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Secretory meningioma

MedGen UID:
277998
•Concept ID:
C1384406
•
Neoplastic Process
Synonyms: Meningioma, Secretory; Meningiomas, Secretory; Secretory Meningioma; Secretory Meningiomas
SNOMED CT: Secretory meningioma (253081009)
 
Monarch Initiative: MONDO:0003055

Definition

A WHO grade I meningioma characterized by the presence of epithelial differentiation and numerous intracellular PAS positive bodies that are rich in glycogen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecretory meningioma

Professional guidelines

PubMed

Clinical features, surgical management, and prognostic factors of secretory meningiomas: a single-center case series of 149 patients.
Tao X, Wang K, Dong J, Hou Z, Wu Z, Zhang J, Liu B
J Neurooncol 2018 Feb;136(3):515-522. Epub 2017 Nov 15 doi: 10.1007/s11060-017-2671-x. PMID: 29143274

Recent clinical studies

Etiology

Radiographic Differentiation of Secretory Meningiomas and WHO Grade 2 Meningiomas: When Atypical Features Are Not Always Predictive of Atypical Tumors.
Trivedi MM, Momin AA, Shao J, Soni P, Almeida JP, Lee J, Recinos PF, Kshettry VR
World Neurosurg 2022 Sep;165:e386-e392. Epub 2022 Jun 17 doi: 10.1016/j.wneu.2022.06.061. PMID: 35724883
Peritumoral Brain Edema and Surgical Outcome in Secretory Meningiomas: A Matched-Cohort Analysis.
Trivedi MM, Worley S, Raghavan A, Das P, Recinos PF, Barnett GH, Kshettry VR
World Neurosurg 2021 Jan;145:e170-e176. Epub 2020 Oct 3 doi: 10.1016/j.wneu.2020.09.151. PMID: 33022430
Secretory meningioma: a diagnostic pitfall.
Tyagi R, Vasishta RK, Kakkar N, Radotra BD, Mukherjee KK
Indian J Pathol Microbiol 2014 Apr-Jun;57(2):183-6. doi: 10.4103/0377-4929.134659. PMID: 24943746
Secretory meningiomas: clinical, radiological and pathological findings in 70 consecutive cases at one institution.
Wang DJ, Xie Q, Gong Y, Wang Y, Cheng HX, Mao Y, Zhong P, Huang FP, Zheng K, Wang YF, Bao WM, Yang BJ, Chen H, Xie LQ, Zheng MZ, Tang HL, Zhu HD, Chen XC, Zhou LF
Int J Clin Exp Pathol 2013;6(3):358-74. Epub 2013 Feb 15 PMID: 23412548Free PMC Article
Secretory meningioma: immunohistochemical findings and evaluation of mast cell infiltration.
Tirakotai W, Mennel HD, Celik I, Hellwig D, Bertalanffy H, Riegel T
Neurosurg Rev 2006 Jan;29(1):41-8. Epub 2005 Jul 12 doi: 10.1007/s10143-005-0402-9. PMID: 16010579

Diagnosis

Secretory meningioma with bone infiltration and orbital spreading.
Kálovits F , Takáts L , Somogyi K , Garzuly F , Tompa M , Kálmán B
Ideggyogy Sz 2019 Mar 30;72(3-4):141-144. doi: 10.18071/isz.72.0141. PMID: 30957470
A Left Frontal Secretory Meningioma Can Mimic Transformed Migraine With and Without Aura.
Evans RW, Timm JS, Baskin DS
Headache 2015 Jun;55(6):849-52. doi: 10.1111/head.12580. PMID: 26084240
Secretory meningioma: a diagnostic pitfall.
Tyagi R, Vasishta RK, Kakkar N, Radotra BD, Mukherjee KK
Indian J Pathol Microbiol 2014 Apr-Jun;57(2):183-6. doi: 10.4103/0377-4929.134659. PMID: 24943746
Cytologic features of secretory meningioma.
Hinton DR, Kovacs K, Chandrasoma PT
Acta Cytol 1999 Mar-Apr;43(2):121-5. doi: 10.1159/000330964. PMID: 10097697
Secretory meningioma with elevated serum carcinoembryonic antigen level.
Tsunoda S, Takeshima T, Sakaki T, Morimoto T, Hoshida T, Watabe Y, Goda K
Surg Neurol 1992 May;37(5):415-8. doi: 10.1016/0090-3019(92)90015-f. PMID: 1631772

