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Micrometastasis

MedGen UID:
307751
•Concept ID:
C1513276
•
Finding
Synonyms: Micrometastase, Neoplasm; Micrometastases; Micrometastases, Neoplasm; Micrometastasis, Neoplasm; Neoplasm Micrometastase; Neoplasm Micrometastases; Neoplasm Micrometastasis

Definition

Metastasis in the form of small clusters of malignant cells identifiable only under the microscope. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicrometastasis

Professional guidelines

PubMed

Nanotechnology for colorectal cancer detection and treatment.
Gogoi P, Kaur G, Singh NK
World J Gastroenterol 2022 Dec 14;28(46):6497-6511. doi: 10.3748/wjg.v28.i46.6497. PMID: 36569271Free PMC Article
Personalized Peptide-based Vaccination for Treatment of Colorectal Cancer: Rational and Progress.
Parizadeh SM, Jafarzadeh-Esfehani R, Ghandehari M, Rezaei-Kalat A, Parizadeh SMR, Javanbakht A, Hassanian SM, Ferns GA, Khazaei M, Avan A
Curr Drug Targets 2019;20(14):1486-1495. doi: 10.2174/1389450120666190619121658. PMID: 31237205
The Diagnosis and Treatment of Penile Cancer.
Hakenberg OW, Dräger DL, Erbersdobler A, Naumann CM, Jünemann KP, Protzel C
Dtsch Arztebl Int 2018 Sep 28;115(39):646-652. doi: 10.3238/arztebl.2018.0646. PMID: 30375327Free PMC Article

Recent clinical studies

Etiology

Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567
Anesthetic care influences long-term outcomes: What is the evidence?
Ramirez MF, Cata JP
Best Pract Res Clin Anaesthesiol 2021 Dec;35(4):491-505. Epub 2021 Feb 3 doi: 10.1016/j.bpa.2021.01.004. PMID: 34801212
Trends in Neoadjuvant Approaches in Pancreatic Cancer.
Du L, Wang-Gillam A
J Natl Compr Canc Netw 2017 Aug;15(8):1070-1077. doi: 10.6004/jnccn.2017.0134. PMID: 28784867
Lymph node micrometastasis in gallbladder cancer.
Shah SH, Gupta N, Gupta G, Mehta A, Singh S
Indian J Gastroenterol 2017 Jul;36(4):268-274. Epub 2017 Aug 7 doi: 10.1007/s12664-017-0775-z. PMID: 28782079
Aberrant metastatic behavior and particular features of early gastric cancer.
Gurzu S, Jung I, Kadar Z
APMIS 2015 Dec;123(12):999-1006. doi: 10.1111/apm.12469. PMID: 26547366

Diagnosis

Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567
Optical innovations in surgery.
de Boer E, Harlaar NJ, Taruttis A, Nagengast WB, Rosenthal EL, Ntziachristos V, van Dam GM
Br J Surg 2015 Jan;102(2):e56-72. doi: 10.1002/bjs.9713. PMID: 25627136
Sentinel lymph node biopsy in the management of gynecologic cancer.
Cibula D, Oonk MH, Abu-Rustum NR
Curr Opin Obstet Gynecol 2015 Feb;27(1):66-72. doi: 10.1097/GCO.0000000000000133. PMID: 25502426
Micrometastasis in gastric cancer.
Zhang ZY, Ge HY
Cancer Lett 2013 Aug 9;336(1):34-45. Epub 2013 Apr 23 doi: 10.1016/j.canlet.2013.04.021. PMID: 23624301
MRI of cerebral microhemorrhages.
Blitstein MK, Tung GA
AJR Am J Roentgenol 2007 Sep;189(3):720-5. doi: 10.2214/AJR.07.2249. PMID: 17715122

Therapy

A comprehensive review of pancreatic cancer and its therapeutic challenges.
Jiang S, Fagman JB, Ma Y, Liu J, Vihav C, Engstrom C, Liu B, Chen C
Aging (Albany NY) 2022 Sep 28;14(18):7635-7649. doi: 10.18632/aging.204310. PMID: 36173644Free PMC Article
Total Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer: A Systematic Review and Meta-analysis.
Kasi A, Abbasi S, Handa S, Al-Rajabi R, Saeed A, Baranda J, Sun W
JAMA Netw Open 2020 Dec 1;3(12):e2030097. doi: 10.1001/jamanetworkopen.2020.30097. PMID: 33326026Free PMC Article
Paget's "Seed and Soil" Theory of Cancer Metastasis: An Idea Whose Time has Come.
Akhtar M, Haider A, Rashid S, Al-Nabet ADMH
Adv Anat Pathol 2019 Jan;26(1):69-74. doi: 10.1097/PAP.0000000000000219. PMID: 30339548
Axillary dissection versus no axillary dissection in patients with breast cancer and sentinel-node micrometastases (IBCSG 23-01): 10-year follow-up of a randomised, controlled phase 3 trial.
Galimberti V, Cole BF, Viale G, Veronesi P, Vicini E, Intra M, Mazzarol G, Massarut S, Zgajnar J, Taffurelli M, Littlejohn D, Knauer M, Tondini C, Di Leo A, Colleoni M, Regan MM, Coates AS, Gelber RD, Goldhirsch A; International Breast Cancer Study Group Trial 23-01
Lancet Oncol 2018 Oct;19(10):1385-1393. Epub 2018 Sep 5 doi: 10.1016/S1470-2045(18)30380-2. PMID: 30196031
Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial.
Galimberti V, Cole BF, Zurrida S, Viale G, Luini A, Veronesi P, Baratella P, Chifu C, Sargenti M, Intra M, Gentilini O, Mastropasqua MG, Mazzarol G, Massarut S, Garbay JR, Zgajnar J, Galatius H, Recalcati A, Littlejohn D, Bamert M, Colleoni M, Price KN, Regan MM, Goldhirsch A, Coates AS, Gelber RD, Veronesi U; International Breast Cancer Study Group Trial 23-01 investigators
Lancet Oncol 2013 Apr;14(4):297-305. Epub 2013 Mar 11 doi: 10.1016/S1470-2045(13)70035-4. PMID: 23491275Free PMC Article

