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Monomorphic B-Cell Post-Transplant Lymphoproliferative Disorder

MedGen UID:
277379
•Concept ID:
C1334797
•
Neoplastic Process
Synonym: Monomorphic B-Cell PTLD

Definition

A clonal B-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed B-lymphocytes or plasma cells. The clonal cellular infiltrates fulfill the criteria for a diffuse large B-cell lymphoma, Burkitt lymphoma, or a plasma cell neoplasm. [from NCI]

Professional guidelines

PubMed

Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Post-transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and current treatment strategies.
Al-Mansour Z, Nelson BP, Evens AM
Curr Hematol Malig Rep 2013 Sep;8(3):173-83. doi: 10.1007/s11899-013-0162-5. PMID: 23737188Free PMC Article
Diagnosis and treatment of post-transplantation lymphoproliferative disorder in pediatric heart transplant patients.
Schubert S, Abdul-Khaliq H, Lehmkuhl HB, Yegitbasi M, Reinke P, Kebelmann-Betzig C, Hauptmann K, Gross-Wieltsch U, Hetzer R, Berger F
Pediatr Transplant 2009 Feb;13(1):54-62. Epub 2008 Jun 1 doi: 10.1111/j.1399-3046.2008.00969.x. PMID: 18518912

Recent clinical studies

Etiology

Distinctive Clinicopathologic Features of Monomorphic B-cell Post-transplant Lymphoproliferative Disorders in Children.
Zhang Y, Mariani R, Gong M, Kirschmann D, Caparelli E, Wallace N, Turner R, Lu X, Gao J, Yap KL, Gong S
Pediatr Dev Pathol 2021 Jul-Aug;24(4):318-326. Epub 2021 Apr 19 doi: 10.1177/10935266211007254. PMID: 33872109
Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Post-transplant Lymphoproliferative Disorder: A Single-Center Experience.
Ferreira H, Bustorff M, Santos J, Ferreira I, Sampaio S, Salomé I, Bastos J, Bergantim R, Príncipe F, Pestana M
Transplant Proc 2015 May;47(4):981-4. doi: 10.1016/j.transproceed.2015.03.017. PMID: 26036499
Post-transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and current treatment strategies.
Al-Mansour Z, Nelson BP, Evens AM
Curr Hematol Malig Rep 2013 Sep;8(3):173-83. doi: 10.1007/s11899-013-0162-5. PMID: 23737188Free PMC Article

Diagnosis

Post-transplant lymphoproliferative disorder myeloradiculopathy.
Coradine TLC, Guida LOC, Fraiman P, Santos AJ, Pedroso JL, Barsottini OGP
Pract Neurol 2023 Oct;23(5):408-410. Epub 2023 May 5 doi: 10.1136/pn-2023-003696. PMID: 37147122
Distinctive Clinicopathologic Features of Monomorphic B-cell Post-transplant Lymphoproliferative Disorders in Children.
Zhang Y, Mariani R, Gong M, Kirschmann D, Caparelli E, Wallace N, Turner R, Lu X, Gao J, Yap KL, Gong S
Pediatr Dev Pathol 2021 Jul-Aug;24(4):318-326. Epub 2021 Apr 19 doi: 10.1177/10935266211007254. PMID: 33872109
Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Post-transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and current treatment strategies.
Al-Mansour Z, Nelson BP, Evens AM
Curr Hematol Malig Rep 2013 Sep;8(3):173-83. doi: 10.1007/s11899-013-0162-5. PMID: 23737188Free PMC Article

Therapy

Distinctive Clinicopathologic Features of Monomorphic B-cell Post-transplant Lymphoproliferative Disorders in Children.
Zhang Y, Mariani R, Gong M, Kirschmann D, Caparelli E, Wallace N, Turner R, Lu X, Gao J, Yap KL, Gong S
Pediatr Dev Pathol 2021 Jul-Aug;24(4):318-326. Epub 2021 Apr 19 doi: 10.1177/10935266211007254. PMID: 33872109
Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Post-transplant Lymphoproliferative Disorder: A Single-Center Experience.
Ferreira H, Bustorff M, Santos J, Ferreira I, Sampaio S, Salomé I, Bastos J, Bergantim R, Príncipe F, Pestana M
Transplant Proc 2015 May;47(4):981-4. doi: 10.1016/j.transproceed.2015.03.017. PMID: 26036499
Post-transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and current treatment strategies.
Al-Mansour Z, Nelson BP, Evens AM
Curr Hematol Malig Rep 2013 Sep;8(3):173-83. doi: 10.1007/s11899-013-0162-5. PMID: 23737188Free PMC Article

