics of vulvar nevocellular nevi.
Christensen WN, Friedman KJ, Woodruff JD, Hood AF
J Cutan Pathol 1987 Apr;14(2):87-91. doi: 10.1111/j.1600-0560.1987.tb00478.x. PMID: 3597916

Diagnosis

Dermatopathology updates on melanocytic lesions.
Cheung WL, Smoller BR
Dermatol Clin 2012 Oct;30(4):617-22, vi. Epub 2012 Aug 3 doi: 10.1016/j.det.2012.06.014. PMID: 23021049
Atypical genital nevus.
Brenn T
Arch Pathol Lab Med 2011 Mar;135(3):317-20. doi: 10.5858/2009-0382-RA.1. PMID: 21366454
Pigmented vulvar lesions.
Edwards L
Dermatol Ther 2010 Sep-Oct;23(5):449-57. doi: 10.1111/j.1529-8019.2010.01349.x. PMID: 20868400
Melanocytic lesions of the genital area with attention given to atypical genital nevi.
Ribé A
J Cutan Pathol 2008 Nov;35 Suppl 2:24-7. doi: 10.1111/j.1600-0560.2008.01150.x. PMID: 18976416
Dysplastic vulvar nevi.
Blickstein I, Feldberg E, Dgani R, Ben-Hur H, Czernobilsky B
Obstet Gynecol 1991 Nov;78(5 Pt 2):968-70. PMID: 1923241

Prognosis

Melanocytic lesions of the genital area with attention given to atypical genital nevi.
Ribé A
J Cutan Pathol 2008 Nov;35 Suppl 2:24-7. doi: 10.1111/j.1600-0560.2008.01150.x. PMID: 18976416

Clinical prediction guides

Dermatopathology updates on melanocytic lesions.
Cheung WL, Smoller BR
Dermatol Clin 2012 Oct;30(4):617-22, vi. Epub 2012 Aug 3 doi: 10.1016/j.det.2012.06.014. PMID: 23021049
Melanocytic lesions of the genital area with attention given to atypical genital nevi.
Ribé A
J Cutan Pathol 2008 Nov;35 Suppl 2:24-7. doi: 10.1111/j.1600-0560.2008.01150.x. PMID: 18976416
Histologic characteristics of vulvar nevocellular nevi.
Christensen WN, Friedman KJ, Woodruff JD, Hood AF
J Cutan Pathol 1987 Apr;14(2):87-91. doi: 10.1111/j.1600-0560.1987.tb00478.x. PMID: 3597916

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