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Pharyngeal Mucositis

MedGen UID:
306501
•Concept ID:
C1699324
•
Disease or Syndrome

Definition

An inflammatory process affecting the mucous membrane of the pharynx. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPharyngeal Mucositis

Professional guidelines

PubMed

Enteral nutrition support and treatment toxicities in patients with head and neck cancer receiving definitive or adjuvant helical intensity-modulated radiotherapy with concurrent chemotherapy.
Blake CL, Brown TE, Pelecanos A, Moroney LB, Helios J, Hughes BGM, Chua B, Kenny LM
Head Neck 2023 Feb;45(2):417-430. Epub 2022 Nov 25 doi: 10.1002/hed.27249. PMID: 36433667
Mucositis: current management and investigations.
Garden AS
Semin Radiat Oncol 2003 Jul;13(3):267-73. doi: 10.1016/S1053-4296(03)00028-6. PMID: 12903015

Recent clinical studies

Etiology

Cetuximab Plus Concurrent Radiotherapy in Patients With Nasopharyngeal Carcinoma.
Yamauchi M, Sato Y, Ishida T, Minesaki A, Shimazaki E, Kuratomi Y
In Vivo 2023 Sep-Oct;37(5):2224-2228. doi: 10.21873/invivo.13323. PMID: 37652522Free PMC Article
Objective evaluation of nutritional status using the prognostic nutritional index during and after chemoradiotherapy in Japanese patients with head and neck cancer: a retrospective study.
Fujiwara D, Tsubaki M, Takeda T, Miura M, Nishida S, Sakaguchi K
Eur J Hosp Pharm 2021 Sep;28(5):266-270. Epub 2019 Aug 17 doi: 10.1136/ejhpharm-2019-001979. PMID: 34426479Free PMC Article
Retrospective evaluation of the safety of low-level laser therapy/photobiomodulation in patients with head/neck cancer.
Genot-Klastersky MT, Paesmans M, Ameye L, Kayumba A, Beauvois S, Dragan T, Van Gestel D, Lalami Y, Klastersky JA
Support Care Cancer 2020 Jul;28(7):3015-3022. Epub 2019 Sep 9 doi: 10.1007/s00520-019-05041-3. PMID: 31502227
Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT±concurrent chemotherapy.
Moroney LB, Helios J, Ward EC, Crombie J, Wockner LF, Burns CL, Spurgin AL, Blake C, Kenny L, Hughes BG
Oral Oncol 2017 Jan;64:1-8. Epub 2016 Nov 25 doi: 10.1016/j.oraloncology.2016.11.009. PMID: 28024718
A randomised controlled trial of Caphosol mouthwash in management of radiation-induced mucositis in head and neck cancer.
Wong KH, Kuciejewska A, Sharabiani MTA, Ng-Cheng-Hin B, Hoy S, Hurley T, Rydon J, Grove L, Santos A, Ryugenji M, Bhide SA, Nutting CM, Harrington KJ, Newbold KL
Radiother Oncol 2017 Feb;122(2):207-211. Epub 2016 Jul 5 doi: 10.1016/j.radonc.2016.06.015. PMID: 27393218Free PMC Article

