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Small Intestinal Mucositis

MedGen UID:
305632
•Concept ID:
C1698626
•
Disease or Syndrome

Definition

An inflammatory process affecting the mucous membrane of the small intestine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal Mucositis

Professional guidelines

PubMed

The use of glutamine in the treatment of gastrointestinal disorders in man.
Elia M, Lunn PG
Nutrition 1997 Jul-Aug;13(7-8):743-7. doi: 10.1016/s0899-9007(97)83037-7. PMID: 9263280

Recent clinical studies

Etiology

Dark Agouti rat model of chemotherapy-induced mucositis: establishment and current state of the art.
Vanhoecke B, Bateman E, Mayo B, Vanlancker E, Stringer A, Thorpe D, Keefe D
Exp Biol Med (Maywood) 2015 Jun;240(6):725-41. Epub 2015 May 12 doi: 10.1177/1535370215581309. PMID: 25966981Free PMC Article
The nature of small intestinal mucositis: a video-capsule endoscopy study.
Triantafyllou K, Dervenoulas J, Tsirigotis P, Ladas SD
Support Care Cancer 2008 Oct;16(10):1173-8. Epub 2008 Feb 7 doi: 10.1007/s00520-008-0404-6. PMID: 18256857
A novel non-invasive biomarker for assessment of small intestinal mucositis in children with cancer undergoing chemotherapy.
Tooley KL, Saxon BR, Webster J, Zacharakis B, McNeil Y, Davidson GP, Butler RN
Cancer Biol Ther 2006 Oct;5(10):1275-81. Epub 2006 Oct 20 doi: 10.4161/cbt.5.10.3303. PMID: 17012839

Diagnosis

The nature of small intestinal mucositis: a video-capsule endoscopy study.
Triantafyllou K, Dervenoulas J, Tsirigotis P, Ladas SD
Support Care Cancer 2008 Oct;16(10):1173-8. Epub 2008 Feb 7 doi: 10.1007/s00520-008-0404-6. PMID: 18256857
Roles of growth factors in chemotherapy-induced intestinal mucosal damage repair.
Xian CJ
Curr Pharm Biotechnol 2003 Aug;4(4):260-9. doi: 10.2174/1389201033489793. PMID: 14529428

Therapy

Dark Agouti rat model of chemotherapy-induced mucositis: establishment and current state of the art.
Vanhoecke B, Bateman E, Mayo B, Vanlancker E, Stringer A, Thorpe D, Keefe D
Exp Biol Med (Maywood) 2015 Jun;240(6):725-41. Epub 2015 May 12 doi: 10.1177/1535370215581309. PMID: 25966981Free PMC Article
Chemotherapy-induced modifications to gastrointestinal microflora: evidence and implications of change.
Stringer AM, Gibson RJ, Bowen JM, Keefe DM
Curr Drug Metab 2009 Jan;10(1):79-83. doi: 10.2174/138920009787048419. PMID: 19149515
Chemotherapy-induced mucositis: the role of gastrointestinal microflora and mucins in the luminal environment.
Stringer AM, Gibson RJ, Bowen JM, Logan RM, Yeoh AS, Keefe DM
J Support Oncol 2007 Jun;5(6):259-67. PMID: 17624050
Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies.
Gibson RJ, Keefe DM
Support Care Cancer 2006 Sep;14(9):890-900. Epub 2006 Apr 8 doi: 10.1007/s00520-006-0040-y. PMID: 16604351
The use of glutamine in the treatment of gastrointestinal disorders in man.
Elia M, Lunn PG
Nutrition 1997 Jul-Aug;13(7-8):743-7. doi: 10.1016/s0899-9007(97)83037-7. PMID: 9263280

Prognosis

Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans.
Keefe DM, Brealey J, Goland GJ, Cummins AG
Gut 2000 Nov;47(5):632-7. doi: 10.1136/gut.47.5.632. PMID: 11034578Free PMC Article

Clinical prediction guides

Grape seed extract protects IEC-6 cells from chemotherapy-induced cytotoxicity and improves parameters of small intestinal mucositis in rats with experimentally-induced mucositis.
Cheah KY, Howarth GS, Yazbeck R, Wright TH, Whitford EJ, Payne C, Butler RN, Bastian SE
Cancer Biol Ther 2009 Feb;8(4):382-90. Epub 2009 Feb 18 doi: 10.4161/cbt.8.4.7453. PMID: 19305141
Chemotherapy-induced modifications to gastrointestinal microflora: evidence and implications of change.
Stringer AM, Gibson RJ, Bowen JM, Keefe DM
Curr Drug Metab 2009 Jan;10(1):79-83. doi: 10.2174/138920009787048419. PMID: 19149515
Chemotherapy-induced mucositis: the role of gastrointestinal microflora and mucins in the luminal environment.
Stringer AM, Gibson RJ, Bowen JM, Logan RM, Yeoh AS, Keefe DM
J Support Oncol 2007 Jun;5(6):259-67. PMID: 17624050
A novel non-invasive biomarker for assessment of small intestinal mucositis in children with cancer undergoing chemotherapy.
Tooley KL, Saxon BR, Webster J, Zacharakis B, McNeil Y, Davidson GP, Butler RN
Cancer Biol Ther 2006 Oct;5(10):1275-81. Epub 2006 Oct 20 doi: 10.4161/cbt.5.10.3303. PMID: 17012839
Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies.
Gibson RJ, Keefe DM
Support Care Cancer 2006 Sep;14(9):890-900. Epub 2006 Apr 8 doi: 10.1007/s00520-006-0040-y. PMID: 16604351

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