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Vaginal Adenosquamous Carcinoma

MedGen UID:
275571
•Concept ID:
C1519915
•
Neoplastic Process

Definition

A carcinoma that arises from the vagina and is characterized by the presence of malignant glandular and malignant squamous epithelial components. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Adenosquamous Carcinoma

Professional guidelines

PubMed

Cervical cancer in women under 25 years of age and outside the screening age: Diagnosis profile and long-term outcomes.
Teixeira JC, Santos DZ, Campos CS, Vale DB, Bragança JF, Zeferino LC
Int J Gynaecol Obstet 2021 Jul;154(1):150-156. Epub 2021 Jan 27 doi: 10.1002/ijgo.13553. PMID: 33341962
Management and outcomes of primary vaginal Cancer.
Yang J, Delara R, Magrina J, Magtibay P, Langstraat C, Dinh T, Karlin N, Vora SA, Butler K
Gynecol Oncol 2020 Nov;159(2):456-463. Epub 2020 Sep 22 doi: 10.1016/j.ygyno.2020.08.036. PMID: 32972784
Stage at diagnosis and mortality in patients with adenocarcinoma and adenosquamous carcinoma of the uterine cervix diagnosed as a consequence of cytologic screening.
Kinney W, Sawaya GF, Sung HY, Kearney KA, Miller M, Hiatt RA
Acta Cytol 2003 Mar-Apr;47(2):167-71. doi: 10.1159/000326498. PMID: 12685183

Recent clinical studies

Etiology

Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
Open vs minimally invasive radical trachelectomy in early-stage cervical cancer: International Radical Trachelectomy Assessment Study.
Salvo G, Ramirez PT, Leitao MM, Cibula D, Wu X, Falconer H, Persson J, Perrotta M, Mosgaard BJ, Kucukmetin A, Berlev I, Rendon G, Liu K, Vieira M, Capilna ME, Fotopoulou C, Baiocchi G, Kaidarova D, Ribeiro R, Pedra-Nobre S, Kocian R, Li X, Li J, Pálsdóttir K, Noll F, Rundle S, Ulrikh E, Hu Z, Gheorghe M, Saso S, Bolatbekova R, Tsunoda A, Pitcher B, Wu J, Urbauer D, Pareja R
Am J Obstet Gynecol 2022 Jan;226(1):97.e1-97.e16. Epub 2021 Aug 27 doi: 10.1016/j.ajog.2021.08.029. PMID: 34461074Free PMC Article
MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study.
Pötter R, Tanderup K, Schmid MP, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Ristl R, Petric P, Nesvacil N, Kirchheiner K, Kirisits C, Lindegaard JC; EMBRACE Collaborative Group
Lancet Oncol 2021 Apr;22(4):538-547. doi: 10.1016/S1470-2045(20)30753-1. PMID: 33794207
Management and outcomes of primary vaginal Cancer.
Yang J, Delara R, Magrina J, Magtibay P, Langstraat C, Dinh T, Karlin N, Vora SA, Butler K
Gynecol Oncol 2020 Nov;159(2):456-463. Epub 2020 Sep 22 doi: 10.1016/j.ygyno.2020.08.036. PMID: 32972784
Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma.
Creutzberg CL, van Putten WL, Koper PC, Lybeert ML, Jobsen JJ, Wárlám-Rodenhuis CC, De Winter KA, Lutgens LC, van den Bergh AC, van de Steen-Banasik E, Beerman H, van Lent M
Lancet 2000 Apr 22;355(9213):1404-11. doi: 10.1016/s0140-6736(00)02139-5. PMID: 10791524

Diagnosis

Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
Vaginal vault smear cytology in detection of recurrence after hysterectomy for early cervical cancer.
Grace L, Sanday K, Garrett A, Land R, Nicklin J, Obermair A, Rao A, Tang A, Allanson ER
Int J Gynecol Cancer 2022 Jul 4;32(7):853-860. doi: 10.1136/ijgc-2021-003302. PMID: 35288459
Cervical cancer in women under 25 years of age and outside the screening age: Diagnosis profile and long-term outcomes.
Teixeira JC, Santos DZ, Campos CS, Vale DB, Bragança JF, Zeferino LC
Int J Gynaecol Obstet 2021 Jul;154(1):150-156. Epub 2021 Jan 27 doi: 10.1002/ijgo.13553. PMID: 33341962
Clinical outcomes of transarterial chemotherapy and embolization for vaginal cancer.
Bi Y, Yi M, Yu Z, Han X, Ren J
J Obstet Gynaecol Res 2020 Jun;46(6):924-930. Epub 2020 Mar 6 doi: 10.1111/jog.14234. PMID: 32144875
Stage at diagnosis and mortality in patients with adenocarcinoma and adenosquamous carcinoma of the uterine cervix diagnosed as a consequence of cytologic screening.
Kinney W, Sawaya GF, Sung HY, Kearney KA, Miller M, Hiatt RA
Acta Cytol 2003 Mar-Apr;47(2):167-71. doi: 10.1159/000326498. PMID: 12685183

