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Urethra clear cell adenocarcinoma

MedGen UID:
277846
•Concept ID:
C1336886
•
Neoplastic Process
Synonyms: Clear Cell Adenocarcinoma of the Urethra; clear cell adenocarcinoma of the urethra; Clear Cell Adenocarcinoma of Urethra; clear cell adenocarcinoma of urethra; Urethra Clear Cell Adenocarcinoma; urethra clear cell adenocarcinoma; Urethral Clear Cell Adenocarcinoma; urethral clear cell adenocarcinoma
 
Monarch Initiative: MONDO:0003387

Definition

A morphologic variant of urethral adenocarcinoma characterized by the presence of tubulocystic or papillary structures lined with clear cuboidal or hobnail cells. [from NCI]

Professional guidelines

PubMed

The epidemiology and role of surgery in the treatment of urethral clear cell carcinoma.
Patel M, Im J, Ivy A, Maraboyina S, Kim T
Int Urol Nephrol 2020 Jan;52(1):51-57. Epub 2019 Sep 25 doi: 10.1007/s11255-019-02289-w. PMID: 31555949
Treatment and Outcomes of Primary Urethra Cancer.
Eng TY, Chen TW, Patel AJ, Vincent JN, Ha CS
Am J Clin Oncol 2018 Sep;41(9):905-908. doi: 10.1097/COC.0000000000000391. PMID: 28537991
Surgical treatment of female urethral carcinoma.
Narayan P, Konety B
Urol Clin North Am 1992 May;19(2):373-82. PMID: 1574827

Recent clinical studies

Etiology

Clear Cell Adenocarcinoma of Urethra: Clinical and Pathologic Implications and Characterization of Molecular Aberrations.
Song B, Lee SH, Park JH, Moon KC
Cancer Res Treat 2024 Jan;56(1):280-293. Epub 2023 Sep 11 doi: 10.4143/crt.2023.577. PMID: 37697729Free PMC Article
GATA3 expression in clear cell adenocarcinoma of the lower urinary tract: a potential diagnostic pitfall.
Akgul M, Humble R, Osme A, Yuce S, Kocak EN, Najafzadeh P, Sangoi A, Pattnaik N, Mishra S, Sharma S, Shaker N, Kaushal S, Baisakh M, Lightle AR, Balzer BL, Xiao GQ, MacLennan GT, Osunkoya AO, Parwani A, Cheng L, Bellizzi A, Mohanty SK
Diagn Pathol 2022 Nov 1;17(1):87. doi: 10.1186/s13000-022-01269-6. PMID: 36320040Free PMC Article
Female urethral carcinoma: a contemporary review of the clinicopathologic features, with emphasis on the histoanatomic landmarks and potential staging issues.
Lagarde-Lenon MS, Aron M
Hum Pathol 2022 Nov;129:71-80. Epub 2022 Aug 28 doi: 10.1016/j.humpath.2022.08.003. PMID: 36037997
Primary adenocarcinomas of the vulva and related structures: An enigmatic and diverse group of tumors(✰).
Desouki MM, Fadare O
Semin Diagn Pathol 2021 Jan;38(1):71-84. Epub 2020 Sep 25 doi: 10.1053/j.semdp.2020.09.011. PMID: 33032903
The epidemiology and role of surgery in the treatment of urethral clear cell carcinoma.
Patel M, Im J, Ivy A, Maraboyina S, Kim T
Int Urol Nephrol 2020 Jan;52(1):51-57. Epub 2019 Sep 25 doi: 10.1007/s11255-019-02289-w. PMID: 31555949

Diagnosis

Morphologic spectrum of the epithelial tumors of the male and female urethra.
Cimadamore A, Lopez-Beltran A, Cheng L, Montironi R
Virchows Arch 2023 Dec;483(6):751-764. Epub 2023 May 26 doi: 10.1007/s00428-023-03565-y. PMID: 37233807Free PMC Article
GATA3 expression in clear cell adenocarcinoma of the lower urinary tract: a potential diagnostic pitfall.
Akgul M, Humble R, Osme A, Yuce S, Kocak EN, Najafzadeh P, Sangoi A, Pattnaik N, Mishra S, Sharma S, Shaker N, Kaushal S, Baisakh M, Lightle AR, Balzer BL, Xiao GQ, MacLennan GT, Osunkoya AO, Parwani A, Cheng L, Bellizzi A, Mohanty SK
Diagn Pathol 2022 Nov 1;17(1):87. doi: 10.1186/s13000-022-01269-6. PMID: 36320040Free PMC Article
Primary clear cell adenocarcinoma of female urinary tract: a case report and literature review.
Miao J, Hu J, Wu J, Guo W, Chen J, Li J
BMC Womens Health 2022 Jun 24;22(1):251. doi: 10.1186/s12905-022-01835-6. PMID: 35751118Free PMC Article
Clear Cell Adenocarcinoma in Men: A Series of 15 Cases.
Grosser D, Matoso A, Epstein JI
Am J Surg Pathol 2021 Feb 1;45(2):270-276. doi: 10.1097/PAS.0000000000001589. PMID: 32960833
Clear cell adenocarcinoma of the urethra: review of the literature.
Venyo AK
Int J Surg Oncol 2015;2015:790235. Epub 2015 Jan 20 doi: 10.1155/2015/790235. PMID: 25685552Free PMC Article

