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Midgut Neuroendocrine Tumor G1

MedGen UID:
277371
•Concept ID:
C1334763
•
Neoplastic Process
Synonym: Midgut Carcinoid Tumor

Definition

A well-differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the jejunum, ileum, proximal colon, or appendix. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. [from NCI]

Professional guidelines

PubMed

The Impact of 68Ga-DOTATATE PET/CT Imaging on Management of Patients with Neuroendocrine Tumors: Experience from a National Referral Center in the United Kingdom.
Skoura E, Michopoulou S, Mohmaduvesh M, Panagiotidis E, Al Harbi M, Toumpanakis C, Almukhailed O, Kayani I, Syed R, Navalkissoor S, Ell PJ, Caplin ME, Bomanji J
J Nucl Med 2016 Jan;57(1):34-40. Epub 2015 Oct 15 doi: 10.2967/jnumed.115.166017. PMID: 26471695
A retrospective review of diagnosis and treatment modalities of neuroendocrine tumors (excluding primary lung cancer) in 10 oncological institutions of the East German Study Group of Hematology and Oncology (OSHO), 2010-2012.
Maschmeyer G, Mügge LO, Kämpfe D, Kreibich U, Wilhelm S, Aßmann M, Schwarz M, Kahl C, Köhler S, Grobe N, Niederwieser D
J Cancer Res Clin Oncol 2015 Sep;141(9):1639-44. Epub 2015 Mar 15 doi: 10.1007/s00432-015-1954-x. PMID: 25773126
Interferon in the management of neuroendocrine GEP-tumors: a review.
Oberg K
Digestion 2000;62 Suppl 1:92-7. doi: 10.1159/000051862. PMID: 10940694

Recent clinical studies

Etiology

Is There a Role for Surgical Resection of Grade 3 Neuroendocrine Neoplasms?
Borbon LC, Tran CG, Sherman SK, Ear PH, Chandrasekharan C, Bellizzi AM, Dillon JS, O'Dorisio TM, Howe JR
Ann Surg Oncol 2022 Oct;29(11):6936-6946. Epub 2022 Jul 8 doi: 10.1245/s10434-022-12100-3. PMID: 35802214Free PMC Article
Initial experience and lessons learned with implementing Lutetium-177-dotatate radiopharmaceutical therapy in a radiation oncology-based program.
Maughan NM, Kim H, Hao Y, Unangst S, Roach MC Jr, Garcia-Ramirez JL, Amurao M, Luechtefeld D, Abdin K, Altman MB, Banks A, Riepe M, Bovard E, Jenkins S, Zoberi JE
Brachytherapy 2021 Jan-Feb;20(1):237-247. Epub 2020 Aug 17 doi: 10.1016/j.brachy.2020.07.004. PMID: 32819853
Clinical outcomes of patients with G1/G2 neuroendocrine tumors arising from foregut or hindgut treated with somatostatin analogs: a retrospective study.
Ida H, Honma Y, Hirano H, Shoji H, Iwasa S, Okita N, Takashima A, Kato K, Fukuda T, Boku N
Invest New Drugs 2019 Jun;37(3):573-578. Epub 2018 Sep 28 doi: 10.1007/s10637-018-0669-7. PMID: 30267338
A retrospective review of diagnosis and treatment modalities of neuroendocrine tumors (excluding primary lung cancer) in 10 oncological institutions of the East German Study Group of Hematology and Oncology (OSHO), 2010-2012.
Maschmeyer G, Mügge LO, Kämpfe D, Kreibich U, Wilhelm S, Aßmann M, Schwarz M, Kahl C, Köhler S, Grobe N, Niederwieser D
J Cancer Res Clin Oncol 2015 Sep;141(9):1639-44. Epub 2015 Mar 15 doi: 10.1007/s00432-015-1954-x. PMID: 25773126
Potent antitumor activity of the novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells.
Zitzmann K, Ailer G, Vlotides G, Spoettl G, Maurer J, Göke B, Beuschlein F, Auernhammer CJ
Int J Oncol 2013 Dec;43(6):1824-32. Epub 2013 Oct 4 doi: 10.3892/ijo.2013.2130. PMID: 24100469Free PMC Article

