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Vaginal Mucinous Adenocarcinoma

MedGen UID:
276951
•Concept ID:
C1519925
•
Neoplastic Process

Definition

A rare adenocarcinoma that arises from the vagina with histologic features resembling cervical mucinous adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Mucinous Adenocarcinoma

Professional guidelines

PubMed

Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Treatment failure in endometrial carcinoma.
Huang HJ, Tang YH, Chou HH, Yang LY, Chao A, Huang YT, Lin G, Liu FY, Chang TC, Lai CH
Int J Gynecol Cancer 2014 Jun;24(5):885-93. doi: 10.1097/IGC.0000000000000131. PMID: 24819657
Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings.
Takatsu A, Shiozawa T, Miyamoto T, Kurosawa K, Kashima H, Yamada T, Kaku T, Mikami Y, Kiyokawa T, Tsuda H, Ishii K, Togashi K, Koyama T, Fujinaga Y, Kadoya M, Hashi A, Susumu N, Konishi I
Int J Gynecol Cancer 2011 Oct;21(7):1287-96. doi: 10.1097/IGC.0b013e31821f746c. PMID: 21685796

Recent clinical studies

Etiology

Clinicopathological and Molecular Differences Between Gastric-type Mucinous Carcinoma and Usual-type Endocervical Adenocarcinoma of the Uterine Cervix.
Jung H, Bae GE, Kim HM, Kim HS
Cancer Genomics Proteomics 2020 Sep-Oct;17(5):627-641. doi: 10.21873/cgp.20219. PMID: 32859641Free PMC Article
American Brachytherapy Task Group Report: Adjuvant vaginal brachytherapy for early-stage endometrial cancer: A comprehensive review.
Harkenrider MM, Block AM, Alektiar KM, Gaffney DK, Jones E, Klopp A, Viswanathan AN, Small W Jr
Brachytherapy 2017 Jan-Feb;16(1):95-108. Epub 2016 May 31 doi: 10.1016/j.brachy.2016.04.005. PMID: 27260082Free PMC Article
Comparative safety and effectiveness of robot-assisted laparoscopic hysterectomy versus conventional laparoscopy and laparotomy for endometrial cancer: A systematic review and meta-analysis.
Park DA, Lee DH, Kim SW, Lee SH
Eur J Surg Oncol 2016 Sep;42(9):1303-14. Epub 2016 Jun 29 doi: 10.1016/j.ejso.2016.06.400. PMID: 27439723
Papillary proliferation of the endometrium: a clinicopathologic study of 59 cases of simple and complex papillae without cytologic atypia.
Ip PP, Irving JA, McCluggage WG, Clement PB, Young RH
Am J Surg Pathol 2013 Feb;37(2):167-77. doi: 10.1097/PAS.0b013e318272d428. PMID: 23211295
Mucinous adenocarcinoma of the endometrium: a clinico-pathological review of 18 cases.
Melhem MF, Tobon H
Int J Gynecol Pathol 1987;6(4):347-55. doi: 10.1097/00004347-198712000-00007. PMID: 2826354

Diagnosis

Primary Vaginal Mucinous Adenocarcinoma of Intestinal Type-Clinical, Radiological and Morphological Aspects.
Betova T, Trifonov R, Popovska S, Yordanov A, Karakadieva K, Dancheva Z, Kostov S
Medicina (Kaunas) 2024 Mar 22;60(4) doi: 10.3390/medicina60040525. PMID: 38674171Free PMC Article
Gastric-type mucinous endocervical adenocarcinomas: A case report and literature review.
Lu J, Na J, Li Y, Wang X, Wang J, Han S
Front Cell Infect Microbiol 2022;12:917009. Epub 2022 Oct 13 doi: 10.3389/fcimb.2022.917009. PMID: 36310872Free PMC Article
Clinicopathological and Molecular Differences Between Gastric-type Mucinous Carcinoma and Usual-type Endocervical Adenocarcinoma of the Uterine Cervix.
Jung H, Bae GE, Kim HM, Kim HS
Cancer Genomics Proteomics 2020 Sep-Oct;17(5):627-641. doi: 10.21873/cgp.20219. PMID: 32859641Free PMC Article
Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Papillary proliferation of the endometrium: a clinicopathologic study of 59 cases of simple and complex papillae without cytologic atypia.
Ip PP, Irving JA, McCluggage WG, Clement PB, Young RH
Am J Surg Pathol 2013 Feb;37(2):167-77. doi: 10.1097/PAS.0b013e318272d428. PMID: 23211295

