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Cerebral abscess

MedGen UID:
307135
•Concept ID:
C1510428
•
Disease or Syndrome
Synonyms: Abscess, Cerebral; Abscesses, Cerebral; Cerebral Abscess; Cerebral Abscesses
SNOMED CT: Cerebral abscess (60404007); Parenchymal intracranial abscess (60404007)

Definition

A bacterial, fungal, or parasitic abscess that develops in the cerebral hemispheres. Causes include skull trauma, middle ear infection, congenital heart disease, and frontal and ethmoid sinus infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebral abscess

Professional guidelines

PubMed

European society of Clinical Microbiology and Infectious Diseases guidelines on diagnosis and treatment of brain abscess in children and adults.
Bodilsen J, D'Alessandris QG, Humphreys H, Iro MA, Klein M, Last K, Montesinos IL, Pagliano P, Sipahi OR, San-Juan R, Tattevin P, Thurnher M, de J Treviño-Rangel R, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2024 Jan;30(1):66-89. Epub 2023 Aug 29 doi: 10.1016/j.cmi.2023.08.016. PMID: 37648062
Diagnosis and endovascular management of pulmonary arteriovenous malformations.
Kramdhari H, Valakkada J, Ayyappan A
Br J Radiol 2021 Jul 1;94(1123):20200695. Epub 2021 May 26 doi: 10.1259/bjr.20200695. PMID: 34038182Free PMC Article
Diagnosis, management and treatment of orbital and periorbital cellulitis in children.
Rashed F, Cannon A, Heaton PA, Paul SP
Emerg Nurse 2016 Apr;24(1):30-5; quiz 37. doi: 10.7748/en.24.1.30.s25. PMID: 27056016

Recent clinical studies

Etiology

European society of Clinical Microbiology and Infectious Diseases guidelines on diagnosis and treatment of brain abscess in children and adults.
Bodilsen J, D'Alessandris QG, Humphreys H, Iro MA, Klein M, Last K, Montesinos IL, Pagliano P, Sipahi OR, San-Juan R, Tattevin P, Thurnher M, de J Treviño-Rangel R, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2024 Jan;30(1):66-89. Epub 2023 Aug 29 doi: 10.1016/j.cmi.2023.08.016. PMID: 37648062
Brain abscess in pediatric age: a review.
Mameli C, Genoni T, Madia C, Doneda C, Penagini F, Zuccotti G
Childs Nerv Syst 2019 Jul;35(7):1117-1128. Epub 2019 May 6 doi: 10.1007/s00381-019-04182-4. PMID: 31062139
Embolisation for pulmonary arteriovenous malformation.
Hsu CC, Kwan GN, Evans-Barns H, van Driel ML
Cochrane Database Syst Rev 2018 Jan 4;1(1):CD008017. doi: 10.1002/14651858.CD008017.pub5. PMID: 29298459Free PMC Article
Neurological sequelae of bacterial meningitis.
Lucas MJ, Brouwer MC, van de Beek D
J Infect 2016 Jul;73(1):18-27. Epub 2016 Apr 19 doi: 10.1016/j.jinf.2016.04.009. PMID: 27105658
Pulmonary arteriovenous malformations.
Cartin-Ceba R, Swanson KL, Krowka MJ
Chest 2013 Sep;144(3):1033-1044. doi: 10.1378/chest.12-0924. PMID: 24008954

Diagnosis

European society of Clinical Microbiology and Infectious Diseases guidelines on diagnosis and treatment of brain abscess in children and adults.
Bodilsen J, D'Alessandris QG, Humphreys H, Iro MA, Klein M, Last K, Montesinos IL, Pagliano P, Sipahi OR, San-Juan R, Tattevin P, Thurnher M, de J Treviño-Rangel R, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2024 Jan;30(1):66-89. Epub 2023 Aug 29 doi: 10.1016/j.cmi.2023.08.016. PMID: 37648062
Role of imaging in CNS infections.
Sharath Kumar GG, Adiga CP, Iyer PP, Goolahally LN
Indian J Pathol Microbiol 2022 May;65(Supplement):S153-S163. doi: 10.4103/ijpm.ijpm_1162_21. PMID: 35562146
Brain abscess in pediatric age: a review.
Mameli C, Genoni T, Madia C, Doneda C, Penagini F, Zuccotti G
Childs Nerv Syst 2019 Jul;35(7):1117-1128. Epub 2019 May 6 doi: 10.1007/s00381-019-04182-4. PMID: 31062139
Maxillofacial cellulitis.
de-Vicente-Rodríguez JC
Med Oral Patol Oral Cir Bucal 2004;9 Suppl:133-8; 126-33. PMID: 15580131
Cerebral abscess.
Williams B
Br J Neurosurg 1990;4(4):248-51. doi: 10.3109/02688699008992733. PMID: 1977413

