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Neurocirculatory asthenia

MedGen UID:: 283928
•Concept ID:: C1535893
•: Finding

Synonyms:	Irritable heart; Mitral valve prolapse syndrome; Norepinephrine Transporter Deficiency; Orthostatic intolerance; Soldiers heart
SNOMED CT:	Orthostatic intolerance (870368003)

Gene (location): Gene(s) directly associated with this condition or phenotype.	SLC6A2 (16q12.2)

Monarch Initiative:	MONDO:0001315
OMIM®:	604715

Definition

A condition characterized by development of symptoms while standing. It is an autonomic nervous system disorder and the symptoms are relieved once the person sits back down. Symptoms include heart palpitations, sweating, anxiety, lightheadedness, hyperpnea, anxiety, and blurred vision. [from NCI]

Clinical features

From HPO

Elevated urinary norepinephrine level

MedGen UID:: 1841548
•Concept ID:: C5826344
•: Finding

The concentration of noradrenaline in the urine, normalized for urine concentration, is above the upper limit of normal.

See: Feature record | Search on this feature

Orthostatic tachycardia

MedGen UID:: 866749
•Concept ID:: C4021099
•: Finding

An increase in heart rate with standing of 30 beats per minute or more.

See: Feature record | Search on this feature

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Abnormality of the genitourinary system
- Elevated urinary norepinephrine level
Abnormality of the nervous system
- Orthostatic tachycardia

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeurocirculatory asthenia

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Finding by Cause
    - Neurocirculatory asthenia
      - Chronic Orthostatic Intolerance
      - Post-Exercise Hypotension

Professional guidelines

PubMed

Neurocirculatory asthenia: a reassessment using modern psychosomatic criteria.

Fava GA, Magelli C, Savron G, Conti S, Bartolucci G, Grandi S, Semprini F, Saviotti FM, Belluardo P, Magnani B
Acta Psychiatr Scand 1994 May;89(5):314-9. doi: 10.1111/j.1600-0447.1994.tb01521.x. PMID: 8067269

Propranolol in the treatment of neurocirculatory asthenia--an open pilot study.

Rimón R, Kampman R, Viukari M
Isr Ann Psychiatr Relat Discip 1979 Jun;17(2):144-8. PMID: 291588

Diagnosis and treatment of NCA.

OHSUZU H
Jpn Circ J 1963 Feb;27:206-9. doi: 10.1253/jcj.27.206. PMID: 13939695

See all (5)

Recent clinical studies

Etiology

Life events and neurocirculatory asthenia. A controlled study.

Sonino N, Fava GA, Boscaro M, Fallo F
J Intern Med 1998 Dec;244(6):523-8. PMID: 9893106

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Durlach J, Bac P, Durlach V, Bara M, Guiet-Bara A
Magnes Res 1997 Jun;10(2):169-95. PMID: 9368238

Psychological aspects of non-cardiac chest pain.

Serlie AW, Erdman RA, Passchier J, Trijsburg RW, ten Cate FJ
Psychother Psychosom 1995;64(2):62-73. doi: 10.1159/000288993. PMID: 8559955

Neurocirculatory asthenia: a reassessment using modern psychosomatic criteria.

Increased cardiac awareness in panic disorder.

Ehlers A, Breuer P
J Abnorm Psychol 1992 Aug;101(3):371-82. doi: 10.1037//0021-843x.101.3.371. PMID: 1500594

See all (56)

Diagnosis

On chronic fatigue syndrome and nosological categories.

Sharif K, Watad A, Bragazzi NL, Lichtbroun M, Martini M, Perricone C, Amital H, Shoenfeld Y
Clin Rheumatol 2018 May;37(5):1161-1170. Epub 2018 Feb 7 doi: 10.1007/s10067-018-4009-2. PMID: 29417255

Psychological aspects of non-cardiac chest pain.

Serlie AW, Erdman RA, Passchier J, Trijsburg RW, ten Cate FJ
Psychother Psychosom 1995;64(2):62-73. doi: 10.1159/000288993. PMID: 8559955

Cardiac neurosis and psychopathology.

Conti S, Savron G, Bartolucci G, Grandi S, Magelli C, Semprini F, Saviotti FM, Trombini G, Fava GA, Magnani B
Psychother Psychosom 1989;52(1-3):88-91. doi: 10.1159/000288304. PMID: 2486407

Hyperventilation syndrome: a review.

