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Middle ear adenoma

MedGen UID:
277370
•Concept ID:
C1334759
•
Neoplastic Process
Synonyms: Adenoma of middle ear; Adenoma of Middle Ear; adenoma of middle ear; Adenoma of the Middle Ear; adenoma of the middle ear; Middle Ear Adenoma; middle ear adenoma
SNOMED CT: Adenoma of middle ear (734078009)
 
Monarch Initiative: MONDO:0003423

Definition

A benign, well-circumscribed glandular neoplasm that arises from the middle ear and may exhibit neuroendocrine differentiation. It usually presents with conductive hearing loss. [from NCI]

Professional guidelines

PubMed

Middle ear adenoma: Cytohistologic features and differential diagnosis.
Almajnooni A, Vega M, Cheng L, Gattuso P, Allen-Proctor MK
Diagn Cytopathol 2023 Apr;51(4):E137-E141. Epub 2023 Jan 23 doi: 10.1002/dc.25103. PMID: 36688374

Recent clinical studies

Etiology

Middle Ear "Adenoma": a Neuroendocrine Tumor with Predominant L Cell Differentiation.
Asa SL, Arkun K, Tischler AS, Qamar A, Deng FM, Perez-Ordonez B, Weinreb I, Bishop JA, Wenig BM, Mete O
Endocr Pathol 2021 Dec;32(4):433-441. Epub 2021 May 27 doi: 10.1007/s12022-021-09684-z. PMID: 34041698
Adenomatous tumors of the middle ear and temporal bone: clinical, morphological and tumor biological characteristics of challenging neoplastic lesions.
Duderstadt M, Förster C, Welkoborsky HJ, Ostertag H
Eur Arch Otorhinolaryngol 2012 Mar;269(3):823-31. Epub 2011 Aug 24 doi: 10.1007/s00405-011-1729-1. PMID: 21863251
Middle ear adenoma/carcinoid tumour: a case report and review of the literature.
Angouridakis N, Hytiroglou P, Markou K, Bouzakis A, Vital V
Rev Laryngol Otol Rhinol (Bord) 2009;130(3):199-202. PMID: 20345079
Adenoma versus carcinoid tumor of the middle ear: a study of 48 cases and review of the literature.
Torske KR, Thompson LD
Mod Pathol 2002 May;15(5):543-55. doi: 10.1038/modpathol.3880561. PMID: 12011260
Middle ear adenoma and adenocarcinoma.
Amble FR, Harner SG, Weiland LH, McDonald TJ, Facer GW
Otolaryngol Head Neck Surg 1993 Nov;109(5):871-6. doi: 10.1177/019459989310900516. PMID: 8247568

Diagnosis

Middle ear adenoma: Cytohistologic features and differential diagnosis.
Almajnooni A, Vega M, Cheng L, Gattuso P, Allen-Proctor MK
Diagn Cytopathol 2023 Apr;51(4):E137-E141. Epub 2023 Jan 23 doi: 10.1002/dc.25103. PMID: 36688374
Middle Ear "Adenoma": a Neuroendocrine Tumor with Predominant L Cell Differentiation.
Asa SL, Arkun K, Tischler AS, Qamar A, Deng FM, Perez-Ordonez B, Weinreb I, Bishop JA, Wenig BM, Mete O
Endocr Pathol 2021 Dec;32(4):433-441. Epub 2021 May 27 doi: 10.1007/s12022-021-09684-z. PMID: 34041698
Neuroendocrine Neoplasms of the Ear.
Katabi N
Head Neck Pathol 2018 Sep;12(3):362-366. Epub 2018 Aug 1 doi: 10.1007/s12105-018-0924-4. PMID: 30069842Free PMC Article
Middle ear adenoma with uncommon presentation and literature review.
Wang L, Ouyang N, Guo HX, Liu QY
BMJ Case Rep 2017 Jun 13;2017 doi: 10.1136/bcr-2016-216694. PMID: 28611057Free PMC Article
Middle ear adenoma.
Berns S, Pearl G
Arch Pathol Lab Med 2006 Jul;130(7):1067-9. doi: 10.5858/2006-130-1067-MEA. PMID: 16831038

Therapy

Middle Ear Adenoma Imitating Late Postoperative Complication.
Fedorová K, Formánek M, Zeleník K, Židlík V, Komínek P
Ear Nose Throat J 2021 Dec;100(10_suppl):1082S-1085S. Epub 2020 Jun 24 doi: 10.1177/0145561320935846. PMID: 32579388

Prognosis

Adenomatous tumors of the middle ear.
Pelosi S, Koss S
Otolaryngol Clin North Am 2015 Apr;48(2):305-15. doi: 10.1016/j.otc.2014.12.005. PMID: 25769353
Adenomatous tumors of the middle ear and temporal bone: clinical, morphological and tumor biological characteristics of challenging neoplastic lesions.
Duderstadt M, Förster C, Welkoborsky HJ, Ostertag H
Eur Arch Otorhinolaryngol 2012 Mar;269(3):823-31. Epub 2011 Aug 24 doi: 10.1007/s00405-011-1729-1. PMID: 21863251
Middle ear adenoma.
Berns S, Pearl G
Arch Pathol Lab Med 2006 Jul;130(7):1067-9. doi: 10.5858/2006-130-1067-MEA. PMID: 16831038
Adenoma versus carcinoid tumor of the middle ear: a study of 48 cases and review of the literature.
Torske KR, Thompson LD
Mod Pathol 2002 May;15(5):543-55. doi: 10.1038/modpathol.3880561. PMID: 12011260
Middle ear adenoma and adenocarcinoma.
Amble FR, Harner SG, Weiland LH, McDonald TJ, Facer GW
Otolaryngol Head Neck Surg 1993 Nov;109(5):871-6. doi: 10.1177/019459989310900516. PMID: 8247568

Clinical prediction guides

INSM1 is a Sensitive and Specific Marker of Neuroendocrine Differentiation in Head and Neck Tumors.
Rooper LM, Bishop JA, Westra WH
Am J Surg Pathol 2018 May;42(5):665-671. doi: 10.1097/PAS.0000000000001037. PMID: 29438167
Huge middle ear adenoma with delayed facial nerve paralysis.
Lee SH, Choi H, Chu YC, Kim YH, Kim KS
Ear Nose Throat J 2012 Jun;91(6):E11-4. PMID: 22711394
Middle ear adenoma diagnosed by recurrent facial paralysis.
Mori E, Kojima H, Wada K, Moriyama H
Auris Nasus Larynx 2009 Feb;36(1):75-8. Epub 2008 Mar 6 doi: 10.1016/j.anl.2007.12.006. PMID: 18328653
Middle-ear adenoma (MEA): a report of two cases, one with predominant "plasmacytoid' features.
Ribé A, Fernández PL, Ostertarg H, Clarós P, Bombí JA, Palacín A, Cardesa A
Histopathology 1997 Apr;30(4):359-64. doi: 10.1046/j.1365-2559.1997.d01-625.x. PMID: 9147085
Adenocarcinoma and adenoma of the middle ear.
Pallanch JF, Weiland LH, McDonald TJ, Facer GW, Harner SG
Laryngoscope 1982 Jan;92(1):47-54. doi: 10.1288/00005537-198201000-00010. PMID: 7162295

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