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Acinar prostate mucinous adenocarcinoma

MedGen UID:
277536
•Concept ID:
C1335513
•
Neoplastic Process
Synonyms: Acinar Colloid Prostate Adenocarcinoma; acinar colloid prostate adenocarcinoma; Acinar Prostate Mucinous Adenocarcinoma; acinar prostate mucinous adenocarcinoma; Colloid Adenocarcinoma of Prostate; colloid adenocarcinoma of prostate; Colloid Adenocarcinoma of the Prostate; colloid adenocarcinoma of the prostate; Colloidal Adenocarcinoma of Prostate; colloidal adenocarcinoma of prostate; Colloidal Adenocarcinoma of the Prostate; colloidal adenocarcinoma of the prostate; Colloidal Prostate Adenocarcinoma; colloidal prostate adenocarcinoma; Mucinous Adenocarcinoma of Prostate; mucinous adenocarcinoma of prostate; Mucinous Adenocarcinoma of the Prostate; mucinous adenocarcinoma of the prostate; Prostate Acinar Mucinous Adenocarcinoma; prostate colloid adenocarcinoma
 
Monarch Initiative: MONDO:0006067

Definition

Acinar adenocarcinoma of the prostate gland characterized by the presence of lakes of extracellular mucin. This diagnosis applies when at least 25% of the resected tumor contains extracellular mucin. [from NCI]

Professional guidelines

PubMed

Beyond Prostate Adenocarcinoma: Expanding the Differential Diagnosis in Prostate Pathologic Conditions.
Li Y, Mongan J, Behr SC, Sud S, Coakley FV, Simko J, Westphalen AC
Radiographics 2016 Jul-Aug;36(4):1055-75. Epub 2016 Jun 17 doi: 10.1148/rg.2016150226. PMID: 27315446
Variants and unusual patterns of prostate cancer: clinicopathologic and differential diagnostic considerations.
Fine SW
Adv Anat Pathol 2012 Jul;19(4):204-16. doi: 10.1097/PAP.0b013e31825c6b92. PMID: 22692283
Histologic variants of adenocarcinoma and other carcinomas of prostate: pathologic criteria and clinical significance.
Randolph TL, Amin MB, Ro JY, Ayala AG
Mod Pathol 1997 Jun;10(6):612-29. PMID: 9195581

Recent clinical studies

Etiology

Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: a study of 47 cases.
Osunkoya AO, Nielsen ME, Epstein JI
Am J Surg Pathol 2008 Mar;32(3):468-72. doi: 10.1097/PAS.0b013e3181589f72. PMID: 18300802
Study of prostate cancer pathologic features in Chinese populations.
Chuang AY, Chang SJ, Horng CF, Tsou MH
Urology 2007 May;69(5):915-20. doi: 10.1016/j.urology.2007.01.051. PMID: 17482934
Rare prostatic carcinomas: histogenesis and morphologic pattern.
Losi L, Brausi M, Di Gregorio C
Pathologica 1994 Aug;86(4):366-70. PMID: 7708435
Unusual primary prostatic malignancies.
Efros MD, Fischer J, Mallouh C, Choudhury M, Georgsson S
Urology 1992 May;39(5):407-10. doi: 10.1016/0090-4295(92)90234-n. PMID: 1315994

Diagnosis

Histological patterns, subtypes and aspects of prostate cancer: different aspects, different outcomes.
Wasinger G, Oszwald A, Shariat SF, Compérat E
Curr Opin Urol 2022 Nov 1;32(6):643-648. Epub 2022 Sep 8 doi: 10.1097/MOU.0000000000001038. PMID: 36081403
Acinar with ductal and mucinous adenocarcinoma of prostate cancer complicated with lung metastasis: a case report and literature review.
Cui Y, Miao C, Xu A, Wang Z, Liu B
Ann Palliat Med 2021 Feb;10(2):2366-2370. Epub 2020 Jun 23 doi: 10.21037/apm-20-386. PMID: 32576002
Mucinous and secondary tumors of the prostate.
Osunkoya AO
Mod Pathol 2018 Jan;31(S1):S80-S95. doi: 10.1038/modpathol.2017.132. PMID: 29297488
Beyond Prostate Adenocarcinoma: Expanding the Differential Diagnosis in Prostate Pathologic Conditions.
Li Y, Mongan J, Behr SC, Sud S, Coakley FV, Simko J, Westphalen AC
Radiographics 2016 Jul-Aug;36(4):1055-75. Epub 2016 Jun 17 doi: 10.1148/rg.2016150226. PMID: 27315446
Variants and unusual patterns of prostate cancer: clinicopathologic and differential diagnostic considerations.
Fine SW
Adv Anat Pathol 2012 Jul;19(4):204-16. doi: 10.1097/PAP.0b013e31825c6b92. PMID: 22692283