Diagnosis

Cetuximab Plus Concurrent Radiotherapy in Patients With Nasopharyngeal Carcinoma.
Yamauchi M, Sato Y, Ishida T, Minesaki A, Shimazaki E, Kuratomi Y
In Vivo 2023 Sep-Oct;37(5):2224-2228. doi: 10.21873/invivo.13323. PMID: 37652522Free PMC Article
Endoscopic surgery compared with intensity-modulated radiotherapy in resectable locally recurrent nasopharyngeal carcinoma: a multicentre, open-label, randomised, controlled, phase 3 trial.
Liu YP, Wen YH, Tang J, Wei Y, You R, Zhu XL, Li J, Chen L, Ling L, Zhang N, Zou X, Hua YJ, Chen YM, Chen L, Lu LX, Chen MY, Wen WP
Lancet Oncol 2021 Mar;22(3):381-390. Epub 2021 Feb 15 doi: 10.1016/S1470-2045(20)30673-2. PMID: 33600761
Retrospective evaluation of the safety of low-level laser therapy/photobiomodulation in patients with head/neck cancer.
Genot-Klastersky MT, Paesmans M, Ameye L, Kayumba A, Beauvois S, Dragan T, Van Gestel D, Lalami Y, Klastersky JA
Support Care Cancer 2020 Jul;28(7):3015-3022. Epub 2019 Sep 9 doi: 10.1007/s00520-019-05041-3. PMID: 31502227
Non-endemic locoregionally advanced nasopharyngeal carcinoma: long-term outcome after induction plus concurrent chemoradiotherapy in everyday clinical practice.
Boscolo-Rizzo P, Tirelli G, Mantovani M, Baggio V, Lupato V, Spinato G, Gava A, Da Mosto MC
Eur Arch Otorhinolaryngol 2015 Nov;272(11):3491-8. Epub 2014 Nov 4 doi: 10.1007/s00405-014-3369-8. PMID: 25367705
General anesthetic management for diagnostic splenectomy in a patient with paraneoplastic pemphigus.
Jeng CS, Chan KC, Su CF, Mok MS, Lin CJ, Sun WZ
J Formos Med Assoc 2003 Jul;102(7):497-500. PMID: 14517589

Therapy

Cetuximab Plus Concurrent Radiotherapy in Patients With Nasopharyngeal Carcinoma.
Yamauchi M, Sato Y, Ishida T, Minesaki A, Shimazaki E, Kuratomi Y
In Vivo 2023 Sep-Oct;37(5):2224-2228. doi: 10.21873/invivo.13323. PMID: 37652522Free PMC Article
Radiobiological modeling of radiation-induced acute mucosal toxicity (oral mucositis and pharyngeal mucositis): A single-institutional study of head-and-neck carcinoma.
Singh B, Singh G, Oinam AS, Kumar V, Vashistha R, Sidhu MS, Singh M
J Cancer Res Ther 2023 Apr;19(Supplement):S0-S1715. doi: 10.4103/jcrt.jcrt_504_21. PMID: 37147947
Clinical Implementation of Robust Multi-isocentric Volumetric Modulated Arc Radiotherapy for Craniospinal Irradiation.
Smyth G, Mowat S, Chia K, Robinson K, Warren-Oseni K, Welsh LC, Blasiak-Wal I, Mandeville HC
Clin Oncol (R Coll Radiol) 2022 Apr;34(4):211-219. Epub 2022 Jan 19 doi: 10.1016/j.clon.2022.01.004. PMID: 35063327
Objective evaluation of nutritional status using the prognostic nutritional index during and after chemoradiotherapy in Japanese patients with head and neck cancer: a retrospective study.
Fujiwara D, Tsubaki M, Takeda T, Miura M, Nishida S, Sakaguchi K
Eur J Hosp Pharm 2021 Sep;28(5):266-270. Epub 2019 Aug 17 doi: 10.1136/ejhpharm-2019-001979. PMID: 34426479Free PMC Article
Mucositis: current management and investigations.
Garden AS
Semin Radiat Oncol 2003 Jul;13(3):267-73. doi: 10.1016/S1053-4296(03)00028-6. PMID: 12903015

