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Occult Lung Non-Small Cell Carcinoma

MedGen UID:
277444
•Concept ID:
C1335098
•
Neoplastic Process
Synonyms: Occult Non-Small Cell Carcinoma of Lung; Occult Non-Small Cell Carcinoma of the Lung; Occult Non-Small Cell Lung Carcinoma

Definition

A non-small cell lung carcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOccult Lung Non-Small Cell Carcinoma

Professional guidelines

PubMed

Adjuvant therapy in non-small cell lung cancer: future treatment prospects and paradigms.
Carbone DP, Felip E
Clin Lung Cancer 2011 Sep;12(5):261-71. Epub 2011 Aug 10 doi: 10.1016/j.cllc.2011.06.002. PMID: 21831720
Intratumoural chemotherapy of lung cancer for diagnosis and treatment of draining lymph node metastasis.
Celikoglu F, Celikoglu SI, Goldberg EP
J Pharm Pharmacol 2010 Mar;62(3):287-95. doi: 10.1211/jpp.62.03.0001. PMID: 20487210
Follow-up and surveillance of the lung cancer patient following curative-intent therapy.
Colice GL, Rubins J, Unger M; American College of Chest Physicians
Chest 2003 Jan;123(1 Suppl):272S-283S. doi: 10.1378/chest.123.1_suppl.272s. PMID: 12527585

Recent clinical studies

Etiology

Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567
Incidence and survival analyses for occult lung cancer between 2004 and 2015: a population-based study.
Wu LL, Li CW, Lin WK, Qiu LH, Xie D
BMC Cancer 2021 Sep 9;21(1):1009. doi: 10.1186/s12885-021-08741-4. PMID: 34496775Free PMC Article
18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of clinically node-negative non-small cell lung cancer.
Takahashi Y, Suzuki S, Matsutani N, Kawamura M
Thorac Cancer 2019 Mar;10(3):413-420. Epub 2019 Jan 21 doi: 10.1111/1759-7714.12978. PMID: 30666803Free PMC Article
Nodal recurrence after stereotactic body radiotherapy for early stage non-small cell lung cancer: Incidence and proposed risk factors.
Wink KCJ, van Baardwijk A, Troost EGC, De Ruysscher D
Cancer Treat Rev 2017 May;56:8-15. Epub 2017 Apr 12 doi: 10.1016/j.ctrv.2017.04.001. PMID: 28437679
Adjuvant therapy in non-small cell lung cancer: future treatment prospects and paradigms.
Carbone DP, Felip E
Clin Lung Cancer 2011 Sep;12(5):261-71. Epub 2011 Aug 10 doi: 10.1016/j.cllc.2011.06.002. PMID: 21831720

Diagnosis

Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567
Oligometastasis: Past, Present, Future.
Gutiontov SI, Pitroda SP, Weichselbaum RR
Int J Radiat Oncol Biol Phys 2020 Nov 1;108(3):530-538. doi: 10.1016/j.ijrobp.2020.02.019. PMID: 32976785
18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of clinically node-negative non-small cell lung cancer.
Takahashi Y, Suzuki S, Matsutani N, Kawamura M
Thorac Cancer 2019 Mar;10(3):413-420. Epub 2019 Jan 21 doi: 10.1111/1759-7714.12978. PMID: 30666803Free PMC Article
Mediastinal Staging in Non-Small Cell Lung Cancer.
Gamliel Z
Surg Oncol Clin N Am 2016 Jul;25(3):493-502. doi: 10.1016/j.soc.2016.02.004. PMID: 27261911
The ectopic ACTH syndrome.
Alexandraki KI, Grossman AB
Rev Endocr Metab Disord 2010 Jun;11(2):117-26. doi: 10.1007/s11154-010-9139-z. PMID: 20544290

Therapy

Non-Small Cell Lung Cancer Causing Atraumatic Splenic Rupture Without Splenic Metastasis.
Amro C, Pepe RJ, Parekh AT, Butts CA
Am Surg 2023 Aug;89(8):3487-3489. Epub 2023 Mar 5 doi: 10.1177/00031348231161697. PMID: 36871964
Oligometastasis: Past, Present, Future.
Gutiontov SI, Pitroda SP, Weichselbaum RR
Int J Radiat Oncol Biol Phys 2020 Nov 1;108(3):530-538. doi: 10.1016/j.ijrobp.2020.02.019. PMID: 32976785
18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of clinically node-negative non-small cell lung cancer.
Takahashi Y, Suzuki S, Matsutani N, Kawamura M
Thorac Cancer 2019 Mar;10(3):413-420. Epub 2019 Jan 21 doi: 10.1111/1759-7714.12978. PMID: 30666803Free PMC Article
Adjuvant therapy in non-small cell lung cancer: future treatment prospects and paradigms.
Carbone DP, Felip E
Clin Lung Cancer 2011 Sep;12(5):261-71. Epub 2011 Aug 10 doi: 10.1016/j.cllc.2011.06.002. PMID: 21831720
Adjuvant therapy of resected non-small-cell lung cancer.
Socinski MA
Clin Lung Cancer 2004 Nov;6(3):162-9. doi: 10.3816/CLC.2004.n.029. PMID: 15555217

