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Fallopian tube mucinous adenocarcinoma

MedGen UID:
274489
•Concept ID:
C1517119
•
Neoplastic Process
Synonyms: Fallopian Tube Mucinous Adenocarcinoma; fallopian tube mucinous adenocarcinoma
 
Monarch Initiative: MONDO:0002744

Definition

An extremely rare adenocarcinoma that arises from the fallopian tube. It is characterized by the presence of neoplastic epithelial cells that contain intracytoplasmic mucin. The cases that have been reported are predominantly in situ mucinous adenocarcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFallopian tube mucinous adenocarcinoma

Professional guidelines

PubMed

Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Feasibility study on biweekly paclitaxel treatment as maintenance chemotherapy in advanced müllerian carcinoma.
Minagawa Y, Shimada M, Itamochi H, Sato S, Sato S, Okada M, Kitada F, Kigawa J
Gynecol Obstet Invest 2012;73(4):272-6. Epub 2012 Mar 1 doi: 10.1159/000332368. PMID: 22378216
Treatment of ovarian cancer in young women.
Gershenson DM
Clin Obstet Gynecol 2012 Mar;55(1):65-74. doi: 10.1097/GRF.0b013e318248045b. PMID: 22343230

Recent clinical studies

Etiology

Outcome and Management of Serous Tubal Intraepithelial Carcinoma Following Opportunistic Salpingectomy: Systematic Review and Meta-Analysis.
Ruel-Laliberté J, Kasasni SM, Oprea D, Viau M
J Obstet Gynaecol Can 2022 Nov;44(11):1174-1180. Epub 2022 Sep 12 doi: 10.1016/j.jogc.2022.08.018. PMID: 36099965
The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded.
Kurman RJ, Shih IeM
Am J Pathol 2016 Apr;186(4):733-47. doi: 10.1016/j.ajpath.2015.11.011. PMID: 27012190Free PMC Article
Recent concepts of ovarian carcinogenesis: type I and type II.
Koshiyama M, Matsumura N, Konishi I
Biomed Res Int 2014;2014:934261. Epub 2014 Apr 23 doi: 10.1155/2014/934261. PMID: 24868556Free PMC Article
Mucinous metaplasia of the fallopian tube: a diagnostic pitfall mimicking metastasis.
Wong AK, Seidman JD, Barbuto DA, McPhaul LW, Silva EG
Int J Gynecol Pathol 2011 Jan;30(1):36-40. doi: 10.1097/PGP.0b013e3181f45f28. PMID: 21131836
The fallopian tube: primary site of most pelvic high-grade serous carcinomas.
Salvador S, Gilks B, Köbel M, Huntsman D, Rosen B, Miller D
Int J Gynecol Cancer 2009 Jan;19(1):58-64. doi: 10.1111/IGC.0b013e318199009c. PMID: 19258943

Diagnosis

Mucinous appendiceal adenocarcinoma invading the bladder: not always an easy diagnosis. A case report.
Eugenia L, Giovanni A, Andrea M, Maria Rosaria R, Gianni V, Mara B, Gherardo M, Daniele L, Lorenzo A, Andrea M, Paolo P
Anticancer Drugs 2023 Sep 1;34(8):967-969. Epub 2023 Jan 24 doi: 10.1097/CAD.0000000000001499. PMID: 36688906
Outcome and Management of Serous Tubal Intraepithelial Carcinoma Following Opportunistic Salpingectomy: Systematic Review and Meta-Analysis.
Ruel-Laliberté J, Kasasni SM, Oprea D, Viau M
J Obstet Gynaecol Can 2022 Nov;44(11):1174-1180. Epub 2022 Sep 12 doi: 10.1016/j.jogc.2022.08.018. PMID: 36099965
Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Primary Mucinous Carcinoma of the Fallopian Tube: Case Report and Review of Literature.
Wheal A, Jenkins R, Mikami Y, Das N, Hirschowitz L
Int J Gynecol Pathol 2017 Jul;36(4):393-399. doi: 10.1097/PGP.0000000000000330. PMID: 27662036
Mucinous metaplasia of the fallopian tube: a diagnostic pitfall mimicking metastasis.
Wong AK, Seidman JD, Barbuto DA, McPhaul LW, Silva EG
Int J Gynecol Pathol 2011 Jan;30(1):36-40. doi: 10.1097/PGP.0b013e3181f45f28. PMID: 21131836

