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Cervical lymphoepithelioma-like carcinoma

MedGen UID:
308946
•Concept ID:
C1516418
•
Neoplastic Process
Synonyms: Cervical Lymphoepithelioma-Like Carcinoma; cervical lymphoepithelioma-like carcinoma
 
Monarch Initiative: MONDO:0004296

Definition

A variant of cervical squamous cell carcinoma characterized by the presence of islands of cells with uniform, vesicular nuclei and prominent nucleoli and a dense lymphocytic infiltrate. [from NCI]

Professional guidelines

PubMed

Clinical characteristics, prognostic factors, and treatment modalities for head and neck lymphoepithelioma-like carcinoma: A real-world study from southern China.
Liu ZQ, Feng YF, Xiao Y, Zhang XM, Li JB, Xie FY, Mao YP
Radiother Oncol 2023 Oct;187:109814. Epub 2023 Jul 20 doi: 10.1016/j.radonc.2023.109814. PMID: 37480992
A multicenter analysis of genomic profiles and PD-L1 expression of primary lymphoepithelioma-like carcinoma of the lung.
Xie Z, Liu L, Lin X, Xie X, Gu Y, Liu M, Zhang J, Ouyang M, Lizaso A, Zhang H, Feng W, Li B, Han-Zhang H, Chen S, Li S, Zhong N, Liu H, Zhou C, Qin Y
Mod Pathol 2020 Apr;33(4):626-638. Epub 2019 Oct 28 doi: 10.1038/s41379-019-0391-9. PMID: 31659278Free PMC Article
Lymphoepithelioma-like carcinoma of salivary glands: treatment results and failure patterns.
Hsiung CY, Huang CC, Wang CJ, Huang EY, Huang HY
Br J Radiol 2006 Jan;79(937):52-5. doi: 10.1259/bjr/17905092. PMID: 16421405

Recent clinical studies

Etiology

Expression Profiles and Prognostic Value of Multiple Inhibitory Checkpoints in Head and Neck Lymphoepithelioma-Like Carcinoma.
Zou WQ, Luo WJ, Feng YF, Liu F, Liang SB, Fang XL, Liang YL, Liu N, Wang YQ, Mao YP
Front Immunol 2022;13:818411. Epub 2022 Jan 24 doi: 10.3389/fimmu.2022.818411. PMID: 35140722Free PMC Article
Demographics, clinical features, and prognosis of rare lymphoepithelioma-like carcinoma across different anatomic sites.
Zhai X, Liu J, Lu D, Zhou Q
J Egypt Natl Canc Inst 2022 Feb 1;34(1):5. doi: 10.1186/s43046-021-00103-2. PMID: 35102459
Epidemiology and prognosis of lymphoepithelioma-like carcinoma: a comprehensive analysis of surveillance, epidemiology, and end results (SEER) database.
Qi WX, Zhao S, Chen J
Int J Clin Oncol 2021 Jul;26(7):1203-1211. Epub 2021 Apr 12 doi: 10.1007/s10147-021-01921-z. PMID: 33844112
Single-Center Study of Lymphoepithelioma-Like Carcinoma of Uterine Cervix over a 10-Year Period.
Yordanov A, Karamanliev M, Karcheva M, Konsoulova A, Vasileva-Slaveva M, Strashilov S
Medicina (Kaunas) 2019 Dec 9;55(12) doi: 10.3390/medicina55120780. PMID: 31835382Free PMC Article
Primary lymphoepithelioma-like carcinoma of salivary gland: sixty-nine cases with long-term follow-up.
Ma H, Lin Y, Wang L, Rao H, Xu G, He Y, Liang Y
Head Neck 2014 Sep;36(9):1305-12. Epub 2014 Jan 16 doi: 10.1002/hed.23450. PMID: 23966284

Diagnosis

Demographics, clinical features, and prognosis of rare lymphoepithelioma-like carcinoma across different anatomic sites.
Zhai X, Liu J, Lu D, Zhou Q
J Egypt Natl Canc Inst 2022 Feb 1;34(1):5. doi: 10.1186/s43046-021-00103-2. PMID: 35102459
Lymphoepithelioma-like carcinoma of uterine cervix: Preoperative diagnosis and course in three cases.
Ikeda A, Abiko K, Emoto I, Ujita M, Takao Y, Konishi I
J Obstet Gynaecol Res 2021 Nov;47(11):4093-4100. Epub 2021 Aug 10 doi: 10.1111/jog.14969. PMID: 34378271
Epidemiology and prognosis of lymphoepithelioma-like carcinoma: a comprehensive analysis of surveillance, epidemiology, and end results (SEER) database.
Qi WX, Zhao S, Chen J
Int J Clin Oncol 2021 Jul;26(7):1203-1211. Epub 2021 Apr 12 doi: 10.1007/s10147-021-01921-z. PMID: 33844112
Lymphoepithelioma-like carcinoma of cervix: Cytological Features on Conventional Cervical Smear.
Rathore R, Arora VK, Singh B
Diagn Cytopathol 2017 Mar;45(3):239-242. Epub 2016 Nov 7 doi: 10.1002/dc.23629. PMID: 28211234
Lymphoepithelioma-like carcinoma of head and neck skin: a systematic analysis of 11 cases and review of literature.
Welch PQ, Williams SB, Foss RD, Tomaszewski MM, Gupta A, Ojha J
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 Jan;111(1):78-86. Epub 2010 Oct 16 doi: 10.1016/j.tripleo.2010.05.075. PMID: 20952226

