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Chronic uveitis

MedGen UID:
307139
•Concept ID:
C1510449
•
Disease or Syndrome
Synonyms: Chronic inflammation of uveal tract; Chronic Iridocyclitis
SNOMED CT: Chronic inflammation of uveal tract (444248002); Chronic uveitis (444248002)

Definition

Uveitis that is usually insidious in onset, bilateral, and can be asymptomatic, most often affecting the anterior uveal tract, including the iris and ciliary body, and can result in long-term complications. It is most commonly associated with certain forms of juvenile idiopathic arthritis, but may occur independent of arthritis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic uveitis

Professional guidelines

PubMed

French recommendations for the management of non-infectious chronic uveitis.
Quartier P, Saadoun D, Belot A, Errera MH, Kaplanski G, Kodjikian L, Kone-Paut I, Miceli-Richard C, Monnet D, Audouin-Pajot C, Seve P, Uettwiller F, Weber M, Bodaghi B; Collaborators
Rev Med Interne 2023 May;44(5):227-252. Epub 2023 May 3 doi: 10.1016/j.revmed.2023.04.002. PMID: 37147233
Challenges and management of childhood noninfectious chronic uveitis.
Maccora I, Marrani E, Pagnini I, Mastrolia MV, de Libero C, Caputo R, Simonini G
Expert Rev Clin Immunol 2023 Jun;19(6):599-611. Epub 2023 Apr 3 doi: 10.1080/1744666X.2023.2198210. PMID: 36996498
Treatment Options for Juvenile Idiopathic Arthritis (JIA) Associated Uveitis.
Amin RM, Miserocchi E, Thorne JE, Hornbeak D, Jabs DA, Zierhut M
Ocul Immunol Inflamm 2016;24(1):81-90. Epub 2015 Dec 11 doi: 10.3109/09273948.2015.1077976. PMID: 26652068

Recent clinical studies

Etiology

Challenges and management of childhood noninfectious chronic uveitis.
Maccora I, Marrani E, Pagnini I, Mastrolia MV, de Libero C, Caputo R, Simonini G
Expert Rev Clin Immunol 2023 Jun;19(6):599-611. Epub 2023 Apr 3 doi: 10.1080/1744666X.2023.2198210. PMID: 36996498
ROSAH syndrome mimicking chronic uveitis.
Fardeau C, Alafaleq M, Dhaenens CM, Dollfus H, Koné-Paut I, Grunewald O, Morel JB, Titah C, Saadoun D, Lazeran PO, Meunier I
Clin Genet 2023 Apr;103(4):453-458. Epub 2022 Dec 30 doi: 10.1111/cge.14286. PMID: 36543582
Chronic Uveitis in Children.
Kumar P, Gupta A, Bansal R, Suri D, Gupta V, Gupta A, Singh S
Indian J Pediatr 2022 Apr;89(4):358-363. Epub 2021 Nov 3 doi: 10.1007/s12098-021-03884-5. PMID: 34731440
Epidemiology of Macular Edema in Uveitis.
Accorinti M, Okada AA, Smith JR, Gilardi M
Ocul Immunol Inflamm 2019;27(2):169-180. Epub 2019 Mar 1 doi: 10.1080/09273948.2019.1576910. PMID: 30821631
Uveitis: Diagnostic work-up. A literature review and recommendations from an expert committee.
Sève P, Cacoub P, Bodaghi B, Trad S, Sellam J, Bellocq D, Bielefeld P, Sène D, Kaplanski G, Monnet D, Brézin A, Weber M, Saadoun D, Chiquet C, Kodjikian L
Autoimmun Rev 2017 Dec;16(12):1254-1264. Epub 2017 Oct 14 doi: 10.1016/j.autrev.2017.10.010. PMID: 29037906

Diagnosis

Challenges and management of childhood noninfectious chronic uveitis.
Maccora I, Marrani E, Pagnini I, Mastrolia MV, de Libero C, Caputo R, Simonini G
Expert Rev Clin Immunol 2023 Jun;19(6):599-611. Epub 2023 Apr 3 doi: 10.1080/1744666X.2023.2198210. PMID: 36996498
ROSAH syndrome mimicking chronic uveitis.
Fardeau C, Alafaleq M, Dhaenens CM, Dollfus H, Koné-Paut I, Grunewald O, Morel JB, Titah C, Saadoun D, Lazeran PO, Meunier I
Clin Genet 2023 Apr;103(4):453-458. Epub 2022 Dec 30 doi: 10.1111/cge.14286. PMID: 36543582
Chronic Uveitis in Children.
Kumar P, Gupta A, Bansal R, Suri D, Gupta V, Gupta A, Singh S
Indian J Pediatr 2022 Apr;89(4):358-363. Epub 2021 Nov 3 doi: 10.1007/s12098-021-03884-5. PMID: 34731440
Rheumatology Panel in Pediatric Practice.
Pilania RK, Singh S
Indian Pediatr 2019 May 15;56(5):407-414. PMID: 31102381
Uveitis: Diagnostic work-up. A literature review and recommendations from an expert committee.
Sève P, Cacoub P, Bodaghi B, Trad S, Sellam J, Bellocq D, Bielefeld P, Sène D, Kaplanski G, Monnet D, Brézin A, Weber M, Saadoun D, Chiquet C, Kodjikian L
Autoimmun Rev 2017 Dec;16(12):1254-1264. Epub 2017 Oct 14 doi: 10.1016/j.autrev.2017.10.010. PMID: 29037906

