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Aphasia, Wernicke

MedGen UID:
307140
•Concept ID:
C1510456
•
Mental or Behavioral Dysfunction
Synonyms: Aphasia, Wernicke's Fluent; Aphasias, Wernicke; Dysphasia, Wernicke; Dysphasia, Wernicke's; Dysphasia, Wernickes; Fluent Aphasia, Wernicke; Fluent Aphasia, Wernicke's; Fluent Aphasia, Wernickes; Wernicke Aphasia; Wernicke Aphasias; Wernicke Dysphasia; Wernicke's Dysphasia; Wernicke's Fluent Aphasia

Definition

Impairment in the comprehension of speech and meaning of words, both spoken and written, and of the meanings conveyed by their grammatical relationships in sentences. It is caused by lesions that primarily affect Wernicke''s area, which lies in the posterior perisylvian region of the temporal lobe of the dominant hemisphere. (From Brain & Bannister, Clinical Neurology, 7th ed, p141; Kandel et al., Principles of Neural Science, 3d ed, p846) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAphasia, Wernicke

Professional guidelines

PubMed

Exploring Treatment Fidelity in Persons With Aphasia Autonomously Practicing With Computerized Therapy Materials.
Ball AL, de Riesthal M, Steele RD
Am J Speech Lang Pathol 2018 Mar 1;27(1S):454-463. doi: 10.1044/2017_AJSLP-16-0204. PMID: 29497755
Drug treatment of poststroke aphasia.
Bakheit AM
Expert Rev Neurother 2004 Mar;4(2):211-7. doi: 10.1586/14737175.4.2.211. PMID: 15853562
Stroke and neurodegenerative disorders. 3. Stroke: rehabilitation management.
Bogey RA, Geis CC, Bryant PR, Moroz A, O'neill BJ
Arch Phys Med Rehabil 2004 Mar;85(3 Suppl 1):S15-20. doi: 10.1053/j.apmr.2003.11.011. PMID: 15034852

Recent clinical studies

Etiology

The Wernicke conundrum revisited: evidence from connectome-based lesion-symptom mapping.
Matchin W, den Ouden DB, Hickok G, Hillis AE, Bonilha L, Fridriksson J
Brain 2022 Nov 21;145(11):3916-3930. doi: 10.1093/brain/awac219. PMID: 35727949Free PMC Article
Book talk and aphasia: the power of a book.
Henriksson I, Laakso K
Int J Lang Commun Disord 2020 Jan;55(1):136-148. Epub 2019 Nov 7 doi: 10.1111/1460-6984.12509. PMID: 31697032
Acquired dyslexia in Serbian speakers with Broca's and Wernicke's aphasia.
Vuković M, Vuković I, Miller N
J Commun Disord 2016 May-Jun;61:106-118. Epub 2016 Apr 11 doi: 10.1016/j.jcomdis.2016.04.005. PMID: 27135368
Semantic dementia and persisting Wernicke's aphasia: linguistic and anatomical profiles.
Ogar JM, Baldo JV, Wilson SM, Brambati SM, Miller BL, Dronkers NF, Gorno-Tempini ML
Brain Lang 2011 Apr;117(1):28-33. Epub 2011 Feb 18 doi: 10.1016/j.bandl.2010.11.004. PMID: 21315437Free PMC Article
Picture-naming in aphasia.
Kohn SE, Goodglass H
Brain Lang 1985 Mar;24(2):266-83. doi: 10.1016/0093-934x(85)90135-x. PMID: 3978406

Diagnosis

How Do Clinicians Judge Fluency in Aphasia?
Gordon JK, Clough S
J Speech Lang Hear Res 2022 Apr 4;65(4):1521-1542. Epub 2022 Mar 10 doi: 10.1044/2021_JSLHR-21-00484. PMID: 35271379
Acquired dyslexia in Serbian speakers with Broca's and Wernicke's aphasia.
Vuković M, Vuković I, Miller N
J Commun Disord 2016 May-Jun;61:106-118. Epub 2016 Apr 11 doi: 10.1016/j.jcomdis.2016.04.005. PMID: 27135368
Subcortical aphasia.
Nadeau SE, Crosson B
Brain Lang 1997 Jul;58(3):355-402; discussion 418-23. doi: 10.1006/brln.1997.1707. PMID: 9222518
Clinical forms of aphasia.
Kertesz A
Acta Neurochir Suppl (Wien) 1993;56:52-8. doi: 10.1007/978-3-7091-9239-9_9. PMID: 8498201
Picture-naming in aphasia.
Kohn SE, Goodglass H
Brain Lang 1985 Mar;24(2):266-83. doi: 10.1016/0093-934x(85)90135-x. PMID: 3978406

