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Rh Incompatibility

MedGen UID:
306156
•Concept ID:
C1504421
•
Pathologic Function
Synonyms: Incompatibility, Rh; Rh Incompatibilities

Definition

A complication during pregnancy; it occurs when the mother is Rh-negative and the infant is Rh-positive. This complication generally does not affect first-born Rh-positive babies. Rh-positive newborn babies from subsequent pregnancies develop complications of Rh incompatibility which include hemolysis, jaundice, enlarged liver and spleen, petechiae, hypotonia, neurologic damage, and heart problems. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRh Incompatibility

Professional guidelines

PubMed

Neonatal Hyperbilirubinemia treatment by Locally Made Low-Cost Phototherapy Units.
Gidi NW, Siebeck M
Ethiop J Health Sci 2021 Jan;31(1):55-62. doi: 10.4314/ejhs.v31i1.7. PMID: 34158752Free PMC Article
Cardiac anesthesia risk management. Hemorrhage, coagulation, and transfusion: a risk-benefit analysis.
Spiess BD
J Cardiothorac Vasc Anesth 1994 Feb;8(1 Suppl 1):19-22. doi: 10.1016/1053-0770(94)90612-2. PMID: 8167299
Treatment in Rh incompatibility.
Lozińska D
Arch Immunol Ther Exp (Warsz) 1978;26(1-6):1111-5. PMID: 107912

Recent clinical studies

Etiology

Comparison of severity and prognosis of jaundice due to Rh incompatibility and G6PD deficiency.
Zakerihamidi M, Moradi A, Boskabadi H
Transfus Apher Sci 2023 Aug;62(4):103714. Epub 2023 Apr 25 doi: 10.1016/j.transci.2023.103714. PMID: 37164807
Bilirubin crystals in neutrophils of a newborn with Rh incompatibility.
Niu X, Liu L, Li H, Wang J, Zhao J, Liu J
Pediatr Blood Cancer 2023 Mar;70(3):e30040. Epub 2022 Nov 1 doi: 10.1002/pbc.30040. PMID: 36317559
Determinants of neonatal jaundice in Ethiopia: a systematic review and meta-analysis.
Belay HG, Debebe GA, Ayele AD, Kassa BG, Mihretie GN, Worke MD
World J Pediatr 2022 Nov;18(11):725-733. Epub 2022 Sep 16 doi: 10.1007/s12519-022-00597-3. PMID: 36114364
Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis.
Gardener H, Spiegelman D, Buka SL
Pediatrics 2011 Aug;128(2):344-55. Epub 2011 Jul 11 doi: 10.1542/peds.2010-1036. PMID: 21746727Free PMC Article
The environment and susceptibility to schizophrenia.
Brown AS
Prog Neurobiol 2011 Jan;93(1):23-58. Epub 2010 Oct 16 doi: 10.1016/j.pneurobio.2010.09.003. PMID: 20955757Free PMC Article

Diagnosis

Comparison of severity and prognosis of jaundice due to Rh incompatibility and G6PD deficiency.
Zakerihamidi M, Moradi A, Boskabadi H
Transfus Apher Sci 2023 Aug;62(4):103714. Epub 2023 Apr 25 doi: 10.1016/j.transci.2023.103714. PMID: 37164807
Retrospective analysis of direct antiglobulin test positivity at tertiary academic hospital over 10 years.
Rahmati A, Farhat AS, Boroumand-Noughabi S, Soleymani F, Keramati M
Transfus Apher Sci 2022 Jun;61(3):103358. Epub 2022 Jan 19 doi: 10.1016/j.transci.2022.103358. PMID: 35074271
Hematological profile in neonatal jaundice.
Mishra JP, Mishra J, Padhi RK, Mishra S, Manjareeka M
J Basic Clin Physiol Pharmacol 2014 May 1;25(2):225-8. doi: 10.1515/jbcpp-2013-0087. PMID: 24114906
The role of calprotectin in obstetrics and gynecology.
Kostakis ID, Cholidou KG, Kallianidis K, Perrea D, Antsaklis A
Eur J Obstet Gynecol Reprod Biol 2010 Jul;151(1):3-9. Epub 2010 Apr 7 doi: 10.1016/j.ejogrb.2010.03.006. PMID: 20378239
Diagnosis and therapy in Rh-incompatibility.
Dudenhausen JW
Early Hum Dev 1992 Jun-Jul;29(1-3):237-40. doi: 10.1016/0378-3782(92)90159-e. PMID: 1396246

