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Prolactin-producing pituitary gland carcinoma

MedGen UID:
277338
•Concept ID:
C1334614
•
Neoplastic Process
Synonyms: Malignant Pituitary Gland Prolactinoma; malignant pituitary gland prolactinoma; Malignant Pituitary Prolactinoma; malignant pituitary prolactinoma; Malignant Prolactin Producing Neoplasm of Pituitary; malignant prolactin producing neoplasm of pituitary; Malignant Prolactin Producing Neoplasm of Pituitary Gland; malignant prolactin producing neoplasm of pituitary gland; Malignant Prolactin Producing Neoplasm of the Pituitary; malignant prolactin producing neoplasm of the pituitary; Malignant Prolactin Producing Neoplasm of the Pituitary Gland; malignant prolactin producing neoplasm of the pituitary gland; Malignant Prolactin Producing Pituitary Gland Neoplasm; malignant prolactin producing pituitary gland neoplasm; Malignant Prolactin Producing Pituitary Gland Tumor; malignant prolactin producing pituitary gland tumor; malignant prolactin producing pituitary gland tumour; Malignant Prolactin Producing Pituitary Neoplasm; malignant prolactin producing pituitary neoplasm; Malignant Prolactin Producing Pituitary Tumor; malignant prolactin producing pituitary tumor; malignant prolactin producing pituitary tumour; Malignant Prolactin Producing Tumor; malignant prolactin producing tumor; Malignant Prolactin Producing Tumor of Pituitary; malignant prolactin producing tumor of pituitary; Malignant Prolactin Producing Tumor of Pituitary Gland; malignant prolactin producing tumor of pituitary gland; Malignant Prolactin Producing Tumor of the Pituitary; malignant prolactin producing tumor of the pituitary; Malignant Prolactin Producing Tumor of the Pituitary Gland; malignant prolactin producing tumor of the pituitary gland; malignant prolactin producing tumour; malignant prolactin producing tumour of pituitary; malignant prolactin producing tumour of pituitary gland; malignant prolactin producing tumour of the pituitary; malignant prolactin producing tumour of the pituitary gland; Malignant Prolactin Secreting Neoplasm of Pituitary; malignant prolactin secreting neoplasm of pituitary; Malignant Prolactin Secreting Neoplasm of Pituitary Gland; malignant prolactin secreting neoplasm of pituitary gland; Malignant Prolactin Secreting Neoplasm of the Pituitary; malignant prolactin secreting neoplasm of the pituitary; Malignant Prolactin Secreting Neoplasm of the Pituitary Gland; malignant prolactin secreting neoplasm of the pituitary gland; Malignant Prolactin Secreting Pituitary Gland Neoplasm; malignant prolactin secreting pituitary gland neoplasm; Malignant Prolactin Secreting Pituitary Gland Tumor; malignant prolactin secreting pituitary gland tumor; malignant prolactin secreting pituitary gland tumour; Malignant Prolactin Secreting Pituitary Neoplasm; malignant prolactin secreting pituitary neoplasm; Malignant Prolactin Secreting Pituitary Tumor; malignant prolactin secreting pituitary tumor; malignant prolactin secreting pituitary tumour; Malignant Prolactin Secreting Tumor of Pituitary; malignant prolactin secreting tumor of pituitary; Malignant Prolactin Secreting Tumor of Pituitary Gland; malignant prolactin secreting tumor of pituitary gland; Malignant Prolactin Secreting Tumor of the Pituitary; malignant prolactin secreting tumor of the pituitary; Malignant Prolactin Secreting Tumor of the Pituitary Gland; malignant prolactin secreting tumor of the pituitary gland; malignant prolactin secreting tumour of pituitary; malignant prolactin secreting tumour of pituitary gland; malignant prolactin secreting tumour of the pituitary; malignant prolactin secreting tumour of the pituitary gland; Malignant Prolactinoma; malignant prolactinoma; Malignant Prolactinoma of Pituitary; malignant prolactinoma of pituitary; Malignant Prolactinoma of Pituitary Gland; malignant prolactinoma of pituitary gland; Malignant Prolactinoma of the Pituitary; malignant prolactinoma of the pituitary; Malignant Prolactinoma of the Pituitary Gland; malignant prolactinoma of the pituitary gland; Metastatic Lactotroph Pituitary Neuroendocrine Tumor; Metastatic Prolactin-Producing PitNET; PRL Producing Pituitary Gland Carcinoma; PRL producing pituitary gland carcinoma; Prolactin Producing Pituitary Gland Carcinoma; prolactin producing pituitary gland carcinoma; prolactin-producing pituitary gland carcinoma
 
