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Gain of Chromosome 17q22-q24

MedGen UID:: 274553
•Concept ID:: C1517395
•: Cell or Molecular Dysfunction

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGain of Chromosome 17q22-q24

Molecular Abnormality
- Cytogenetic Abnormality
  - Numerical Chromosomal Abnormality
    - Chromosomal Gain
      - Gain of Chromosome 17q22-q24

Recent clinical studies

Etiology

Copy-number intratumor heterogeneity increases the risk of relapse in chemotherapy-naive stage II colon cancer.

Lahoz S, Archilla I, Asensio E, Hernández-Illán E, Ferrer Q, López-Prades S, Nadeu F, Del Rey J, Sanz-Pamplona R, Lozano JJ, Castells A, Cuatrecasas M, Camps J
J Pathol 2022 May;257(1):68-81. Epub 2022 Apr 6 doi: 10.1002/path.5870. PMID: 35066875 Free PMC Article

Diagnosis

Genomic abnormalities acquired in the blastic transformation of splenic marginal zone B-cell lymphoma.

Martinez-Climent JA, Sanchez-Izquierdo D, Sarsotti E, Blesa D, Benet I, Climent J, Vizcarra E, Marugan I, Terol MJ, Sole F, Cigudosad JC, Siebert R, Dyer MJ, García-Conde J
Leuk Lymphoma 2003 Mar;44(3):459-64. doi: 10.1080/1042819021000055129. PMID: 12688315

Prognosis

Copy-number intratumor heterogeneity increases the risk of relapse in chemotherapy-naive stage II colon cancer.

Lahoz S, Archilla I, Asensio E, Hernández-Illán E, Ferrer Q, López-Prades S, Nadeu F, Del Rey J, Sanz-Pamplona R, Lozano JJ, Castells A, Cuatrecasas M, Camps J
J Pathol 2022 May;257(1):68-81. Epub 2022 Apr 6 doi: 10.1002/path.5870. PMID: 35066875 Free PMC Article

Clinical prediction guides

Copy-number intratumor heterogeneity increases the risk of relapse in chemotherapy-naive stage II colon cancer.

Lahoz S, Archilla I, Asensio E, Hernández-Illán E, Ferrer Q, López-Prades S, Nadeu F, Del Rey J, Sanz-Pamplona R, Lozano JJ, Castells A, Cuatrecasas M, Camps J
J Pathol 2022 May;257(1):68-81. Epub 2022 Apr 6 doi: 10.1002/path.5870. PMID: 35066875 Free PMC Article

Genomic abnormalities acquired in the blastic transformation of splenic marginal zone B-cell lymphoma.

Martinez-Climent JA, Sanchez-Izquierdo D, Sarsotti E, Blesa D, Benet I, Climent J, Vizcarra E, Marugan I, Terol MJ, Sole F, Cigudosad JC, Siebert R, Dyer MJ, García-Conde J
Leuk Lymphoma 2003 Mar;44(3):459-64. doi: 10.1080/1042819021000055129. PMID: 12688315

17q21-q25 aberrations in breast cancer: combined allelotyping and CGH analysis reveals 5 regions of allelic imbalance among which two correspond to DNA amplification.

Orsetti B, Courjal F, Cuny M, Rodriguez C, Theillet C
Oncogene 1999 Nov 4;18(46):6262-70. doi: 10.1038/sj.onc.1203006. PMID: 10597224

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