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Grade 1 Nodular Sclerosis Classic Hodgkin Lymphoma

MedGen UID:
279352
•Concept ID:
C1521899
•
Neoplastic Process
Synonyms: Classical Hodgkin lymphoma, nodular sclerosis, grade 1; Grade 1 Nodular Sclerosis Classical Hodgkin Lymphoma; Grade 1 Nodular Sclerosis Hodgkin Lymphoma; Grade 1 Nodular Sclerosis Hodgkin's Lymphoma; Grade I Nodular Sclerosis Hodgkin's Lymphoma; Hodgkin lymphoma, nodular sclerosis, grade 1
SNOMED CT: Classical Hodgkin lymphoma, nodular sclerosis, grade 1 (45572000); Hodgkin lymphoma, nodular sclerosis, grade 1 (45572000)

Definition

Nodular sclerosis Hodgkin lymphoma in which at least 75% of the tumor nodules contain scattered Reed-Sternberg cells. The background cellular infiltrate is lymphocytic, mixed, or fibrohistiocytic. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 1 Nodular Sclerosis Classic Hodgkin Lymphoma

Recent clinical studies

Etiology

Lymphocyte depleted Hodgkin lymphoma: an evaluation with immunophenotyping and genetic analysis.
Slack GW, Ferry JA, Hasserjian RP, Sohani AR, Longtine JA, Harris NL, Zukerberg LR
Leuk Lymphoma 2009 Jun;50(6):937-43. doi: 10.1080/10428190902930488. PMID: 19455461
Prognostic significance of T-cell or cytotoxic molecules phenotype in classical Hodgkin's lymphoma: a clinicopathologic study.
Asano N, Oshiro A, Matsuo K, Kagami Y, Ishida F, Suzuki R, Kinoshita T, Shimoyama Y, Tamaru J, Yoshino T, Kitamura K, Fukutani H, Morishima Y, Nakamura S
J Clin Oncol 2006 Oct 1;24(28):4626-33. Epub 2006 Sep 5 doi: 10.1200/JCO.2006.06.5342. PMID: 16954517
Limited field radiotherapy for early stage, infra-diaphragmatic Hodgkin's lymphoma.
Harris MA, Radford JA, Deakin DP, James RD, Swindell R, Cowan RA
Clin Oncol (R Coll Radiol) 2004 Feb;16(1):53-7. doi: 10.1016/j.clon.2003.08.007. PMID: 14768756
The pattern of lymphoma in east Malaysian patients as experienced in the University Hospital, Kuala Lumpur.
Chai SP, Peh SC, Kim LH, Lim MY, Gudum HR
Malays J Pathol 1999 Jun;21(1):45-50. PMID: 10879278
Nodular type of lymphocyte predominant Hodgkin's disease. A clinical study of 50 cases.
Pappa VI, Norton AJ, Gupta RK, Wilson AM, Rohatiner AZ, Lister TA
Ann Oncol 1995 Jul;6(6):559-65. doi: 10.1093/oxfordjournals.annonc.a059244. PMID: 8573534

Diagnosis

Composite Classic Hodgkin Lymphoma and Follicular Lymphoma: A Clinicopathologic Study of 22 Cases With Review of 27 Additional Cases in the Literature.
Huang Y, Hu S, Larson DP, Shi M, He R, Dave BJ, Greiner TC, Fu K, McPhail ED, Ketterling RP, Medeiros LJ, Yuan J
Am J Surg Pathol 2022 Jun 1;46(6):793-800. Epub 2022 Jan 24 doi: 10.1097/PAS.0000000000001828. PMID: 35067515
Diagnostic challenge of soft tissue extranodal Hodgkin lymphoma in core-needle biopsy: case report.
Jonjić N, Valković T, Vujaklija DV, Ilijaš KM
Scott Med J 2021 Feb;66(1):40-45. Epub 2020 Jul 12 doi: 10.1177/0036933020941262. PMID: 32659181
GATA3 Immunohistochemical Staining in Hodgkin Lymphoma: Diagnostic Utility in Differentiating Classic Hodgkin Lymphoma From Nodular Lymphocyte Predominant Hodgkin Lymphoma and Other Mimicking Entities.
Kezlarian B, Alhyari M, Venkataraman G, Karner K, Inamdar KV, Menon MP
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):180-184. doi: 10.1097/PAI.0000000000000581. PMID: 28877074
Nodular sclerosis classical Hodgkin lymphoma grade 2: A diagnostic challenge to the cytopathologists.
Sharma S, Dey P, Mitra S, Rajwanshi A, Nijhawan R, Srinivasan R, Gupta N, Das A
Cancer Cytopathol 2017 Feb;125(2):104-113. Epub 2016 Nov 21 doi: 10.1002/cncy.21799. PMID: 27870472
Lymphocyte depleted Hodgkin lymphoma: an evaluation with immunophenotyping and genetic analysis.
Slack GW, Ferry JA, Hasserjian RP, Sohani AR, Longtine JA, Harris NL, Zukerberg LR
Leuk Lymphoma 2009 Jun;50(6):937-43. doi: 10.1080/10428190902930488. PMID: 19455461

