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Metastatic carcinoma in the adrenal medulla

MedGen UID:
277362
•Concept ID:
C1334717
•
Neoplastic Process
Synonyms: Metastatic Carcinoma in the Adrenal Medulla; metastatic carcinoma in the adrenal medulla; Metastatic Carcinoma to the Adrenal Medulla; metastatic carcinoma to the adrenal medulla
 
Monarch Initiative: MONDO:0024868

Definition

A carcinoma that has spread to the adrenal medulla from an adjacent or distant anatomic site. [from NCI]

Professional guidelines

PubMed

Treatment of metastatic disease in patients with neuroendocrine tumors.
Niederhuber JE, Fojo T
Surg Oncol Clin N Am 2006 Jul;15(3):511-33, viii. doi: 10.1016/j.soc.2006.05.004. PMID: 16882495
Adrenal incidentalomas: surgical treatment in 28 patients and update of the literature.
Porcaro AB, Novella G, Ficarra V, Curti P, Antoniolli SZ, Suangwoua HS, Malossini G
Int Urol Nephrol 2001;32(3):295-302. doi: 10.1023/a:1017587312369. PMID: 11583337
Immunocytochemical differential diagnosis of adrenocortical neoplasms using the monoclonal antibody D11.
Schröder S, Niendorf A, Achilles E, Dietel M, Padberg BC, Beisiegel U, Dralle H, Bressel M, Klöppel G
Virchows Arch A Pathol Anat Histopathol 1990;417(2):89-96. doi: 10.1007/BF02190525. PMID: 2114700

Recent clinical studies

Etiology

Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311
Gastric paraganglioma: a case report and a review of the literature.
Pruiti V, Mazzeo F, Rossitto M, Foti A, Macrì A, Cucinotta E
Ann Ital Chir 2014 Dec 29;85(ePub) PMID: 25559752
Vagus nerve regulates breast cancer metastasis to the adrenal gland.
Erin N, Barkan GA, Clawson GA
Anticancer Res 2013 Sep;33(9):3675-82. PMID: 24023295
Treatment of metastatic disease in patients with neuroendocrine tumors.
Niederhuber JE, Fojo T
Surg Oncol Clin N Am 2006 Jul;15(3):511-33, viii. doi: 10.1016/j.soc.2006.05.004. PMID: 16882495
Adrenal incidentalomas: surgical treatment in 28 patients and update of the literature.
Porcaro AB, Novella G, Ficarra V, Curti P, Antoniolli SZ, Suangwoua HS, Malossini G
Int Urol Nephrol 2001;32(3):295-302. doi: 10.1023/a:1017587312369. PMID: 11583337

Diagnosis

Hand2 Immunohistochemistry in the Diagnosis of Paragangliomas and Other Neuroendocrine Neoplasms.
Soukup J, Manethova M, Stejskal V, Novakova M, Duskova J, Hornychova H, Hacova M, Staniczkova-Zambo I, Zelinka T, Kosak M, Cesak T, Netuka D, Ryska A, Gabalec F
Endocr Pathol 2024 Mar;35(1):14-24. Epub 2024 Feb 28 doi: 10.1007/s12022-024-09803-6. PMID: 38416360
Inflammation in the neoplasms of the adrenal gland: Is there a prognostic role? An immunohistochemical study.
Guadagno E, Russo D, Pignatiello S, Del Basso De Caro M
Pathol Res Pract 2020 Sep;216(9):153070. Epub 2020 Jun 20 doi: 10.1016/j.prp.2020.153070. PMID: 32825943
The role of PET in the surgical approach to adrenal disease.
Gross MD, Gauger PG, Djekidel M, Rubello D
Eur J Surg Oncol 2009 Nov;35(11):1137-45. Epub 2009 Feb 25 doi: 10.1016/j.ejso.2009.01.010. PMID: 19243910
Treatment of metastatic disease in patients with neuroendocrine tumors.
Niederhuber JE, Fojo T
Surg Oncol Clin N Am 2006 Jul;15(3):511-33, viii. doi: 10.1016/j.soc.2006.05.004. PMID: 16882495
Adrenal incidentalomas: surgical treatment in 28 patients and update of the literature.
Porcaro AB, Novella G, Ficarra V, Curti P, Antoniolli SZ, Suangwoua HS, Malossini G
Int Urol Nephrol 2001;32(3):295-302. doi: 10.1023/a:1017587312369. PMID: 11583337