Therapy

European society of Clinical Microbiology and Infectious Diseases guidelines on diagnosis and treatment of brain abscess in children and adults.
Bodilsen J, D'Alessandris QG, Humphreys H, Iro MA, Klein M, Last K, Montesinos IL, Pagliano P, Sipahi OR, San-Juan R, Tattevin P, Thurnher M, de J Treviño-Rangel R, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2024 Jan;30(1):66-89. Epub 2023 Aug 29 doi: 10.1016/j.cmi.2023.08.016. PMID: 37648062
Brain abscess in pediatric age: a review.
Mameli C, Genoni T, Madia C, Doneda C, Penagini F, Zuccotti G
Childs Nerv Syst 2019 Jul;35(7):1117-1128. Epub 2019 May 6 doi: 10.1007/s00381-019-04182-4. PMID: 31062139
Embolisation for pulmonary arteriovenous malformation.
Hsu CC, Kwan GN, Evans-Barns H, van Driel ML
Cochrane Database Syst Rev 2018 Jan 4;1(1):CD008017. doi: 10.1002/14651858.CD008017.pub5. PMID: 29298459Free PMC Article
Cerebral nocardiosis.
Naqi R, Ahsan H, Azeemuddin M
J Pak Med Assoc 2011 Jul;61(7):697-9. PMID: 22204250
Maxillofacial cellulitis.
de-Vicente-Rodríguez JC
Med Oral Patol Oral Cir Bucal 2004;9 Suppl:133-8; 126-33. PMID: 15580131

Prognosis

Clinical features and prognostic factors in adults with brain abscess.
Bodilsen J, Duerlund LS, Mariager T, Brandt CT, Petersen PT, Larsen L, Hansen BR, Omland LH, Tetens MM, Wiese L, Jørgensen RL, Leth S, Nielsen H; DASGIB study group
Brain 2023 Apr 19;146(4):1637-1647. doi: 10.1093/brain/awac312. PMID: 36037264
First case report of cerebral abscess from Nocardia terpenica and literature review.
Sher M, Heard T, Munckhof W, Schwindack C
Clin Neurol Neurosurg 2022 Sep;220:107341. Epub 2022 Jun 21 doi: 10.1016/j.clineuro.2022.107341. PMID: 35779502
Neurological sequelae of bacterial meningitis.
Lucas MJ, Brouwer MC, van de Beek D
J Infect 2016 Jul;73(1):18-27. Epub 2016 Apr 19 doi: 10.1016/j.jinf.2016.04.009. PMID: 27105658
Pulmonary arteriovenous malformations.
Cartin-Ceba R, Swanson KL, Krowka MJ
Chest 2013 Sep;144(3):1033-1044. doi: 10.1378/chest.12-0924. PMID: 24008954
Neurosurgical aspects of central nervous system infections.
Heth JA
Neuroimaging Clin N Am 2012 Nov;22(4):791-9. doi: 10.1016/j.nic.2012.05.005. PMID: 23122267

Clinical prediction guides

European society of Clinical Microbiology and Infectious Diseases guidelines on diagnosis and treatment of brain abscess in children and adults.
Bodilsen J, D'Alessandris QG, Humphreys H, Iro MA, Klein M, Last K, Montesinos IL, Pagliano P, Sipahi OR, San-Juan R, Tattevin P, Thurnher M, de J Treviño-Rangel R, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2024 Jan;30(1):66-89. Epub 2023 Aug 29 doi: 10.1016/j.cmi.2023.08.016. PMID: 37648062
Early switch to oral antimicrobials in brain abscess: a narrative review.
Bodilsen J, Nielsen H
Clin Microbiol Infect 2023 Sep;29(9):1139-1143. Epub 2023 Apr 28 doi: 10.1016/j.cmi.2023.04.026. PMID: 37119987
Brain abscess in pediatric age: a review.
Mameli C, Genoni T, Madia C, Doneda C, Penagini F, Zuccotti G
Childs Nerv Syst 2019 Jul;35(7):1117-1128. Epub 2019 May 6 doi: 10.1007/s00381-019-04182-4. PMID: 31062139
Embolisation for pulmonary arteriovenous malformation.
Hsu CC, Kwan GN, Evans-Barns H, van Driel ML
Cochrane Database Syst Rev 2018 Jan 4;1(1):CD008017. doi: 10.1002/14651858.CD008017.pub5. PMID: 29298459Free PMC Article
Embolisation for pulmonary arteriovenous malformation.
Hsu CC, Kwan GN, Thompson SA, Evans-Barns H, van Driel ML
Cochrane Database Syst Rev 2015 Jan 29;1:CD008017. doi: 10.1002/14651858.CD008017.pub4. PMID: 25634560

Recent systematic reviews

The connection between brain abscess and odontogenic infections: A systematic review.
Lisboa ECC, Silva WO, Rodrigues RCV, Brum SC, Alves FRF
Arch Oral Biol 2022 Mar;135:105360. Epub 2022 Jan 31 doi: 10.1016/j.archoralbio.2022.105360. PMID: 35121265
Nocardia farcinica cerebral abscess: A systematic review of treatment strategies.
Beucler N, Farah K, Choucha A, Meyer M, Fuentes S, Seng P, Dufour H
Neurochirurgie 2022 Jan;68(1):94-101. Epub 2021 May 11 doi: 10.1016/j.neuchi.2021.04.022. PMID: 33989644
Embolisation for pulmonary arteriovenous malformation.
Hsu CC, Kwan GN, Evans-Barns H, van Driel ML
Cochrane Database Syst Rev 2018 Jan 4;1(1):CD008017. doi: 10.1002/14651858.CD008017.pub5. PMID: 29298459Free PMC Article
Central nervous system melioidosis in the pediatric age group: review.
Prasad GL, Kini P, Divya S
Childs Nerv Syst 2017 Jun;33(6):1-6. Epub 2017 Apr 27 doi: 10.1007/s00381-017-3422-1. PMID: 28451778
Embolisation for pulmonary arteriovenous malformation.
Hsu CC, Kwan GN, Thompson SA, Evans-Barns H, van Driel ML
Cochrane Database Syst Rev 2015 Jan 29;1:CD008017. doi: 10.1002/14651858.CD008017.pub4. PMID: 25634560

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