Prognosis

Non-Small Cell Lung Cancer Causing Atraumatic Splenic Rupture Without Splenic Metastasis.
Amro C, Pepe RJ, Parekh AT, Butts CA
Am Surg 2023 Aug;89(8):3487-3489. Epub 2023 Mar 5 doi: 10.1177/00031348231161697. PMID: 36871964
Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567
Oligometastasis: Past, Present, Future.
Gutiontov SI, Pitroda SP, Weichselbaum RR
Int J Radiat Oncol Biol Phys 2020 Nov 1;108(3):530-538. doi: 10.1016/j.ijrobp.2020.02.019. PMID: 32976785
Adjuvant therapy in non-small cell lung cancer: future treatment prospects and paradigms.
Carbone DP, Felip E
Clin Lung Cancer 2011 Sep;12(5):261-71. Epub 2011 Aug 10 doi: 10.1016/j.cllc.2011.06.002. PMID: 21831720
Prognostic significance of micrometastasis in non-small-cell lung cancer.
Coello MC, Luketich JD, Litle VR, Godfrey TE
Clin Lung Cancer 2004 Jan;5(4):214-25. doi: 10.3816/CLC.2004.n.002. PMID: 14967073

Clinical prediction guides

Endoscopic nodal staging in oligometastatic non-small cell lung cancer (NSCLC) being treated with stereotactic ablative radiotherapy (ENDO-SABR).
Dhaliwal I, Kassirian S, Mitchell MA, Qiabi M, Warner A, Louie AV, Wong HH, McDonald CM, Rajchgot J, Palma DA
BMC Cancer 2022 Apr 28;22(1):468. doi: 10.1186/s12885-022-09563-8. PMID: 35484614Free PMC Article
Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567
18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of clinically node-negative non-small cell lung cancer.
Takahashi Y, Suzuki S, Matsutani N, Kawamura M
Thorac Cancer 2019 Mar;10(3):413-420. Epub 2019 Jan 21 doi: 10.1111/1759-7714.12978. PMID: 30666803Free PMC Article
Clinical and surgical staging of non-small cell lung cancer.
Deslauriers J, Grégoire J
Chest 2000 Apr;117(4 Suppl 1):96S-103S. doi: 10.1378/chest.117.4_suppl_1.96s. PMID: 10777462
Detection of occult metastases in lung carcinomas: progress and implications for lung cancer staging.
Cote RJ, Hawes D, Chaiwun B, Beattie EJ Jr
J Surg Oncol 1998 Dec;69(4):265-74. doi: 10.1002/(sici)1096-9098(199812)69:4<265::aid-jso12>3.0.co;2-7. PMID: 9881945

Recent systematic reviews

Systematic review and meta-analysis of the prognostic impact of lymph node micrometastasis and isolated tumour cells in patients with stage I-IIIA non-small cell lung cancer.
Hüyük M, Fiocco M, Postmus PE, Cohen D, von der Thüsen JH
Histopathology 2023 Apr;82(5):650-663. Epub 2022 Nov 9 doi: 10.1111/his.14831. PMID: 36282087
Predictive Value of 18F-Fluorodeoxyglucose Positron Emission Tomography or Positron Emission Tomography/Computed Tomography for Assessment of Occult Lymph Node Metastasis in Non-Small Cell Lung Cancer.
Seol HY, Kim YS, Kim SJ
Oncology 2021;99(2):96-104. Epub 2020 Sep 25 doi: 10.1159/000509988. PMID: 32980838
Preoperative Staging by EBUS in cN0/N1 Lung Cancer: Systematic Review and Meta-Analysis.
Leong TL, Loveland PM, Gorelik A, Irving L, Steinfort DP
J Bronchology Interv Pulmonol 2019 Jul;26(3):155-165. doi: 10.1097/LBR.0000000000000545. PMID: 30119069
Endobronchial Ultrasound for Nodal Staging of Patients with Non-Small-Cell Lung Cancer with Radiologically Normal Mediastinum. A Meta-Analysis.
El-Osta H, Jani P, Mansour A, Rascoe P, Jafri S
Ann Am Thorac Soc 2018 Jul;15(7):864-874. doi: 10.1513/AnnalsATS.201711-863OC. PMID: 29684288
Nodal recurrence after stereotactic body radiotherapy for early stage non-small cell lung cancer: Incidence and proposed risk factors.
Wink KCJ, van Baardwijk A, Troost EGC, De Ruysscher D
Cancer Treat Rev 2017 May;56:8-15. Epub 2017 Apr 12 doi: 10.1016/j.ctrv.2017.04.001. PMID: 28437679

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