Therapy

Secretory meningiomas: a benign subgroup causing life-threatening complications.
Regelsberger J, Hagel C, Emami P, Ries T, Heese O, Westphal M
Neuro Oncol 2009 Dec;11(6):819-24. doi: 10.1215/15228517-2008-109. PMID: 19066343Free PMC Article
Secretory meningioma: immunohistochemical findings and evaluation of mast cell infiltration.
Tirakotai W, Mennel HD, Celik I, Hellwig D, Bertalanffy H, Riegel T
Neurosurg Rev 2006 Jan;29(1):41-8. Epub 2005 Jul 12 doi: 10.1007/s10143-005-0402-9. PMID: 16010579

Prognosis

Radiographic Differentiation of Secretory Meningiomas and WHO Grade 2 Meningiomas: When Atypical Features Are Not Always Predictive of Atypical Tumors.
Trivedi MM, Momin AA, Shao J, Soni P, Almeida JP, Lee J, Recinos PF, Kshettry VR
World Neurosurg 2022 Sep;165:e386-e392. Epub 2022 Jun 17 doi: 10.1016/j.wneu.2022.06.061. PMID: 35724883
Clinical features, surgical management, and prognostic factors of secretory meningiomas: a single-center case series of 149 patients.
Tao X, Wang K, Dong J, Hou Z, Wu Z, Zhang J, Liu B
J Neurooncol 2018 Feb;136(3):515-522. Epub 2017 Nov 15 doi: 10.1007/s11060-017-2671-x. PMID: 29143274
Secretory meningioma: a diagnostic pitfall.
Tyagi R, Vasishta RK, Kakkar N, Radotra BD, Mukherjee KK
Indian J Pathol Microbiol 2014 Apr-Jun;57(2):183-6. doi: 10.4103/0377-4929.134659. PMID: 24943746
Secretory meningiomas: clinical, radiological and pathological findings in 70 consecutive cases at one institution.
Wang DJ, Xie Q, Gong Y, Wang Y, Cheng HX, Mao Y, Zhong P, Huang FP, Zheng K, Wang YF, Bao WM, Yang BJ, Chen H, Xie LQ, Zheng MZ, Tang HL, Zhu HD, Chen XC, Zhou LF
Int J Clin Exp Pathol 2013;6(3):358-74. Epub 2013 Feb 15 PMID: 23412548Free PMC Article
Secretory meningioma: immunohistochemical findings and evaluation of mast cell infiltration.
Tirakotai W, Mennel HD, Celik I, Hellwig D, Bertalanffy H, Riegel T
Neurosurg Rev 2006 Jan;29(1):41-8. Epub 2005 Jul 12 doi: 10.1007/s10143-005-0402-9. PMID: 16010579

Clinical prediction guides

Radiographic Differentiation of Secretory Meningiomas and WHO Grade 2 Meningiomas: When Atypical Features Are Not Always Predictive of Atypical Tumors.
Trivedi MM, Momin AA, Shao J, Soni P, Almeida JP, Lee J, Recinos PF, Kshettry VR
World Neurosurg 2022 Sep;165:e386-e392. Epub 2022 Jun 17 doi: 10.1016/j.wneu.2022.06.061. PMID: 35724883
Clinical features, surgical management, and prognostic factors of secretory meningiomas: a single-center case series of 149 patients.
Tao X, Wang K, Dong J, Hou Z, Wu Z, Zhang J, Liu B
J Neurooncol 2018 Feb;136(3):515-522. Epub 2017 Nov 15 doi: 10.1007/s11060-017-2671-x. PMID: 29143274
Genetic landscape of meningioma.
Yuzawa S, Nishihara H, Tanaka S
Brain Tumor Pathol 2016 Oct;33(4):237-247. Epub 2016 Sep 13 doi: 10.1007/s10014-016-0271-7. PMID: 27624470
Secretory meningiomas: clinical, radiological and pathological findings in 70 consecutive cases at one institution.
Wang DJ, Xie Q, Gong Y, Wang Y, Cheng HX, Mao Y, Zhong P, Huang FP, Zheng K, Wang YF, Bao WM, Yang BJ, Chen H, Xie LQ, Zheng MZ, Tang HL, Zhu HD, Chen XC, Zhou LF
Int J Clin Exp Pathol 2013;6(3):358-74. Epub 2013 Feb 15 PMID: 23412548Free PMC Article
Secretory meningioma: clinical, histologic, and immunohistochemical findings in 31 cases.
Probst-Cousin S, Villagran-Lillo R, Lahl R, Bergmann M, Schmid KW, Gullotta F
Cancer 1997 May 15;79(10):2003-15. doi: 10.1002/(sici)1097-0142(19970515)79:10<2003::aid-cncr23>3.0.co;2-x. PMID: 9149029

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