Monarch Initiative: MONDO:0006388

Definition

Prolactin-producing pituitary neuroendocrine tumor that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProlactin-producing pituitary gland carcinoma

Recent clinical studies

Etiology

Co-occurrence of Pituitary Neuroendocrine Tumors (PitNETs) and Tumors of the Neurohypophysis.
Saeger W, von Schöning J, Flitsch J, Jautzke G, Bergmann M, Hagel C, Knappe UJ
Endocr Pathol 2021 Dec;32(4):473-479. Epub 2021 Jun 15 doi: 10.1007/s12022-021-09677-y. PMID: 34129177
The pituitary gland in patients with breast carcinoma: a histologic and immunocytochemical study of 125 cases.
Marin F, Kovacs KT, Scheithauer BW, Young WF Jr
Mayo Clin Proc 1992 Oct;67(10):949-56. doi: 10.1016/s0025-6196(12)60925-2. PMID: 1434855
Effects of estrogen on the human pituitary: a clinicopathologic study.
Scheithauer BW, Kovacs KT, Randall RV, Ryan N
Mayo Clin Proc 1989 Sep;64(9):1077-84. doi: 10.1016/s0025-6196(12)64976-3. PMID: 2811485

Diagnosis

Co-occurrence of Pituitary Neuroendocrine Tumors (PitNETs) and Tumors of the Neurohypophysis.
Saeger W, von Schöning J, Flitsch J, Jautzke G, Bergmann M, Hagel C, Knappe UJ
Endocr Pathol 2021 Dec;32(4):473-479. Epub 2021 Jun 15 doi: 10.1007/s12022-021-09677-y. PMID: 34129177
No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia.
Raitila A, Georgitsi M, Karhu A, Tuppurainen K, Mäkinen MJ, Birkenkamp-Demtröder K, Salmenkivi K, Orntoft TF, Arola J, Launonen V, Vahteristo P, Aaltonen LA
Endocr Relat Cancer 2007 Sep;14(3):901-6. doi: 10.1677/ERC-07-0025. PMID: 17914118
Telomerase activity and the expression of telomerase components in pituitary adenoma with malignant transformation.
Harada K, Arita K, Kurisu K, Tahara H
Surg Neurol 2000 Mar;53(3):267-74. doi: 10.1016/s0090-3019(00)00181-6. PMID: 10773260

Therapy

Effects of estrogen on the human pituitary: a clinicopathologic study.
Scheithauer BW, Kovacs KT, Randall RV, Ryan N
Mayo Clin Proc 1989 Sep;64(9):1077-84. doi: 10.1016/s0025-6196(12)64976-3. PMID: 2811485

Prognosis

Telomerase activity and the expression of telomerase components in pituitary adenoma with malignant transformation.
Harada K, Arita K, Kurisu K, Tahara H
Surg Neurol 2000 Mar;53(3):267-74. doi: 10.1016/s0090-3019(00)00181-6. PMID: 10773260

Clinical prediction guides

Co-occurrence of Pituitary Neuroendocrine Tumors (PitNETs) and Tumors of the Neurohypophysis.
Saeger W, von Schöning J, Flitsch J, Jautzke G, Bergmann M, Hagel C, Knappe UJ
Endocr Pathol 2021 Dec;32(4):473-479. Epub 2021 Jun 15 doi: 10.1007/s12022-021-09677-y. PMID: 34129177
No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia.
Raitila A, Georgitsi M, Karhu A, Tuppurainen K, Mäkinen MJ, Birkenkamp-Demtröder K, Salmenkivi K, Orntoft TF, Arola J, Launonen V, Vahteristo P, Aaltonen LA
Endocr Relat Cancer 2007 Sep;14(3):901-6. doi: 10.1677/ERC-07-0025. PMID: 17914118

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