Prognosis

Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Post-transplant lymphoproliferative disease in liver transplant recipients.
Rubio-Manzanares Dorado M, Álamo Martínez JM, Bernal Bellido C, Marín Gómez LM, Suárez Artacho G, Cepeda Franco C, Wang J, Gómez Bravo MÁ, Padillo FJ
Rev Esp Enferm Dig 2017 Jun;109(6):406-413. doi: 10.17235/reed.2017.4228/2016. PMID: 28508661
Post-transplant Lymphoproliferative Disorder: A Single-Center Experience.
Ferreira H, Bustorff M, Santos J, Ferreira I, Sampaio S, Salomé I, Bastos J, Bergantim R, Príncipe F, Pestana M
Transplant Proc 2015 May;47(4):981-4. doi: 10.1016/j.transproceed.2015.03.017. PMID: 26036499
Pediatric post-transplant lymphoproliferative disorder after cardiac transplantation.
Ohta H, Fukushima N, Ozono K
Int J Hematol 2009 Sep;90(2):127-136. Epub 2009 Aug 12 doi: 10.1007/s12185-009-0399-x. PMID: 19669857

Clinical prediction guides

Real-world evidence of the safety and survival with CD19 CAR-T cell therapy for relapsed/refractory solid organ transplant-related PTLD.
McKenna M, Epperla N, Ghobadi A, Liu J, Lazaryan A, Ibrahim U, Jacobson CA, Naik SG, Nastoupil L, Chowdhury SM, Voorhees TJ, Jacobs MT, Farooq U, Osman K, Olszewski AJ, Ahmed S, Evens AM
Br J Haematol 2023 Jul;202(2):248-255. Epub 2023 May 2 doi: 10.1111/bjh.18828. PMID: 37129856
Tumor Infiltrating Lymphocytes Predict Survival in Solid Organ Transplant Recipients With Monomorphic Post-transplant Lymphoproliferative Disorders.
Stubbins RJ, Lam R, Zhu J, Ghosh S, Mabilangan C, Kuruvilla J, Goswami RS, Lai R, Preiksaitis JK, Jain MD, Peters AC
Clin Lymphoma Myeloma Leuk 2022 Oct;22(10):744-752. Epub 2022 May 23 doi: 10.1016/j.clml.2022.05.006. PMID: 35717340
Risk factors evaluation of post-transplant lymphoproliferative disorders after allogeneic haematopoietic stem cell transplantation with comparison between paediatric and adult.
Chen DB, Liu XY, Kong FZ, Jiang Q, Shen DH
J Clin Pathol 2021 Nov;74(11):697-703. Epub 2021 May 19 doi: 10.1136/jclinpath-2021-207492. PMID: 34011618
Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Post-transplant lymphoproliferative disease in liver transplant recipients.
Rubio-Manzanares Dorado M, Álamo Martínez JM, Bernal Bellido C, Marín Gómez LM, Suárez Artacho G, Cepeda Franco C, Wang J, Gómez Bravo MÁ, Padillo FJ
Rev Esp Enferm Dig 2017 Jun;109(6):406-413. doi: 10.17235/reed.2017.4228/2016. PMID: 28508661

Recent systematic reviews

Impact of the posttransplant lymphoproliferative disorder subtype on survival.
Koff JL, Li JX, Zhang X, Switchenko JM, Flowers CR, Waller EK
Cancer 2018 Jun 1;124(11):2327-2336. Epub 2018 Mar 26 doi: 10.1002/cncr.31339. PMID: 29579330Free PMC Article

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