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Vaginal Soft Tissue Neoplasm

MedGen UID:
276955
•Concept ID:
C1519930
•
Neoplastic Process
Synonym: Vaginal Soft Tissue Tumor

Definition

A benign or malignant mesenchymal neoplasm that arises from the vagina. Representative examples include leiomyoma, rhabdomyoma, leiomyosarcoma, endometrioid stromal sarcoma, and botryoid-type embryonal rhabdomyosarcoma. [from NCI]

Professional guidelines

PubMed

ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer.
Small W Jr, Mell LK, Anderson P, Creutzberg C, De Los Santos J, Gaffney D, Jhingran A, Portelance L, Schefter T, Iyer R, Varia M, Winter K, Mundt AJ
Int J Radiat Oncol Biol Phys 2008 Jun 1;71(2):428-34. Epub 2007 Nov 26 doi: 10.1016/j.ijrobp.2007.09.042. PMID: 18037584Free PMC Article
The complexity of management of pregnancy-associated malignant soft tissue and bone tumors.
Molho RB, Kollender Y, Issakov J, Bickels J, Flusser G, Azem F, Alon A, Inbar MJ, Meller I, Merimsky O
Gynecol Obstet Invest 2008;65(2):89-95. Epub 2007 Sep 18 doi: 10.1159/000108402. PMID: 17878735

Recent clinical studies

Etiology

High-Grade Sarcomas with Myogenic Differentiation Harboring Hotspot PDGFRB Mutations.
Dermawan JK, Chiang S, Hensley ML, Tap WD, Antonescu CR
Mod Pathol 2023 May;36(5):100104. Epub 2023 Jan 23 doi: 10.1016/j.modpat.2023.100104. PMID: 36788091Free PMC Article
Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.
Croce S, Devouassoux-Shisheboran M, Pautier P, Ray-Coquard I, Treilleux I, Neuville A, Arnould L, Just PA, Belda MALF, Averous G, Leroux A, Mery E, Loussouarn D, Weinbreck N, Le Guellec S, Mishellany F, Morice P, Guyon F, Genestie C
Gynecol Oncol 2022 Nov;167(2):373-389. Epub 2022 Sep 14 doi: 10.1016/j.ygyno.2022.07.031. PMID: 36114030
Uterine rhabdomyosarcoma in adults.
Pinto A, Kahn RM, Rosenberg AE, Slomovitz B, Quick CM, Whisman MK, Huang M
Hum Pathol 2018 Apr;74:122-128. Epub 2018 Jan 7 doi: 10.1016/j.humpath.2018.01.007. PMID: 29320751
Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy in postoperative treatment of endometrial and cervical cancer.
Small W Jr, Mell LK, Anderson P, Creutzberg C, De Los Santos J, Gaffney D, Jhingran A, Portelance L, Schefter T, Iyer R, Varia M, Winter K, Mundt AJ
Int J Radiat Oncol Biol Phys 2008 Jun 1;71(2):428-34. Epub 2007 Nov 26 doi: 10.1016/j.ijrobp.2007.09.042. PMID: 18037584Free PMC Article
Soft tissue and pelvic dystocia.
Compton AA
Clin Obstet Gynecol 1987 Mar;30(1):69-76. doi: 10.1097/00003081-198703000-00010. PMID: 3555919

Diagnosis

Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.
Croce S, Devouassoux-Shisheboran M, Pautier P, Ray-Coquard I, Treilleux I, Neuville A, Arnould L, Just PA, Belda MALF, Averous G, Leroux A, Mery E, Loussouarn D, Weinbreck N, Le Guellec S, Mishellany F, Morice P, Guyon F, Genestie C
Gynecol Oncol 2022 Nov;167(2):373-389. Epub 2022 Sep 14 doi: 10.1016/j.ygyno.2022.07.031. PMID: 36114030
Uterine rhabdomyosarcoma in adults.
Pinto A, Kahn RM, Rosenberg AE, Slomovitz B, Quick CM, Whisman MK, Huang M
Hum Pathol 2018 Apr;74:122-128. Epub 2018 Jan 7 doi: 10.1016/j.humpath.2018.01.007. PMID: 29320751
Imaging of the female perineum in adults.
Hosseinzadeh K, Heller MT, Houshmand G
Radiographics 2012 Jul-Aug;32(4):E129-68. doi: 10.1148/rg.324115134. PMID: 22787005
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053
Soft tissue and pelvic dystocia.
Compton AA
Clin Obstet Gynecol 1987 Mar;30(1):69-76. doi: 10.1097/00003081-198703000-00010. PMID: 3555919