Therapy

Challenges and management of childhood noninfectious chronic uveitis.
Maccora I, Marrani E, Pagnini I, Mastrolia MV, de Libero C, Caputo R, Simonini G
Expert Rev Clin Immunol 2023 Jun;19(6):599-611. Epub 2023 Apr 3 doi: 10.1080/1744666X.2023.2198210. PMID: 36996498
A review of patient-reported outcome measures used in uveitis.
Senthil MP, Simon S, Constable PA
Surv Ophthalmol 2023 Mar-Apr;68(2):225-240. Epub 2022 Nov 15 doi: 10.1016/j.survophthal.2022.11.004. PMID: 36395825
Ocular manifestations of seronegative spondyloarthropathies.
Zagora SL, McCluskey P
Curr Opin Ophthalmol 2014 Nov;25(6):495-501. doi: 10.1097/ICU.0000000000000098. PMID: 25260061
Interleukin-6 blockade in ocular inflammatory diseases.
Mesquida M, Leszczynska A, Llorenç V, Adán A
Clin Exp Immunol 2014 Jun;176(3):301-9. doi: 10.1111/cei.12295. PMID: 24528300Free PMC Article
Uveitis (acute anterior).
Islam N, Pavesio C
BMJ Clin Evid 2010 Apr 8;2010 PMID: 21736765Free PMC Article

Prognosis

ROSAH syndrome mimicking chronic uveitis.
Fardeau C, Alafaleq M, Dhaenens CM, Dollfus H, Koné-Paut I, Grunewald O, Morel JB, Titah C, Saadoun D, Lazeran PO, Meunier I
Clin Genet 2023 Apr;103(4):453-458. Epub 2022 Dec 30 doi: 10.1111/cge.14286. PMID: 36543582
Epidemiology of Macular Edema in Uveitis.
Accorinti M, Okada AA, Smith JR, Gilardi M
Ocul Immunol Inflamm 2019;27(2):169-180. Epub 2019 Mar 1 doi: 10.1080/09273948.2019.1576910. PMID: 30821631
Treatment of uveitis associated with juvenile idiopathic arthritis.
Bou R, Iglesias E, Antón J
Curr Rheumatol Rep 2014 Aug;16(8):437. doi: 10.1007/s11926-014-0437-4. PMID: 24938442
Cataract.
Allen D
BMJ Clin Evid 2011 Feb 15;2011 PMID: 21718561Free PMC Article
Uveitis (acute anterior).
Islam N, Pavesio C
BMJ Clin Evid 2010 Apr 8;2010 PMID: 21736765Free PMC Article

Clinical prediction guides

ROSAH syndrome mimicking chronic uveitis.
Fardeau C, Alafaleq M, Dhaenens CM, Dollfus H, Koné-Paut I, Grunewald O, Morel JB, Titah C, Saadoun D, Lazeran PO, Meunier I
Clin Genet 2023 Apr;103(4):453-458. Epub 2022 Dec 30 doi: 10.1111/cge.14286. PMID: 36543582
Epidemiology of Macular Edema in Uveitis.
Accorinti M, Okada AA, Smith JR, Gilardi M
Ocul Immunol Inflamm 2019;27(2):169-180. Epub 2019 Mar 1 doi: 10.1080/09273948.2019.1576910. PMID: 30821631
Magnetic resonance imaging of uveitis.
Li CQ, Cho AA, Edward NJ, Edward DP, Fajardo RG, Mafee MF
Neuroradiology 2015 Aug;57(8):825-32. Epub 2015 Apr 24 doi: 10.1007/s00234-015-1531-7. PMID: 25903430
Cataract.
Allen D
BMJ Clin Evid 2011 Feb 15;2011 PMID: 21718561Free PMC Article
Uveitis (acute anterior).
Islam N, Pavesio C
BMJ Clin Evid 2010 Apr 8;2010 PMID: 21736765Free PMC Article

Recent systematic reviews

Non-anti-TNF biologic modifier drugs in non-infectious refractory chronic uveitis: The current evidence from a systematic review.
Simonini G, Cimaz R, Jones GT, Macfarlane GJ
Semin Arthritis Rheum 2015 Oct;45(2):238-50. Epub 2015 May 21 doi: 10.1016/j.semarthrit.2015.05.006. PMID: 26164255
Current evidence of anti-tumor necrosis factor α treatment efficacy in childhood chronic uveitis: a systematic review and meta-analysis approach of individual drugs.
Simonini G, Druce K, Cimaz R, Macfarlane GJ, Jones GT
Arthritis Care Res (Hoboken) 2014 Jul;66(7):1073-84. doi: 10.1002/acr.22214. PMID: 24740981
Current evidence of methotrexate efficacy in childhood chronic uveitis: a systematic review and meta-analysis approach.
Simonini G, Paudyal P, Jones GT, Cimaz R, Macfarlane GJ
Rheumatology (Oxford) 2013 May;52(5):825-31. Epub 2012 Aug 9 doi: 10.1093/rheumatology/kes186. PMID: 22879466
Cataract.
Allen D
BMJ Clin Evid 2011 Feb 15;2011 PMID: 21718561Free PMC Article
Uveitis (acute anterior).
Islam N, Pavesio C
BMJ Clin Evid 2010 Apr 8;2010 PMID: 21736765Free PMC Article

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