Therapy

Histopathological Subtypes and PD-L1 Expression in Primary Urethral Adenocarcinoma: A Series of 5 Cases.
Padilla-Ansala C, García-Fernández E, González-Peramato P
Int J Surg Pathol 2021 Aug;29(5):488-495. Epub 2021 Jan 19 doi: 10.1177/1066896920988348. PMID: 33463392
Treatment and Outcomes of Primary Urethra Cancer.
Eng TY, Chen TW, Patel AJ, Vincent JN, Ha CS
Am J Clin Oncol 2018 Sep;41(9):905-908. doi: 10.1097/COC.0000000000000391. PMID: 28537991
Metastatic clear cell adenocarcinoma of the urethra in a male patient: report of a case.
Liu SV, Truskinovsky AM, Dudek AZ, Ramanathan RK
Clin Genitourin Cancer 2012 Mar;10(1):47-9. Epub 2011 Nov 6 doi: 10.1016/j.clgc.2011.10.002. PMID: 22056213
Tubulocystic clear cell adenocarcinoma arising within the prostate.
Pan CC, Chiang H, Chang YH, Epstein JI
Am J Surg Pathol 2000 Oct;24(10):1433-6. doi: 10.1097/00000478-200010000-00016. PMID: 11023108
Clear cell adenocarcinoma of the female urethra.
Maier U, Dorfinger K, Susani M
J Urol 1998 Aug;160(2):492-3. PMID: 9679907

Prognosis

Clear Cell Adenocarcinoma of Urethra: Clinical and Pathologic Implications and Characterization of Molecular Aberrations.
Song B, Lee SH, Park JH, Moon KC
Cancer Res Treat 2024 Jan;56(1):280-293. Epub 2023 Sep 11 doi: 10.4143/crt.2023.577. PMID: 37697729Free PMC Article
Female urethral carcinoma: a contemporary review of the clinicopathologic features, with emphasis on the histoanatomic landmarks and potential staging issues.
Lagarde-Lenon MS, Aron M
Hum Pathol 2022 Nov;129:71-80. Epub 2022 Aug 28 doi: 10.1016/j.humpath.2022.08.003. PMID: 36037997
The epidemiology and role of surgery in the treatment of urethral clear cell carcinoma.
Patel M, Im J, Ivy A, Maraboyina S, Kim T
Int Urol Nephrol 2020 Jan;52(1):51-57. Epub 2019 Sep 25 doi: 10.1007/s11255-019-02289-w. PMID: 31555949
Clear cell adenocarcinoma of the urethra: review of the literature.
Venyo AK
Int J Surg Oncol 2015;2015:790235. Epub 2015 Jan 20 doi: 10.1155/2015/790235. PMID: 25685552Free PMC Article
Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing.
Mehra R, Vats P, Kalyana-Sundaram S, Udager AM, Roh M, Alva A, Pan J, Lonigro RJ, Siddiqui J, Weizer A, Lee C, Cao X, Wu YM, Robinson DR, Dhanasekaran SM, Chinnaiyan AM
Am J Pathol 2014 Mar;184(3):584-91. Epub 2014 Jan 3 doi: 10.1016/j.ajpath.2013.11.023. PMID: 24389164Free PMC Article

Clinical prediction guides

GATA3 expression in clear cell adenocarcinoma of the lower urinary tract: a potential diagnostic pitfall.
Akgul M, Humble R, Osme A, Yuce S, Kocak EN, Najafzadeh P, Sangoi A, Pattnaik N, Mishra S, Sharma S, Shaker N, Kaushal S, Baisakh M, Lightle AR, Balzer BL, Xiao GQ, MacLennan GT, Osunkoya AO, Parwani A, Cheng L, Bellizzi A, Mohanty SK
Diagn Pathol 2022 Nov 1;17(1):87. doi: 10.1186/s13000-022-01269-6. PMID: 36320040Free PMC Article
Histopathological Subtypes and PD-L1 Expression in Primary Urethral Adenocarcinoma: A Series of 5 Cases.
Padilla-Ansala C, García-Fernández E, González-Peramato P
Int J Surg Pathol 2021 Aug;29(5):488-495. Epub 2021 Jan 19 doi: 10.1177/1066896920988348. PMID: 33463392
The epidemiology and role of surgery in the treatment of urethral clear cell carcinoma.
Patel M, Im J, Ivy A, Maraboyina S, Kim T
Int Urol Nephrol 2020 Jan;52(1):51-57. Epub 2019 Sep 25 doi: 10.1007/s11255-019-02289-w. PMID: 31555949
Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems.
Alexiev BA, Tavora F
Virchows Arch 2013 Feb;462(2):193-201. Epub 2013 Jan 11 doi: 10.1007/s00428-012-1363-3. PMID: 23307189
Clear cell adenocarcinoma and nephrogenic adenoma of the urethra and urinary bladder: a histopathologic and immunohistochemical comparison.
Gilcrease MZ, Delgado R, Vuitch F, Albores-Saavedra J
Hum Pathol 1998 Dec;29(12):1451-6. doi: 10.1016/s0046-8177(98)90015-6. PMID: 9865832

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