Prognosis

Lymph Node Mapping for Tumor Micrometastasis.
Han M, Kang R, Zhang C
ACS Biomater Sci Eng 2022 Jun 13;8(6):2307-2320. Epub 2022 May 12 doi: 10.1021/acsbiomaterials.2c00111. PMID: 35548973
Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567
Lymph Node Metastasis in Colorectal Cancer.
Jin M, Frankel WL
Surg Oncol Clin N Am 2018 Apr;27(2):401-412. Epub 2017 Dec 15 doi: 10.1016/j.soc.2017.11.011. PMID: 29496097
Micrometastasis in gastric cancer.
Zhang ZY, Ge HY
Cancer Lett 2013 Aug 9;336(1):34-45. Epub 2013 Apr 23 doi: 10.1016/j.canlet.2013.04.021. PMID: 23624301
Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial.
Galimberti V, Cole BF, Zurrida S, Viale G, Luini A, Veronesi P, Baratella P, Chifu C, Sargenti M, Intra M, Gentilini O, Mastropasqua MG, Mazzarol G, Massarut S, Garbay JR, Zgajnar J, Galatius H, Recalcati A, Littlejohn D, Bamert M, Colleoni M, Price KN, Regan MM, Goldhirsch A, Coates AS, Gelber RD, Veronesi U; International Breast Cancer Study Group Trial 23-01 investigators
Lancet Oncol 2013 Apr;14(4):297-305. Epub 2013 Mar 11 doi: 10.1016/S1470-2045(13)70035-4. PMID: 23491275Free PMC Article

Clinical prediction guides

Lymph node micrometastasis in non-small cell lung cancer.
Sun J, Wu S, Jin Z, Ren S, Cho WC, Zhu C, Shen J
Biomed Pharmacother 2022 May;149:112817. Epub 2022 Mar 15 doi: 10.1016/j.biopha.2022.112817. PMID: 35303567
Lymph Node Metastasis in Colorectal Cancer.
Jin M, Frankel WL
Surg Oncol Clin N Am 2018 Apr;27(2):401-412. Epub 2017 Dec 15 doi: 10.1016/j.soc.2017.11.011. PMID: 29496097
Therapeutic Advances in Localized Pancreatic Cancer.
Tsai S, Evans DB
JAMA Surg 2016 Sep 1;151(9):862-8. doi: 10.1001/jamasurg.2016.1113. PMID: 27276001
Early stage colon cancer.
Freeman HJ
World J Gastroenterol 2013 Dec 14;19(46):8468-73. doi: 10.3748/wjg.v19.i46.8468. PMID: 24379564Free PMC Article
Micrometastasis in gastric cancer.
Zhang ZY, Ge HY
Cancer Lett 2013 Aug 9;336(1):34-45. Epub 2013 Apr 23 doi: 10.1016/j.canlet.2013.04.021. PMID: 23624301

Recent systematic reviews

Post-diagnostic statin use and its association with cancer recurrence and mortality in breast cancer patients: a systematic review and meta-analysis.
Jaiswal V, Agrawal V, Ang SP, Saleeb M, Ishak A, Hameed M, Rajak K, Kalra K, Jaiswal A
Eur Heart J Cardiovasc Pharmacother 2023 Dec 14;9(8):731-740. doi: 10.1093/ehjcvp/pvad057. PMID: 37562940
Advances in the diagnosis and prognosis of minimal residual lesions of breast cancer.
Cui S, Liu W, Wang W, Miao K, Guan X
Pathol Res Pract 2023 May;245:154428. Epub 2023 Mar 28 doi: 10.1016/j.prp.2023.154428. PMID: 37028109
Systematic review and meta-analysis of the prognostic impact of lymph node micrometastasis and isolated tumour cells in patients with stage I-IIIA non-small cell lung cancer.
Hüyük M, Fiocco M, Postmus PE, Cohen D, von der Thüsen JH
Histopathology 2023 Apr;82(5):650-663. Epub 2022 Nov 9 doi: 10.1111/his.14831. PMID: 36282087
Total Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer: A Systematic Review and Meta-analysis.
Kasi A, Abbasi S, Handa S, Al-Rajabi R, Saeed A, Baranda J, Sun W
JAMA Netw Open 2020 Dec 1;3(12):e2030097. doi: 10.1001/jamanetworkopen.2020.30097. PMID: 33326026Free PMC Article
Systematic review of the clinical significance of lymph node micrometastases of pancreatic adenocarcinoma following surgical resection.
Choi SB, Han HJ, Park P, Kim WB, Song TJ, Choi SY
Pancreatology 2017 May-Jun;17(3):342-349. Epub 2017 Mar 18 doi: 10.1016/j.pan.2017.03.008. PMID: 28336226

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