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Non-Neoplastic Laryngeal Disorder

MedGen UID:
277426
•Concept ID:
C1335018
•
Disease or Syndrome
Synonym: Non-Neoplastic Laryngeal Disease

Definition

A non-neoplastic pathologic process that affects the larynx. Representative examples include laryngitis, vocal cord nodule, and laryngeal cleft. [from NCI]

Professional guidelines

PubMed

Benign tracheal and laryngotracheal stenosis: surgical treatment and results.
Rea F, Callegaro D, Loy M, Zuin A, Narne S, Gobbi T, Grapeggia M, Sartori F
Eur J Cardiothorac Surg 2002 Sep;22(3):352-6. doi: 10.1016/s1010-7940(02)00342-1. PMID: 12204722

Recent clinical studies

Etiology

Serum concentration of total sialic acids in patients with primary laryngeal carcinoma.
Bronikowska I, Świętochowska E, Morawski R, Ścierski W, Czecior E
Otolaryngol Pol 2022 Nov 24;77(2):1-5. doi: 10.5604/01.3001.0016.1094. PMID: 36804774
Post-thyroidectomy complications in southwestern Saudi Arabia: a retrospective study of a 6-year period.
Bawa D, Alghamdi A, Albishi H, Al-Tufail N, Sharma SP, Khalifa YM, Khan S, Alhajmohammed MA
Ann Saudi Med 2021 Nov-Dec;41(6):369-375. Epub 2021 Dec 2 doi: 10.5144/0256-4947.2021.369. PMID: 34873936Free PMC Article
The association between lncRNA H19 and EZH2 expression in patients with EBV-positive laryngeal carcinoma.
Hotoboc IE, Fudulu A, Grigore R, Bertesteanu S, Huica I, Iancu IV, Botezatu A, Bleotu C, Anton G
Acta Otorhinolaryngol Ital 2021 Dec;41(6):537-543. Epub 2021 Nov 26 doi: 10.14639/0392-100X-N1527. PMID: 34825669Free PMC Article
Prevalence of Dysphagia in Patients With Non-neoplastic Vocal Fold Pathology.
Hamdan AL, Khalifee E, Jaffal H, Ghanem A, Rizk SA, El Hage A
J Voice 2019 Sep;33(5):708-711. Epub 2018 Jun 5 doi: 10.1016/j.jvoice.2018.05.003. PMID: 29884508
Micronutrients and laryngeal cancer risk in Italy and Switzerland: a case-control study.
Bidoli E, Bosetti C, La Vecchia C, Levi F, Parpinel M, Talamini R, Negri E, Maso LD, Franceschi S
Cancer Causes Control 2003 Jun;14(5):477-84. doi: 10.1023/a:1024991618398. PMID: 12946043

Diagnosis

Difficult glottis: Diagnostic dilemma in viewof the clinical presentation.
Klimza H, Witkiewicz J, Jackowska J, Wierzbicka M
Otolaryngol Pol 2023 Jul 21;77(4):53-57. doi: 10.5604/01.3001.0053.7263. PMID: 37772377
Primary laryngeal cryptococcosis mimicking laryngeal malignancy: a case report.
Tonai K, Nishio N, Yokoi S, Kobayashi M, Sone M
Nagoya J Med Sci 2022 Nov;84(4):900-905. doi: 10.18999/nagjms.84.4.900. PMID: 36544607Free PMC Article
Prevalence of Dysphagia in Patients With Non-neoplastic Vocal Fold Pathology.
Hamdan AL, Khalifee E, Jaffal H, Ghanem A, Rizk SA, El Hage A
J Voice 2019 Sep;33(5):708-711. Epub 2018 Jun 5 doi: 10.1016/j.jvoice.2018.05.003. PMID: 29884508
Family history of cancer and the risk of laryngeal cancer: a case-control study from Italy and Switzerland.
Garavello W, Turati F, Bosetti C, Talamini R, Levi F, Lucenteforte E, Chiesa F, Franceschi S, La Vecchia C, Negri E
Int J Cancer 2012 Feb 1;130(3):665-70. Epub 2011 Apr 27 doi: 10.1002/ijc.26055. PMID: 21400506
Imaging of the larynx and hypopharynx.
Becker M, Burkhardt K, Dulguerov P, Allal A
Eur J Radiol 2008 Jun;66(3):460-79. Epub 2008 May 20 doi: 10.1016/j.ejrad.2008.03.027. PMID: 18495402