Therapy

A Phase II Trial of Pembrolizumab and Vorinostat in Recurrent Metastatic Head and Neck Squamous Cell Carcinomas and Salivary Gland Cancer.
Rodriguez CP, Wu QV, Voutsinas J, Fromm JR, Jiang X, Pillarisetty VG, Lee SM, Santana-Davila R, Goulart B, Baik CS, Chow LQM, Eaton K, Martins R
Clin Cancer Res 2020 Feb 15;26(4):837-845. Epub 2019 Dec 3 doi: 10.1158/1078-0432.CCR-19-2214. PMID: 31796519
A multicenter analysis of genomic profiles and PD-L1 expression of primary lymphoepithelioma-like carcinoma of the lung.
Xie Z, Liu L, Lin X, Xie X, Gu Y, Liu M, Zhang J, Ouyang M, Lizaso A, Zhang H, Feng W, Li B, Han-Zhang H, Chen S, Li S, Zhong N, Liu H, Zhou C, Qin Y
Mod Pathol 2020 Apr;33(4):626-638. Epub 2019 Oct 28 doi: 10.1038/s41379-019-0391-9. PMID: 31659278Free PMC Article
Epstein-barr virus-associated lymphoepithelioma-like carcinoma of mandible.
Shet T, Arora B, Laskar S, Basak R, Kane S, Kurkure P
Pediatr Dev Pathol 2009 Mar-Apr;12(2):152-5. Epub 2008 May 5 doi: 10.2350/07-12-0395.1. PMID: 18457481
Lymphoepithelioma-like carcinoma of the parotid gland in a patient with rheumatoid arthritis.
Mok MY, Shek WH, Wong RW
Clin Exp Rheumatol 2002 Nov-Dec;20(6):848-50. PMID: 12508780

Prognosis

Demographics, clinical features, and prognosis of rare lymphoepithelioma-like carcinoma across different anatomic sites.
Zhai X, Liu J, Lu D, Zhou Q
J Egypt Natl Canc Inst 2022 Feb 1;34(1):5. doi: 10.1186/s43046-021-00103-2. PMID: 35102459
Lymphoepithelioma-like carcinoma of uterine cervix: Preoperative diagnosis and course in three cases.
Ikeda A, Abiko K, Emoto I, Ujita M, Takao Y, Konishi I
J Obstet Gynaecol Res 2021 Nov;47(11):4093-4100. Epub 2021 Aug 10 doi: 10.1111/jog.14969. PMID: 34378271
Epidemiology and prognosis of lymphoepithelioma-like carcinoma: a comprehensive analysis of surveillance, epidemiology, and end results (SEER) database.
Qi WX, Zhao S, Chen J
Int J Clin Oncol 2021 Jul;26(7):1203-1211. Epub 2021 Apr 12 doi: 10.1007/s10147-021-01921-z. PMID: 33844112
Lymphoepithelioma-like carcinoma of cervix: Cytological Features on Conventional Cervical Smear.
Rathore R, Arora VK, Singh B
Diagn Cytopathol 2017 Mar;45(3):239-242. Epub 2016 Nov 7 doi: 10.1002/dc.23629. PMID: 28211234
Non-nasopharyngeal head and neck lymphoepithelioma-like carcinoma in the United States: A population-based study.
Chan JY, Wong EW, Ng SK, Vlantis AC
Head Neck 2016 Apr;38 Suppl 1:E1294-300. Epub 2015 Aug 28 doi: 10.1002/hed.24215. PMID: 26316257

Clinical prediction guides

Clinical characteristics, prognostic factors, and treatment modalities for head and neck lymphoepithelioma-like carcinoma: A real-world study from southern China.
Liu ZQ, Feng YF, Xiao Y, Zhang XM, Li JB, Xie FY, Mao YP
Radiother Oncol 2023 Oct;187:109814. Epub 2023 Jul 20 doi: 10.1016/j.radonc.2023.109814. PMID: 37480992
Expression Profiles and Prognostic Value of Multiple Inhibitory Checkpoints in Head and Neck Lymphoepithelioma-Like Carcinoma.
Zou WQ, Luo WJ, Feng YF, Liu F, Liang SB, Fang XL, Liang YL, Liu N, Wang YQ, Mao YP
Front Immunol 2022;13:818411. Epub 2022 Jan 24 doi: 10.3389/fimmu.2022.818411. PMID: 35140722Free PMC Article
Demographics, clinical features, and prognosis of rare lymphoepithelioma-like carcinoma across different anatomic sites.
Zhai X, Liu J, Lu D, Zhou Q
J Egypt Natl Canc Inst 2022 Feb 1;34(1):5. doi: 10.1186/s43046-021-00103-2. PMID: 35102459
Epidemiology and prognosis of lymphoepithelioma-like carcinoma: a comprehensive analysis of surveillance, epidemiology, and end results (SEER) database.
Qi WX, Zhao S, Chen J
Int J Clin Oncol 2021 Jul;26(7):1203-1211. Epub 2021 Apr 12 doi: 10.1007/s10147-021-01921-z. PMID: 33844112
EBV-associated lymphoepithelioma-like thyroid carcinoma with favorable outcome: case report with cytopathologic and histopathologic study.
Liu CY, Huang SH
Diagn Pathol 2018 Jun 9;13(1):39. doi: 10.1186/s13000-018-0713-0. PMID: 29885658Free PMC Article

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