Therapy

Fibronectin and Periostin as Prognostic Markers in Ovarian Cancer.
Kujawa KA, Zembala-Nożyńska E, Cortez AJ, Kujawa T, Kupryjańczyk J, Lisowska KM
Cells 2020 Jan 8;9(1) doi: 10.3390/cells9010149. PMID: 31936272Free PMC Article
Exploring the added value of hospital-registry data for showing local service outcomes: cancers of the ovary, fallopian tube and peritoneum.
Roder D, Davy M, Selva-Nayagam S, Paramasivam S, Adams J, Keefe D, Miller C, Powell K, Fusco K, Buranyi-Trevarton D, Oehler MK
BMJ Open 2019 Feb 19;9(2):e024036. doi: 10.1136/bmjopen-2018-024036. PMID: 30782891Free PMC Article
Weekly topotecan for recurrent ovarian, fallopian tube and primary peritoneal carcinoma: tolerability and efficacy study--the Israeli experience.
Safra T, Berman T, Yachnin A, Bruchim I, Meirovitz M, Barak F, Atlas I, Levy T, Rosengarten OS
Int J Gynecol Cancer 2013 Mar;23(3):475-80. doi: 10.1097/IGC.0b013e3182866944. PMID: 23435437
Cancerous ovarian stem cells: obscure targets for therapy but relevant to chemoresistance.
Ahmed N, Abubaker K, Findlay J, Quinn M
J Cell Biochem 2013 Jan;114(1):21-34. doi: 10.1002/jcb.24317. PMID: 22887554
The fallopian tube: primary site of most pelvic high-grade serous carcinomas.
Salvador S, Gilks B, Köbel M, Huntsman D, Rosen B, Miller D
Int J Gynecol Cancer 2009 Jan;19(1):58-64. doi: 10.1111/IGC.0b013e318199009c. PMID: 19258943

Prognosis

Mucinous appendiceal adenocarcinoma invading the bladder: not always an easy diagnosis. A case report.
Eugenia L, Giovanni A, Andrea M, Maria Rosaria R, Gianni V, Mara B, Gherardo M, Daniele L, Lorenzo A, Andrea M, Paolo P
Anticancer Drugs 2023 Sep 1;34(8):967-969. Epub 2023 Jan 24 doi: 10.1097/CAD.0000000000001499. PMID: 36688906
Fibronectin and Periostin as Prognostic Markers in Ovarian Cancer.
Kujawa KA, Zembala-Nożyńska E, Cortez AJ, Kujawa T, Kupryjańczyk J, Lisowska KM
Cells 2020 Jan 8;9(1) doi: 10.3390/cells9010149. PMID: 31936272Free PMC Article
The new WHO classification of ovarian, fallopian tube, and primary peritoneal cancer and its clinical implications.
Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J
Arch Gynecol Obstet 2016 Apr;293(4):695-700. Epub 2016 Feb 19 doi: 10.1007/s00404-016-4035-8. PMID: 26894303
Recent concepts of ovarian carcinogenesis: type I and type II.
Koshiyama M, Matsumura N, Konishi I
Biomed Res Int 2014;2014:934261. Epub 2014 Apr 23 doi: 10.1155/2014/934261. PMID: 24868556Free PMC Article
Neuroendocrine tumors of the genital tract.
Eichhorn JH, Young RH
Am J Clin Pathol 2001 Jun;115 Suppl:S94-112. doi: 10.1309/64CW-WKGK-49EF-BYD1. PMID: 11993694

Clinical prediction guides

Fibronectin and Periostin as Prognostic Markers in Ovarian Cancer.
Kujawa KA, Zembala-Nożyńska E, Cortez AJ, Kujawa T, Kupryjańczyk J, Lisowska KM
Cells 2020 Jan 8;9(1) doi: 10.3390/cells9010149. PMID: 31936272Free PMC Article
Clinical Outcomes among Women with Mucinous Adenocarcinoma of the Ovary.
Massad LS, Gao F, Hagemann I, Powell M
Gynecol Obstet Invest 2016;81(5):411-5. Epub 2015 Nov 20 doi: 10.1159/000441791. PMID: 26583769Free PMC Article
Expression of LATS family proteins in ovarian tumors and its significance.
Xu B, Sun D, Wang Z, Weng H, Wu D, Zhang X, Zhou Y, Hu W
Hum Pathol 2015 Jun;46(6):858-67. Epub 2015 Mar 5 doi: 10.1016/j.humpath.2015.02.012. PMID: 25841306
Nongynecologic metastases to fallopian tube mucosa: a potential mimic of tubal high-grade serous carcinoma and benign tubal mucinous metaplasia or nonmucinous hyperplasia.
Rabban JT, Vohra P, Zaloudek CJ
Am J Surg Pathol 2015 Jan;39(1):35-51. doi: 10.1097/PAS.0000000000000293. PMID: 25025442
Mucinous adenocarcinoma developed from human fallopian tube epithelial cells through defined genetic modifications.
Shan W, Mercado-Uribe I, Zhang J, Rosen D, Zhang S, Wei J, Liu J
Cell Cycle 2012 Jun 1;11(11):2107-13. doi: 10.4161/cc.20544. PMID: 22592533Free PMC Article

Recent systematic reviews

Outcome and Management of Serous Tubal Intraepithelial Carcinoma Following Opportunistic Salpingectomy: Systematic Review and Meta-Analysis.
Ruel-Laliberté J, Kasasni SM, Oprea D, Viau M
J Obstet Gynaecol Can 2022 Nov;44(11):1174-1180. Epub 2022 Sep 12 doi: 10.1016/j.jogc.2022.08.018. PMID: 36099965

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