Prognosis

A multicenter phase Ib trial of the histone deacetylase inhibitor entinostat in combination with pembrolizumab in patients with myelodysplastic syndromes/neoplasms or acute myeloid leukemia refractory to hypomethylating agents.
Bewersdorf JP, Shallis RM, Sharon E, Park S, Ramaswamy R, Roe CE, Irish JM, Caldwell A, Wei W, Yacoub A, Madanat YF, Zeidner JF, Altman JK, Odenike O, Yerrabothala S, Kovacsovics T, Podoltsev NA, Halene S, Little RF, Piekarz R, Gore SD, Kim TK, Zeidan AM
Ann Hematol 2024 Jan;103(1):105-116. Epub 2023 Dec 1 doi: 10.1007/s00277-023-05552-4. PMID: 38036712
Objective evaluation of nutritional status using the prognostic nutritional index during and after chemoradiotherapy in Japanese patients with head and neck cancer: a retrospective study.
Fujiwara D, Tsubaki M, Takeda T, Miura M, Nishida S, Sakaguchi K
Eur J Hosp Pharm 2021 Sep;28(5):266-270. Epub 2019 Aug 17 doi: 10.1136/ejhpharm-2019-001979. PMID: 34426479Free PMC Article
Endoscopic surgery compared with intensity-modulated radiotherapy in resectable locally recurrent nasopharyngeal carcinoma: a multicentre, open-label, randomised, controlled, phase 3 trial.
Liu YP, Wen YH, Tang J, Wei Y, You R, Zhu XL, Li J, Chen L, Ling L, Zhang N, Zou X, Hua YJ, Chen YM, Chen L, Lu LX, Chen MY, Wen WP
Lancet Oncol 2021 Mar;22(3):381-390. Epub 2021 Feb 15 doi: 10.1016/S1470-2045(20)30673-2. PMID: 33600761
Retrospective evaluation of the safety of low-level laser therapy/photobiomodulation in patients with head/neck cancer.
Genot-Klastersky MT, Paesmans M, Ameye L, Kayumba A, Beauvois S, Dragan T, Van Gestel D, Lalami Y, Klastersky JA
Support Care Cancer 2020 Jul;28(7):3015-3022. Epub 2019 Sep 9 doi: 10.1007/s00520-019-05041-3. PMID: 31502227
Non-endemic locoregionally advanced nasopharyngeal carcinoma: long-term outcome after induction plus concurrent chemoradiotherapy in everyday clinical practice.
Boscolo-Rizzo P, Tirelli G, Mantovani M, Baggio V, Lupato V, Spinato G, Gava A, Da Mosto MC
Eur Arch Otorhinolaryngol 2015 Nov;272(11):3491-8. Epub 2014 Nov 4 doi: 10.1007/s00405-014-3369-8. PMID: 25367705

Clinical prediction guides

Cetuximab Plus Concurrent Radiotherapy in Patients With Nasopharyngeal Carcinoma.
Yamauchi M, Sato Y, Ishida T, Minesaki A, Shimazaki E, Kuratomi Y
In Vivo 2023 Sep-Oct;37(5):2224-2228. doi: 10.21873/invivo.13323. PMID: 37652522Free PMC Article
Clinical Outcomes of Intensity-modulated Carbon-ion Radiotherapy for Bone and Soft Tissue Tumors.
Takakusagi Y, Koge H, Kano K, Shima S, Tsuchida K, Mizoguchi N, Yoshida D, Kamada T, Katoh H
Anticancer Res 2023 Jun;43(6):2777-2781. doi: 10.21873/anticanres.16446. PMID: 37247930
Real-world clinical outcomes in Japanese patients with locally advanced squamous cell carcinoma of the head and neck treated with radiotherapy plus cetuximab: a prospective observational study (JROSG12-2).
Ota Y, Kodaira T, Fujii H, Shimokawa M, Yokota T, Nakashima T, Monden N, Homma A, Ueda S, Akimoto T
Int J Clin Oncol 2022 Nov;27(11):1675-1683. Epub 2022 Aug 24 doi: 10.1007/s10147-022-02228-3. PMID: 36001247
Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT±concurrent chemotherapy.
Moroney LB, Helios J, Ward EC, Crombie J, Wockner LF, Burns CL, Spurgin AL, Blake C, Kenny L, Hughes BG
Oral Oncol 2017 Jan;64:1-8. Epub 2016 Nov 25 doi: 10.1016/j.oraloncology.2016.11.009. PMID: 28024718
A randomised controlled trial of Caphosol mouthwash in management of radiation-induced mucositis in head and neck cancer.
Wong KH, Kuciejewska A, Sharabiani MTA, Ng-Cheng-Hin B, Hoy S, Hurley T, Rydon J, Grove L, Santos A, Ryugenji M, Bhide SA, Nutting CM, Harrington KJ, Newbold KL
Radiother Oncol 2017 Feb;122(2):207-211. Epub 2016 Jul 5 doi: 10.1016/j.radonc.2016.06.015. PMID: 27393218Free PMC Article

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