Morgan WP
Am Ind Hyg Assoc J 1983 Sep;44(9):685-9. doi: 10.1080/15298668391405562. PMID: 6356858

IATROGENIC HEART DESEASE.

KEYES JW
JAMA 1965 Jun 14;192:951-5. doi: 10.1001/jama.1965.03080240021004. PMID: 14290433

See all (110)

Therapy

Hepatocyte growth factor and vascular endothelial growth factor in ischaemic heart disease.

Suzuki H, Murakami M, Shoji M, Iso Y, Kondo T, Shibata M, Ezumi H, Hamazaki Y, Koba S, Katagiri T
Coron Artery Dis 2003 Jun;14(4):301-7. doi: 10.1097/01.mca.0000073431.02845.a1. PMID: 12826929

Pharmacology, clinical pharmacology and potential therapeutic uses of the specific bradycardiac agent alinidine.

Harron DW, Shanks RG
Eur Heart J 1985 Sep;6(9):722-9. doi: 10.1093/oxfordjournals.eurheartj.a061932. PMID: 2866961

Asthenia in cancer.

Theologides A
Am J Med 1982 Jul;73(1):1-3. doi: 10.1016/0002-9343(82)90910-x. PMID: 7091166

Editorial: Da Costa syndrome revisited.

Vaisrub S
JAMA 1975 Apr 14;232(2):164. PMID: 235031

Nervous and behavioral effects of microwave radiation in humans.

Silverman C
Am J Epidemiol 1973 Apr;97(4):219-24. doi: 10.1093/oxfordjournals.aje.a121502. PMID: 4577165

See all (43)

Prognosis

Soldier's heart: the forgotten circulatory neurasthenia - a systematic review.

Borges GP, Tonon JHA, Zunini PAADS, Martins da Silva AS, Garcia MFV, de Azevedo-Marques Périco C, Lima DR, Torales J, Ventriglio A, Bhugra D, Castaldelli-Maia JM
Int Rev Psychiatry 2020 Aug-Sep;32(5-6):510-519. Epub 2020 May 27 doi: 10.1080/09540261.2020.1757925. PMID: 32459107

On chronic fatigue syndrome and nosological categories.

Sharif K, Watad A, Bragazzi NL, Lichtbroun M, Martini M, Perricone C, Amital H, Shoenfeld Y
Clin Rheumatol 2018 May;37(5):1161-1170. Epub 2018 Feb 7 doi: 10.1007/s10067-018-4009-2. PMID: 29417255

Psychological aspects of non-cardiac chest pain.

Serlie AW, Erdman RA, Passchier J, Trijsburg RW, ten Cate FJ
Psychother Psychosom 1995;64(2):62-73. doi: 10.1159/000288993. PMID: 8559955

Cardiac involvement in liver cirrhosis.

Gatta A, Merkel C, Sacerdoti D, Angeli P
Ann Ital Med Int 1993 Oct-Dec;8(4):244-7. PMID: 8161481

Panic disorder in cardiology patients.

Beitman BD, Mukerji V, Alpert M, Peters JC
Psychiatr Med 1990;8(2):67-81. PMID: 2185503

See all (38)

Clinical prediction guides

On chronic fatigue syndrome and nosological categories.

Sharif K, Watad A, Bragazzi NL, Lichtbroun M, Martini M, Perricone C, Amital H, Shoenfeld Y
Clin Rheumatol 2018 May;37(5):1161-1170. Epub 2018 Feb 7 doi: 10.1007/s10067-018-4009-2. PMID: 29417255

The impact of depression and cardiophobia on quality of life in patients with essential hypertension.

Tsartsalis D, Dragioti E, Kontoangelos K, Pitsavos C, Sakkas P, Papadimitriou GN, Stefanadis C, Kallikazaros I
Psychiatriki 2016 Jul-Sep;27(3):192-203. doi: 10.22365/jpsych.2016.273.192. PMID: 27837573

Psychological aspects of non-cardiac chest pain.

Serlie AW, Erdman RA, Passchier J, Trijsburg RW, ten Cate FJ
Psychother Psychosom 1995;64(2):62-73. doi: 10.1159/000288993. PMID: 8559955

Neurocirculatory asthenia: a reassessment using modern psychosomatic criteria.

Cardiac involvement in liver cirrhosis.

Gatta A, Merkel C, Sacerdoti D, Angeli P
Ann Ital Med Int 1993 Oct-Dec;8(4):244-7. PMID: 8161481

See all (29)