Therapy

Laparoscopic radiofrequency thermal ablation of adrenal tumors: technical details.
Berber E, Siperstein A
Surg Laparosc Endosc Percutan Tech 2010 Feb;20(1):58-62. doi: 10.1097/SLE.0b013e3181cd44fc. PMID: 20173624
Breast metastasis by medullary thyroid carcinoma detected by FDG positron emission tomography.
Nofech-Mozes S, Mackenzie R, Kahn HJ, Ehrlich L, Raphael SJ
Ann Diagn Pathol 2008 Feb;12(1):67-71. Epub 2007 Jul 24 doi: 10.1016/j.anndiagpath.2006.08.004. PMID: 18164420
Treatment of metastatic disease in patients with neuroendocrine tumors.
Niederhuber JE, Fojo T
Surg Oncol Clin N Am 2006 Jul;15(3):511-33, viii. doi: 10.1016/j.soc.2006.05.004. PMID: 16882495

Prognosis

Inflammation in the neoplasms of the adrenal gland: Is there a prognostic role? An immunohistochemical study.
Guadagno E, Russo D, Pignatiello S, Del Basso De Caro M
Pathol Res Pract 2020 Sep;216(9):153070. Epub 2020 Jun 20 doi: 10.1016/j.prp.2020.153070. PMID: 32825943
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311
Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development.
Berthon A, Sahut-Barnola I, Lambert-Langlais S, de Joussineau C, Damon-Soubeyrand C, Louiset E, Taketo MM, Tissier F, Bertherat J, Lefrançois-Martinez AM, Martinez A, Val P
Hum Mol Genet 2010 Apr 15;19(8):1561-76. Epub 2010 Jan 27 doi: 10.1093/hmg/ddq029. PMID: 20106872
Treatment of metastatic disease in patients with neuroendocrine tumors.
Niederhuber JE, Fojo T
Surg Oncol Clin N Am 2006 Jul;15(3):511-33, viii. doi: 10.1016/j.soc.2006.05.004. PMID: 16882495
Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors.
Minn AJ, Kang Y, Serganova I, Gupta GP, Giri DD, Doubrovin M, Ponomarev V, Gerald WL, Blasberg R, Massagué J
J Clin Invest 2005 Jan;115(1):44-55. doi: 10.1172/JCI22320. PMID: 15630443Free PMC Article

Clinical prediction guides

Hand2 Immunohistochemistry in the Diagnosis of Paragangliomas and Other Neuroendocrine Neoplasms.
Soukup J, Manethova M, Stejskal V, Novakova M, Duskova J, Hornychova H, Hacova M, Staniczkova-Zambo I, Zelinka T, Kosak M, Cesak T, Netuka D, Ryska A, Gabalec F
Endocr Pathol 2024 Mar;35(1):14-24. Epub 2024 Feb 28 doi: 10.1007/s12022-024-09803-6. PMID: 38416360
Inflammation in the neoplasms of the adrenal gland: Is there a prognostic role? An immunohistochemical study.
Guadagno E, Russo D, Pignatiello S, Del Basso De Caro M
Pathol Res Pract 2020 Sep;216(9):153070. Epub 2020 Jun 20 doi: 10.1016/j.prp.2020.153070. PMID: 32825943
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311
Gastric paraganglioma: a case report and a review of the literature.
Pruiti V, Mazzeo F, Rossitto M, Foti A, Macrì A, Cucinotta E
Ann Ital Chir 2014 Dec 29;85(ePub) PMID: 25559752
Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development.
Berthon A, Sahut-Barnola I, Lambert-Langlais S, de Joussineau C, Damon-Soubeyrand C, Louiset E, Taketo MM, Tissier F, Bertherat J, Lefrançois-Martinez AM, Martinez A, Val P
Hum Mol Genet 2010 Apr 15;19(8):1561-76. Epub 2010 Jan 27 doi: 10.1093/hmg/ddq029. PMID: 20106872

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