Therapy

Deciphering the mechanisms of phonological therapy in jargon aphasia.
Bose A, Höbler F, Saddy D
Int J Lang Commun Disord 2019 Jan;54(1):123-142. Epub 2018 Nov 26 doi: 10.1111/1460-6984.12437. PMID: 30474174Free PMC Article
Constraint-induced aphasia therapy versus intensive semantic treatment in fluent aphasia.
Wilssens I, Vandenborre D, van Dun K, Verhoeven J, Visch-Brink E, Mariën P
Am J Speech Lang Pathol 2015 May;24(2):281-94. doi: 10.1044/2015_AJSLP-14-0018. PMID: 25765602
Phonological therapy in jargon aphasia: effects on naming and neologisms.
Bose A
Int J Lang Commun Disord 2013 Sep-Oct;48(5):582-95. Epub 2013 Jul 11 doi: 10.1111/1460-6984.12038. PMID: 24033655
Negotiation of identity in group therapy for aphasia: the Aphasia Café.
Simmons-Mackie N, Elman RJ
Int J Lang Commun Disord 2011 May-Jun;46(3):312-23. doi: 10.3109/13682822.2010.507616. PMID: 21575072
Vascular aphasias: main characteristics of patients hospitalized in acute stroke units.
Godefroy O, Dubois C, Debachy B, Leclerc M, Kreisler A; Lille Stroke Program
Stroke 2002 Mar;33(3):702-5. doi: 10.1161/hs0302.103653. PMID: 11872891

Prognosis

The memory for words: Armand Trousseau on aphasia.
Leblanc R
J Hist Neurosci 2022 Jan-Mar;31(1):1-19. Epub 2021 Jun 11 doi: 10.1080/0964704X.2021.1898909. PMID: 34115961
Auditory, Phonological, and Semantic Factors in the Recovery From Wernicke's Aphasia Poststroke: Predictive Value and Implications for Rehabilitation.
Robson H, Griffiths TD, Grube M, Woollams AM
Neurorehabil Neural Repair 2019 Oct;33(10):800-812. Epub 2019 Aug 16 doi: 10.1177/1545968319868709. PMID: 31416400
The Relationship Between Confrontation Naming and Story Gist Production in Aphasia.
Richardson JD, Dalton SG, Fromm D, Forbes M, Holland A, MacWhinney B
Am J Speech Lang Pathol 2018 Mar 1;27(1S):406-422. doi: 10.1044/2017_AJSLP-16-0211. PMID: 29497752Free PMC Article
Varieties of semantic 'access' deficit in Wernicke's aphasia and semantic aphasia.
Thompson HE, Robson H, Lambon Ralph MA, Jefferies E
Brain 2015 Dec;138(Pt 12):3776-92. Epub 2015 Oct 9 doi: 10.1093/brain/awv281. PMID: 26454668Free PMC Article
Acquired aphasia in children.
Rapin I
J Child Neurol 1995 Jul;10(4):267-70. doi: 10.1177/088307389501000401. PMID: 7594260

Clinical prediction guides

The memory for words: Armand Trousseau on aphasia.
Leblanc R
J Hist Neurosci 2022 Jan-Mar;31(1):1-19. Epub 2021 Jun 11 doi: 10.1080/0964704X.2021.1898909. PMID: 34115961
Book talk and aphasia: the power of a book.
Henriksson I, Laakso K
Int J Lang Commun Disord 2020 Jan;55(1):136-148. Epub 2019 Nov 7 doi: 10.1111/1460-6984.12509. PMID: 31697032
Varieties of semantic 'access' deficit in Wernicke's aphasia and semantic aphasia.
Thompson HE, Robson H, Lambon Ralph MA, Jefferies E
Brain 2015 Dec;138(Pt 12):3776-92. Epub 2015 Oct 9 doi: 10.1093/brain/awv281. PMID: 26454668Free PMC Article
Differences between conduction aphasia and Wernicke's aphasia.
Anzaki F, Izumi S
Tokai J Exp Clin Med 2001 Jul;26(2):45-61. PMID: 11806442
Thalamic aphasia syndrome.
Ozeren A, Sarica Y, Efe R
Acta Neurol Belg 1994;94(3):205-8. PMID: 7526590

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