Therapy

ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Definitive radiotherapy with image-guided adaptive brachytherapy for primary vaginal cancer.
Westerveld H, Nesvacil N, Fokdal L, Chargari C, Schmid MP, Milosevic M, Mahantshetty UM, Nout RA
Lancet Oncol 2020 Mar;21(3):e157-e167. doi: 10.1016/S1470-2045(19)30855-1. PMID: 32135119
Comparison of tissue trauma after abdominal, vaginal and total laparoscopic hysterectomy.
Oksuzoglu A, Seckin B, Turkcapar AF, Ozcan S, Gungor T
Ginekol Pol 2015 Apr;86(4):268-73. doi: 10.17772/gp/2072. PMID: 26117985
Melatonin as antioxidant, geroprotector and anticarcinogen.
Anisimov VN, Popovich IG, Zabezhinski MA, Anisimov SV, Vesnushkin GM, Vinogradova IA
Biochim Biophys Acta 2006 May-Jun;1757(5-6):573-89. Epub 2006 Apr 17 doi: 10.1016/j.bbabio.2006.03.012. PMID: 16678784
Clinical trials of immunotherapy: present status.
Morton DL, Goodnight JE Jr
Cancer 1978 Nov;42(5):2224-33. doi: 10.1002/1097-0142(197811)42:5<2224::aid-cncr2820420521>3.0.co;2-f. PMID: 363256

Prognosis

MR Imaging of Gynecologic Tumors: Pearls, Pitfalls, and Tumor Mimics.
Lupinelli M, Sbarra M, Kilcoyne A, Venkatesan AM, Nougaret S
Radiol Clin North Am 2023 Jul;61(4):687-711. doi: 10.1016/j.rcl.2023.02.011. PMID: 37169432
High-Grade Sarcomas with Myogenic Differentiation Harboring Hotspot PDGFRB Mutations.
Dermawan JK, Chiang S, Hensley ML, Tap WD, Antonescu CR
Mod Pathol 2023 May;36(5):100104. Epub 2023 Jan 23 doi: 10.1016/j.modpat.2023.100104. PMID: 36788091Free PMC Article
Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.
Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
Uterine rhabdomyosarcoma in adults.
Pinto A, Kahn RM, Rosenberg AE, Slomovitz B, Quick CM, Whisman MK, Huang M
Hum Pathol 2018 Apr;74:122-128. Epub 2018 Jan 7 doi: 10.1016/j.humpath.2018.01.007. PMID: 29320751
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

Clinical prediction guides

Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.
Croce S, Devouassoux-Shisheboran M, Pautier P, Ray-Coquard I, Treilleux I, Neuville A, Arnould L, Just PA, Belda MALF, Averous G, Leroux A, Mery E, Loussouarn D, Weinbreck N, Le Guellec S, Mishellany F, Morice P, Guyon F, Genestie C
Gynecol Oncol 2022 Nov;167(2):373-389. Epub 2022 Sep 14 doi: 10.1016/j.ygyno.2022.07.031. PMID: 36114030
Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.
Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
MUC4 is expressed in alveolar rhabdomyosarcoma.
Forgó E, Hornick JL, Charville GW
Histopathology 2021 May;78(6):905-908. Epub 2021 Mar 16 doi: 10.1111/his.14321. PMID: 33368602Free PMC Article
Definitive radiotherapy with image-guided adaptive brachytherapy for primary vaginal cancer.
Westerveld H, Nesvacil N, Fokdal L, Chargari C, Schmid MP, Milosevic M, Mahantshetty UM, Nout RA
Lancet Oncol 2020 Mar;21(3):e157-e167. doi: 10.1016/S1470-2045(19)30855-1. PMID: 32135119
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

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