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Villoglandular endometrial endometrioid adenocarcinoma

MedGen UID:
277869
•Concept ID:
C1336962
•
Neoplastic Process
Synonyms: Villoglandular Endometrial Endometrioid Adenocarcinoma; villoglandular endometrial endometrioid adenocarcinoma
 
Monarch Initiative: MONDO:0003991

Definition

A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of numerous finger-like villi lined by neoplastic columnar cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVilloglandular endometrial endometrioid adenocarcinoma

Professional guidelines

PubMed

Problems in the differential diagnosis of endometrial hyperplasia and carcinoma.
Silverberg SG
Mod Pathol 2000 Mar;13(3):309-27. doi: 10.1038/modpathol.3880053. PMID: 10757341

Recent clinical studies

Etiology

Could E-Cadherin and CD10 Expression be Used to Differentiate Between Atypical Endometrial Hyperplasia and Endometrial Carcinoma?
Youssef MY, Mohamed MA
Int J Gynecol Pathol 2019 Mar;38(2):128-137. doi: 10.1097/PGP.0000000000000492. PMID: 30726192
Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors.
Pirog EC
Arch Pathol Lab Med 2017 Dec;141(12):1653-1667. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0356-RA. PMID: 28644686
Mixed and Ambiguous Endometrial Carcinomas: A Heterogenous Group of Tumors With Different Clinicopathologic and Molecular Genetic Features.
Espinosa I, D'Angelo E, Palacios J, Prat J
Am J Surg Pathol 2016 Jul;40(7):972-81. doi: 10.1097/PAS.0000000000000640. PMID: 26975040
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Clinicopathologic features and genetic alterations in endometrioid carcinoma of the uterus with villoglandular differentiation.
Esteller M, Garcia A, Martinez-Palones JM, Xercavins J, Reventos J
Am J Clin Pathol 1999 Mar;111(3):336-42. doi: 10.1093/ajcp/111.3.336. PMID: 10078108

Diagnosis

Low grade endometrial endometrioid adenocarcinoma: A review and update with emphasis on morphologic variants, mimics, immunohistochemical and molecular features.
Lucas E, Carrick KS
Semin Diagn Pathol 2022 May;39(3):159-175. Epub 2022 Feb 11 doi: 10.1053/j.semdp.2022.02.002. PMID: 35397943
Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors.
Pirog EC
Arch Pathol Lab Med 2017 Dec;141(12):1653-1667. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0356-RA. PMID: 28644686
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Endometrial carcinomas: a review emphasizing overlapping and distinctive morphological and immunohistochemical features.
Bartosch C, Manuel Lopes J, Oliva E
Adv Anat Pathol 2011 Nov;18(6):415-37. doi: 10.1097/PAP.0b013e318234ab18. PMID: 21993268
Problems in the differential diagnosis of endometrial hyperplasia and carcinoma.
Silverberg SG
Mod Pathol 2000 Mar;13(3):309-27. doi: 10.1038/modpathol.3880053. PMID: 10757341

Prognosis

How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Endometrioid carcinoma of the endometrium: pathologic and molecular features.
Azueta A, Gatius S, Matias-Guiu X
Semin Diagn Pathol 2010 Nov;27(4):226-40. doi: 10.1053/j.semdp.2010.09.001. PMID: 21309258
Problems in the differential diagnosis of endometrial hyperplasia and carcinoma.
Silverberg SG
Mod Pathol 2000 Mar;13(3):309-27. doi: 10.1038/modpathol.3880053. PMID: 10757341
Clinicopathologic features and genetic alterations in endometrioid carcinoma of the uterus with villoglandular differentiation.
Esteller M, Garcia A, Martinez-Palones JM, Xercavins J, Reventos J
Am J Clin Pathol 1999 Mar;111(3):336-42. doi: 10.1093/ajcp/111.3.336. PMID: 10078108
Significance of papillary (villoglandular) differentiation in endometrioid carcinoma of the uterus.
Ambros RA, Ballouk F, Malfetano JH, Ross JS
Am J Surg Pathol 1994 Jun;18(6):569-75. PMID: 8179072

Clinical prediction guides

Prognostic significance of pretreatment thrombocytosis in endometrial cancer: an Israeli Gynecologic Oncology Group study.
Tal O, Eitan R, Gemer O, Helpman L, Vaknin Z, Leytes S, Lavie O, Ben-Arie A, Amit A, Namazov A, Ben Shahar I, Atlas I, Bruchim I, Levy T
Int J Gynecol Cancer 2021 Nov;31(11):1437-1442. doi: 10.1136/ijgc-2021-002810. PMID: 34725243
Incidence and survival trends of uncommon corpus uteri malignancies in the Netherlands, 1989-2008.
Boll D, Verhoeven RH, van der Aa MA, Pauwels P, Karim-Kos HE, Coebergh JW, van Doorn HC
Int J Gynecol Cancer 2012 May;22(4):599-606. doi: 10.1097/IGC.0b013e318244cedc. PMID: 22398706
Clinicopathologic features and genetic alterations in endometrioid carcinoma of the uterus with villoglandular differentiation.
Esteller M, Garcia A, Martinez-Palones JM, Xercavins J, Reventos J
Am J Clin Pathol 1999 Mar;111(3):336-42. doi: 10.1093/ajcp/111.3.336. PMID: 10078108
Cell proliferation-associated proteins in endometrial carcinomas, including papillary serous and endometrioid subtypes.
Kallakury BV, Ambros RA, Hayner-Buchan AM, Sheehan CE, Malfetano JH, Ross JS
Int J Gynecol Pathol 1998 Oct;17(4):320-6. doi: 10.1097/00004347-199810000-00005. PMID: 9785132

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