Diagnosis

Is There a Role for Surgical Resection of Grade 3 Neuroendocrine Neoplasms?
Borbon LC, Tran CG, Sherman SK, Ear PH, Chandrasekharan C, Bellizzi AM, Dillon JS, O'Dorisio TM, Howe JR
Ann Surg Oncol 2022 Oct;29(11):6936-6946. Epub 2022 Jul 8 doi: 10.1245/s10434-022-12100-3. PMID: 35802214Free PMC Article
Determination of neuron-specific enolase in patients with midgut-type tumour treated with somatostatin analogues.
Gut P, Czarnywojtek A, Sawicka-Gutaj N, Woliński K, Maciejewski A, Komarnicki P, Ruchała M
Endokrynol Pol 2021;72(4):308-318. Epub 2021 Jul 22 doi: 10.5603/EP.a2021.0060. PMID: 34292567
Expression of somatostatin receptors 2 and 5 in circulating tumour cells from patients with neuroendocrine tumours.
Childs A, Vesely C, Ensell L, Lowe H, Luong TV, Caplin ME, Toumpanakis C, Thirlwell C, Hartley JA, Meyer T
Br J Cancer 2016 Dec 6;115(12):1540-1547. Epub 2016 Nov 22 doi: 10.1038/bjc.2016.377. PMID: 27875519Free PMC Article
The Impact of 68Ga-DOTATATE PET/CT Imaging on Management of Patients with Neuroendocrine Tumors: Experience from a National Referral Center in the United Kingdom.
Skoura E, Michopoulou S, Mohmaduvesh M, Panagiotidis E, Al Harbi M, Toumpanakis C, Almukhailed O, Kayani I, Syed R, Navalkissoor S, Ell PJ, Caplin ME, Bomanji J
J Nucl Med 2016 Jan;57(1):34-40. Epub 2015 Oct 15 doi: 10.2967/jnumed.115.166017. PMID: 26471695
A retrospective review of diagnosis and treatment modalities of neuroendocrine tumors (excluding primary lung cancer) in 10 oncological institutions of the East German Study Group of Hematology and Oncology (OSHO), 2010-2012.
Maschmeyer G, Mügge LO, Kämpfe D, Kreibich U, Wilhelm S, Aßmann M, Schwarz M, Kahl C, Köhler S, Grobe N, Niederwieser D
J Cancer Res Clin Oncol 2015 Sep;141(9):1639-44. Epub 2015 Mar 15 doi: 10.1007/s00432-015-1954-x. PMID: 25773126

Therapy

Determination of neuron-specific enolase in patients with midgut-type tumour treated with somatostatin analogues.
Gut P, Czarnywojtek A, Sawicka-Gutaj N, Woliński K, Maciejewski A, Komarnicki P, Ruchała M
Endokrynol Pol 2021;72(4):308-318. Epub 2021 Jul 22 doi: 10.5603/EP.a2021.0060. PMID: 34292567
Initial experience and lessons learned with implementing Lutetium-177-dotatate radiopharmaceutical therapy in a radiation oncology-based program.
Maughan NM, Kim H, Hao Y, Unangst S, Roach MC Jr, Garcia-Ramirez JL, Amurao M, Luechtefeld D, Abdin K, Altman MB, Banks A, Riepe M, Bovard E, Jenkins S, Zoberi JE
Brachytherapy 2021 Jan-Feb;20(1):237-247. Epub 2020 Aug 17 doi: 10.1016/j.brachy.2020.07.004. PMID: 32819853
Three-dimensional Monte Carlo-based voxel-wise tumor dosimetry in patients with neuroendocrine tumors who underwent (177)Lu-DOTATOC therapy.
Goetz TI, Lang EW, Prante O, Maier A, Cordes M, Kuwert T, Ritt P, Schmidkonz C
Ann Nucl Med 2020 Apr;34(4):244-253. Epub 2020 Feb 29 doi: 10.1007/s12149-020-01440-3. PMID: 32114682Free PMC Article
Clinical outcomes of patients with G1/G2 neuroendocrine tumors arising from foregut or hindgut treated with somatostatin analogs: a retrospective study.
Ida H, Honma Y, Hirano H, Shoji H, Iwasa S, Okita N, Takashima A, Kato K, Fukuda T, Boku N
Invest New Drugs 2019 Jun;37(3):573-578. Epub 2018 Sep 28 doi: 10.1007/s10637-018-0669-7. PMID: 30267338
Interferon in the management of neuroendocrine GEP-tumors: a review.
Oberg K
Digestion 2000;62 Suppl 1:92-7. doi: 10.1159/000051862. PMID: 10940694