Therapy

Limited field radiotherapy for early stage, infra-diaphragmatic Hodgkin's lymphoma.
Harris MA, Radford JA, Deakin DP, James RD, Swindell R, Cowan RA
Clin Oncol (R Coll Radiol) 2004 Feb;16(1):53-7. doi: 10.1016/j.clon.2003.08.007. PMID: 14768756
Nodular type of lymphocyte predominant Hodgkin's disease. A clinical study of 50 cases.
Pappa VI, Norton AJ, Gupta RK, Wilson AM, Rohatiner AZ, Lister TA
Ann Oncol 1995 Jul;6(6):559-65. doi: 10.1093/oxfordjournals.annonc.a059244. PMID: 8573534

Prognosis

3D analysis of morphological alterations of the fibroblastic reticular cells in reactive and neoplastic human lymph nodes.
Oswald MS, Wurzel P, Hansmann ML
Acta Histochem 2019 Oct;121(7):769-775. Epub 2019 Jul 5 doi: 10.1016/j.acthis.2019.07.002. PMID: 31285059
GATA3 Immunohistochemical Staining in Hodgkin Lymphoma: Diagnostic Utility in Differentiating Classic Hodgkin Lymphoma From Nodular Lymphocyte Predominant Hodgkin Lymphoma and Other Mimicking Entities.
Kezlarian B, Alhyari M, Venkataraman G, Karner K, Inamdar KV, Menon MP
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):180-184. doi: 10.1097/PAI.0000000000000581. PMID: 28877074
Nodular sclerosis classical Hodgkin lymphoma grade 2: A diagnostic challenge to the cytopathologists.
Sharma S, Dey P, Mitra S, Rajwanshi A, Nijhawan R, Srinivasan R, Gupta N, Das A
Cancer Cytopathol 2017 Feb;125(2):104-113. Epub 2016 Nov 21 doi: 10.1002/cncy.21799. PMID: 27870472
Tissue eosinophilia correlates strongly with poor prognosis in nodular sclerosing Hodgkin's disease, allowing for known prognostic factors.
von Wasielewski R, Seth S, Franklin J, Fischer R, Hübner K, Hansmann ML, Diehl V, Georgii A
Blood 2000 Feb 15;95(4):1207-13. PMID: 10666192
Nodular type of lymphocyte predominant Hodgkin's disease. A clinical study of 50 cases.
Pappa VI, Norton AJ, Gupta RK, Wilson AM, Rohatiner AZ, Lister TA
Ann Oncol 1995 Jul;6(6):559-65. doi: 10.1093/oxfordjournals.annonc.a059244. PMID: 8573534

Clinical prediction guides

GATA3 Immunohistochemical Staining in Hodgkin Lymphoma: Diagnostic Utility in Differentiating Classic Hodgkin Lymphoma From Nodular Lymphocyte Predominant Hodgkin Lymphoma and Other Mimicking Entities.
Kezlarian B, Alhyari M, Venkataraman G, Karner K, Inamdar KV, Menon MP
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):180-184. doi: 10.1097/PAI.0000000000000581. PMID: 28877074
Clusterin expression in malignant lymphomas: a survey of 266 cases.
Saffer H, Wahed A, Rassidakis GZ, Medeiros LJ
Mod Pathol 2002 Nov;15(11):1221-6. doi: 10.1097/01.MP.0000036386.87517.AA. PMID: 12429802
Tissue eosinophilia correlates strongly with poor prognosis in nodular sclerosing Hodgkin's disease, allowing for known prognostic factors.
von Wasielewski R, Seth S, Franklin J, Fischer R, Hübner K, Hansmann ML, Diehl V, Georgii A
Blood 2000 Feb 15;95(4):1207-13. PMID: 10666192
Nodular type of lymphocyte predominant Hodgkin's disease. A clinical study of 50 cases.
Pappa VI, Norton AJ, Gupta RK, Wilson AM, Rohatiner AZ, Lister TA
Ann Oncol 1995 Jul;6(6):559-65. doi: 10.1093/oxfordjournals.annonc.a059244. PMID: 8573534

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