Therapy

Post-thyroidectomy complications in southwestern Saudi Arabia: a retrospective study of a 6-year period.
Bawa D, Alghamdi A, Albishi H, Al-Tufail N, Sharma SP, Khalifa YM, Khan S, Alhajmohammed MA
Ann Saudi Med 2021 Nov-Dec;41(6):369-375. Epub 2021 Dec 2 doi: 10.5144/0256-4947.2021.369. PMID: 34873936Free PMC Article
Inflammatory potential of diet and risk of laryngeal cancer in a case-control study from Italy.
Shivappa N, Hébert JR, Rosato V, Serraino D, La Vecchia C
Cancer Causes Control 2016 Aug;27(8):1027-34. Epub 2016 Jul 5 doi: 10.1007/s10552-016-0781-y. PMID: 27379989Free PMC Article
Laryngeal cancer: smoking is not the only risk factor.
Vassileiou A, Vlastarakos PV, Kandiloros D, Delicha E, Ferekidis E, Tzagaroulakis A, Nikolopoulos TP
B-ENT 2012;8(4):273-8. PMID: 23409557
Diet diversity and the risk of laryngeal cancer: a case-control study from Italy and Switzerland.
Garavello W, Lucenteforte E, Bosetti C, Talamini R, Levi F, Tavani A, Franceschi S, Negri E, La Vecchia C
Oral Oncol 2009 Jan;45(1):85-9. Epub 2008 May 19 doi: 10.1016/j.oraloncology.2008.02.011. PMID: 18487075
Micronutrients and laryngeal cancer risk in Italy and Switzerland: a case-control study.
Bidoli E, Bosetti C, La Vecchia C, Levi F, Parpinel M, Talamini R, Negri E, Maso LD, Franceschi S
Cancer Causes Control 2003 Jun;14(5):477-84. doi: 10.1023/a:1024991618398. PMID: 12946043

Prognosis

Immunohistochemical detection of "ex novo" HLA-DR in tumor cells determines clinical outcome in laryngeal cancer patients.
Prampolini C, Almadori G, Bonvissuto D, Barba M, Giraldi L, Boccia S, Paludetti G, Galli J, Parolini O, Settimi S, Cadoni G
HLA 2021 Dec;98(6):517-524. Epub 2021 Oct 12 doi: 10.1111/tan.14441. PMID: 34605215
Nuclear EGFR Expression Is Associated With Poor Survival in Laryngeal Carcinoma.
Marijić B, Braut T, Babarović E, Krstulja M, Maržić D, Avirović M, Kujundžić M, Hadžisejdić I
Appl Immunohistochem Mol Morphol 2021 Sep 1;29(8):576-584. doi: 10.1097/PAI.0000000000000932. PMID: 33758141
Expression and prognostic significance of YAP, TAZ, TEAD4 and p73 in human laryngeal cancer.
Tsinias G, Nikou S, Mastronikolis N, Bravou V, Papadaki H
Histol Histopathol 2020 Sep;35(9):983-995. Epub 2020 May 7 doi: 10.14670/HH-18-228. PMID: 32378727
Increased expression of lncRNA FTH1P3 predicts a poor prognosis and promotes aggressive phenotypes of laryngeal squamous cell carcinoma.
Yuan H, Jiang H, Wang Y, Dong Y
Biosci Rep 2019 Jun 28;39(6) Epub 2019 Jun 18 doi: 10.1042/BSR20181644. PMID: 31142627Free PMC Article
Effect of DACH1 on proliferation and invasion of laryngeal squamous cell carcinoma.
Zhang J, Ren X, Wang B, Cao J, Tian L, Liu M
Head Face Med 2018 Sep 27;14(1):20. doi: 10.1186/s13005-018-0177-1. PMID: 30261897Free PMC Article

Clinical prediction guides

Difficult glottis: Diagnostic dilemma in viewof the clinical presentation.
Klimza H, Witkiewicz J, Jackowska J, Wierzbicka M
Otolaryngol Pol 2023 Jul 21;77(4):53-57. doi: 10.5604/01.3001.0053.7263. PMID: 37772377
Serum concentration of total sialic acids in patients with primary laryngeal carcinoma.
Bronikowska I, Świętochowska E, Morawski R, Ścierski W, Czecior E
Otolaryngol Pol 2022 Nov 24;77(2):1-5. doi: 10.5604/01.3001.0016.1094. PMID: 36804774
Expression and prognostic significance of YAP, TAZ, TEAD4 and p73 in human laryngeal cancer.
Tsinias G, Nikou S, Mastronikolis N, Bravou V, Papadaki H
Histol Histopathol 2020 Sep;35(9):983-995. Epub 2020 May 7 doi: 10.14670/HH-18-228. PMID: 32378727
Prevalence of Dysphagia in Patients With Non-neoplastic Vocal Fold Pathology.
Hamdan AL, Khalifee E, Jaffal H, Ghanem A, Rizk SA, El Hage A
J Voice 2019 Sep;33(5):708-711. Epub 2018 Jun 5 doi: 10.1016/j.jvoice.2018.05.003. PMID: 29884508
Quality-of-life impact of non-neoplastic voice disorders: a meta-analysis.
Cohen SM, Dupont WD, Courey MS
Ann Otol Rhinol Laryngol 2006 Feb;115(2):128-34. doi: 10.1177/000348940611500209. PMID: 16514796

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