Therapy

Determinants of neonatal jaundice in Ethiopia: a systematic review and meta-analysis.
Belay HG, Debebe GA, Ayele AD, Kassa BG, Mihretie GN, Worke MD
World J Pediatr 2022 Nov;18(11):725-733. Epub 2022 Sep 16 doi: 10.1007/s12519-022-00597-3. PMID: 36114364
Is the management of Rh-Rh incompatibility with noninvasive fetal Rh genotyping for targeted prophylaxis cost-effective in the Turkish population?
Demirel E, Kelekçi S, Ekmekci E, Şengül M, İri R, Atasever M
Turk J Med Sci 2018 Feb 23;48(1):1-4. doi: 10.3906/sag-1511-87. PMID: 29479934
Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis.
Gardener H, Spiegelman D, Buka SL
Pediatrics 2011 Aug;128(2):344-55. Epub 2011 Jul 11 doi: 10.1542/peds.2010-1036. PMID: 21746727Free PMC Article
The environment and susceptibility to schizophrenia.
Brown AS
Prog Neurobiol 2011 Jan;93(1):23-58. Epub 2010 Oct 16 doi: 10.1016/j.pneurobio.2010.09.003. PMID: 20955757Free PMC Article
Massive blood transfusion.
Downes K, Sarode R
Indian J Pediatr 2001 Feb;68(2):145-9. doi: 10.1007/BF02722034. PMID: 11284183

Prognosis

Comparison of severity and prognosis of jaundice due to Rh incompatibility and G6PD deficiency.
Zakerihamidi M, Moradi A, Boskabadi H
Transfus Apher Sci 2023 Aug;62(4):103714. Epub 2023 Apr 25 doi: 10.1016/j.transci.2023.103714. PMID: 37164807
Direct antiglobulin test in the prediction of hyperbilirubinemia and predischarge bilirubin levels in infants with mother-infant blood type incompatibility.
Mehta R, Petrova A
Pediatr Neonatol 2021 Jul;62(4):406-411. Epub 2021 Apr 22 doi: 10.1016/j.pedneo.2021.04.002. PMID: 33967007
Effect of Amniotomy on Outcome of Spontaneous Labour.
Afrose R, Mirza TT, Sarker K, Shamsi S, Chowdhury UW, Shikha SS, Akhter S, Jahan R, Fatema S, Dey S
Mymensingh Med J 2021 Jan;30(1):6-12. PMID: 33397844
The role of calprotectin in obstetrics and gynecology.
Kostakis ID, Cholidou KG, Kallianidis K, Perrea D, Antsaklis A
Eur J Obstet Gynecol Reprod Biol 2010 Jul;151(1):3-9. Epub 2010 Apr 7 doi: 10.1016/j.ejogrb.2010.03.006. PMID: 20378239
Prognosis in Rh incompatibility.
Lozińska D
Arch Immunol Ther Exp (Warsz) 1978;26(1-6):1121-5. PMID: 107914

Clinical prediction guides

Direct antiglobulin test in the prediction of hyperbilirubinemia and predischarge bilirubin levels in infants with mother-infant blood type incompatibility.
Mehta R, Petrova A
Pediatr Neonatol 2021 Jul;62(4):406-411. Epub 2021 Apr 22 doi: 10.1016/j.pedneo.2021.04.002. PMID: 33967007
Effect of Amniotomy on Outcome of Spontaneous Labour.
Afrose R, Mirza TT, Sarker K, Shamsi S, Chowdhury UW, Shikha SS, Akhter S, Jahan R, Fatema S, Dey S
Mymensingh Med J 2021 Jan;30(1):6-12. PMID: 33397844
Evaluation of neonatal jaundice in the Makkah region.
Alkhotani A, Eldin EE, Zaghloul A, Mujahid S
Sci Rep 2014 Apr 25;4:4802. doi: 10.1038/srep04802. PMID: 24763104Free PMC Article
Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis.
Gardener H, Spiegelman D, Buka SL
Pediatrics 2011 Aug;128(2):344-55. Epub 2011 Jul 11 doi: 10.1542/peds.2010-1036. PMID: 21746727Free PMC Article
The environment and susceptibility to schizophrenia.
Brown AS
Prog Neurobiol 2011 Jan;93(1):23-58. Epub 2010 Oct 16 doi: 10.1016/j.pneurobio.2010.09.003. PMID: 20955757Free PMC Article

Recent systematic reviews

Determinants of neonatal jaundice in Ethiopia: a systematic review and meta-analysis.
Belay HG, Debebe GA, Ayele AD, Kassa BG, Mihretie GN, Worke MD
World J Pediatr 2022 Nov;18(11):725-733. Epub 2022 Sep 16 doi: 10.1007/s12519-022-00597-3. PMID: 36114364

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