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Penis basal cell carcinoma

MedGen UID:
275349
•Concept ID:
C1518949
•
Neoplastic Process
Synonyms: Basal Cell Carcinoma of the Penis; basal cell carcinoma of the penis; penile basal cell cancer; Penile Basal Cell Carcinoma; penile basal cell carcinoma; penis basal cell carcinoma; penis skin basal cell carcinoma; skin basal cell carcinoma of penis; skin of penis skin basal cell carcinoma
 
Monarch Initiative: MONDO:0002935

Definition

A basal cell carcinoma of the penis with an indolent clinical course. It is usually superficial and arises from the shaft and rarely the glans. [from NCI]

Recent clinical studies

Etiology

Treatment of penoscrotal basal cell carcinoma - an institutional retrospective review.
Light JG, Muñoz G, Council ML
Arch Dermatol Res 2023 Oct;315(8):2423-2425. Epub 2023 Apr 7 doi: 10.1007/s00403-023-02617-2. PMID: 37024690
WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges.
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
Malignant tumors of the penis.
Brady KL, Mercurio MG, Brown MD
Dermatol Surg 2013 Apr;39(4):527-47. Epub 2012 Nov 16 doi: 10.1111/dsu.12029. PMID: 23164051
Lichen sclerosus.
Yesudian PD, Sugunendran H, Bates CM, O'Mahony C
Int J STD AIDS 2005 Jul;16(7):465-73, test 474. doi: 10.1258/0956462054308440. PMID: 16004624

Diagnosis

Treatment of penoscrotal basal cell carcinoma - an institutional retrospective review.
Light JG, Muñoz G, Council ML
Arch Dermatol Res 2023 Oct;315(8):2423-2425. Epub 2023 Apr 7 doi: 10.1007/s00403-023-02617-2. PMID: 37024690
Zebras in Foreskin Dermatopathology: A Review.
Alhatem A, Patel N, Lambert WC, Heller DS
J Low Genit Tract Dis 2019 Jul;23(3):235-240. doi: 10.1097/LGT.0000000000000478. PMID: 31149956
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article
Malignant tumors of the penis.
Brady KL, Mercurio MG, Brown MD
Dermatol Surg 2013 Apr;39(4):527-47. Epub 2012 Nov 16 doi: 10.1111/dsu.12029. PMID: 23164051
Perianal and genital basal cell carcinoma: A clinicopathologic review of 51 cases.
Gibson GE, Ahmed I
J Am Acad Dermatol 2001 Jul;45(1):68-71. doi: 10.1067/mjd.2001.114588. PMID: 11423837

Therapy

HPV16 induces penile intraepithelial neoplasia and squamous cell carcinoma in transgenic mice: first mouse model for HPV-related penile cancer.
Medeiros-Fonseca B, Mestre VF, Estêvão D, Sánchez DF, Cañete-Portillo S, Fernández-Nestosa MJ, Casaca F, Silva S, Brito H, Félix A, Medeiros R, Colaço B, Oliveira PA, Bastos MM, Nelson PS, Vakar-Lopez F, Gaivão I, Brito L, Lopes C, Cubilla AL, Gil da Costa RM
J Pathol 2020 Aug;251(4):411-419. doi: 10.1002/path.5475. PMID: 32488868
Photoprotective potential of Cordyceps polysaccharides against ultraviolet B radiation-induced DNA damage to human skin cells.
Wong WC, Wu JY, Benzie IF
Br J Dermatol 2011 May;164(5):980-6. Epub 2011 Mar 22 doi: 10.1111/j.1365-2133.2010.10201.x. PMID: 21198539
Cutaneous neoplasia following PUVA therapy for psoriasis.
McKenna KE, Patterson CC, Handley J, McGinn S, Allen G
Br J Dermatol 1996 Apr;134(4):639-42. doi: 10.1111/j.1365-2133.1996.tb06962.x. PMID: 8733363
Cutaneous manifestations of long-term hydroxyurea therapy.
Kelly RI, Bull RH, Marsden A
Australas J Dermatol 1994;35(2):61-4. doi: 10.1111/j.1440-0960.1994.tb00897.x. PMID: 7702489
Erythroplasia (Queyrat) of conjunctiva.
Dixon RS, Mikhail GR
J Am Acad Dermatol 1981 Feb;4(2):160-5. doi: 10.1016/s0190-9622(81)70019-7. PMID: 7217386

Prognosis

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article
Basal cell carcinoma of the penis.
Lidder S, Lang KJ, Nakhdjevani A
Singapore Med J 2011 Oct;52(10):e201-2. PMID: 22009407
Lichen sclerosus.
Yesudian PD, Sugunendran H, Bates CM, O'Mahony C
Int J STD AIDS 2005 Jul;16(7):465-73, test 474. doi: 10.1258/0956462054308440. PMID: 16004624
Carcinoma of the penis.
Persky L, deKernion J
CA Cancer J Clin 1986 Sep-Oct;36(5):258-73. doi: 10.3322/canjclin.36.5.258. PMID: 3093013

Clinical prediction guides

A population-level analysis of nonsquamous penile cancer: The importance of histology.
Bhambhvani HP, Greenberg DR, Parham MJ, Eisenberg ML
Urol Oncol 2021 Feb;39(2):136.e1-136.e10. Epub 2020 Nov 27 doi: 10.1016/j.urolonc.2020.11.025. PMID: 33257222
HPV16 induces penile intraepithelial neoplasia and squamous cell carcinoma in transgenic mice: first mouse model for HPV-related penile cancer.
Medeiros-Fonseca B, Mestre VF, Estêvão D, Sánchez DF, Cañete-Portillo S, Fernández-Nestosa MJ, Casaca F, Silva S, Brito H, Félix A, Medeiros R, Colaço B, Oliveira PA, Bastos MM, Nelson PS, Vakar-Lopez F, Gaivão I, Brito L, Lopes C, Cubilla AL, Gil da Costa RM
J Pathol 2020 Aug;251(4):411-419. doi: 10.1002/path.5475. PMID: 32488868
D2-40 immunoreactivity in penile squamous cell carcinoma: a marker of aggressiveness.
Minardi D, d'Anzeo G, Lucarini G, Filosa A, Zizzi A, Simonetti O, Polito M Jr, Offidani AM, Di Primio R, Montironi R, Muzzonigro G
Hum Pathol 2011 Nov;42(11):1596-602. Epub 2011 Apr 15 doi: 10.1016/j.humpath.2010.12.020. PMID: 21497368
Cytopathological features of warty (condylomatous) carcinoma of the penis: a case report and distinction from other verruciform penile tumors.
Hayashi T, Haba R, Kushida Y, Kadota K, Katsuki N, Miyai Y, Bando K, Shibuya S, Funamoto Y, Kakehi Y
Diagn Cytopathol 2010 Nov;38(11):841-5. doi: 10.1002/dc.21341. PMID: 20301209
HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis.
Stankiewicz E, Kudahetti SC, Prowse DM, Ktori E, Cuzick J, Ambroisine L, Zhang X, Watkin N, Corbishley C, Berney DM
Mod Pathol 2009 Sep;22(9):1160-8. Epub 2009 May 22 doi: 10.1038/modpathol.2009.77. PMID: 19465901

Recent systematic reviews

Zebras in Foreskin Dermatopathology: A Review.
Alhatem A, Patel N, Lambert WC, Heller DS
J Low Genit Tract Dis 2019 Jul;23(3):235-240. doi: 10.1097/LGT.0000000000000478. PMID: 31149956

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