Prognosis

Is There a Role for Surgical Resection of Grade 3 Neuroendocrine Neoplasms?
Borbon LC, Tran CG, Sherman SK, Ear PH, Chandrasekharan C, Bellizzi AM, Dillon JS, O'Dorisio TM, Howe JR
Ann Surg Oncol 2022 Oct;29(11):6936-6946. Epub 2022 Jul 8 doi: 10.1245/s10434-022-12100-3. PMID: 35802214Free PMC Article
Three-dimensional Monte Carlo-based voxel-wise tumor dosimetry in patients with neuroendocrine tumors who underwent (177)Lu-DOTATOC therapy.
Goetz TI, Lang EW, Prante O, Maier A, Cordes M, Kuwert T, Ritt P, Schmidkonz C
Ann Nucl Med 2020 Apr;34(4):244-253. Epub 2020 Feb 29 doi: 10.1007/s12149-020-01440-3. PMID: 32114682Free PMC Article
Clinical outcomes of patients with G1/G2 neuroendocrine tumors arising from foregut or hindgut treated with somatostatin analogs: a retrospective study.
Ida H, Honma Y, Hirano H, Shoji H, Iwasa S, Okita N, Takashima A, Kato K, Fukuda T, Boku N
Invest New Drugs 2019 Jun;37(3):573-578. Epub 2018 Sep 28 doi: 10.1007/s10637-018-0669-7. PMID: 30267338
Potent antitumor activity of the novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells.
Zitzmann K, Ailer G, Vlotides G, Spoettl G, Maurer J, Göke B, Beuschlein F, Auernhammer CJ
Int J Oncol 2013 Dec;43(6):1824-32. Epub 2013 Oct 4 doi: 10.3892/ijo.2013.2130. PMID: 24100469Free PMC Article
A comparison of Ki-67 and mitotic count as prognostic markers for metastatic pancreatic and midgut neuroendocrine neoplasms.
Khan MS, Luong TV, Watkins J, Toumpanakis C, Caplin ME, Meyer T
Br J Cancer 2013 May 14;108(9):1838-45. Epub 2013 Apr 11 doi: 10.1038/bjc.2013.156. PMID: 23579216Free PMC Article

Clinical prediction guides

Initial experience and lessons learned with implementing Lutetium-177-dotatate radiopharmaceutical therapy in a radiation oncology-based program.
Maughan NM, Kim H, Hao Y, Unangst S, Roach MC Jr, Garcia-Ramirez JL, Amurao M, Luechtefeld D, Abdin K, Altman MB, Banks A, Riepe M, Bovard E, Jenkins S, Zoberi JE
Brachytherapy 2021 Jan-Feb;20(1):237-247. Epub 2020 Aug 17 doi: 10.1016/j.brachy.2020.07.004. PMID: 32819853
Three-dimensional Monte Carlo-based voxel-wise tumor dosimetry in patients with neuroendocrine tumors who underwent (177)Lu-DOTATOC therapy.
Goetz TI, Lang EW, Prante O, Maier A, Cordes M, Kuwert T, Ritt P, Schmidkonz C
Ann Nucl Med 2020 Apr;34(4):244-253. Epub 2020 Feb 29 doi: 10.1007/s12149-020-01440-3. PMID: 32114682Free PMC Article
Clinical outcomes of patients with G1/G2 neuroendocrine tumors arising from foregut or hindgut treated with somatostatin analogs: a retrospective study.
Ida H, Honma Y, Hirano H, Shoji H, Iwasa S, Okita N, Takashima A, Kato K, Fukuda T, Boku N
Invest New Drugs 2019 Jun;37(3):573-578. Epub 2018 Sep 28 doi: 10.1007/s10637-018-0669-7. PMID: 30267338
The Impact of 68Ga-DOTATATE PET/CT Imaging on Management of Patients with Neuroendocrine Tumors: Experience from a National Referral Center in the United Kingdom.
Skoura E, Michopoulou S, Mohmaduvesh M, Panagiotidis E, Al Harbi M, Toumpanakis C, Almukhailed O, Kayani I, Syed R, Navalkissoor S, Ell PJ, Caplin ME, Bomanji J
J Nucl Med 2016 Jan;57(1):34-40. Epub 2015 Oct 15 doi: 10.2967/jnumed.115.166017. PMID: 26471695
Potent antitumor activity of the novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells.
Zitzmann K, Ailer G, Vlotides G, Spoettl G, Maurer J, Göke B, Beuschlein F, Auernhammer CJ
Int J Oncol 2013 Dec;43(6):1824-32. Epub 2013 Oct 4 doi: 10.3892/ijo.2013.2130. PMID: 24100469Free PMC Article

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