Therapy

Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study.
Pötter R, Tanderup K, Schmid MP, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Ristl R, Petric P, Nesvacil N, Kirchheiner K, Kirisits C, Lindegaard JC; EMBRACE Collaborative Group
Lancet Oncol 2021 Apr;22(4):538-547. doi: 10.1016/S1470-2045(20)30753-1. PMID: 33794207
Management and outcomes of primary vaginal Cancer.
Yang J, Delara R, Magrina J, Magtibay P, Langstraat C, Dinh T, Karlin N, Vora SA, Butler K
Gynecol Oncol 2020 Nov;159(2):456-463. Epub 2020 Sep 22 doi: 10.1016/j.ygyno.2020.08.036. PMID: 32972784
Clinical outcomes of transarterial chemotherapy and embolization for vaginal cancer.
Bi Y, Yi M, Yu Z, Han X, Ren J
J Obstet Gynaecol Res 2020 Jun;46(6):924-930. Epub 2020 Mar 6 doi: 10.1111/jog.14234. PMID: 32144875
Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma.
Creutzberg CL, van Putten WL, Koper PC, Lybeert ML, Jobsen JJ, Wárlám-Rodenhuis CC, De Winter KA, Lutgens LC, van den Bergh AC, van de Steen-Banasik E, Beerman H, van Lent M
Lancet 2000 Apr 22;355(9213):1404-11. doi: 10.1016/s0140-6736(00)02139-5. PMID: 10791524

Prognosis

Management and outcomes of primary vaginal Cancer.
Yang J, Delara R, Magrina J, Magtibay P, Langstraat C, Dinh T, Karlin N, Vora SA, Butler K
Gynecol Oncol 2020 Nov;159(2):456-463. Epub 2020 Sep 22 doi: 10.1016/j.ygyno.2020.08.036. PMID: 32972784
Clinical outcomes of transarterial chemotherapy and embolization for vaginal cancer.
Bi Y, Yi M, Yu Z, Han X, Ren J
J Obstet Gynaecol Res 2020 Jun;46(6):924-930. Epub 2020 Mar 6 doi: 10.1111/jog.14234. PMID: 32144875
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis.
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463
Stage at diagnosis and mortality in patients with adenocarcinoma and adenosquamous carcinoma of the uterine cervix diagnosed as a consequence of cytologic screening.
Kinney W, Sawaya GF, Sung HY, Kearney KA, Miller M, Hiatt RA
Acta Cytol 2003 Mar-Apr;47(2):167-71. doi: 10.1159/000326498. PMID: 12685183
Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma.
Creutzberg CL, van Putten WL, Koper PC, Lybeert ML, Jobsen JJ, Wárlám-Rodenhuis CC, De Winter KA, Lutgens LC, van den Bergh AC, van de Steen-Banasik E, Beerman H, van Lent M
Lancet 2000 Apr 22;355(9213):1404-11. doi: 10.1016/s0140-6736(00)02139-5. PMID: 10791524

Clinical prediction guides

Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
Vaginal vault smear cytology in detection of recurrence after hysterectomy for early cervical cancer.
Grace L, Sanday K, Garrett A, Land R, Nicklin J, Obermair A, Rao A, Tang A, Allanson ER
Int J Gynecol Cancer 2022 Jul 4;32(7):853-860. doi: 10.1136/ijgc-2021-003302. PMID: 35288459
Open vs minimally invasive radical trachelectomy in early-stage cervical cancer: International Radical Trachelectomy Assessment Study.
Salvo G, Ramirez PT, Leitao MM, Cibula D, Wu X, Falconer H, Persson J, Perrotta M, Mosgaard BJ, Kucukmetin A, Berlev I, Rendon G, Liu K, Vieira M, Capilna ME, Fotopoulou C, Baiocchi G, Kaidarova D, Ribeiro R, Pedra-Nobre S, Kocian R, Li X, Li J, Pálsdóttir K, Noll F, Rundle S, Ulrikh E, Hu Z, Gheorghe M, Saso S, Bolatbekova R, Tsunoda A, Pitcher B, Wu J, Urbauer D, Pareja R
Am J Obstet Gynecol 2022 Jan;226(1):97.e1-97.e16. Epub 2021 Aug 27 doi: 10.1016/j.ajog.2021.08.029. PMID: 34461074Free PMC Article
MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study.
Pötter R, Tanderup K, Schmid MP, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Ristl R, Petric P, Nesvacil N, Kirchheiner K, Kirisits C, Lindegaard JC; EMBRACE Collaborative Group
Lancet Oncol 2021 Apr;22(4):538-547. doi: 10.1016/S1470-2045(20)30753-1. PMID: 33794207
Stage at diagnosis and mortality in patients with adenocarcinoma and adenosquamous carcinoma of the uterine cervix diagnosed as a consequence of cytologic screening.
Kinney W, Sawaya GF, Sung HY, Kearney KA, Miller M, Hiatt RA
Acta Cytol 2003 Mar-Apr;47(2):167-71. doi: 10.1159/000326498. PMID: 12685183

Recent systematic reviews

Glassy cell carcinoma of the cervix: a systematic review and meta-analysis.
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463

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