Therapy

Mixed acinar and macrocystic ductal prostatic adenocarcinoma.
Giganti F, Allen C, Sridhar A, Tandogdu Z, Ramachandran N, Dickinson L, Haider A, Freeman A, Ball R, Moore CM
Lancet Oncol 2021 Jan;22(1):e37. doi: 10.1016/S1470-2045(20)30435-6. PMID: 33387504
Acinar with ductal and mucinous adenocarcinoma of prostate cancer complicated with lung metastasis: a case report and literature review.
Cui Y, Miao C, Xu A, Wang Z, Liu B
Ann Palliat Med 2021 Feb;10(2):2366-2370. Epub 2020 Jun 23 doi: 10.21037/apm-20-386. PMID: 32576002
Stability of the glycoprotein A-80 in prostatic carcinoma subsequent to androgen deprivation therapy.
Gould VE, Doljanskaia V, Gooch GT, Bostwick DG
Am J Surg Pathol 1997 Mar;21(3):319-26. doi: 10.1097/00000478-199703000-00008. PMID: 9060602

Prognosis

Histological patterns, subtypes and aspects of prostate cancer: different aspects, different outcomes.
Wasinger G, Oszwald A, Shariat SF, Compérat E
Curr Opin Urol 2022 Nov 1;32(6):643-648. Epub 2022 Sep 8 doi: 10.1097/MOU.0000000000001038. PMID: 36081403
Mucinous and secondary tumors of the prostate.
Osunkoya AO
Mod Pathol 2018 Jan;31(S1):S80-S95. doi: 10.1038/modpathol.2017.132. PMID: 29297488
Mucinous adenocarcinoma of prostate and prostatic adenocarcinoma with mucinous components: a clinicopathological analysis of 143 cases.
Samaratunga H, Delahunt B, Srigley JR, Yaxley J, Johannsen S, Coughlin G, Gianduzzo T, Kua B, Patterson I, Nacey JN, Egevad L
Histopathology 2017 Oct;71(4):641-647. Epub 2017 Jul 19 doi: 10.1111/his.13278. PMID: 28590015
Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: a study of 47 cases.
Osunkoya AO, Nielsen ME, Epstein JI
Am J Surg Pathol 2008 Mar;32(3):468-72. doi: 10.1097/PAS.0b013e3181589f72. PMID: 18300802

Clinical prediction guides

NKX3.1 Expression in Salivary Gland "Intraductal" Papillary Mucinous Neoplasm: A Low-Grade Subtype of Salivary Gland Mucinous Adenocarcinoma.
Nakaguro M, Sadow PM, Hu R, Hattori H, Kuwabara K, Tsuzuki T, Urano M, Nagao T, Faquin WC
Head Neck Pathol 2022 Dec;16(4):1114-1123. Epub 2022 Jul 14 doi: 10.1007/s12105-022-01471-4. PMID: 35834096Free PMC Article
Mucinous adenocarcinoma of prostate and prostatic adenocarcinoma with mucinous components: a clinicopathological analysis of 143 cases.
Samaratunga H, Delahunt B, Srigley JR, Yaxley J, Johannsen S, Coughlin G, Gianduzzo T, Kua B, Patterson I, Nacey JN, Egevad L
Histopathology 2017 Oct;71(4):641-647. Epub 2017 Jul 19 doi: 10.1111/his.13278. PMID: 28590015
Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Variants and unusual patterns of prostate cancer: clinicopathologic and differential diagnostic considerations.
Fine SW
Adv Anat Pathol 2012 Jul;19(4):204-16. doi: 10.1097/PAP.0b013e31825c6b92. PMID: 22692283
Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: a study of 47 cases.
Osunkoya AO, Nielsen ME, Epstein JI
Am J Surg Pathol 2008 Mar;32(3):468-72. doi: 10.1097/PAS.0b013e3181589f72. PMID: 18300802

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