Therapy

Clinicopathological characteristics of patients with mucinous adenocarcinoma of the uterine cervix: A retrospective study of 21 cases.
Bonin L, Devouassoux-Shisheboran M, Golfier F
J Gynecol Obstet Hum Reprod 2019 May;48(5):319-327. Epub 2019 Feb 23 doi: 10.1016/j.jogoh.2019.02.002. PMID: 30807852
American Brachytherapy Task Group Report: Adjuvant vaginal brachytherapy for early-stage endometrial cancer: A comprehensive review.
Harkenrider MM, Block AM, Alektiar KM, Gaffney DK, Jones E, Klopp A, Viswanathan AN, Small W Jr
Brachytherapy 2017 Jan-Feb;16(1):95-108. Epub 2016 May 31 doi: 10.1016/j.brachy.2016.04.005. PMID: 27260082Free PMC Article
Comparative safety and effectiveness of robot-assisted laparoscopic hysterectomy versus conventional laparoscopy and laparotomy for endometrial cancer: A systematic review and meta-analysis.
Park DA, Lee DH, Kim SW, Lee SH
Eur J Surg Oncol 2016 Sep;42(9):1303-14. Epub 2016 Jun 29 doi: 10.1016/j.ejso.2016.06.400. PMID: 27439723
Primary mucinous adenocarcinoma of the vagina.
Nasu K, Kai K, Matsumoto H, Mori C, Takai N, Narahara H
Eur J Gynaecol Oncol 2010;31(6):679-81. PMID: 21319516
Topographic relation of cervical ectropion and vaginal adenosis to clear cell adenocarcinoma.
Robboy SJ, Welch WR, Young RH, Truslow GY, Herbst AL, Scully RE
Obstet Gynecol 1982 Nov;60(5):546-51. PMID: 6890656

Prognosis

Adenocarcinoma of the uterine cervix, gastric-type (GAS): a review of the literature focused on pathology and multimodality imaging.
Kerwin CM, Markese M, Moroney MR, Smith LP, Patel NU
Abdom Radiol (NY) 2023 Feb;48(2):713-723. Epub 2022 Nov 5 doi: 10.1007/s00261-022-03724-w. PMID: 36334123
Gastric-type mucinous endocervical adenocarcinomas: A case report and literature review.
Lu J, Na J, Li Y, Wang X, Wang J, Han S
Front Cell Infect Microbiol 2022;12:917009. Epub 2022 Oct 13 doi: 10.3389/fcimb.2022.917009. PMID: 36310872Free PMC Article
Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Neuroendocrine tumors of the genital tract.
Eichhorn JH, Young RH
Am J Clin Pathol 2001 Jun;115 Suppl:S94-112. doi: 10.1309/64CW-WKGK-49EF-BYD1. PMID: 11993694
Mucinous adenocarcinoma of the endometrium: a clinico-pathological review of 18 cases.
Melhem MF, Tobon H
Int J Gynecol Pathol 1987;6(4):347-55. doi: 10.1097/00004347-198712000-00007. PMID: 2826354

Clinical prediction guides

Immunohistochemical Loss of DPC4 in Tumors With Mucinous Differentiation Arising in or Involving the Gynecologic Tract.
Kwon DH, Malpica A, Zaleski M, Euscher ED, Ramalingam P
Int J Gynecol Pathol 2021 Nov 1;40(6):523-532. doi: 10.1097/PGP.0000000000000754. PMID: 33405429
Impact of different adjuvant radiotherapy modalities on women with early-stage intermediate- to high-risk endometrial cancer.
Jin M, Hou X, Sun X, Zhang Y, Hu K, Zhang F
Int J Gynecol Cancer 2019 Oct;29(8):1264-1270. Epub 2019 Jul 17 doi: 10.1136/ijgc-2019-000317. PMID: 31320487
Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
The nature of early-stage endometrial cancer recurrence-A national cohort study.
Jeppesen MM, Jensen PT, Gilså Hansen D, Iachina M, Mogensen O
Eur J Cancer 2016 Dec;69:51-60. Epub 2016 Nov 4 doi: 10.1016/j.ejca.2016.09.033. PMID: 27816832
Comparative safety and effectiveness of robot-assisted laparoscopic hysterectomy versus conventional laparoscopy and laparotomy for endometrial cancer: A systematic review and meta-analysis.
Park DA, Lee DH, Kim SW, Lee SH
Eur J Surg Oncol 2016 Sep;42(9):1303-14. Epub 2016 Jun 29 doi: 10.1016/j.ejso.2016.06.400. PMID: 27439723

Recent systematic reviews

Comparative safety and effectiveness of robot-assisted laparoscopic hysterectomy versus conventional laparoscopy and laparotomy for endometrial cancer: A systematic review and meta-analysis.
Park DA, Lee DH, Kim SW, Lee SH
Eur J Surg Oncol 2016 Sep;42(9):1303-14. Epub 2016 Jun 29 doi: 10.1016/j.ejso.2016.06.400. PMID: 27439723

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